Zika virus infection in infants can cause ocular abnormalities. This case series examined the eyes of 29 Brazilian infants with microcephaly presumed to be caused by congenital Zika virus infection. Ocular examinations found abnormalities in 17 eyes of 10 infants, most commonly chorioretinal lesions near the macula or optic disc. Examples of lesions included pigmentary mottling, atrophic scars, and enlarged cup-to-disc ratios. The retinal findings were similar to those seen in other congenital viral infections like West Nile virus. Further research is needed to confirm Zika virus as the cause using serological testing, and ophthalmologists should be aware of the potential for ocular involvement in congenital