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Zika Virus Infection & the Eye
Zika Virus Infection & the Eye
Ocular findings in infants with microcephaly
associated with presumed Zika Virus
congenital infection
Salvador, Brazil
Bruno de Paula Freitas, MD; João Rafael de Oliveira Dias, MD;
Juliana Prazeres, MD; Gielson Almeida Sacramento, BS; Albert
Icksang Ko, MD; Maurício Maia, MD, PhD; Rubens Belfort Jr, MD,
PhD
Department of Ophthalmology, Hospital Geral Roberto Santos, Salvador, Brazil
Vision Institute, Department of Ophthalmology, Paulista Medical School, Federal University of São Paulo, São Paulo, Brazil
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Brazil
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut
JAMA Ophthalmol. Published online February 09, 2016
Design
Case Series at Tertiary Hospital
29 infants with microcephaly and presumed congenital
Zika
2015: 1st Dec - 25 th Dec
Interventions
Wide field digital imaging
DDx of infections ruled out through serological and clinical
examinations
Design and Interventions
23/29 mothers suspected
Zika during pregnancy.
Trimester: 18 = 1st; 4 = 2nd;
1 = 3rd.
58 eyes of 29 children
17 eyes of 10 children =
Ocular Abnormalities
7/10 = Bilateral
Results
Examples
2 month old infant
RE: granular,
pigmentary mottling in
the macular.
LE: Chorioretinal
lobulated atrophic
lesion and slight
pigmentary mottling
1 month old infant
RE & LE: paramacular supertemporal round chorioretinal atrophy
surrounded by a hyper pigmented halo and hyper pigmented
mottling
I month old infant
RE: enlarged cup-disc ratio
and macular pigmentary
mottling
LE: roundish macular
chorioretinal atrophic lesion
with a hyper pigmented halo
and pigmentary mottling, as
well as an enlarged cup-disc
ration
1 month old infant
RE & LE: supertemporal perimacular chorioretinal scar
with perilesional pigmentary mottling
20 day old infant
RE: optic disc hypoplasia,
peripapillary nasal atrophy
and excavated nasal round
lesion with a hyper hyper
pigmented halo, with a
colobomatous-like aspect
LE: optic disc hypoplasia,
peripapillary nasal atrophy,
and a retinal nasal lesion
with a similar pattern
Findings in infants with microcephaly &
presumed Zika Virus congenital
infection
Discussion
Major health problem
Retinal lesions
Posterior pole
Optic disc
Screen infected mothers
without microcephalic
infants?
Limitations
1 hospital
General findings
Lack of prior research
‘Presumed Zika’
Conclusions
Retinal lesions similar
to West Nile virus
Need serological tests
to confirm findings
Micro = routine exam
Ophthalmologists
should be aware…
Article Link:http://archopht.jamanetwork.com/article.aspx?articleid=249189
6

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Zika Virus and the Eye

  • 3. Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection Salvador, Brazil Bruno de Paula Freitas, MD; João Rafael de Oliveira Dias, MD; Juliana Prazeres, MD; Gielson Almeida Sacramento, BS; Albert Icksang Ko, MD; Maurício Maia, MD, PhD; Rubens Belfort Jr, MD, PhD Department of Ophthalmology, Hospital Geral Roberto Santos, Salvador, Brazil Vision Institute, Department of Ophthalmology, Paulista Medical School, Federal University of São Paulo, São Paulo, Brazil Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador, Brazil Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut JAMA Ophthalmol. Published online February 09, 2016
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Design Case Series at Tertiary Hospital 29 infants with microcephaly and presumed congenital Zika 2015: 1st Dec - 25 th Dec Interventions Wide field digital imaging DDx of infections ruled out through serological and clinical examinations Design and Interventions
  • 9. 23/29 mothers suspected Zika during pregnancy. Trimester: 18 = 1st; 4 = 2nd; 1 = 3rd. 58 eyes of 29 children 17 eyes of 10 children = Ocular Abnormalities 7/10 = Bilateral Results
  • 11. 2 month old infant RE: granular, pigmentary mottling in the macular. LE: Chorioretinal lobulated atrophic lesion and slight pigmentary mottling
  • 12. 1 month old infant RE & LE: paramacular supertemporal round chorioretinal atrophy surrounded by a hyper pigmented halo and hyper pigmented mottling
  • 13. I month old infant RE: enlarged cup-disc ratio and macular pigmentary mottling LE: roundish macular chorioretinal atrophic lesion with a hyper pigmented halo and pigmentary mottling, as well as an enlarged cup-disc ration
  • 14. 1 month old infant RE & LE: supertemporal perimacular chorioretinal scar with perilesional pigmentary mottling
  • 15. 20 day old infant RE: optic disc hypoplasia, peripapillary nasal atrophy and excavated nasal round lesion with a hyper hyper pigmented halo, with a colobomatous-like aspect LE: optic disc hypoplasia, peripapillary nasal atrophy, and a retinal nasal lesion with a similar pattern
  • 16. Findings in infants with microcephaly & presumed Zika Virus congenital infection
  • 17. Discussion Major health problem Retinal lesions Posterior pole Optic disc Screen infected mothers without microcephalic infants?
  • 18. Limitations 1 hospital General findings Lack of prior research ‘Presumed Zika’
  • 19. Conclusions Retinal lesions similar to West Nile virus Need serological tests to confirm findings Micro = routine exam Ophthalmologists should be aware…