This document summarizes the education and professional experience of Ykomuro. It lists that he received a PhD from Case Western Reserve University in 2015, with a dissertation on altered adult neurogenesis in a mouse tauopathy model. He is currently a postdoctoral fellow at Radboud University, studying developmental transcriptomics in the mouse somatosensory cortex. It also provides brief summaries of his previous positions, including graduate work on a mouse Alzheimer's disease model and neurogenesis, and research on proteins associated with neuronal migration and development.

1. Department of Neurophysiology, Radboud University
Heyendaalseweg 135, 6525 AJ Nijmegen, Netherlands
Email: ykomuro@post.harvard.edu
Education
Case Western Reserve University Cleveland, Ohio, USA
PhD, Cleveland Clinic Department of Molecular Medicine 2015
Dissertation: “Altered adult neurogenesis in a mouse model of human tauopathy”
Harvard University Cambridge, Massachusetts, USA
BA, Biology 2008
Professional Experience
Radboud University Nijmegen, Netherlands
Postdoctoral Fellow, Department of Neurophysiology 2015 - Present
Project: Developmental transcriptomics in the mouse somatosensory cortex
Supervisor: Tansu Celikel, PhD
Cleveland Clinic/Case Western Reserve University Cleveland, Ohio, USA
Graduate Student, Department of Neurosciences 2009 - 2015
Project: Behavioral, cellular, and molecular phenotyping of a mouse model of Alzheimer’s disease in
the context of adult neurogenesis
Thesis Advisor: Bruce Lamb, PhD
University of North Carolina Chapel Hill Chapel Hill, North Carolina, USA
Research Technician, Neuroscience Center 2008 - 2009
Work: Molecular and cellular manipulation of adenomatous polyposis coli (APC) in mice to investigate
developmental neuronal migration and differentiation of radial glia
Supervisor: Eva Anton, PhD
RIKEN Wako, Japan
Research Intern, Brain Science Institute 2006
Project: Molecular investigation of proteins associated with calcium-dependent secretion activator
(CADPS) in mice in the context of central nervous system development, with a focus on autism
Supervisor: Teiichi Furuichi, PhD
Publications
Articles
Komuro Y, Xu G, Bhaskar K, Lamb BT. “Human tau expression reduces adult neurogenesis in a mouse
model of tauopathy”. Neurobiol Aging, 2015; 36(6), 2034-42. PMID: 25863528
Komuro Y, Galas L, Lebon A, Raoult E, Fahrion JK, Tilot A, Kumada T, Ohno N, Vaudry D, Komuro H. "The
role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and
pathological conditions". Dev Neurobiol, 2015; 75(4), 369-87. PMID: 25066767
Li Y*, Komuro Y*, Fahrion JK, Hu T, Ohno N, Fenner KB, Wooton J, Raoult E, Galas L, Vaudry D, Komuro H.
"Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling".
Proc Natl Acad Sci, 2012; 109(7), 2630-5. PMID: 22308338. PMCID: PMC3289354
Fahrion JK*, Komuro Y*, Li Y, Ohno N, Littner Y, Raoult E, Galas L, Vaudry D, Komuro H. "Rescue of
neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+
spike frequency". Proc Natl Acad Sci, 2012; 109(13), 5057-62. PMID: 22411806. PMCID: PMC3323999
Kumada T, Komuro Y, Li Y, Hu T, Wang Z, Littner Y, Komuro H. "Inhibition of cerebellar granule cell
turning by alcohol". Journal of Neuroscience, 2010; 170(4), 1328-44. PMID: 20691765. PMCID:
PMC2949482
Yokota Y, Kim WY, Chen Y, Wang X, Komuro Y, Snider W, and Anton ES. "The Adenomatous Polyposis
Coli (APC) protein is an essential regulator of radial glial polarity and construction of the cerebral
cortex". Neuron, 2009; 15(61), 42-56. PMID: 19146812. PMCID: PMC2804250

2. Book Chapters
Komuro Y, Kumada T, Ohno N, Foote KD, Komuro H. "Migration in the Cerebellum". Rakic P, Rubenstein J
(editors), Comprehensive Developmental Neuroscience, Elsevier, 2012
Fahrion JK, Komuro Y, Ohno N, Littner Y, Nelson C, Kumada T, Lamb B, Komuro H. "Cerebellar
Patterning". Rakic P, Rubenstein J (editors), Comprehensive Developmental Neuroscience, Elsevier,
2012
Komuro Y, Fahrion JK, Foote KD, Fenner KB, Kumada T, Ohno N, Komuro H. "Granule cell migration and
differentiation". Manto M, Gruol D, Schmahmann J, Koibuchi N, Rossi F (editors), Handbook of the
Cerebellum and Cerebellar Disorders, Springer, 2011
Kumada T, Komuro Y, Li Y, Littner Y, Komuro H. "Neuronal cell migration in fetal alcohol syndrome".
Preedy VR, Watson RR, Martin CR (editors), The International Handbook of Behavior, Food and
Nutrition, Springer, 2011
Research Funding
Molecular Medicine T32-provided fellowship 2012 - 2013
Department of Neuroscience, Cleveland Clinic
Title: The role of pathological tau in mediating adult neurogenesis in the mammalian CNS
Amount: $25,000
Teaching Experience
Radboud University
Lecturer for “Trends in Medical Biology II”, Radboud University, Fall 2016
Lecturer for “Trends in Medical Biology I”, Radboud University, Fall 2016
Lecturer for “Cognitive Neuroscience”, Radboud University, Summer 2016
Lecturer for “Introduction to Neuroscience”, Radboud University, Fall 2015
Case Western Reserve University
Teaching Assistant, Biostatistics, Case Western Reserve University, 05/2012 - 08/2012
Curriculum Committee, Molecular Medicine PhD program, 2011-2013
Honors and Awards
Cleveland Clinic
Graduate Student Award, Lerner Research Institute, Cleveland Clinic, 05/2014
Graduate Student Award, Department of Neurology, Cleveland Clinic, 05/2012
Graduate Student Award, Department of Molecular Medicine, Cleveland Clinic, 04/2012
Harvard University
Harvard Reischauer Institute Research Grant, Harvard Reischauer Institute, 05/2007
External Scientific Presentations
Radboud University
Komuro, Y., Lamb, B.T. “Human tau expression reduces adult neurogenesis in a mouse model of
tauopathy” Federation of European Neuroscience Societies Forum 2016, 7/2016 (Poster)
Cleveland Clinic/Case Western Reserve University
Komuro, Y., Lamb, B.T. "Reduced adult neurogenesis is an early and robust alteration observed in a
mouse model of tauopathy", Society for Neuroscience 2013, 11/2013 (Poster)
Komuro, Y., Lamb, B.T. "Expression of human tau results in reduced neurogenesis in the adult mouse
brain", Society for Neuroscience, 10/2012 (Poster)
Komuro, Y., Lamb, B.T. "Overexpression of human tau results in reduced neurogenesis in the adult
mouse brain", Society for Neuroscience, 11/2011 (Poster)
Fahrion, J., Komuro, Y., Foote, K., Komuro, H. "Control of neuronal cell migration in vivo by
illumination-dependent IGF-1 activity ", Society for Neuroscience, 11/2011 (Poster)
Komuro, Y., Foote, K., Komuro, H. "The effects of methylmercury on cerebellar granule cell migration",

3. Society for Neuroscience, 11/2010 (Poster)
Professional Membership
Society for Neuroscience, 07/2009 - present
Dutch Neuroscience Federation, 01/2016 - present
Languages
English (native)
Japanese (native)
Spanish (working knowledge)