This document outlines a workshop on applying public health guidelines in practice. Participants were split into three groups to discuss rationalization, challenges, and implementation. For rationalization, groups discussed streamlining processes like periodic safety update reports and development safety update reports using modular structures. Challenges included post-authorization safety studies, communications, and other obstacles. For implementation, groups considered individual organization plans covering training, internal and external communication, information technology, and risk management before sharing with the larger group.