The document discusses nephrotic syndrome in children. It provides details on the child's presentation, including generalized edema, dull appearance, and skin cracks. It also covers the disease process of nephrotic syndrome including types, etiology, pathophysiology, diagnosis, and potential complications like renal failure or heart disease. Laboratory tests showed low albumin and elevated globulin levels, with urine tests indicating protein. The child was diagnosed with minimal change nephrotic syndrome based on biopsy results.
The document discusses infertility, defining it as the failure to conceive within one year of regular unprotected intercourse. It outlines the main causes of infertility being faults in the male or female, or combined factors. Diagnostic procedures and treatments are described for both males and females, including medical management using drugs and surgical procedures. The summary emphasizes that infertility is a significant problem worldwide with equal responsibility of male and female factors, and treatment depends on the identified cause.
The document discusses infertility, defining it as the failure to conceive within one year of regular unprotected intercourse. It outlines the main causes of infertility being faults in males, females or combined factors. These include issues with sperm production, hormone imbalances or problems with the reproductive organs. Treatment involves medical management like fertility drugs or surgery to repair damaged organs. Diagnosis involves examining both partners' medical history and testing hormone levels and semen quality.
This document summarizes growth and development from conception through adulthood. It discusses the stages of growth, factors affecting growth like genetics, hormones, nutrition and environment. It also covers the assessment of physical growth using growth charts, common growth disorders like short stature and failure to thrive, and their management. Key points covered include the stages of prenatal, infancy, childhood and adolescent growth, and how different tissues grow at different rates during development.
Living as Well as you Can for As Long as you CanBCCPA
Sit down buffet breakfast featuring keynote speaker Dr. Romayne Gallagher, Head Division of Palliative Care, Department of Family & Community Medicine, Providence Health Care; Clinical Professor, Division of Palliative Care, UBC
Family planning community medicine lectureAmit Bhondve
Family planning aims to space and limit births through contraceptive methods. It provides health benefits by reducing unwanted pregnancies, closely spaced births, and high-risk pregnancies. The document discusses various contraceptive methods including barrier methods like condoms and diaphragms, hormonal methods like pills, and long-acting reversible methods like IUDs. Intrauterine devices are effective and reversible but can have side effects like expulsion, perforation, bleeding, and infection in some cases. Proper counseling and follow up is important when using family planning methods.
This document provides information on neuro-muscular dysfunction in children, specifically discussing spina bifida, cerebral palsy, and muscular dystrophy. It describes the causes, signs and symptoms, types, and treatment options for each condition. Spina bifida is caused by incomplete development of the spine during pregnancy and ranges in severity. Cerebral palsy is caused by abnormal brain development and causes loss of muscle control. Muscular dystrophy is a genetic disorder that causes progressive muscle degeneration and weakness.
The document provides information on cognition and delirium. It defines delirium as an acute organic disorder characterized by impaired consciousness, disorientation, and disturbed perception and restlessness. It describes 5 subtypes of delirium based on etiology in DSM-V. The history section outlines early references to delirium in Hippocrates and developments over centuries in understanding and defining delirium. Risk factors, common etiologies, clinical features, epidemiology, pathophysiology involving several neurotransmitters, and theories of delirium are discussed.
The document discusses nephrotic syndrome in children. It provides details on the child's presentation, including generalized edema, dull appearance, and skin cracks. It also covers the disease process of nephrotic syndrome including types, etiology, pathophysiology, diagnosis, and potential complications like renal failure or heart disease. Laboratory tests showed low albumin and elevated globulin levels, with urine tests indicating protein. The child was diagnosed with minimal change nephrotic syndrome based on biopsy results.
The document discusses infertility, defining it as the failure to conceive within one year of regular unprotected intercourse. It outlines the main causes of infertility being faults in the male or female, or combined factors. Diagnostic procedures and treatments are described for both males and females, including medical management using drugs and surgical procedures. The summary emphasizes that infertility is a significant problem worldwide with equal responsibility of male and female factors, and treatment depends on the identified cause.
The document discusses infertility, defining it as the failure to conceive within one year of regular unprotected intercourse. It outlines the main causes of infertility being faults in males, females or combined factors. These include issues with sperm production, hormone imbalances or problems with the reproductive organs. Treatment involves medical management like fertility drugs or surgery to repair damaged organs. Diagnosis involves examining both partners' medical history and testing hormone levels and semen quality.
This document summarizes growth and development from conception through adulthood. It discusses the stages of growth, factors affecting growth like genetics, hormones, nutrition and environment. It also covers the assessment of physical growth using growth charts, common growth disorders like short stature and failure to thrive, and their management. Key points covered include the stages of prenatal, infancy, childhood and adolescent growth, and how different tissues grow at different rates during development.
Living as Well as you Can for As Long as you CanBCCPA
Sit down buffet breakfast featuring keynote speaker Dr. Romayne Gallagher, Head Division of Palliative Care, Department of Family & Community Medicine, Providence Health Care; Clinical Professor, Division of Palliative Care, UBC
Family planning community medicine lectureAmit Bhondve
Family planning aims to space and limit births through contraceptive methods. It provides health benefits by reducing unwanted pregnancies, closely spaced births, and high-risk pregnancies. The document discusses various contraceptive methods including barrier methods like condoms and diaphragms, hormonal methods like pills, and long-acting reversible methods like IUDs. Intrauterine devices are effective and reversible but can have side effects like expulsion, perforation, bleeding, and infection in some cases. Proper counseling and follow up is important when using family planning methods.
This document provides information on neuro-muscular dysfunction in children, specifically discussing spina bifida, cerebral palsy, and muscular dystrophy. It describes the causes, signs and symptoms, types, and treatment options for each condition. Spina bifida is caused by incomplete development of the spine during pregnancy and ranges in severity. Cerebral palsy is caused by abnormal brain development and causes loss of muscle control. Muscular dystrophy is a genetic disorder that causes progressive muscle degeneration and weakness.
The document provides information on cognition and delirium. It defines delirium as an acute organic disorder characterized by impaired consciousness, disorientation, and disturbed perception and restlessness. It describes 5 subtypes of delirium based on etiology in DSM-V. The history section outlines early references to delirium in Hippocrates and developments over centuries in understanding and defining delirium. Risk factors, common etiologies, clinical features, epidemiology, pathophysiology involving several neurotransmitters, and theories of delirium are discussed.
Update on SUICIDE (2020) By Dr Rahul Jain & Dr Sharda JainLifecare Centre
This document provides an overview and update on suicide in 2020. It discusses that depression is commonly associated with suicide and over 800,000 people die by suicide every year globally. The most common method is hanging. Risk factors include depression, schizophrenia, alcohol dependence, and borderline personality disorder. Protective factors include strong family connections, social support, and access to mental health care. For those who encounter someone expressing suicidal thoughts, it is important to try to redirect the conversation, then contact a helpline for support. Treatment involves addressing any underlying psychiatric conditions through therapy and medication. Myths about suicide are also addressed.
Power Point Chapter 25.ppt...............Kelvinkebu
The document provides information on dementia and Alzheimer's disease. It describes the symptoms and stages of dementia and Alzheimer's. Dementia involves cognitive decline that interferes with daily life. Alzheimer's is the most common cause and involves progressive brain changes that eventually lead to loss of mental and physical function. The stages of Alzheimer's progression are described from mild memory loss to severe cognitive impairment and eventual death. Treatment aims to manage symptoms and slow progression but currently there is no cure.
Spectrum of health & Iceberg Phenomenon of disease.pptxDrSindhuAlmas
1- Understand the spectrum of health in relation to health and sickness
2- Define; health, disease, illness and wellbeing
3- Define and understand the determinants’ of health; biological, behavioural, socio and cultural, environmental, socioeconomic, health services, and ageing and gender
4- Understand the concepts of “right to health “ and “health for all”
5- Ice-berg phenonmenon of disease
case history in detail including objectives, goals, chief complaint, history of present illness, past dental history, medical history, general examination, extraoral examination intraoral examination further dividing into hard and soft tissue examination, provisional diagnosis, differential diagnosis, investigation, final diagnosis, treatment plan, prognosis
The document outlines key milestones in maternal and child health (MCH) care in India, including the establishment of training for dais (traditional birth attendants) in 1880, the first Midwifery Act in 1902, and the establishment of primary health center networks and family planning programmes in the 1950s. It then discusses components and strategies of India's Reproductive and Child Health (RCH) Program Phase I and Phase II, which aimed to reduce maternal and infant mortality and promote adolescent health. The document provides statistics on health indicators like infant mortality rate and maternal mortality rate in various Indian states.
The document discusses various anxiety disorders including specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalized anxiety disorder. It covers clinical descriptions of the disorders based on DSM-5 criteria, common risk factors like genetics and personality traits, and potential etiologies such as classical conditioning and cognitive factors. The disorders are highly comorbid with each other and other mental health conditions. Treatment options for anxiety disorders are also mentioned.
"The Future of Clinical Practice will be Optimizing Health" - Molly Maloof (P...Hyper Wellbeing
"The Future of Clinical Practice will be Optimizing Health" - Molly Maloof (Physician/Technologist/Scientific Wellness Pioneer, Independent)
Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California.
For more information including details of subsequent events, please visit http://hyperwellbeing.com
The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization.
WaaS newsletter sign-up http://eepurl.com/b71fdr
@hyperwellbeing
principles and management of nutritional defiency disorders 4 th year kc.pptxSumit Gaikwad
This document discusses nutritional deficiency disorders, including the principles and management of various deficiencies. It begins by defining primary and secondary nutritional deficiencies. It then covers protein-energy malnutrition and classifications like marasmus and kwashiorkor. The document also discusses various vitamin deficiency disorders like Vitamins A, D, and their signs, symptoms, management and prevention. It concludes by covering mineral deficiency diseases. Overall, the document provides a comprehensive overview of different types of nutritional deficiencies, their causes and treatment approaches.
This document discusses the management and prevention of intellectual disability. It covers primary, secondary, and tertiary prevention strategies, including improving prenatal care, newborn screening, early detection and intervention. Treatment involves a multidisciplinary team and addressing issues like self-image, psychiatric comorbidities, rehabilitation, and parental counseling. Psychological assessment tools and guidelines are also outlined.
This document provides information on behavioral and psychological crises, including behavioral emergencies that interfere with activities of daily living and psychiatric emergencies that threaten health and safety. It discusses medico-legal considerations, legal options for involuntary care, causes of abnormal behavior including biological, environmental, injury/illness, and substance-related causes. It also summarizes techniques for assessing and communicating with psychiatric patients, crisis intervention skills, use of restraints, specific psychiatric disorders, psychiatric medications, special populations, and provides an example call to medical control regarding a psychiatric emergency.
This document provides information on reproductive health and family planning programs in India. It begins with definitions of reproductive health by WHO and discusses key programs like the Family Planning Programme and Reproductive and Child Health Care Programme. It describes various family planning methods like barrier methods (condoms, IUDs), chemical methods (pills, implants), surgical methods (sterilization), and natural methods. Issues related to reproductive health in India like myths, infertility, population growth are covered. The document emphasizes the importance of reproductive health education and availability of family planning services.
This document discusses epidemiology from philosophical, artistic, and scientific perspectives. Epidemiology can be viewed as a philosophical study of health problems, as it examines the non-random distribution of illness. It is also considered an art that requires skills like creativity and innovation to appropriately study populations. As a science, epidemiology follows systematic methods and has wide applications in public health, including disease surveillance, investigating outbreaks, and evaluating health programs and policies.
The document discusses maternal and child health programmes. It begins by noting that mothers and children make up a large vulnerable group, comprising over half the population in developing countries like India. The current strategy is to provide integrated essential health care services to mothers and children. It then discusses various maternal and child health services including antenatal care, intranatal care, postnatal care, and neonatal care. The objectives of these services are to reduce mortality and morbidity for mothers, newborns, and children. Key aspects of care discussed include nutrition, immunizations, health education, and family planning.
This document discusses several global threats including global warming, recession, annihilation, terrorism, and hypoxia. It links these threats to the issues of contraception, abortion, and the pollution of the environment with estrogen from menstrual blood and aborted fetal blood. Specifically, it claims that contraception and abortion lower estrogen levels which can lead to degenerative diseases and changes in brain function that promote behaviors like promiscuity, abuse, and terrorism. It argues that population decline due to these practices is causing economic crisis and that reversing contraception and abortion could help address issues like climate change by reducing greenhouse gas emissions and pollution.
This document provides an overview of Down syndrome including definitions, features in newborns, common abnormalities, and age-specific healthcare guidelines. It summarizes the incidence of Down syndrome as occurring in 1 in 660 newborns. Common physical features in newborns include slanted palpebral fissures, anomalous auricles, and hypotonia. The document outlines numerous potential abnormalities and provides healthcare guidelines for individuals with Down syndrome from the neonatal period through adulthood.
This document defines substance abuse and dependence, describes the signs and symptoms of intoxication and withdrawal for various classes of drugs, and outlines nursing considerations for treatment. Key classes discussed include alcohol, sedatives, stimulants, opioids, and hallucinogens. Intoxication can cause impaired control and risky behavior while withdrawal can involve symptoms like anxiety, insomnia, nausea and seizures. Treatment focuses on safety, monitoring, supportive care, and gradual medication-assisted withdrawal when needed.
This document provides guidelines for the management of sepsis from 2016 and 2018 updates. It begins with discussing the historical perspectives on defining and treating sepsis. Key points include:
- Sepsis and septic shock definitions were revised in 2016 to focus on life-threatening organ dysfunction caused by a dysregulated immune response to infection.
- Screening tools like SOFA and qSOFA are recommended to help identify and monitor sepsis severity. The SOFA score evaluates organ dysfunction in six organ systems while qSOFA is for non-ICU patients.
- The initial management of sepsis focuses on rapid treatment within the first hour of recognition, including measuring lactate, blood cultures, antibiotics, fluid resuscitation, and
This document discusses heroin use among street-involved youth and barriers to treatment. It reports that heroin use is rising internationally and nationally among youth. Research in Canada found that 79% of interviewed street youth had engaged in injection drug use and 58% had shared injection equipment. The document outlines significant health, social, and psychological problems associated with heroin use among youth like depression, HIV exposure, unemployment, homelessness, and overdose. It also discusses risk factors, protective factors, and barriers to treatment from both the youth and service provider perspective. Recommendations include improved assessment/treatment, housing/accommodations, policy changes, and vocational/financial support.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Update on SUICIDE (2020) By Dr Rahul Jain & Dr Sharda JainLifecare Centre
This document provides an overview and update on suicide in 2020. It discusses that depression is commonly associated with suicide and over 800,000 people die by suicide every year globally. The most common method is hanging. Risk factors include depression, schizophrenia, alcohol dependence, and borderline personality disorder. Protective factors include strong family connections, social support, and access to mental health care. For those who encounter someone expressing suicidal thoughts, it is important to try to redirect the conversation, then contact a helpline for support. Treatment involves addressing any underlying psychiatric conditions through therapy and medication. Myths about suicide are also addressed.
Power Point Chapter 25.ppt...............Kelvinkebu
The document provides information on dementia and Alzheimer's disease. It describes the symptoms and stages of dementia and Alzheimer's. Dementia involves cognitive decline that interferes with daily life. Alzheimer's is the most common cause and involves progressive brain changes that eventually lead to loss of mental and physical function. The stages of Alzheimer's progression are described from mild memory loss to severe cognitive impairment and eventual death. Treatment aims to manage symptoms and slow progression but currently there is no cure.
Spectrum of health & Iceberg Phenomenon of disease.pptxDrSindhuAlmas
1- Understand the spectrum of health in relation to health and sickness
2- Define; health, disease, illness and wellbeing
3- Define and understand the determinants’ of health; biological, behavioural, socio and cultural, environmental, socioeconomic, health services, and ageing and gender
4- Understand the concepts of “right to health “ and “health for all”
5- Ice-berg phenonmenon of disease
case history in detail including objectives, goals, chief complaint, history of present illness, past dental history, medical history, general examination, extraoral examination intraoral examination further dividing into hard and soft tissue examination, provisional diagnosis, differential diagnosis, investigation, final diagnosis, treatment plan, prognosis
The document outlines key milestones in maternal and child health (MCH) care in India, including the establishment of training for dais (traditional birth attendants) in 1880, the first Midwifery Act in 1902, and the establishment of primary health center networks and family planning programmes in the 1950s. It then discusses components and strategies of India's Reproductive and Child Health (RCH) Program Phase I and Phase II, which aimed to reduce maternal and infant mortality and promote adolescent health. The document provides statistics on health indicators like infant mortality rate and maternal mortality rate in various Indian states.
The document discusses various anxiety disorders including specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalized anxiety disorder. It covers clinical descriptions of the disorders based on DSM-5 criteria, common risk factors like genetics and personality traits, and potential etiologies such as classical conditioning and cognitive factors. The disorders are highly comorbid with each other and other mental health conditions. Treatment options for anxiety disorders are also mentioned.
"The Future of Clinical Practice will be Optimizing Health" - Molly Maloof (P...Hyper Wellbeing
"The Future of Clinical Practice will be Optimizing Health" - Molly Maloof (Physician/Technologist/Scientific Wellness Pioneer, Independent)
Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California.
For more information including details of subsequent events, please visit http://hyperwellbeing.com
The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization.
WaaS newsletter sign-up http://eepurl.com/b71fdr
@hyperwellbeing
principles and management of nutritional defiency disorders 4 th year kc.pptxSumit Gaikwad
This document discusses nutritional deficiency disorders, including the principles and management of various deficiencies. It begins by defining primary and secondary nutritional deficiencies. It then covers protein-energy malnutrition and classifications like marasmus and kwashiorkor. The document also discusses various vitamin deficiency disorders like Vitamins A, D, and their signs, symptoms, management and prevention. It concludes by covering mineral deficiency diseases. Overall, the document provides a comprehensive overview of different types of nutritional deficiencies, their causes and treatment approaches.
This document discusses the management and prevention of intellectual disability. It covers primary, secondary, and tertiary prevention strategies, including improving prenatal care, newborn screening, early detection and intervention. Treatment involves a multidisciplinary team and addressing issues like self-image, psychiatric comorbidities, rehabilitation, and parental counseling. Psychological assessment tools and guidelines are also outlined.
This document provides information on behavioral and psychological crises, including behavioral emergencies that interfere with activities of daily living and psychiatric emergencies that threaten health and safety. It discusses medico-legal considerations, legal options for involuntary care, causes of abnormal behavior including biological, environmental, injury/illness, and substance-related causes. It also summarizes techniques for assessing and communicating with psychiatric patients, crisis intervention skills, use of restraints, specific psychiatric disorders, psychiatric medications, special populations, and provides an example call to medical control regarding a psychiatric emergency.
This document provides information on reproductive health and family planning programs in India. It begins with definitions of reproductive health by WHO and discusses key programs like the Family Planning Programme and Reproductive and Child Health Care Programme. It describes various family planning methods like barrier methods (condoms, IUDs), chemical methods (pills, implants), surgical methods (sterilization), and natural methods. Issues related to reproductive health in India like myths, infertility, population growth are covered. The document emphasizes the importance of reproductive health education and availability of family planning services.
This document discusses epidemiology from philosophical, artistic, and scientific perspectives. Epidemiology can be viewed as a philosophical study of health problems, as it examines the non-random distribution of illness. It is also considered an art that requires skills like creativity and innovation to appropriately study populations. As a science, epidemiology follows systematic methods and has wide applications in public health, including disease surveillance, investigating outbreaks, and evaluating health programs and policies.
The document discusses maternal and child health programmes. It begins by noting that mothers and children make up a large vulnerable group, comprising over half the population in developing countries like India. The current strategy is to provide integrated essential health care services to mothers and children. It then discusses various maternal and child health services including antenatal care, intranatal care, postnatal care, and neonatal care. The objectives of these services are to reduce mortality and morbidity for mothers, newborns, and children. Key aspects of care discussed include nutrition, immunizations, health education, and family planning.
This document discusses several global threats including global warming, recession, annihilation, terrorism, and hypoxia. It links these threats to the issues of contraception, abortion, and the pollution of the environment with estrogen from menstrual blood and aborted fetal blood. Specifically, it claims that contraception and abortion lower estrogen levels which can lead to degenerative diseases and changes in brain function that promote behaviors like promiscuity, abuse, and terrorism. It argues that population decline due to these practices is causing economic crisis and that reversing contraception and abortion could help address issues like climate change by reducing greenhouse gas emissions and pollution.
This document provides an overview of Down syndrome including definitions, features in newborns, common abnormalities, and age-specific healthcare guidelines. It summarizes the incidence of Down syndrome as occurring in 1 in 660 newborns. Common physical features in newborns include slanted palpebral fissures, anomalous auricles, and hypotonia. The document outlines numerous potential abnormalities and provides healthcare guidelines for individuals with Down syndrome from the neonatal period through adulthood.
This document defines substance abuse and dependence, describes the signs and symptoms of intoxication and withdrawal for various classes of drugs, and outlines nursing considerations for treatment. Key classes discussed include alcohol, sedatives, stimulants, opioids, and hallucinogens. Intoxication can cause impaired control and risky behavior while withdrawal can involve symptoms like anxiety, insomnia, nausea and seizures. Treatment focuses on safety, monitoring, supportive care, and gradual medication-assisted withdrawal when needed.
This document provides guidelines for the management of sepsis from 2016 and 2018 updates. It begins with discussing the historical perspectives on defining and treating sepsis. Key points include:
- Sepsis and septic shock definitions were revised in 2016 to focus on life-threatening organ dysfunction caused by a dysregulated immune response to infection.
- Screening tools like SOFA and qSOFA are recommended to help identify and monitor sepsis severity. The SOFA score evaluates organ dysfunction in six organ systems while qSOFA is for non-ICU patients.
- The initial management of sepsis focuses on rapid treatment within the first hour of recognition, including measuring lactate, blood cultures, antibiotics, fluid resuscitation, and
This document discusses heroin use among street-involved youth and barriers to treatment. It reports that heroin use is rising internationally and nationally among youth. Research in Canada found that 79% of interviewed street youth had engaged in injection drug use and 58% had shared injection equipment. The document outlines significant health, social, and psychological problems associated with heroin use among youth like depression, HIV exposure, unemployment, homelessness, and overdose. It also discusses risk factors, protective factors, and barriers to treatment from both the youth and service provider perspective. Recommendations include improved assessment/treatment, housing/accommodations, policy changes, and vocational/financial support.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
2. ADOLESCENT HEALTH
WHO DEFINES AS ANY PERSON BETWEEN 10 TO 19YRS
PUBERTY-THE STAGE OF LIFESPAN IN WHICH A CHILD DEVELOPS SECONDARY SEXUAL
CHARACTERISTICS.
AV. AGE FOR GIRLS-10-12YRS
AV. AGE FOR BOYS-12-14YRS
THERE WILL BE ATTAINMENT OF
PHYSICAL MATURITY
PSYCHOLOGICAL MATURITY
SOCIAL MATURITY
SEXUAL MATURITY
3. AM I NORMAL?
• RAPID GROWTH…. CAUSE OF CONCERN!
ADOLESCENTS HAVE A FUNDAMENTAL HUMAN RIGHT TO ACCURATE AND
COMPREHENSIVE REPRODUCTIVE AND SEXUAL HEALTH INFORMATION
4. PROBLEMS ENCOUNTERED IN ADOLESCENTS
PERSONAL AND SOCIAL PROBLEMS
PROBLEMS OF HEALTH AND PHYSICAL (SELF ESTEEM)
SEX AND REPRODUCTIVE HEALTH PROBLEMS
HOME AND FAMILY RELATED PROBLEMS
EXCESSIVE DAY DREAMING
EMANCIPATION
ECONOMIC INDEPENDENCS
PEER PRESSURE
This Photo by Unknown Author is licensed under CC BY-NC-ND
5. ADOLESCENTS-SOME FACTS AND
PERCEPTION
ADOLESCENTS BETWEEN 10-19YR MAKE UP ONE FIFTH OF INDIA'S POPULATION
AND ALSO A POTENTIAL GROUP FOR CONTRACTING HIV
ADOLESCENT GIRLS CONSTITUTE A DISPROPORTIONATE(25%) PORTION OF THE 5
MILLION ABORTIONS PERFORMED ANNUALLY.
HIGH MORTALITY AND MORBIDITY IS ASSOCIATED WITH PUBERTAL AND
ADOLESCENT PREGNANCY.
BOYS AND GIRLS REVEAL A POOR UNDERSTANDING OF SEXUAL CHANGES WITHIN
THEM
6. WHEN SHOULD I SEE A DOCTOR?
• HAS NOT STARTED PERIOD BY THE AGE OF 15YRS
• HAS STARTED BEFORE THE AGE OF 10YRS
• ARE DELAYED OR EARLY
• ARE HEAVY(WITH CLOT) OR SCANTY
• ARE VERY PAINFUL
• IF SHE IS UNABLE TO ATTEND SCHOOL
licensed
under
CC
BY-SA-NC
7. GOOD PERINEAL HYGIENE AND CLEANING
HABITS
• SAY NO TO-
o ANTISEPTIC LIQUIDS AND SOAPS
o EXCESSIVE TALCUM
o TISSUE PAPER AND PERSPIRANTS
o DEODORANT POWDERS
o TIGHT NYLON UNDERGARMENTS
GOLDEN RULE- FRONT TO BACK
AFTER URINATION OR BOWEL MOVEMENT , A GIRL SHOULD WASH AREA FROM FRONT TO
BACK AND PAT DRY
8. NUTRITION REQUIREMENTS
IN ADOLESCENT
• ENERGY-2330 KCAL(16-17YRS)
• PROTEIN
• MINERALS-CA (800MG)
• -FE(27 MG/DL)-0.5 MG/DAY LOSE BY WAY OF MENSTRUATION THEREFORE ENSURE ADEQUATE INTAKE OF
IRON
• -ZN (12 MG/ D)SUPPLEMENTS ARE HELPFUL IN TREATING PUBERTAL DELAY
• VITAMIN-B1(1.2 MG/DL)
• VITAMIN –B12(0.2 – 1 MCG/ D)
• VITAMIN – B2 (1.4 MG /D)
• NIACIN (14MG / D)
• PYRIDOXINE (2MG / D)
9. REMEMBER 5 A`S
1) ASK WHAT IS YOUR HB
2) ASK WHEN WAS IT DONE LAST
3) ASK WHAT IS THE NORMAL HB
4) ASK TO GET IT DONE RIGHT AWAY
5) ADVISE-DIET
-TABLET
-DEWORMING
10. LETS PLEDGE TO MAKE
• ANEMIA FREE INDIA
• ANEMIA FREE SCHOOL
• ANEMIA FREE FAMILY
11. REPRODUCTIVE HEALTH
• WHO DEFINES REPRODUCTIVE HEALTH AS A STATE OF COMPLETE PHYSICAL ,
MENTAL AND SOCIAL WELL ,NOT MERELY THE ABSENCE OF REPRODUCTIVE
DISEASE OR INFIRMITY . REPRODUCTIVE HEALTH IS A FUNDAMENTAL
COMPONENT OF AN INDIVIDUALS OVERALL HEALTH STATUS AND CENTRAL
DETERMINANT OF QUALITY OF LIFE
13. REPRODUCTIVE HEALTH-PROBLEMS AND
STRATERGIES
• EARLY MARRIAGE AS SOON AS GIRL ATTAINS PUBERTY
• THE TEEN AGE GIRL IS NOT TO BEAR FOETUS
• AFTER MARRIAGE THE CAREER OF LADY IS BLOCKED IN LOT OF FAMILIES
• MATERNAL AND INFANT MORTALITY RATE ARE HIGH IN EARLY MARRIAGES
• THERE IS LITTLE KNOWLEDGE ABOUT PERSONAL HYGIENE TO AVOID SEXUALLY
TRANSMITTED DISEASES
• THERE MAY BE POPULATION EXPLOSION WITH LACK OF REPRODUCTIVE HEALTH
14. STRATEGIES
• NUMBER OF PROGRAMS ARE LAUNCHED UNDER REPRODUCTIVE AND CHILD HEALTH
CARE,
• AWARENESS PROGRAMME ARE CONDUCTED FOR BOTH MALES AND FEMALES TO LEAD
HEALTHY REPRODUCTIVE LIFE
• AWARENESS CREATING ABOUT FERTILITY REGULATING METHOD
• AWARENESS CREATING ABOUT PERSONAL HYGIENE
• PREVENTION AND PROTECTION AGAINST STD
15. BIRTH CONTROL
• FAMILY WELFARE AND FAMILY PLANNING PROGRAMS COMES FORWARD TO AVOID
UNCONTROLLED HUMAN POPULATION EXPLOSION.
• THE CONTRACEPTION IS THE MAIN AIM OF THE BIRTH CONTROL
• PREVENTION OF CONCEPTION OR FERTILIZATION OF OVUM DURING SEXUAL INTERCOURSE IS
CALLED CONTRACEPTION . DIFFERENT TYPES ARE:
I. NATURAL METHOD
II. BARRIER METHOD
III. INTRA UTERINE DEVICE
IV. ORAL CONTRACEPTION
V. INJECTION AND IMPLANTATION
VI. SURGICAL METHODS
16. THE CHARACTERISTICS OF AN
IDEAL CONTRACEPTIVE ARE
LISTED BELOW:
• HIGHLY EFFECTIVE
• NO SIDE EFFECTS
• INDEPENDENT OF INTERCOURSE
• RAPIDLY REVERSIBLE
• CHEAP
• WIDESPREAD AVAILABILITY
• ACCEPTABLE TO ALL CULTURES AND HEALTHCARE PERSONNEL NOT REQUIRED
• EASILY DISTRIBUTED
18. RHYTHM METHOD'S
• CALENDAR METHODS/SAFE PERIOD METHOD/NATURAL
METHOD.
• DEPEND ON TIME OF OVULATION
• DANGEROUS PERIOD-OVULATION OCCURS ON 14TH DAY
AND OVUM VIABLE FOR 48-78HRS AND SPERM REMAIN
ALIVE FOR 24-48HRS,SO PREGNANCY OCCURS IF COITUS
OCCURS IN THIS PERIOD
• SAFE PERIOD-REST OF CYCLE- I.E 5-6 DAYS AFTER
MENSTRUATION AND 5 TO 6 DAYS BEFORE NEXT CYCLE
• ADVANTAGE-MOST NATURAL
• DISADVANTAGE-MOST UNRELIABLE WHEN CYCLE ARE
IRREGULAR AND OVULATION TIME IS VARIABLE
19. BARRIER METHODS
• MECHANICAL-DIAPHRAGM-
FLEXIBLE RIM MADE UP OF SPRING.
CUP SHAPED SYNTHETIC RUBBER OR PLASTIC
INSERTED INTO VAGINA OVER THE CERVIX
CERVICAL CAP-SMALLER THAN DIAPHRAGM , APPLIED ON CERVIX ITSELF
ADVANTAGES-CHEAP, DO NOT REQUIRE MEDICAL CONSULTATION.
DISADVANTAGES-DEMONSTRATION BY TRAINED PERSON NEEDED FOR PROPER USE.
-FAILURE MOST COMMON –DUE TO DISPLACEMENT OF DEVICE.
-CERVICITIS AND LOCAL IRRITATION
20. CHEMICAL METHODS
• SPERMICIDAL AGENTS-DESTROYS SPERM
RICINOLEIC ACID
NANOXYNOL-9
OCTOXYNOL-3
AVAILABLE IN DIFFERENT FORMS-FOAM TABLETS , PASTES ,
CREAMS , JELLIES AND VAGINAL SPONGES(TODAY-POLYURETHANE
SPONGE IMPREGNATED WITH NANOYMOL)
ADVANTAGES-CHEAP , WELL TOLERATED , PROVIDE GOOD
PROTECTION.
DISADVANTAGES-MESSINESS , LOCAL IRRITATION AND BURNING
SENSATION.
COMBINED
21. • LOCALLY APPLIED CHEMICALS- ANTI SPERMICIDAL (FOAM AND JELLIES)
• DRUGS
STEROIDAL- OCP AND DEPOT PREPARATION
NON STEROIDAL
STEROIDAL –OCP-RECOMMENDED IN WOMEN OF YOUNGER AGE GROUP (UPTO 35YRS)
MOA-NEGATIVE FEEDBACK EFFECT ACT ON ANTERIOR PITUITARY
INHIBIT GNRH (FSH AND LH)
INHIBIT OVULATION
TYPES
COMBINED PILL
SEQUENTIAL PILL
MINIPILL
POSTCOITAL (MORNING AFTER) PILL
22. OCP
ADVANTAGES- 100% EFFECTIVITY
DISADVANTAGES
• HYPERTENSION
• THROMBOEMBOLISM
• METABOLIC EFFECT-DIABETES OBESITY
• CARCINOGENIC EFFECT- BREAST AND CERVIX
CONTRA-INDICATIONS-WOMEN HAVING CARCINOMA OF BREAST AND UTERUS
-LIVER DISEASES
-HYPERLIPIDEMIA
-AGE GROUP ABOVE 35YRS
23. NON STEROIDAL CONTRACEPTIVES
• DEVELOPED BY CENTRAL DRUG RESEARCH INSTITUTE (CDRI)
• TRADE NAME-SAHELI
• DOSE-30MG TWICE/WEEK FOR 12 WEEKS FOLLOWED BY ONCE A WEEK.
• MOA-SUPPRESS CORPUS LUTEAL FUNCTION AND INTERFERE WITH MOTILITY OF
FALLOPIAN TUBE.
• ADVANTAGES- MENSTRUAL CYCLE REMAINS NORMAL
• COMPLETE REVERSIBILITY AFTER WITHDRAWAL.
25. IUCD
• ADVANTAGES-SAFE , EFFECTIVE REVERSIBLE , EASILY PULLED OUT WHEN NOT
REQUIRED LONG TERM CONTRACEPTION WITHOUT ADVERSE EFFECT
• DISADVANTAGE-MAY CAUSE HEAVY BLEEDING
-MAY COME OUT ACCIDENTALLY
-RISK ECTOPIC PREGNANCY
CONTRAINDICATIONS-SUSPECTED PREGNANCY,PID,HEAVY MENSTRUAL
BLEEDING,SUFFERING FROM CA CERVIX
27. ME NOT PAUSE!!
• MENOPAUSE IS AN UNAVOIDABLE CHANGE THAT EVERYNWOMAN WILL EXPERIENCE .
• DEFINITION-MENOPAUSE MEANS PERMANENT CESSATION OF MENSTRUATION AT THE END
OF REPRODUCTIVE LIFE DUE TO LOSS OF OVARIAN FOLLICULAR ACTIVITY.IT IS THE POINT
OF TIME WHEN LAST AND FINAL MENSTRUATION OCCURS.
• AGE-GENETICALLY PRE DETERMINED
• 45-55YRS AVERAGE-50YRS
PHASES OF MENOPAUSE-4 PHASES
PRE-MENOPAUSE
PERI MENOPAUSE
MENOPAUSE
POST MENOPAUSE
28.
29.
30. MENOPAUSAL SYMPTOMS
• VASOMOTOR SYMPTOMS
• UROGENITAL ATROPHY
• OSTEOPOROSIS AND FRACTURE
• CARDIOVASCULAR DISEASE
• CEREBROVASCULAR DISEASE
• PYCHOLOGICAL CHANGES
• SKIN AND HAIR
• SEXUAL DYSFUNCTION
• DEMNTIA AND CONGITIVE DECLINE
34. SKIN AND HAIR SYMPTOMS
• PURSE STRING
• CROW FEET
• LOSS OF SKIN ELASTICITY GRADUALLY
• LOSS OF PUBIC HAIR AND AXILLARY HAIR
• SLIGHT BALDNESS
35. DIAGNOSIS
• CESSATION OF MENSTRUAL CYCLE FOR CONSECUTIVE 12 MONTHS DURING
CLIMACTERIC PERIOD
• AV. AGE OF MENOPAUSE 50 YRS
• APPEARANCE OF MENOPAUSAL SYMPTOMS
• VAGINAL CYTOLOGY
• SERUM ESTRADIOL <20PG/ML
• SERUM FSH AND LH >40MIU/ML
36. MANAGEMENT
• MENOPAUSE REQUIRES NO MEDICAL TREATMENT . INSTEAD , TREATMENT FOCUS ON
RELIEVING YOUR SIGNS AND SYMPTOMS AND PREVENTING OR MANAGING CHRONIC
CONDITIONS THAT MAY OCCUR WITH AGING .
• HORMONAL THERAPHY
• THE MOST EFFECTIVE TREATMENT IN RELIEVING SYMPTOMS. AND ALSO PREVENTS BONE
LOSS
• LOW DOSE ANTI DEPRESSANTS –SSRI
• GABAPENTIN (NEURONTIN)-IS APPROVED TO TREAT SEIZURES, BUT IT HAS ALSO SHOWN
HELP REDUCE HOT FLUSHES , BETTER IN WOMEN WHO DON’T WAS ESTROGEN THERAPHY
AMD THOSE WHO HAVE MIGRAINE
• BISPHOSPHONATES-ORAL MEDICATION IS USED TO PREVENT AND TREAT
POSTMENOPAUSAL OSTEOPOROSIS BY SLOWING BONE LOSS AND INCREASING BONE MASS.
• DENOSUMAB-IS AN IV MEDICATION THAT LOWERS THE RISK OF FRACTURES AND BLOCKS
BONE LOSS
37. FACTORS AFFECTING NUTRITIONAL
STATUS OF A WOMAN
• HOUSEHOLD INCOME AND ITS UTILIZATION
• QUALITY OF THE ENVIRONMENT
• NUMBER OF SIBLING
• VULNERABILITY TO GENDER DICRIMINATION
• EDUCATIONAL LEVEL
• HER ACTIVITY STATUS AND EXPOSURE TO SOCIAL STIGMA