Which 3 amino acids sidechains are not ionizable in any manner? Which 10 amino acid sidechains are not ionizable to significant extent in H2O? WHY? what makes a side chain ionizable and not? Solution Alanine,Cysteine,Glycine,Isoleucine,Leucine,Methoinine,Phenylalanine,Proline,Tryptophan,Vali ne are the 10 amino acids which are not ionizable in H20 because their sidechains are non polar ie, they wont react with the polar compounds.water is a polar compound so that there wont be any ionization.