Disturbed patterns of neuronal activity underlying specific types of behavior correlating with specific genetic alleles thus linking gene to brain development to behavior. The programming of various brain networks is genetically modulated during neurodevelopment and mediated through a range of neuropeptides and interacting neurotransmitter systems.
More than 10 million people suffer from epilepsy in India.Seizures impact the lives of people with epilepsy and their family in many ways including creating barriers to employment and education and facing a sense of discrimination and isolation from their peers who donʼt understand what happens when they see a seizure occur. In India, epilepsy is still thought of as mental illness mainly due to lack of information on the condition among the general public.
This presentation touches every aspect of epilepsy
1. Overview of Epilepsy;
2. Type of Seizures;
3. Diagnosis and Management;
4. Psychological Issues; and
5. Social Perspectives.
Focuses on Epilepsy Management for poeple wth Tuberous Sclerosis. Includes information on:
- Status Epilepticus
- Epilepsy Management
- First Aid Principles
- Seizure Management Planning
“Epilepsy and mental disorder are two states of illness of the very closest relationship; they represent identical pathological conditions in two different areas of the nervous system”
the causes, pathophysiology, clinical manifestations, diagnosis and treatment of epilepsy has been discussed in detail with the perspective of a subject called pathophysiology in both medical sciences as well as the pharmaceutical sciences
More than 10 million people suffer from epilepsy in India.Seizures impact the lives of people with epilepsy and their family in many ways including creating barriers to employment and education and facing a sense of discrimination and isolation from their peers who donʼt understand what happens when they see a seizure occur. In India, epilepsy is still thought of as mental illness mainly due to lack of information on the condition among the general public.
This presentation touches every aspect of epilepsy
1. Overview of Epilepsy;
2. Type of Seizures;
3. Diagnosis and Management;
4. Psychological Issues; and
5. Social Perspectives.
Focuses on Epilepsy Management for poeple wth Tuberous Sclerosis. Includes information on:
- Status Epilepticus
- Epilepsy Management
- First Aid Principles
- Seizure Management Planning
“Epilepsy and mental disorder are two states of illness of the very closest relationship; they represent identical pathological conditions in two different areas of the nervous system”
the causes, pathophysiology, clinical manifestations, diagnosis and treatment of epilepsy has been discussed in detail with the perspective of a subject called pathophysiology in both medical sciences as well as the pharmaceutical sciences
Epilepsy awareness training innovations slidesharePatrick Doyle
This Epilepsy Awareness training course is aimed at raising awareness of the importance of the safe care and management of epilepsy. The course explores some of the common misconceptions about epilepsy and to care for someone who experiences seizures. On completion of this course staff will be aware of the clinical features of epilepsy and contribute to the care and wellbeing of patients who experience epileptic seizures.
Duration: 2 hours
Experience: None required.
This course is suitable for all staff currently working within health and social care settings in the United Kingdom who may come into contact with patients who experience epileptic seizures.
Number of Trainees: 16 maximum
Course Standard: Certificate of attendance
Equipment Needed: Hand-outs will be provided
Candidates will cover:
•Definitions, diagnosis and symptoms of epilepsy, including the nature and incidence of epilepsy
•Seizures and seizure types
•Care and treatment of epilepsy, including basic first aid and emergency care
•What to do when caring for a patient experiencing an epileptic seizure
•Care and management of patients who experience epileptic seizures
•Living with epilepsy
By the end of the course Candidates will be able to:
•Describe the diagnosis, symptoms and different types of epilepsy
•Understand and demonstrate the care and treatment of patients with epilepsy
•Understand the impact of epileptic seizures
•Contribute to the care-planning and safe management and care of patients who experience epileptic seizures, including basic first aid for epileptic sufferers
Epilepsy is a common neurological condition, and still largely shrouded by stigmatisation. This presentation explored practical steps to the management of epilepsy, discusses the new classification of epilepsy, and touched on some relevant lifestyle changes.
Epilepsy awareness training innovations slidesharePatrick Doyle
This Epilepsy Awareness training course is aimed at raising awareness of the importance of the safe care and management of epilepsy. The course explores some of the common misconceptions about epilepsy and to care for someone who experiences seizures. On completion of this course staff will be aware of the clinical features of epilepsy and contribute to the care and wellbeing of patients who experience epileptic seizures.
Duration: 2 hours
Experience: None required.
This course is suitable for all staff currently working within health and social care settings in the United Kingdom who may come into contact with patients who experience epileptic seizures.
Number of Trainees: 16 maximum
Course Standard: Certificate of attendance
Equipment Needed: Hand-outs will be provided
Candidates will cover:
•Definitions, diagnosis and symptoms of epilepsy, including the nature and incidence of epilepsy
•Seizures and seizure types
•Care and treatment of epilepsy, including basic first aid and emergency care
•What to do when caring for a patient experiencing an epileptic seizure
•Care and management of patients who experience epileptic seizures
•Living with epilepsy
By the end of the course Candidates will be able to:
•Describe the diagnosis, symptoms and different types of epilepsy
•Understand and demonstrate the care and treatment of patients with epilepsy
•Understand the impact of epileptic seizures
•Contribute to the care-planning and safe management and care of patients who experience epileptic seizures, including basic first aid for epileptic sufferers
Epilepsy is a common neurological condition, and still largely shrouded by stigmatisation. This presentation explored practical steps to the management of epilepsy, discusses the new classification of epilepsy, and touched on some relevant lifestyle changes.
Autism challenges the individual, their family, the community and the practitioner. The complexity and variety of symptoms that define Autism Spectrum Disorders (ASD) require service providers to constantly update their knowledge and skills to best serve these individuals. Sensorimotor synchronization training with Interactive Metronome (IM), as part of a comprehensive treatment plan, has the potential to directly and positively influence the person’s ability to learn and engage with the world around him. This course will introduce practitioners to new advances in our understanding of ASD, including the pivotal role of timing & rhythm for speech, language, pragmatic, cognitive, motor and sensory processing skills. Participants will learn strategies to evaluate the unique strengths and needs of each individual with ASD as well as how to develop and implement effective IM training with consideration for communication, sensory, motor & behavioral challenges. The expert presenter will incorporate several videos and real examples to illustrate techniques. Take the course at https://secure.interactivemetronome.com/NetSite/IM/CEU/SimpleRegistration.aspx?course_id=2778
Theories on the Brain Function of People with Learning Disabilitiessemualkaira
The term learning disabilities refers to a complex and multidimensional phenomenon that affects many thousands of students. Due to the rich symptomatology of learning
difficulties and the increased differences between individuals, it
has not been possible to analyze all cases exclusively from the
perspective of the neuropsychological approach.
The risk of cognitive impairment assosiated with congenital deafness in child...MaritLobben
Overall poor performance of cognitive and behavioral skills are predictors of poor language skills and vice versa: we need to realise that language, perception, thought, and problem-solving constitute a continuum of interdependent functions.
Some refer to this as polymodal development of the sensory apparatus, as the developing trend in typically developing individuals (Bailey, 2002).
Sensory input participates not only in a simple additive way but also has a reciprocal influence in that it modulates synergistically the unyielding of neural networks.
This is probably why children with deafness exhibit subtle differences from hearing subjects also in functions that seem far removed from the auditory function, such as visuomotor integration or abstract thinking.
From a neuroscientific perspective, this is an interesting demonstration in relation to the extent of the role of hearing in the building of neural networks that result from sensorimotor exposure and practice.
Autism is group of child developmental disabilities that can cause social, communication and behavioural challenges in Kids. Giostar provides Stem Cell Treatment for Autism call us at +91 7043008890.
A Call to Action: Improving brain & mental health via digital platforms,...SharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
8:15–9:45am. A Call to Action: Improving brain & mental health via digital platforms, neuroplasticity research and the White House BRAIN initiative
- Dr. Thomas Insel, Director of the National Institute of Mental Health (NIMH)
- Dr. Adam Gazzaley, Director of UCSF Neuroscience Imaging Center and Co-founder of Akili Interactive Labs
- Dr. Daphne Bavelier, Head of the Brain & Learning Lab at the University of Geneva & U. of Rochester
- Jack Young, Head of Qualcomm Life Fund
- Chair: Alvaro Fernandez, CEO of SharpBrains
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Disordered Brain Modeling Using Artificial Network SOFMSyeful Islam
Autism is known as a neurobiological developmental disorder which affects language,
communication, and cognitive skill. In the case of autism attention shift impairment and
strong familiarity preference are considered to be prime deficiencies. Attention shift
impairment is one of the most seen behavioral disorders found in autistic patients. We
have model this behavior by employing self-organizing feature map (SOFM).
Similar to What lies beneath? Autism Spectrum Disorder (20)
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
Deep Leg Vein Thrombosis (DVT): Meaning, Causes, Symptoms, Treatment, and Mor...The Lifesciences Magazine
Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
How many patients does case series should have In comparison to case reports.pdfpubrica101
Pubrica’s team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
1. What lies beneath ?
A Neurobiological Perspective On
Autism Spectrum Disorder
Vivek Misra | B.Tech, M.S., MIANS
Research Fellow
The Institute of Neurological Sciences
VHS Multi-Specialty Hospital & Research Institute
Chennai. IN
vivek@ubrf.org | @iVivekMisra
http://www.ubrf.org
2. Theories of Autism:
• Deficits in social cognition and related cognitive functions in Autism results from
reduced synchronization between these key brain regions during different social
and emotional tasks: recent research suggests autism to be a ‘Neural
Connectivity Disorder’.
• Neuropsychiatric and neuropsychological evaluations in Autism have revealed
selective dysfunction of ‘social cognition’, with sparing of motor, perceptual and
basic cognitive skills. Social cognition includes a range of skills and functions
required for successful interpersonal interaction, mediated by a ‘Social Brain
Network’.
• One theory of autism proposes that the core deficit is an inability to mentalize
and infer the state of mind of another person, or ‘Theory of Mind’
• The Mirror Neuron System, which is postulated to underlie the ability to mimic,
learn and understand the actions of others has also been implicated in autism.
3. What lies beneath ?
• Disturbed patterns of neuronal activity underlying specific types of behavior
correlating with specific genetic alleles thus linking gene to brain development
to behavior.
• The programming of various brain networks is genetically modulated during
neurodevelopment and mediated through a range of neuropeptides and
interacting neurotransmitter systems.
4. Overview:
“We need to give researchers permission to think outside these traditional (ICD / DSM) silos.”
Steve Hyman
Broad Institute, Massachusetts
Nature Vol. 496 Issue 7446 March 2013
5. Genes:
• There are approximately 103 disease genes, 44 genomic loci are associated
with autism.
• Genetic studies of autism identified three basic phenotype/ genotype
combinations:
– Autism plus phenotype consisting of Autism Spectrum Disorders (ASD) caused
by rare, single-gene mutations; for e.g., fragile X in 5-10% in Autism Plus.
– Broad autism phenotype caused by genetic variations in single or multiple
genes. These variations are common and are present in the general
population, but result in varying clinical phenotypes when they cross a certain
threshold through complex gene-gene and gene-environment interactions.
– A severe and specific phenotype caused by ‘de-novo’ mutations in the patient
or transmitted through asymptomatic carriers of such mutation.
Misra V 2014. Ann of Neurosci. 21(2). 69-73
7. Brain:
A. Imaging studies reveals that young children with ASD have abnormally increased
total brain volume. In addition, juveniles and adults with ASD have reduced corpus-
callosum volume, and children with ASD have increased amygdala volume.
B. The majority of volume-based studies found increased Grey Matter volume in the
frontal and temporal lobes, whereas most density-based studies found decreased
GM density in these regions. For White Matter, both volume and density tend to
decrease in the temporal lobe.
Chen et al., 2012 Pedtric Res
8. Brain:
• The majority of SBM studies of ASD reported increased cortical thickness in the
parietal lobes.
• Longitudinal MRI studies of ASD reported abnormal growth trajectories in the
frontal and temporal lobes.
• DTI studies of ASD consistently reported corpus-callosum abnormality across a wide
age range. Differences in prefrontal white matter, cingulate gyrus, and internal
capsule were also consistently reported.
• MR-based diagnostic models can differentiate individuals with ASD from controls
with high sensitivity and specificity.
Chen et al., 2012 Pedtric Res
9. Circuit:
The putative underlying mechanism of local over-connectivity and long-range over
connectivity is supported by the following cognitive deficits:
• Repetition of domain-specific routines in the absence of domain general
executive integration; for e.g., echolalia but no functional spontaneous speech.
• Deficit in long-range communication between parallel specialized sub-circuits,
such as the amygdalae and fusiform face area, contributing to impaired emotion
perception.
• No cortical global workspace for integration of past and present experience.
• Lack of learning by trial and error through social experience indicates domain
general executive integration and generalizability.
13. Approach:
• Learning is genetically programmed but environmental activity dependent.
• This bi-directional interface offers an opportunity for intervention. Through
modeling, observational and imitation learning in the preschool years that
enhance social –emotional and social-cognitive development can build stronger
circuitry.
• Furthermore, since genetically mediated deficits and consequent functional
impairments involve activity-dependent synapse development that depends on
postnatal learning and experience, early intervention can prevent or reduce the
risk of these deficits cascading into a trajectory toward full expression of the
disorder.
• Understanding these neurobiological underpinnings can lead to the design of
interventions that accommodate the way the brains of children with autism
function and may lead to the promotion of more flexible thinking and learning.