This study assessed North Carolina community pharmacists' attitudes towards working with patients with severe and persistent mental illnesses (SPMI) like schizophrenia and bipolar disorder. The majority of pharmacists feel SPMI are real diseases but require more time than other conditions. While lack of time was a key barrier, pharmacists were most interested in receiving more training on screening, referrals, and engaging with patients. The study concludes that providing additional resources could help pharmacists better care for those with mental illnesses.