siejzushizu sujd I udisj

1. NAME AMAN SHARMA
GROUP 317
Usage of steroids

2. ◆ Corticosteroids and their
biologically synthetic analogs
possess glucocorticoid and
mineralocorticoid action.

3. Adrenocortical Steroids
◆
The adrenal cortex synthesizes two classes of
steroids-
• The glucocorticoids
ex; hydrocortisone
• The mineralocorticoid
ex; aldosterone

4. GLUCOCORTICOIDS
Compound Equiv. dose (anti-
inflammatory
Short acting
1. Hydrocortisone (cortisol)
2. Cortisone
20mg
25mg
3. Prednisolone
4. Methylprednisolone
5. Triamcinolone
Intermediate acting
5mg
4mg
4mg
6. Paramethasone
7. Dexamethasone
8. Betamethasone
Long acting
2mg
0.75mg
0.75 mg

5. MINERALO
CORTICOIDS
9. Desoxycorticosterone
acetate (DOCA)
10. Fludrocortisone
11. Aldosterone
2.5 mg (sublingual)
0.2 mg
Not used clinically

6. ADERNOCORTICAL
STERIODS

7. Adernocortical Steriods
Adernal cortex
(Synthesizes two classes of steroids)
Androgen
(19 carbon atoms)
Corticosteriods
(21 carbon atoms)
Mineralocorticoids
(Electrolyte balance
regulating)
Glucocorticoids
(Carbohydrate
metabolism regulating)
Hydrocortisone
(cortisol)
Aldosterone

8. Pharmacological actions
Increases gluconeogenesis
Increases the peripheral
utilization of glucose.

9. Protein metabolism
◆ Decreases the conversion of of
amino acids to proteins
◆ Increases muscle wasting
◆ Increase in loss of bone matrix

10. Anti inflammatory and
allergy
response
Steroids decreases the production of
inflammatory cells.
Steroids interact with antigen antibody
complex and reduces the allergy
response.

11. Mineral metabolism
◆ Steroids causes sodium and water
retention and produces oedema
◆ Fat metabolism . It produces moon
face in the head and neck region.
◆ Mood changes . It causes euphoria.

12. Anti vitamin D action
◆ Absorption of calcium from the gut is
impaired due to steriod action.

13. Routes of administration
◆ Topical
◆ Oral
◆ Intramuscular
◆ Intra venous

14. Therapeutic uses in oral
and maxillofacial
surgery
◆ Minor surgical procedures
◆ Trauma
◆ Tumors
◆ Orthognathic surgical procedures
◆ Neuro surgical procedures

15. Therapeutic Uses in Non-
endocrine Disease
Rheumatic Disorders( phempigus)
Renal diseases
Allergic Disease
Antiemetic Action
In Asthma
◆
◆
◆
◆
◆
◆
◆
Immunosuppressive Action
Ocular Disease
◆
Skin Disease

16. Contd…
◆
◆
◆
◆
GIT Disease
Hepatic Disease
Malignancies
Cerebral Edema
Apthous stomatitis
Lichen planus

17. MISCELLANEOUS DISEASE
AND CONDITIONS
 Sarcoidosis
Thrombocytopenia
 Autoimmune Destruction of Erythrocytes Organ
Transplantation
 Spinal Cord Injury
•

18. Therapeutic preparation
◆ Topical application
◆ Corlan pellet(hydrocortisone
hemisuccinate.2.5mg)
◆ Triamcinolonepaste(vehicle consist of
gelatin methyl cellulose pectin)

19. Triamcinolone
◆ It is availabe as injectable and water
form
◆ Tablets 8-20 mg
◆ Injection 10mg vial

20. Dexamethasone
◆ Available in oral and injection forms
◆ Oral dose .2-10mg
◆ Iv 4-20 mg
◆ Bethamethasone
◆ available as local drops skin creams
ointment and lotions
◆ Iv 4-20 mg.6-8hrly.

21. Major complications
◆ Suppression of hypothalmohypophyseal
axis.
◆ Git disturbances.dyspepsia
haemorrhage perforation
◆ Infection(tb, fungal,candidiasis)
◆ Iatrogenic cushing syndrome(skin
becomes pale and thin)
◆ Skeletal osteoporosis
◆ Metabolic odema

22. Minor complication
◆ Acne
◆ Striae
◆ Weight gain
◆ Increased apetite