Case study describing a solution UPS put in place for a biopharmaceutical manufacturer shipping investigational medicinal products for a clinical trial.

1. Delivering the future of medicine
A UPS® case study
1

2. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.
New compounds or new bio-
pharmaceutical products are being
discovered and developed all the
time. The biggest challenge often
comes after discovery in the
laboratory, when it is time to trial new
products in real world settings.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved.
That is when Investigational
Medicinal Products or IMPs
have to be distributed
internationally, often from a
single logistics centre,
delivered directly into hospitals
and specialised clinics.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 4
These are not the kinds of deliveries that
can wait around on desks or doorsteps:
they have to be exactly on time, and
delivered into the hands of busy medical
professionals.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 5
Logistics is critical to the whole business
of clinical drug trials, and delays in
bringing a new drug to market can
amount to many millions of dollars.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 6
This particular bio-pharmaceutical
manufacturer was experiencing
difficulties managing the logistics of one
of their trials, so they turned to UPS.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 7
The challenge

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 8
While deliveries were arriving from the
customer’s distribution hub to hospitals and
clinics throughout Europe, they often did not
reach the individual professionals they were
addressed to in good time.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 9
These IMPs require strict temperature
control to stay between 2° and 8° C before
use. If there was a delay in the very last
segment of the delivery process the entire
shipment could be rendered worthless.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 10
They have a window of viability of as little
as 48 hours even in their temperature-
controlled packaging. If a delivery is left for
example at a hospital or university reception
desk or loading bay, it will not be long
before the product becomes unusable.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 11
The second problem was the return of the
high-value passive packaging. The boxes
are designed to be re-useable, with
anything up to 25 cycles of use for each
individual package.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 12
If packaging is not returned, the costs of the
program escalate dramatically - and in up to
half of the roughly 50 deliveries a day, the
packaging never found its way back to the
customer.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 13
The whole process was managed manually.
Hospital staff had to get in touch with the
delivery company to arrange the pick-up of
the packaging. This often didn’t happen.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 14
The solution

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 15
The first part of the problem - getting
delivery to the right person at the right time -
required some preparatory work on the part
of UPS to set up ‘in-room’ delivery.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 16
For obvious reasons, it is not possible to
just walk into hospital clinics and
laboratories without prior agreement.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 17
UPS visited all the delivery locations in
advance and worked towards agreement
that the UPS drivers could carry the
packages past the reception area to where
they are actually needed.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 18
Another advantage is that is then also
possible to manage the packaging return
issue on the spot. The driver can deliver the
IMP and remove the packaging at the same
time, resulting in a 100% return rate.

19. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 19
For hospitals and clinics that do not accept
in-room deliveries, UPS created a second
process to ensure the best possible delivery
and return rate.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 20
First, the packaging was redesigned to
make sure that there are clear and highly
visible instructions on how to save and
return the high-value packaging.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 21
Once delivery is made, UPS automatically
logs that there is an outstanding return, and
instructs the driver to return the next day to
pick up the packaging.

22. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 22
The customer now also receives an
automated report on the status of the
returns of all the packaging, removing the
burden of having to manually monitor every
individual investigator site.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 23
The final piece of the puzzle was UPS
Proactive Response®. This service uses
sophisticated internal systems to monitor
shipments 24/7 and intercept packages if
anticipated scans do not occur.

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© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 24
The quick package interception reduces the
risk of temperature excursions, hospitals
and clinics can prepare for any potential
delays, and the customer has peace of
mind knowing that their high-value products
are under constant surveillance.

25. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 25

26. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 26
The result

27. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 27
Lower administration
costs for the customer
and the investigator sites
More secure delivery
process for IMPs that
can be worth hundreds
or even thousands of
dollars
Significantly better return
rates of high-value
packaging

28. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 28
Learn more about our healthcare
capabilities by visiting
www.ups.com/healthcarelogistics

29. Proprietary and Confidential: This presentation may not be used or disclosed to any person other than employees of Customer, unless expressly authorized by UPS.
© 2017 United Parcel Service of America, Inc. UPS, the UPS brandmark, the color brown and photos are trademarks of United Parcel Service of America, Inc. All rights reserved. 29
It’s a patient,
not a package