Rafael Soto has over 10 years of experience in analytical chemistry and quality control. He has extensive experience developing and validating GC and HPLC methods and performing method transfers between laboratories. Currently he works as a Chemist II at Heron Therapeutics developing analytical methods, validating methods, reviewing data, and training other analysts. Previously he has held roles as a QC Chemist and Technician at various companies performing quality control testing, instrument operation, and data reporting. He has a Bachelor's degree in Biochemistry from San Francisco State University.
We focus on providing you lab testing services that accelerate R&D intensive projects. Follow us to share & learn about analytical testing research and more.
Guide for executives in small and emerging pharmaceutical and biotech companies to select contract development and manufacturing organization (CDMO) and contract research organization (CRO) partners
We focus on providing you lab testing services that accelerate R&D intensive projects. Follow us to share & learn about analytical testing research and more.
Guide for executives in small and emerging pharmaceutical and biotech companies to select contract development and manufacturing organization (CDMO) and contract research organization (CRO) partners
Webinar: Is Phase-Appropriate Validation the Right Choice for your Cell or Ge...MilliporeSigma
Participate in the interactive webinar now: http://bit.ly/CGTWebinar
This webinar will introduce phase-appropriate validation and why it may be advantageous for cell and gene therapy development. We will also describe how validated platform assays can help you meet your critical development timelines.
Explore our webinar library: www.emdmillipore.com/webinars
Scynexis Fully Integrated Drug Discovery & Development 2011 Overviewbrycechaney
SCYNEXIS provides fully-integrated contract research solutions including medicinal chemistry, discovery biology, ADMET-PK, bioanalysis and analytical chemistry, process chemistry and cGMP manufacturing. We have delivered 11 Preclinical Candidates (PCCs) to our clients since 2005. We are FDA and DEA inspected.
Ask yourself - Do you want compounds... Or do you want DRUGS?
Report Calc for Quality Control (RCQC) is an interpreter for the RCQC scripting language for text-mining log and data files to create reports and to control workflow within a workflow engine. It works as a python command line tool and also as a Galaxy bioinformatics platform tool. We're building a library of simple "recipe" scripts that extract quality control (QC) data from various reports like FastQC, QUAST, CheckM and SPAdes into a common JSON data format. By placing the RCQC app in your workflow downstream from one of these apps, you can convert their textual or tabular data into a much more standardized and software-friendly format.
Webinar: Is Phase-Appropriate Validation the Right Choice for your Cell or Ge...MilliporeSigma
Participate in the interactive webinar now: http://bit.ly/CGTWebinar
This webinar will introduce phase-appropriate validation and why it may be advantageous for cell and gene therapy development. We will also describe how validated platform assays can help you meet your critical development timelines.
Explore our webinar library: www.emdmillipore.com/webinars
Scynexis Fully Integrated Drug Discovery & Development 2011 Overviewbrycechaney
SCYNEXIS provides fully-integrated contract research solutions including medicinal chemistry, discovery biology, ADMET-PK, bioanalysis and analytical chemistry, process chemistry and cGMP manufacturing. We have delivered 11 Preclinical Candidates (PCCs) to our clients since 2005. We are FDA and DEA inspected.
Ask yourself - Do you want compounds... Or do you want DRUGS?
Report Calc for Quality Control (RCQC) is an interpreter for the RCQC scripting language for text-mining log and data files to create reports and to control workflow within a workflow engine. It works as a python command line tool and also as a Galaxy bioinformatics platform tool. We're building a library of simple "recipe" scripts that extract quality control (QC) data from various reports like FastQC, QUAST, CheckM and SPAdes into a common JSON data format. By placing the RCQC app in your workflow downstream from one of these apps, you can convert their textual or tabular data into a much more standardized and software-friendly format.
1. RAFAEL SOTO
5830 California Ave, Tracy CA 95304
c4if4s@hotmail.com 4156064029·(C)
QUALIFICATIONS SUMMARY
Laboratory Skills: Skilled analyzing raw chromatographic data, which includes
creating excel spread sheets and standard curves under GMP regulations.
Experienced using RP-HPLC and GC (FID direct injection and head space) to quantify
API’s and residual solvents, respectively. Knowledgeable in chromatographic method
development/optimization and validation (GC and RP-HPLC). Skilled reviewing and
executing validation protocols as well as preparing and writing respective validation
reports in compliance with cGMP guidelines.
Communication: Ability to communicate effectively with diverse individuals in
variety of environments; keep record of clear and concise information, provided to
audiences of varying technical skills; function as presenter in both group and one-on-
one settings.
Administration: Solid research and analysis skills with traditional and electronic
methods; talent creating and maintaining comprehensive lab notes to serve as
communication and research tools; ability to organize and manage priorities and
resources to consistently meet expectations.
Achievements/Strengths: Excellent self-discipline and motivation along with
reliability, consistently meeting deadlines and requirements. Strong commitment to
continuous growth, with ambition to become a high quality scientist. Demonstrated
ability to follow compendial protocols and standard operation procedures (SOP’s);
perform them in a safe, accurate and ethical manner. Fluent in English and Spanish
as well as multiple cultures.
EDUCATIONAL BACKGROUND
Bachelor of Science Degree in Biochemistry, 2009
SAN FRANCISCO STATE UNIVERSITY, San Francisco, CA
TECHNICAL EXPERTISE:
Equipment: GC (FID, TCD,) GC Head Space, Agilent HPLC, DEAE-Sephadex
column, GPC, VersaMax microplate reader, UV-Vis, Particle size
analyzer (HIAC), FTIR spectrometer, Nitrogen/Sulfur analyzer (Antek
9000), Rheometers (Brookfield), Coulometric KF Titrators (Mettler
Toledo), and general laboratory equipment
Techniques: Chromatography (GC, HPLC and GPC), protein concentration assays
(Bradford / DC protocols), enzymatic assays, SDS-PAGE, protein
extraction and purification, ion exchange chromatography.
Software: ChromPerfect, Chemstation, ChemStation Open Lab, Cirrus, Softmax,
Kaleidograph, Excel, PowerPoint, LIMS (Thermo Scientific), SAP LIMS,
SLIM (H & A Scientfic) and Outlook.
2. EXPERIENCE HIGHLIGHTS
Heron Therapeutics, 123 Saginaw Drive, Redwood City, CA
Chemist II Analytics and Development 2014- Now
GC and HPLC Method development/optimization
HPLC and GC method validation and co-validation--in harmony with external
contract laboratories--for NDA submission
Data review and SOP’s writing
Review and execution of validation protocols and writing of validation
reports.
Training of other analysts while implementing cGMP and GDP guidelines.
Instrument trouble shooting
Lab investigations (OOS/OOT)
QC data review
Heron Therapeutics (Formerly AP-Pharma), 123 Saginaw Drive, Redwood City, CA
QC chemist I October 2012- 2014
Responsible for QC activities which include but are not limited to physical and
visual inspection of products necessary for release and stability exercising
cGMP and GDP.
Related substances assays by HPLC
In Vitro Release (dissolution)assays by HPLC
Determination of molecular mass distribution of polyorthoesters by Gel
Permeation Chromatography (GPC)
Viscosity analysis
IR identification
Particle counting by light obscuration (HIAC)
Dow Chemicals, Hayward, CA
QC Technician, August 13th 2012 – October (Temp)
Performed quality control analysis on all different manufactured products—
water based paints— using GC, Particle size analyzer, FTIR, pH meter, and
Titrators.
Data entry and acquisition through SAP
Decision making in regards to how to proceed with bad product batches, by
being in constant communication with the production and chemical engineers
teams.
Sasol Wax, Richmond, CA
GC Technician, March 5th 2012- March 23rd 2012 (Temp)
Responsible for optimizing suitable GC methods for the analysis of wax
samples produced and or imported by Sasol Wax.
Determine quantitative carbon number distribution of petroleum waxes in the
range from n-C17 through n-C44 by GC direct injection (FID).
Compile and reported results to R&D manager.
Intertek Caleb Brett, Benicia, CA
Analytical chemist, July 2010-July 2011
Run and documented statistical quality control data (SQC) on various
analytical instruments.
3. Analysis of Nitrogen, Sulfur, Bromine, Chlorides, particulate matter, and
water content on different petroleum derivatives such gasoline, diesels, jet
fuels, crude oils, lube oils, ethanol, among others, using a wide variety of
ASTM methods, techniques and instruments such as Karl Fisher, GC, HPLC,
Antek 9000 and Horiba.
Improve other methods suitable for evaluating enhancer quantities in
gasoline, using gas chromatography.
Evaluate obtained results and reported them into LIMS Thermo Scientific.
Receive samples delivered by inspectors, and logged them in into LIMS.
Other tasks included prioritizing samples and tests, given the fact that clients
often require sample analysis on a rush basis.
San Francisco State University, San Francisco, CA
Biochemistry Student, January 2005 – May 2009
Acquired and applied understanding of biochemistry theories, history, standards, practice
and applications in academic environment. Conducted extensive research and information
analysis; planned and conducted laboratory experiments and projects. Partnered with
colleagues to plan and manage lab and research projects; developed and delivered
presentations in individual and group environments.
Enzymatic assays on β-galactosidase.
Purification of E. coli Alkaline Phosphatase by heat treatment, ammonium sulfate
precipitation, dialysis, and DEAE-Sephadex column
Protein analysis by SDS-PAGE.
Successfully utilized gas chromatography (GC) and high-pressure liquid
chromatography (HPLC) to quantify organic compounds using Kovats indices.
Conducted quantitative analysis of organic compounds in commercial flavorings,
pharmaceuticals, and caffeine and antioxidants in commercial teas, using GC and
HPLC.
Separated acid, basic and neutral components found in over-the-counter (OTC)
pharmaceutical product