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A series of novel (Z)-3-(2-(4-(2-oxo-2H-chromen-3-yl) thiazol-2-yl-)hydrazono)indolin-2-one (8a-8d, 9) were synthesized with various substituted indole derivatives. Structures of the newly synthesized compounds were elucidated by FT-IR, 1H-NMR, 13C-NMR and API-ES Mass spectral data. The in vitro cytotoxic activities of the complexes measurement against the human cancer T-lymphocyte cell lines. In vitro evaluation of these title complexes revealed cytotoxicity from 6.8-18µg/mL against CEM, 9.2-21µg/mL against L1210, 10-19µg/mL against Molt4/C8, 8-12µg/mL against HL60 and 8-16µg/mL against BEL7402. Coumarin derivatives 8c and 8d showed that quite significant anticancer activities. The antioxidant activity of the synthesized compounds was evaluated by DPPH scavenging method. Compounds 8c, 8d and 9 showed significant antioxidant activity compared with that of standard drug, ascorbic acid.
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The FTIR and FT Raman spectra of 1-4-Dichloro-2-NitroBenzene (14DC2NB) have been recorded in the region 4000-400 cm-1 and 3500-50 cm-1 respectively. The optimized geometry ,frequency and intensity of the vibrational bands of 1-4-Dichloro-2-NitroBenzene (14DC2NB) was obtained by the Density functional theory (DFT)using the basis set 6-31g(d,p). The harmonic vibrational frequencies were calculated and scaled values have been compared with experimental FT-IR and FT-Raman spectra. The Calculated and Observed frequencies are found to be in good agreement. UV-Visible spectrum of the compound was recorded, the electronic properties and HOMO - LUMO energies were calculated by Time Dependent DFT (TD-DFT) approach. A detailed interpretation of the infrared and Raman spectra were also reported based on Potential Energy Distribution (PED). The 1H and 13C nuclear magnetic resonance (NMR) chemical shifts of 14DC2NB were calculated using the GIAO approach by applying B3LYP method. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. The Chemical reactivity and Thermodynamic properties of 14DC2NB at different temperatures were also calculated
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Three new heteroleptic dithiocarbamate complexes with formula [M(Phen-dione)(Fcdtc)]PF6 (where M ¼
Ni(II) Ni-Fc, Cu(II) Cu-Fc) and [Co(Phen-dione)(Fcdtc)2]PF6 (Co-Fc) (Fcdtc ¼ N-ethanol-Nmethylferrocene
dithiocarbamate and Phen-dione ¼ 1,10-phenanthroline-5,6-dione; PF6
− ¼
hexafluorophosphate) were synthesized and characterized using microanalysis
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at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
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impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
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UNSYMMETRICAL DERIVATIZATION OF THE BENZENE PLATFORM WITH 8-HYDROXYQUINOLINE or 2- AMINOTHIOPHENOL
1. UNSYMMETRICAL DERIVATIZATION OF THE BENZENE
PLATFORM WITH 8-HYDROXYQUINOLINE or 2-
AMINOTHIOPHENOL
A
THESIS
SUBMITTED TO THE GURU NANAK DEV UNIVERSITY
AMRITSAR
FOR PARTIAL FULFILLMENT OF THE DEGREE
MASTER OF SCIENCE
IN
CHEMISTRY (HONOURS SCHOOL)
2013
Supervised By
Dr. Prabhpreet Singh
Submitted By
Ankit Grover
DEPARTMENT OF CHEMISTRY
GURU NANAK DEV UNIVERSITY
AMRITSAR-143005 (pb)
2. INTRODUCTION
The Benzene ring is useful as a small, rigid platform for receptor systems. However, in the easily
accessible 1,3,5-substituted benzene (A), mesitylene based host molecules (B), Durene based host
molecules (C) a conformational control of the binding groups is essentially non-existent. In 1976.
McNicol discover the preorganization of the functional groups in hexa-substituted benzene derivatives
(D) .In these systems, six identical substituents are disposed alternatingly above and below the
benzene plane. The major limitation for a wider use of these per- substituted benzene systems was
the difficulty to synthesize receptors with different functionalities on one phenyl ring that is the fact
that all six substituents had to be the same.
3. In this present research project, we have exploited the planer platform such as benzene for
multiple unsymmetrical functionalization. This could provide a platform for doing the sensing
R
RR
R
R
R
X
R
X
R
X
R
X
R
X
R
X
R
X
R
X
R
A B C D
X = S or CH2
4. Luigi Fabbrizzi et. al. described that molecular luminescent sensor for anions or cations can be built
through a modular approach, i.e. by covalently linking an appropriate photoactive fragment to the
receptor displaying a satisfactory affinity towards the desired substrate.
Perylene diimides (PDIs) are inexpensive, readily available compounds. Perylene diimides have
attracted great interest as a result of their unique optical and photo physical properties.
Benzene platform with 8-hydroxyquinoline on one and 2-aminothiophenol functionality on the other
arm could be utilized for functionalization of the perylene dianhydride. This could provide a
platform for doing the sensing on the perylene core.
5. EXPERIMENTAL SECTION
We started our project with the synthesis of these starting materials. We have carried out
bromomethylation of mesitylene and Durene core.
Br
potassiumphthalimide
90o
C,12h N
O
O
With these bromides in our hand, we carried out phthalation reaction with potassium phthalimide
by dissolving bromide in dimethylformamide (DMF) followed by addition of potassium phthalimide
slowly.
1-(Bromomethyl)-2, 3, 5, 6-tetramethylbenzene
2-(2,3,5,6-tetramethylbenzyl)isoindoline-1,3-dione
Br
HBr/Acetic acid
paraformaldehyde
40 °C, 8h
N
O
O
(HCHO)n,ZnBr2
HBr/Aceticacid(33%)
Aceticacid,100o
C,18h
N
O
O
Br
Now we are concern with doing the bromomethylation of these phthalimide derivatives allows
the complete conversion of the ArH into bromo-methylated derivatives
6. Next step in the way of next challenge is to synthesize benzene core either with 8-hydroxy
quinoline or 2-aminothiophenol functionality.
2-(2,4,6-trimethyl
-3,5-bis((quinolin-8-yloxy)methyl)benzyl)
isoindoline-1,3-dione
2-(4-(bromomethyl)
-2,3,5,6-tetramethylbenzyl)
isoindoline-1,3-dione
N
O
O
Br N
O
O
O
N
K2CO3, 8-hydroxyquinoline
DMF, 90o
C,10h
1H NMR (300 MHz, CDCl3, 25 ○C, TMS) δ (ppm): 2.33 (s, 6H, 2x CH3), δ 2.36 (s, 6H, 2x CH3), 5.00 (s,
2H, CH2O), 5.20 (s, 2H, CH2N), 7.29 (d, 1H), 7.39 (m, 1H), 7.43 (m, 1H), 7.41 (d, 1H), 7.61 (m,
2H), 7.70 (m, 2H), 8.13 (m, 1H), 8.91 (m, 1H).
7. 1H NMR (300 MHz, CDCl3, 25 ○C, TMS) δ (ppm): 2.2 (s, 6H), 2.3 (s, 6H), 4.0 (s, 2H), 4.91 (s, 2H), 6.58
(m, 1H), 6.71 (m, 1H), 7.09 (d, 1H), 7.16 (d, 1H), 7.69 (m, 2H), 7.79 (m, 2H).
N
O
O
B r N
O
O
S
N H 2
N a H , 2 - a m i n o t h i o p h e n o l
D M F , 9 0 o
C ,1 0 h
2-(4-((2-aminophenylthio)methyl)
-2,3,5,6-tetramethylbenzyl)
isoindoline-1,3-dione
2-(4-(bromomethyl)
-2,3,5,6-tetramethylbenzyl)
isoindoline-1,3-dione
8. 8-Hydroxyquinoline and its derivatives possess good photo-stability and strong ability to complex
metal ions and are used in organic light emitting diode devices in chromatography and in
electrochemi-luminescence etc. Recently, 8-hydroxyquinoline based fluoroionophores have been
developed for detecting Cd2+, Hg2+, Zn2+ ions and have proved to be effective in discriminating
Cd2+ over Zn2+.
2-aminothiophenol is a sulphur and nitrogen containing compound and can be introduced around
the benzene platforms and this will leads to introduction of more than one thiol groups on
benzene platform and thus could leads to the enhanced bond strength to metal cations.
CONCLUSION