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TEACHER MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	1
Process Overview
Note: This can be treated as a one-day or two-day activity
1.	 Part 1 (Day 1)
Explore, Read, and Analyze Texts - Establish the purpose of the Investigation, have students identify the
question, read the texts in the Investigation Library, and apply disciplinary concepts to develop an answer
to the Investigation question. This could be part of one class or even be assigned as homework.
2.	 Part 2 (Day 2)
Communicating Conclusions – Give students no more than 50 minutes to complete a five- to six-
paragraph essay (about 2 pages) responding to the Investigation question. Do not assign as homework.
Please make sure this is an in-class activity. Allow students to use their work from the prewriting
activity to help them during the in-class writing time.
Note: You are, of course, free to use this Investigation any way you want. That is, you might add or subtract
texts from the Library, extend the time students work on the question, or adjust the ways they communicate
their conclusions. However, sticking to the suggested process helps prepare students for the Investigations
you’ll submit to BHP Score, and also mimics some standardized testing environments.
UNIT 8 - TEACHING INVESTIGATION 8
HOW AND WHY HAVE OUR
REACTION AND RESPONSE TO
DISEASE CHANGED?
Purpose
Historical Purpose of the Investigation: Making comparisons is an important intellectual tool for all people and
especially for historians and scientists. Historians, in particular, make comparisons across time to understand what
has changed and what has remained constant. This question looks at the spread of plague and our collective
reaction to plague at two different times in human history—the fourteenth century and the nineteenth century. Such
a comparison enables us to see clearly how we have changed.
Pedagogical Purpose of the Investigation: This Investigation engages students in a formal comparison as they look
at the same phenomenon — plague — at two different points in time to analyze changes in our collective
understanding of it.
In this Investigation, more so than in others, it is important to help students connect the events covered to other
events in Big History. For example, students might not immediately see that we are asking them to compare events
before and after the Columbian Exchange, before and after the development of truly global networks. They should
use what they have been learning in Big History—particularly the changes discussed in Units 7 and 8 that have
enhanced our collective learning—but they might need your help in making such connections.
TEACHER MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	 2
Process
Framing the Problem: Discussing the Driving Question and Capturing Students’ Initial Conjectures
First, make sure students are familiar with the Investigation question: How and why have our reaction and response
to disease changed?
Then, introduce students to the problem framing:
Plague! The term evokes horror in most people and for good reason. Outbreaks of bubonic plague have killed well
over 100 million people throughout human history. And plague is what students are going to study in this
Investigation.
Actually, we’re going to compare two outbreaks of bubonic plague to try to explain whether or not they show
anything about how and why our responses to disease have changed.
Ask students, “What do you think? How has our collective response to major diseases changed over time?”
To help your students think about this, we are going to look at how humans responded to the same disease —
bubonic plague — at two different time periods. We have gathered some sources that show how those living in the
fourteenth century reacted to the spread of plague that killed at least one of every three people in Europe and the
Middle East.
And, we have found some sources to show how those in the nineteenth century responded to the same disease— an
outbreak of plague that killed about 15 million people.
We provide a chart to help students make their comparisons as they try to figure out how our reaction to disease
has changed.
Then, ask students to write a five- to six- paragraph explanation of how our collective reaction to disease has
changed over time. They should be able to use their chart, their notes, and the Investigation documents to write their
essay.
Part 1 – Explore, Read, and Analyze Texts
As students have done before, have them begin with their conjectures — their best guesses — before digging into
the evidence. Do they think there have been changes in our reactions and responses to major diseases over the past
500 years? What have they been? What explains these changes?
Analyzing Documents and Making Claims
Have students read the materials in the Investigation Library. We provide a chart for them to use to help them
capture information and organize their thinking. Students should complete the chart based on information they
gather from multiple sources to compare events in the fourteenth and nineteenth centuries.
Have them use this chart, their initial conjectures, notes, and any other information they have to try to figure how
our reactions to disease have changed.
TEACHER MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	 3
Part 2 – Communicating Conclusions
After students have done some research, ask them to show their thinking. Have them use what they have learned
about plague to explain in a five- to six-paragraph essay how and why our reactions to disease have changed over
the last 500 years.
•	 Use Big History ideas and content
•	 Acknowledge opposing viewpoints and explain why they reject them
•	 Support their thinking with logic and evidence
•	 Write a concluding paragraph to close their explanation
Give students no more than 50 minutes to complete the five- to six-paragraph essay responding to the Investigation
question.
Remind students that Investigations do not end with their answer. Have them read or discuss their classmates’
essays to compare their thinking with their peers. Do other students’ explanations support, extend, or challenge
their explanation?
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	1
UNIT 8 - INVESTIGATION 8
HOW AND WHY HAVE OUR
REACTION AND RESPONSE TO
DISEASE CHANGED?
Purpose
Making comparisons is an important intellectual tool for all people and especially for historians and scientists.
Historians, in particular, make comparisons across time to understand what has changed and what has remained
constant. This question looks at the spread of plague and our collective reaction to plague at two different times in
human history, the fourteenth century and the nineteenth century. Such a comparison enables us to see clearly how
we have changed.
Process
Framing the Problem: Discussing the Driving Question and Capturing Your Initial Conjectures
First, make sure you are familiar with the Investigation question: How and why have our reaction and response to
disease changed?
Then, read the problem framing:
Plague! The term evokes horror in most people and for good reason. Outbreaks of bubonic plague have
killed well over 100 million people throughout human history. And plague is what you’re going to study
in this Investigation.
Actually, you’re going to compare two outbreaks of bubonic plague to try to explain if they show
anything about how and why our responses to disease have changed.
What do you think? How has our collective response to major diseases changed over time?
To help you think about this we are going to look at how humans responded to the same disease —
bubonic plague — at two different time periods. We have gathered some sources that show how those
living in the fourteenth century reacted to the spread of plague that killed at least one of every three
people in Europe and the Middle East.
And, we have found some sources to show how those in the nineteenth century responded to the same
disease, an outbreak of plague that killed about 15 million people.
We provide a chart to help you make your comparisons as you try to figure out how our reaction to
disease has changed.
Then, write a five- to six- paragraph explanation of how our collective reaction to disease has changed
over time. You will be able to use your chart, your notes, and the Investigation documents to write your
essay.
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	2
Part 1 – Explore, Read, and Analyze Texts
As you have done before, please begin with your conjectures — your best guesses — before digging into the
evidence. Do you think there have been changes in our reactions and responses to major diseases over the past 500
years? What have they been? What explains these changes?
Analyzing Documents and Making Claims
Read the materials in the Investigation Library. We provide a chart for you to use to help you capture information
and organize your thinking.
Use this chart, your initial conjectures, notes, and any other information you have to try to figure how our reactions
to disease have changed.
Part 2 – Communicating Conclusions
After you’ve done some research, show your thinking. Use what you learned about plague to explain in a five- to
six-paragraph essay on how and why our reactions to disease have changed over the last 500 years.
Please make sure to explain your thinking. In your essay, you should:
•	 Use Big History ideas and content
•	 Acknowledge opposing viewpoints and explain why you reject them
•	 Support your thinking with logic and evidence
•	 Write a concluding paragraph to close your explanation
Investigations do not end with your answer. Read or discuss your classmates’ essays to compare their thinking with
yours. Do others students’ explanations support, extend, or challenge your explanation?
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	3
Plague and our response to it: comparing the 14th and 19th centuries
Use this table to organize your thinking. As you take notes on each of the “points of comparison,” record which texts
provide information for your argument. If you need to, make a copy of this table so you have more space to keep
notes.
Points of comparison Plague in the 14th century Plague in the 19th century
Causes of the plague
Treatment of patients
Measures taken by governments and
institutions to counter plague
outbreaks
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	4
8
INVESTIGATION
LIBRARY
TEXT 01	 PLAGUE IN THE 14TH AND 19TH CENTURIES	5
TEXT 02	 PLAGUE IN THE 14TH CENTURY: OUTBREAK IN CITIES	6
TEXT 03	 PLAGUE IN THE 14TH CENTURY: PLAGUE DOCTORS	7
TEXT 04	 PLAGUE IN THE 14TH CENTURY:
	 DOCTORS EXPLAIN THE CAUSES OF PLAGUE	8
TEXT 05	 PLAGUE IN THE 14TH CENTURY: PUBLIC HEALTH MEASURES	10
TEXT 06	 PLAGUE IN THE 19TH CENTURY: OUTBREAK IN CITIES	11
TEXT 07	 PLAGUE IN THE 19TH CENTURY:
	 SCIENTISTS DISCOVER THE PLAGUE BACILLUS	12
TEXT 08	 PLAGUE IN THE 19TH CENTURY: DISCOVERING THE ROLE OF FLEAS	13
TEXT 09	 PLAGUE IN THE 19TH CENTURY: PUBLIC HEALTH MEASURES	15
STUDENT MATERIALS
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	5BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 5
TEXT 01
PLAGUE IN THE 14TH
AND 19TH CENTURIES
There have been a number of outbreaks of bubonic plague in human history. This inves-
tigation focuses on two of the most horrific, the first of which began in the 1320s in
China before spreading to other parts of the world. Historians estimate that it killed
at least 20 million people; some think it might have wiped out half of the population in
Europe and the Middle East. This outbreak of plague is the most famous and is often
called the Black Death, because one of the symptoms of the disease is the blackening
of the skin around swellings called buboes. The second outbreak that we will focus
on began in 1884 in Hong Kong.
In the text below, Myron Echenberg discusses these two pandemics. Dr. Echenberg
was professor of African history at McGill University who has written several books on
how people in the past have responded to disease.
The Black Death has received the most attention from historians. It reached Europe
from Central Asia in 1347. Within four years, no fewer than 20 million Europeans
died, and estimates of deaths from plague during the rest of the 14th century range
from a low of one-quarter to a high of one-half the total population of both Europe
and the Middle East.
The most recent plague pandemic lasted from 1894 to roughly 1950. Bubonic plague
infected the densely populated provinces of south China before attacking the port
of Hong Kong in 1894. There it rekindled international fears, especially when it
reached Macao and Fuzhou a year later, and struck Singapore and Bombay in 1896.
Bubonic plague took only a few years to reach every continent. This time around,
the plague pandemic produced a highly variable death toll. Most of the roughly
15 million lives it ended prematurely were inhabitants of India, China, and Indonesia.
For India alone, recent estimates exceed 12 million. Europe’s death toll was 7,000
people between 1899 and 1950. Central and South America lost roughly 30,000 people
to plague over this long time span. In the United States, approximately 500 deaths
were attributed to plague during mild outbreaks in San Francisco, Los Angeles, and
New Orleans and in isolated rural settings in Arizona and New Mexico during this
same period.
Source
Modified from Myron Echenberg, Plague Ports: The Global Urban Impact of Bubonic Plague Between
1894 and 1901 (New York: New York University Press, 2007) 4–5.
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	6
THINGSTO
THINKABOUT
Canyouseeapatternin
thespreadofthedisease?
Whatexplainsthispattern?
Didyounoticethatplague
didnotstrikecitiesinthe
Americas,southernAfrica,
orAustralia?Whynot?
TEXT02
PLAGUEINTHE14THCENTURY:
OUTBREAKINCITIES
Themapbelowlistscitiesthathadmajoroutbreaksofplagueinthe14thcentury.
BIGHISTORYPROJECT/UNIT8INVESTIGATION6
LONDON,1349
BARCELONA,1348
PARIS,1348
ROME,1348
ALEXANDRIA,1348
CONSTANTINOPLE,
1347
KIEV,1350
MOSCOW,1353
PEKING,
1320s
BOMBAY,1340s
OutbreakofPlagueinCities
1320s—1353
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	7
THINGS TO
THINK ABOUT
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 7
Why do you think they
wore such clothes and
such a mask? What
does it suggest to you
about what these doctors
thought caused plague?
TEXT 03
PLAGUE IN THE
14TH CENTURY:
PLAGUE DOCTORS
Plague doctors were special physicians who treated plague during the 14th century and
later. The picture below shows the type of protective clothing they wore when treating
someone with plague — long coats, heavy gloves, and thick boots. Plague doctors also
wore beaklike masks in which they put spices, herbs, and vinegar, and they carried long
wands.
Doctor Schnabel von Rom, an engraving of a plague doctor by Paulus FĂĽrst, 1656
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	8BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8
TEXT 04
PLAGUE IN THE
14TH CENTURY:
DOCTORS EXPLAIN THE
CAUSES OF PLAGUE
Physicians of the 14th century had many different explanations for what caused plague.
Here are three. As you read, ask yourself four questions: (1) What claims were these
doctors making about the disease? (2) What claim testers were they using? (3) If someone
believed this claim, then how might they prevent catching the plague? (4) Finally, what
do you think of the claim?
A Muslim doctor living in Spain, Lisan al-Din Ibn al-Khatib, wrote this explanation of
how plague spread between 1349 and 1352. His claim is that plague is contagious, that
is, healthy people get it from sick people.
Contagion has been proved by experience, deduction, the senses, and observation,
and unanimous reports to cause plague. It is not a secret: those who come into contact
with [plague] patients mostly die, while those who do not come into contact survive.
Moreover, disease occurs in a household or neighborhood because of the mere pres-
ence of a contagious dress or utensil. Even [a contaminated] earring has been known
to kill whoever wears it and his whole household. And when it happens in a city, it
starts in one house and then affects the visitors of the house, then the neighbors, the
relatives, and other visitors until it spreads throughout the city. Reports were unani-
mous that isolated places that have no roads to them and are not frequented by people
have escaped unscathed from the plague.
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	9BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 9
The king of France asked the doctors at the Paris medical school to explain what was
causing plague. They claimed that constellations had created vapors that polluted the air.
We, the Members of the College of Physicians of Paris, intend to make known the
causes of this pestilence. We, therefore, declare as follows: It is known that in India
the constellations exerted their power against the sea and the waters of the ocean
arose in the form of vapor. Thereby the waters were so corrupted that the fish which
they contained died. This vapor spread itself through the air in many places on Earth.
On all the islands and adjoining countries to which the corrupted sea-wind extends,
if the inhabitants of those parts do not take the following advice, we announce to them
inevitable death.
Every one of you should protect himself [and herself] from the air. Wormwood and
chamomile should be burnt in great quantity in the market places and in the houses.
Going out at night is dangerous on account of the dew. Rainwater must not be
employed in cooking, and everyone should guard against exposure to wet weather,
fasting and anxiety of mind, anger, and immoderate drinking. Bathing is injurious.
Some people thought that evil people had caused the plague. In fact, many minorities,
including Jews, were persecuted unjustly because people blamed them for the
plague. Here a physician, Alphanso of Cordoba, explains how someone could spread
plague to an entire city and not catch it himself.
Air can be infected artificially and placed in a glass bottle. When this preparation is
well fermented, whoever wishes to produce this evil will wait for a strong and
steady wind. Then he will walk against the wind opposite the city or town he wishes
to infect. Going back against the wind, so as not to be infected by the vapor, he will
throw the glass bottle [with the disease in it] with against the stones. As soon as the
bottle is broken the [disease] vapor will spread out and disperse in the air. Whoever
is touched by this vapor will die very soon.
Sources
Modified from John Aberth, The First Horseman: Disease in Human History (Upper Saddle River, NJ:
Pearson Prentice Hall, 2007) 44–45.
Modified from George Deaux, The Black Death: 1347 (New York: Weybright and Talley, 1969), 52–53.
Modified from Jon Arrizabalaga, “Facing the Black Death: Perceptions and Reactions of University
Medical Practitioners,” in Luis García-Ballester, Roger French, Jon Arrizabalaga, and Andrew
Cunningham (ed.) Practical Medicine from Salerno to the Black Death (New York: Cambridge University
Press, 1993), 257.
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	10BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 10
TEXT 05
PLAGUE IN THE
14TH CENTURY: PUBLIC
HEALTH MEASURES
Cities infected by plague and those not yet infected took action to contain or prevent
the disease from spreading. Here are some laws that the city of Pistoia, Italy, passed
after neighboring cities of Pisa and Lucca became infected in 1348.
Ordinances against the Spread of the Plague, Pistoia, Italy
1. So that the sickness which is now threatening the region around Pistoia shall
be prevented from taking hold of the citizens of Pistoia, no citizen or resident of
Pistoia shall dare go to Pisa or Lucca. No one shall come to Pistoia from those
places. And no one from Pistoia shall receive or give hospitality to people who
have come from those places. And the guards who keep the gates of the city of
Pistoia shall not permit anyone travelling to the city from Pisa or Lucca to enter.
2. No one, whether from Pistoia or elsewhere, shall dare to bring to Pistoia any old
linen or woolen clothes.
3. The bodies of the dead shall not be removed from the place of death until they
have been enclosed in a wooden box, and the lid of planks nailed down.
5. No one, of whatever condition, status or standing, shall dare or presume to
bring a corpse into the city whether coffined or not.
13. So that the living are not made ill by rotten and corrupt food, no butcher or
retailer of meat shall dare to hang up meat, or keep and sell meat hung up in their
storehouse or over the counter.
14. Butchers and retailers of meat shall not stable horses or allow any mud or dung
where they sell meat
Source
Modified from Rosemary Horrox, The Black Death (Manchester: Manchester University Press, 1994)
194–196.
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	11
THINGSTO
THINKABOUT
Canyouseeapattern
inthespreadofthe
disease?Whatexplains
thispattern?Whydo
youthinkthisoutbreak
includedcitiesinthe
Americas,southern
AfricaandAustralia?
TEXT06
PLAGUEINTHE19THCENTURY:
OUTBREAKINCITIES
Themapbelowlistscitiesthathadmajoroutbreaksofplagueinthe19thcentury.
Source
MapcreatedfrominformationinMyronEchenberg,PlaguePorts:TheGlobalUrbanImpactofBubonicPlagueBetween1894and1901(NewYork:NewYorkUniversity
Press,2007),30.
BIGHISTORYPROJECT/UNIT8INVESTIGATION11
PORTO,1899
ALEXANDRIA,1899
BOMBAY,1896
RIODEJANERIO,1900
SANFRANCISCO,
1900
BUENOSAIRES,1900
HONGKONG,1894
SYDNEY,1900CAPETOWN,1901
OutbreakofPlagueinCities
1894—1901
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	12BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 12
TEXT 07
PLAGUE IN THE 19TH
CENTURY: SCIENTISTS
DISCOVER THE
PLAGUE BACILLUS
Medical science made a dramatic leap forward in the modern era with the discovery of
bacteria and the link between some of the microorganisms and disease. Using micro-
scopes and working in labs, 19th-century researchers such as Louis Pasteur and Robert
Koch connected bacteria to such diseases as tuberculosis, diphtheria, tetanus, and plague.
People worldwide read about such discoveries in new scientific journals or learned
about them at scientific conferences. Sometimes scientists or nations competed with
each other to make an important contribution to our collective learning. Such is the story
of the discovery of the bacteria that causes plague.
When the news spread of plague’s outbreak in Hong Kong in 1884, there was immedi-
ate interest from scientists’ eager to find a cause, a cure, and possibly fame for
themselves and their countries. In June 1884, two researchers — Shibasaburo Kitasato
from Japan and Alexandre Yersin from Switzerland — using microscopes to study the
blood from infected rats and people almost simultaneously identified the bacteria that
caused plague. For years there was a great rivalry over whether Kitasato or Yersin
was first and more accurate in identifying the plague bacillus, or the bacteria that
caused plague. Eventually, scientists found that Yersin was more accurate and today
that bacteria is called Yersina pestis.
Not only did Yersin identify the bacteria, he made the connection – a mistaken connection,
by the way — between rats and plague. He wrote in a journal shortly after his discovery:
I have placed healthy mice and inoculated [diseased] mice in the same cage. The
inoculated ones died first, but within a few days all of the others die from the invasive
plague bacillus. Plague is therefore a contagious and transmissible disease. It is
probable that rats are the major vector [carrier of the disease].
Yersin was wrong about rats spreading the infection. The next text will explain how
another scientist corrected Yersin’s mistake.
Sources
Myron Echenberg, Plague Ports: The Global Urban Impact of Bubonic Plague Between 1894 and 1901
(New York: New York University Press, 2007) 6.
Roy Porter, The Greatest Benefit to Mankind: A Medical History of Humanity (New York: Norton, 1997)
443–44.
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	13BIG HISTORY PROJECT / UNIT 7 INVESTIGATION 13
TEXT 08
PLAGUE IN THE 19TH
CENTURY: DISCOVERING
THE ROLE OF FLEAS
It was French physician and biologist Paul-Louis Simond who discovered the link
between the flea and plague. In 1898, he proved it using a very clever experiment that
he describes below. As you read, ask yourself three things: (1) What claim is Simond
making? (2) How did he test his claims? (3) With this new information, how might people
protect themselves from plague?
Without delay I proceeded to the experiment I had in mind since the time I had dis-
covered Yersin’s bacillus in the digestive tract of fleas taken from plague-ridden rats.
I prepared a device consisting of a large glass bottle. The lid consisted of wire mesh
covered with fabric held tightly to the neck of the bottle with a drawstring. I was fortu-
nate enough to catch a plague-infected rat in the home of a plague victim. In the rat’s
fur there were several fleas running around.
After 24 hours the animal I was experimenting on rolled up into a little ball, with its hair
standing on end. I then introduced into the bottle a small metal cage containing a per-
fectly healthy young Alexandria rat caught several weeks before and kept sequestered
from any danger of infection. The cage was suspended inside of the bottle. The cage
had three solid sides, but the other covered by wire screen with a mesh size of about
six millimeters. The rat inside the cage could not have any contact with the sick rat.
The next morning the sick rat had died. I left its body in the bottle for one more day.
Then I carefully removed it.
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	14BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 14
During the next four days the other Alexandria rat remained imprisoned in its cage
and continued to eat normally. About the fifth day, it seemed to have difficulty moving.
By the evening of the sixth day it was dead. An autopsy of this one (previously
uninfected rat) revealed there were abundant plague bacilli in the organs and blood.
That day, 2 June 1898, I felt an emotion that was inexpressible in the face of the
thought that I had uncovered a secret that had tortured man since the appearance of
plague in the world.
I subsequently repeated the same experiment with similar results.
Source
Marc Simond, Margaret L. Godley, and Pierre D.E. Mouriquand, “Paul-Louis Simond and His Discovery
of Plague Transmission by Rat Fleas: A Centenary,” Journal of the Royal Society of Medicine 91, no. 2
(1998): 102.
STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	15BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 15
TEXT 09
PLAGUE IN THE
19TH CENTURY: PUBLIC
HEALTH MEASURES
The outbreak of plague in one city made other cities fear they might be next. Some ended
trade with infected cities. As knowledge spread of the role that infected fleas and rats
played in the plague epidemic, many cities launched a full-scale assault on rats that lasted
for many years. The poster below, from about 1915, shows Philadelphia’s continuing
efforts to stay plague free. Many cities did as Philadelphia did and paid people for turn-
ing in rats. Philadelphia and other cities also created special “rat patrol” inspectors who
kept watch on waterfront rat traps and incoming ships. For example, Sydney, Australia,
declared “rat Wednesdays” and gave free rat poison to residents.
Source
Timothy Horning, “Kill the Rats!” The Philly History Blog, May 23, 2011. http://www.phillyhistory.org/blog/
index.php/2011/05/kill-the-rats/
1
Lexile measure indicates the reading demand of the text in terms of its semantic difficulty and syntactic complexity. The Lexile scale
generally ranges from 200L to 1700L. The Common Core emphasizes the role of text complexity in evaluating student readiness for
college and careers.
2
We are using the Common Core “stretch” grade bands. The Common Core Standards advocate a “staircase” of increasing text complexity
so that students “stretch” to read a certain proportion of texts from the next higher text complexity band. 

3
In the Flesch Reading Ease test, higher scores indicate that the material is relatively easy to read while lower scores indicate greater
difficulty. Scores in the 50–70 range should be easily understood by 13- to 15-year-olds, while those in the 0–30 range are appropriate for
university graduates. 

4
The introduction to Text 05 tests out as 960 Lexile, or within the 6th- to 8th-grade level. As the primary text is a translated list with
long
sentences, Lexile analysis scored it at 1660, which is quite advanced, while Flesch Ease scored it at 62.9, which is in the range of most
13- to 15-year-olds. We think, given the context, that students should be able to handle the document, but teachers should be aware of this
issue. 

5
See note 4. 

STUDENT MATERIALS
BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8	16
Analysis of texts in this investigation
Text Name Lexile
Measure1
Common Core
Stretch
Grade Band2
Mean
Sentence
Length
Flesch
Ease3
Plague in the 14th and 19th centuries 1070 6–8 15.4 44.6
Plague in the 14th century: Outbreak in cities 650 2–3 3.62 73.7
Plague in the 14th century: Plague doctors 1040 6–8 14.7 76.5
Plague in the 14th century: Doctors explain
plague’s causes
1000 6–8 14.4 63.2
Plague in the 14th century: Public health mea-
sures4
1570 Advanced5
26.0 63.2
Plague in the 19th century: Outbreak in cities 770 4–5 12.0 65.9
Plague in the 19th century: Scientists discover
plague bacillus
1230 9–10 16.9 38.4
Plague in the 19th century: Discovering the
role of fleas
960 6–8 15.7 63.7
Plague in the 19th century: Public health mea-
sures
1020 6–8 13.6 58.2

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Unit 8: Investigation 8

  • 1. TEACHER MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 1 Process Overview Note: This can be treated as a one-day or two-day activity 1. Part 1 (Day 1) Explore, Read, and Analyze Texts - Establish the purpose of the Investigation, have students identify the question, read the texts in the Investigation Library, and apply disciplinary concepts to develop an answer to the Investigation question. This could be part of one class or even be assigned as homework. 2. Part 2 (Day 2) Communicating Conclusions – Give students no more than 50 minutes to complete a five- to six- paragraph essay (about 2 pages) responding to the Investigation question. Do not assign as homework. Please make sure this is an in-class activity. Allow students to use their work from the prewriting activity to help them during the in-class writing time. Note: You are, of course, free to use this Investigation any way you want. That is, you might add or subtract texts from the Library, extend the time students work on the question, or adjust the ways they communicate their conclusions. However, sticking to the suggested process helps prepare students for the Investigations you’ll submit to BHP Score, and also mimics some standardized testing environments. UNIT 8 - TEACHING INVESTIGATION 8 HOW AND WHY HAVE OUR REACTION AND RESPONSE TO DISEASE CHANGED? Purpose Historical Purpose of the Investigation: Making comparisons is an important intellectual tool for all people and especially for historians and scientists. Historians, in particular, make comparisons across time to understand what has changed and what has remained constant. This question looks at the spread of plague and our collective reaction to plague at two different times in human history—the fourteenth century and the nineteenth century. Such a comparison enables us to see clearly how we have changed. Pedagogical Purpose of the Investigation: This Investigation engages students in a formal comparison as they look at the same phenomenon — plague — at two different points in time to analyze changes in our collective understanding of it. In this Investigation, more so than in others, it is important to help students connect the events covered to other events in Big History. For example, students might not immediately see that we are asking them to compare events before and after the Columbian Exchange, before and after the development of truly global networks. They should use what they have been learning in Big History—particularly the changes discussed in Units 7 and 8 that have enhanced our collective learning—but they might need your help in making such connections.
  • 2. TEACHER MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 2 Process Framing the Problem: Discussing the Driving Question and Capturing Students’ Initial Conjectures First, make sure students are familiar with the Investigation question: How and why have our reaction and response to disease changed? Then, introduce students to the problem framing: Plague! The term evokes horror in most people and for good reason. Outbreaks of bubonic plague have killed well over 100 million people throughout human history. And plague is what students are going to study in this Investigation. Actually, we’re going to compare two outbreaks of bubonic plague to try to explain whether or not they show anything about how and why our responses to disease have changed. Ask students, “What do you think? How has our collective response to major diseases changed over time?” To help your students think about this, we are going to look at how humans responded to the same disease — bubonic plague — at two different time periods. We have gathered some sources that show how those living in the fourteenth century reacted to the spread of plague that killed at least one of every three people in Europe and the Middle East. And, we have found some sources to show how those in the nineteenth century responded to the same disease— an outbreak of plague that killed about 15 million people. We provide a chart to help students make their comparisons as they try to figure out how our reaction to disease has changed. Then, ask students to write a five- to six- paragraph explanation of how our collective reaction to disease has changed over time. They should be able to use their chart, their notes, and the Investigation documents to write their essay. Part 1 – Explore, Read, and Analyze Texts As students have done before, have them begin with their conjectures — their best guesses — before digging into the evidence. Do they think there have been changes in our reactions and responses to major diseases over the past 500 years? What have they been? What explains these changes? Analyzing Documents and Making Claims Have students read the materials in the Investigation Library. We provide a chart for them to use to help them capture information and organize their thinking. Students should complete the chart based on information they gather from multiple sources to compare events in the fourteenth and nineteenth centuries. Have them use this chart, their initial conjectures, notes, and any other information they have to try to figure how our reactions to disease have changed.
  • 3. TEACHER MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 3 Part 2 – Communicating Conclusions After students have done some research, ask them to show their thinking. Have them use what they have learned about plague to explain in a five- to six-paragraph essay how and why our reactions to disease have changed over the last 500 years. • Use Big History ideas and content • Acknowledge opposing viewpoints and explain why they reject them • Support their thinking with logic and evidence • Write a concluding paragraph to close their explanation Give students no more than 50 minutes to complete the five- to six-paragraph essay responding to the Investigation question. Remind students that Investigations do not end with their answer. Have them read or discuss their classmates’ essays to compare their thinking with their peers. Do other students’ explanations support, extend, or challenge their explanation?
  • 4. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 1 UNIT 8 - INVESTIGATION 8 HOW AND WHY HAVE OUR REACTION AND RESPONSE TO DISEASE CHANGED? Purpose Making comparisons is an important intellectual tool for all people and especially for historians and scientists. Historians, in particular, make comparisons across time to understand what has changed and what has remained constant. This question looks at the spread of plague and our collective reaction to plague at two different times in human history, the fourteenth century and the nineteenth century. Such a comparison enables us to see clearly how we have changed. Process Framing the Problem: Discussing the Driving Question and Capturing Your Initial Conjectures First, make sure you are familiar with the Investigation question: How and why have our reaction and response to disease changed? Then, read the problem framing: Plague! The term evokes horror in most people and for good reason. Outbreaks of bubonic plague have killed well over 100 million people throughout human history. And plague is what you’re going to study in this Investigation. Actually, you’re going to compare two outbreaks of bubonic plague to try to explain if they show anything about how and why our responses to disease have changed. What do you think? How has our collective response to major diseases changed over time? To help you think about this we are going to look at how humans responded to the same disease — bubonic plague — at two different time periods. We have gathered some sources that show how those living in the fourteenth century reacted to the spread of plague that killed at least one of every three people in Europe and the Middle East. And, we have found some sources to show how those in the nineteenth century responded to the same disease, an outbreak of plague that killed about 15 million people. We provide a chart to help you make your comparisons as you try to figure out how our reaction to disease has changed. Then, write a five- to six- paragraph explanation of how our collective reaction to disease has changed over time. You will be able to use your chart, your notes, and the Investigation documents to write your essay.
  • 5. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 2 Part 1 – Explore, Read, and Analyze Texts As you have done before, please begin with your conjectures — your best guesses — before digging into the evidence. Do you think there have been changes in our reactions and responses to major diseases over the past 500 years? What have they been? What explains these changes? Analyzing Documents and Making Claims Read the materials in the Investigation Library. We provide a chart for you to use to help you capture information and organize your thinking. Use this chart, your initial conjectures, notes, and any other information you have to try to figure how our reactions to disease have changed. Part 2 – Communicating Conclusions After you’ve done some research, show your thinking. Use what you learned about plague to explain in a five- to six-paragraph essay on how and why our reactions to disease have changed over the last 500 years. Please make sure to explain your thinking. In your essay, you should: • Use Big History ideas and content • Acknowledge opposing viewpoints and explain why you reject them • Support your thinking with logic and evidence • Write a concluding paragraph to close your explanation Investigations do not end with your answer. Read or discuss your classmates’ essays to compare their thinking with yours. Do others students’ explanations support, extend, or challenge your explanation?
  • 6. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 3 Plague and our response to it: comparing the 14th and 19th centuries Use this table to organize your thinking. As you take notes on each of the “points of comparison,” record which texts provide information for your argument. If you need to, make a copy of this table so you have more space to keep notes. Points of comparison Plague in the 14th century Plague in the 19th century Causes of the plague Treatment of patients Measures taken by governments and institutions to counter plague outbreaks
  • 7. BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 4 8 INVESTIGATION LIBRARY TEXT 01 PLAGUE IN THE 14TH AND 19TH CENTURIES 5 TEXT 02 PLAGUE IN THE 14TH CENTURY: OUTBREAK IN CITIES 6 TEXT 03 PLAGUE IN THE 14TH CENTURY: PLAGUE DOCTORS 7 TEXT 04 PLAGUE IN THE 14TH CENTURY: DOCTORS EXPLAIN THE CAUSES OF PLAGUE 8 TEXT 05 PLAGUE IN THE 14TH CENTURY: PUBLIC HEALTH MEASURES 10 TEXT 06 PLAGUE IN THE 19TH CENTURY: OUTBREAK IN CITIES 11 TEXT 07 PLAGUE IN THE 19TH CENTURY: SCIENTISTS DISCOVER THE PLAGUE BACILLUS 12 TEXT 08 PLAGUE IN THE 19TH CENTURY: DISCOVERING THE ROLE OF FLEAS 13 TEXT 09 PLAGUE IN THE 19TH CENTURY: PUBLIC HEALTH MEASURES 15 STUDENT MATERIALS
  • 8. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 5BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 5 TEXT 01 PLAGUE IN THE 14TH AND 19TH CENTURIES There have been a number of outbreaks of bubonic plague in human history. This inves- tigation focuses on two of the most horrific, the first of which began in the 1320s in China before spreading to other parts of the world. Historians estimate that it killed at least 20 million people; some think it might have wiped out half of the population in Europe and the Middle East. This outbreak of plague is the most famous and is often called the Black Death, because one of the symptoms of the disease is the blackening of the skin around swellings called buboes. The second outbreak that we will focus on began in 1884 in Hong Kong. In the text below, Myron Echenberg discusses these two pandemics. Dr. Echenberg was professor of African history at McGill University who has written several books on how people in the past have responded to disease. The Black Death has received the most attention from historians. It reached Europe from Central Asia in 1347. Within four years, no fewer than 20 million Europeans died, and estimates of deaths from plague during the rest of the 14th century range from a low of one-quarter to a high of one-half the total population of both Europe and the Middle East. The most recent plague pandemic lasted from 1894 to roughly 1950. Bubonic plague infected the densely populated provinces of south China before attacking the port of Hong Kong in 1894. There it rekindled international fears, especially when it reached Macao and Fuzhou a year later, and struck Singapore and Bombay in 1896. Bubonic plague took only a few years to reach every continent. This time around, the plague pandemic produced a highly variable death toll. Most of the roughly 15 million lives it ended prematurely were inhabitants of India, China, and Indonesia. For India alone, recent estimates exceed 12 million. Europe’s death toll was 7,000 people between 1899 and 1950. Central and South America lost roughly 30,000 people to plague over this long time span. In the United States, approximately 500 deaths were attributed to plague during mild outbreaks in San Francisco, Los Angeles, and New Orleans and in isolated rural settings in Arizona and New Mexico during this same period. Source Modified from Myron Echenberg, Plague Ports: The Global Urban Impact of Bubonic Plague Between 1894 and 1901 (New York: New York University Press, 2007) 4–5.
  • 9. BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 6 THINGSTO THINKABOUT Canyouseeapatternin thespreadofthedisease? Whatexplainsthispattern? Didyounoticethatplague didnotstrikecitiesinthe Americas,southernAfrica, orAustralia?Whynot? TEXT02 PLAGUEINTHE14THCENTURY: OUTBREAKINCITIES Themapbelowlistscitiesthathadmajoroutbreaksofplagueinthe14thcentury. BIGHISTORYPROJECT/UNIT8INVESTIGATION6 LONDON,1349 BARCELONA,1348 PARIS,1348 ROME,1348 ALEXANDRIA,1348 CONSTANTINOPLE, 1347 KIEV,1350 MOSCOW,1353 PEKING, 1320s BOMBAY,1340s OutbreakofPlagueinCities 1320s—1353
  • 10. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 7 THINGS TO THINK ABOUT BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 7 Why do you think they wore such clothes and such a mask? What does it suggest to you about what these doctors thought caused plague? TEXT 03 PLAGUE IN THE 14TH CENTURY: PLAGUE DOCTORS Plague doctors were special physicians who treated plague during the 14th century and later. The picture below shows the type of protective clothing they wore when treating someone with plague — long coats, heavy gloves, and thick boots. Plague doctors also wore beaklike masks in which they put spices, herbs, and vinegar, and they carried long wands. Doctor Schnabel von Rom, an engraving of a plague doctor by Paulus FĂĽrst, 1656
  • 11. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 8BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 TEXT 04 PLAGUE IN THE 14TH CENTURY: DOCTORS EXPLAIN THE CAUSES OF PLAGUE Physicians of the 14th century had many different explanations for what caused plague. Here are three. As you read, ask yourself four questions: (1) What claims were these doctors making about the disease? (2) What claim testers were they using? (3) If someone believed this claim, then how might they prevent catching the plague? (4) Finally, what do you think of the claim? A Muslim doctor living in Spain, Lisan al-Din Ibn al-Khatib, wrote this explanation of how plague spread between 1349 and 1352. His claim is that plague is contagious, that is, healthy people get it from sick people. Contagion has been proved by experience, deduction, the senses, and observation, and unanimous reports to cause plague. It is not a secret: those who come into contact with [plague] patients mostly die, while those who do not come into contact survive. Moreover, disease occurs in a household or neighborhood because of the mere pres- ence of a contagious dress or utensil. Even [a contaminated] earring has been known to kill whoever wears it and his whole household. And when it happens in a city, it starts in one house and then affects the visitors of the house, then the neighbors, the relatives, and other visitors until it spreads throughout the city. Reports were unani- mous that isolated places that have no roads to them and are not frequented by people have escaped unscathed from the plague.
  • 12. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 9BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 9 The king of France asked the doctors at the Paris medical school to explain what was causing plague. They claimed that constellations had created vapors that polluted the air. We, the Members of the College of Physicians of Paris, intend to make known the causes of this pestilence. We, therefore, declare as follows: It is known that in India the constellations exerted their power against the sea and the waters of the ocean arose in the form of vapor. Thereby the waters were so corrupted that the fish which they contained died. This vapor spread itself through the air in many places on Earth. On all the islands and adjoining countries to which the corrupted sea-wind extends, if the inhabitants of those parts do not take the following advice, we announce to them inevitable death. Every one of you should protect himself [and herself] from the air. Wormwood and chamomile should be burnt in great quantity in the market places and in the houses. Going out at night is dangerous on account of the dew. Rainwater must not be employed in cooking, and everyone should guard against exposure to wet weather, fasting and anxiety of mind, anger, and immoderate drinking. Bathing is injurious. Some people thought that evil people had caused the plague. In fact, many minorities, including Jews, were persecuted unjustly because people blamed them for the plague. Here a physician, Alphanso of Cordoba, explains how someone could spread plague to an entire city and not catch it himself. Air can be infected artificially and placed in a glass bottle. When this preparation is well fermented, whoever wishes to produce this evil will wait for a strong and steady wind. Then he will walk against the wind opposite the city or town he wishes to infect. Going back against the wind, so as not to be infected by the vapor, he will throw the glass bottle [with the disease in it] with against the stones. As soon as the bottle is broken the [disease] vapor will spread out and disperse in the air. Whoever is touched by this vapor will die very soon. Sources Modified from John Aberth, The First Horseman: Disease in Human History (Upper Saddle River, NJ: Pearson Prentice Hall, 2007) 44–45. Modified from George Deaux, The Black Death: 1347 (New York: Weybright and Talley, 1969), 52–53. Modified from Jon Arrizabalaga, “Facing the Black Death: Perceptions and Reactions of University Medical Practitioners,” in Luis GarcĂ­a-Ballester, Roger French, Jon Arrizabalaga, and Andrew Cunningham (ed.) Practical Medicine from Salerno to the Black Death (New York: Cambridge University Press, 1993), 257.
  • 13. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 10BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 10 TEXT 05 PLAGUE IN THE 14TH CENTURY: PUBLIC HEALTH MEASURES Cities infected by plague and those not yet infected took action to contain or prevent the disease from spreading. Here are some laws that the city of Pistoia, Italy, passed after neighboring cities of Pisa and Lucca became infected in 1348. Ordinances against the Spread of the Plague, Pistoia, Italy 1. So that the sickness which is now threatening the region around Pistoia shall be prevented from taking hold of the citizens of Pistoia, no citizen or resident of Pistoia shall dare go to Pisa or Lucca. No one shall come to Pistoia from those places. And no one from Pistoia shall receive or give hospitality to people who have come from those places. And the guards who keep the gates of the city of Pistoia shall not permit anyone travelling to the city from Pisa or Lucca to enter. 2. No one, whether from Pistoia or elsewhere, shall dare to bring to Pistoia any old linen or woolen clothes. 3. The bodies of the dead shall not be removed from the place of death until they have been enclosed in a wooden box, and the lid of planks nailed down. 5. No one, of whatever condition, status or standing, shall dare or presume to bring a corpse into the city whether coffined or not. 13. So that the living are not made ill by rotten and corrupt food, no butcher or retailer of meat shall dare to hang up meat, or keep and sell meat hung up in their storehouse or over the counter. 14. Butchers and retailers of meat shall not stable horses or allow any mud or dung where they sell meat Source Modified from Rosemary Horrox, The Black Death (Manchester: Manchester University Press, 1994) 194–196.
  • 14. BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 11 THINGSTO THINKABOUT Canyouseeapattern inthespreadofthe disease?Whatexplains thispattern?Whydo youthinkthisoutbreak includedcitiesinthe Americas,southern AfricaandAustralia? TEXT06 PLAGUEINTHE19THCENTURY: OUTBREAKINCITIES Themapbelowlistscitiesthathadmajoroutbreaksofplagueinthe19thcentury. Source MapcreatedfrominformationinMyronEchenberg,PlaguePorts:TheGlobalUrbanImpactofBubonicPlagueBetween1894and1901(NewYork:NewYorkUniversity Press,2007),30. BIGHISTORYPROJECT/UNIT8INVESTIGATION11 PORTO,1899 ALEXANDRIA,1899 BOMBAY,1896 RIODEJANERIO,1900 SANFRANCISCO, 1900 BUENOSAIRES,1900 HONGKONG,1894 SYDNEY,1900CAPETOWN,1901 OutbreakofPlagueinCities 1894—1901
  • 15. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 12BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 12 TEXT 07 PLAGUE IN THE 19TH CENTURY: SCIENTISTS DISCOVER THE PLAGUE BACILLUS Medical science made a dramatic leap forward in the modern era with the discovery of bacteria and the link between some of the microorganisms and disease. Using micro- scopes and working in labs, 19th-century researchers such as Louis Pasteur and Robert Koch connected bacteria to such diseases as tuberculosis, diphtheria, tetanus, and plague. People worldwide read about such discoveries in new scientific journals or learned about them at scientific conferences. Sometimes scientists or nations competed with each other to make an important contribution to our collective learning. Such is the story of the discovery of the bacteria that causes plague. When the news spread of plague’s outbreak in Hong Kong in 1884, there was immedi- ate interest from scientists’ eager to find a cause, a cure, and possibly fame for themselves and their countries. In June 1884, two researchers — Shibasaburo Kitasato from Japan and Alexandre Yersin from Switzerland — using microscopes to study the blood from infected rats and people almost simultaneously identified the bacteria that caused plague. For years there was a great rivalry over whether Kitasato or Yersin was first and more accurate in identifying the plague bacillus, or the bacteria that caused plague. Eventually, scientists found that Yersin was more accurate and today that bacteria is called Yersina pestis. Not only did Yersin identify the bacteria, he made the connection – a mistaken connection, by the way — between rats and plague. He wrote in a journal shortly after his discovery: I have placed healthy mice and inoculated [diseased] mice in the same cage. The inoculated ones died first, but within a few days all of the others die from the invasive plague bacillus. Plague is therefore a contagious and transmissible disease. It is probable that rats are the major vector [carrier of the disease]. Yersin was wrong about rats spreading the infection. The next text will explain how another scientist corrected Yersin’s mistake. Sources Myron Echenberg, Plague Ports: The Global Urban Impact of Bubonic Plague Between 1894 and 1901 (New York: New York University Press, 2007) 6. Roy Porter, The Greatest Benefit to Mankind: A Medical History of Humanity (New York: Norton, 1997) 443–44.
  • 16. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 13BIG HISTORY PROJECT / UNIT 7 INVESTIGATION 13 TEXT 08 PLAGUE IN THE 19TH CENTURY: DISCOVERING THE ROLE OF FLEAS It was French physician and biologist Paul-Louis Simond who discovered the link between the flea and plague. In 1898, he proved it using a very clever experiment that he describes below. As you read, ask yourself three things: (1) What claim is Simond making? (2) How did he test his claims? (3) With this new information, how might people protect themselves from plague? Without delay I proceeded to the experiment I had in mind since the time I had dis- covered Yersin’s bacillus in the digestive tract of fleas taken from plague-ridden rats. I prepared a device consisting of a large glass bottle. The lid consisted of wire mesh covered with fabric held tightly to the neck of the bottle with a drawstring. I was fortu- nate enough to catch a plague-infected rat in the home of a plague victim. In the rat’s fur there were several fleas running around. After 24 hours the animal I was experimenting on rolled up into a little ball, with its hair standing on end. I then introduced into the bottle a small metal cage containing a per- fectly healthy young Alexandria rat caught several weeks before and kept sequestered from any danger of infection. The cage was suspended inside of the bottle. The cage had three solid sides, but the other covered by wire screen with a mesh size of about six millimeters. The rat inside the cage could not have any contact with the sick rat. The next morning the sick rat had died. I left its body in the bottle for one more day. Then I carefully removed it.
  • 17. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 14BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 14 During the next four days the other Alexandria rat remained imprisoned in its cage and continued to eat normally. About the fifth day, it seemed to have difficulty moving. By the evening of the sixth day it was dead. An autopsy of this one (previously uninfected rat) revealed there were abundant plague bacilli in the organs and blood. That day, 2 June 1898, I felt an emotion that was inexpressible in the face of the thought that I had uncovered a secret that had tortured man since the appearance of plague in the world. I subsequently repeated the same experiment with similar results. Source Marc Simond, Margaret L. Godley, and Pierre D.E. Mouriquand, “Paul-Louis Simond and His Discovery of Plague Transmission by Rat Fleas: A Centenary,” Journal of the Royal Society of Medicine 91, no. 2 (1998): 102.
  • 18. STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 15BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 15 TEXT 09 PLAGUE IN THE 19TH CENTURY: PUBLIC HEALTH MEASURES The outbreak of plague in one city made other cities fear they might be next. Some ended trade with infected cities. As knowledge spread of the role that infected fleas and rats played in the plague epidemic, many cities launched a full-scale assault on rats that lasted for many years. The poster below, from about 1915, shows Philadelphia’s continuing efforts to stay plague free. Many cities did as Philadelphia did and paid people for turn- ing in rats. Philadelphia and other cities also created special “rat patrol” inspectors who kept watch on waterfront rat traps and incoming ships. For example, Sydney, Australia, declared “rat Wednesdays” and gave free rat poison to residents. Source Timothy Horning, “Kill the Rats!” The Philly History Blog, May 23, 2011. http://www.phillyhistory.org/blog/ index.php/2011/05/kill-the-rats/
  • 19. 1 Lexile measure indicates the reading demand of the text in terms of its semantic difficulty and syntactic complexity. The Lexile scale generally ranges from 200L to 1700L. The Common Core emphasizes the role of text complexity in evaluating student readiness for college and careers. 2 We are using the Common Core “stretch” grade bands. The Common Core Standards advocate a “staircase” of increasing text complexity so that students “stretch” to read a certain proportion of texts from the next higher text complexity band. 
 3 In the Flesch Reading Ease test, higher scores indicate that the material is relatively easy to read while lower scores indicate greater difficulty. Scores in the 50–70 range should be easily understood by 13- to 15-year-olds, while those in the 0–30 range are appropriate for university graduates. 
 4 The introduction to Text 05 tests out as 960 Lexile, or within the 6th- to 8th-grade level. As the primary text is a translated list with
long sentences, Lexile analysis scored it at 1660, which is quite advanced, while Flesch Ease scored it at 62.9, which is in the range of most 13- to 15-year-olds. We think, given the context, that students should be able to handle the document, but teachers should be aware of this issue. 
 5 See note 4. 
 STUDENT MATERIALS BIG HISTORY PROJECT / UNIT 8 INVESTIGATION 8 16 Analysis of texts in this investigation Text Name Lexile Measure1 Common Core Stretch Grade Band2 Mean Sentence Length Flesch Ease3 Plague in the 14th and 19th centuries 1070 6–8 15.4 44.6 Plague in the 14th century: Outbreak in cities 650 2–3 3.62 73.7 Plague in the 14th century: Plague doctors 1040 6–8 14.7 76.5 Plague in the 14th century: Doctors explain plague’s causes 1000 6–8 14.4 63.2 Plague in the 14th century: Public health mea- sures4 1570 Advanced5 26.0 63.2 Plague in the 19th century: Outbreak in cities 770 4–5 12.0 65.9 Plague in the 19th century: Scientists discover plague bacillus 1230 9–10 16.9 38.4 Plague in the 19th century: Discovering the role of fleas 960 6–8 15.7 63.7 Plague in the 19th century: Public health mea- sures 1020 6–8 13.6 58.2