The aim of this presentation is to promote an understanding of the origins of pesticide residues, and current industry challenges due to increasing regulations for the management and compliance of food products destined for international markets.
Analytical Development of Biosimilar Mabs: From Vision to Reality SGS
The approval of the first biosimilar mAbs in Europe last June (Celltrion’s Remsima™ and Hospira’s Inflectra™ versions of infliximab) paves the way for the advent of more widespread access to biological treatments in indications such as rheumatology and oncology. One year on, lessons learned from these approvals will guide the global regulatory framework for such complex biomolecules. Indeed, several more biosimilar mAbs are currently in late-stage clinical trials and can be expected to be submitted to Regulatory Authorities shortly. Read more or listen to live streaming http://bit.ly/SGSBiosimilarWebinar
Impact of Sample Handling and Processing on Bioanalycial OutcomeSGS
Data from clinical assays (biomarkers, PK, PD, and immunogenicity) are often key outcomes from clinical trials. Implementing these endpoints in clinical trials is very costly and also time - and resource-consuming. Therefore, ensuring that appropriate measures are taken from the collection of samples until the completion of laboratory testing is paramount.
The purpose of this presentation is to discuss the challenges and potential pitfalls of sample collection, processing, and storage on the final bioanalytical endpoints and laboratory assays. Key parameters affecting various assay endpoints will be discussed and illustrated with specific examples, highlighting the SGS approach to handling and controlling these critical activities for the successful delivery of these studies outcomes.
Contact Us: clinicalresearch@sgs.com
Visit our Website: http://www.sgs.com/cro
Follow Us on LinkedIn: http://bit.ly/SGSLifeSciences
In this presentation from CPhi 2014, Elise Gallais outlines the guidelines for cleaning validation: and focuses on analytical methods and their validation.
Understanding Persistent Organic Pollutants (POPs) and Managing their ImpactSGS
The aim of this presentation is to promote an understanding of the origins of POPs, current industry challenges due to increasing EU and US regulations, and the principles of POPs management and compliance.
Food Safety: A Shared Responsibility – Key Highlights from the Global Food Sa...SGS
The GFSI Global Food Safety Conference is a unique annual event for bringing together over 800 leading food safety specialists from over 50 countries to advance Food Safety globally. The Conference provides the opportunity to meet and network with industry peers, share knowledge, benefit from though-provoking presentations from internationally reputed industry experts and hear innovative ideas to implement in your workplace.
In this presentation, we share highlights on key takeaways from the SGS Special Session and Breakout Sessions during the GFSC 2015 in Kuala Lumpur, Malaysia.
Analytical Development of Biosimilar Mabs: From Vision to Reality SGS
The approval of the first biosimilar mAbs in Europe last June (Celltrion’s Remsima™ and Hospira’s Inflectra™ versions of infliximab) paves the way for the advent of more widespread access to biological treatments in indications such as rheumatology and oncology. One year on, lessons learned from these approvals will guide the global regulatory framework for such complex biomolecules. Indeed, several more biosimilar mAbs are currently in late-stage clinical trials and can be expected to be submitted to Regulatory Authorities shortly. Read more or listen to live streaming http://bit.ly/SGSBiosimilarWebinar
Impact of Sample Handling and Processing on Bioanalycial OutcomeSGS
Data from clinical assays (biomarkers, PK, PD, and immunogenicity) are often key outcomes from clinical trials. Implementing these endpoints in clinical trials is very costly and also time - and resource-consuming. Therefore, ensuring that appropriate measures are taken from the collection of samples until the completion of laboratory testing is paramount.
The purpose of this presentation is to discuss the challenges and potential pitfalls of sample collection, processing, and storage on the final bioanalytical endpoints and laboratory assays. Key parameters affecting various assay endpoints will be discussed and illustrated with specific examples, highlighting the SGS approach to handling and controlling these critical activities for the successful delivery of these studies outcomes.
Contact Us: clinicalresearch@sgs.com
Visit our Website: http://www.sgs.com/cro
Follow Us on LinkedIn: http://bit.ly/SGSLifeSciences
In this presentation from CPhi 2014, Elise Gallais outlines the guidelines for cleaning validation: and focuses on analytical methods and their validation.
Understanding Persistent Organic Pollutants (POPs) and Managing their ImpactSGS
The aim of this presentation is to promote an understanding of the origins of POPs, current industry challenges due to increasing EU and US regulations, and the principles of POPs management and compliance.
Food Safety: A Shared Responsibility – Key Highlights from the Global Food Sa...SGS
The GFSI Global Food Safety Conference is a unique annual event for bringing together over 800 leading food safety specialists from over 50 countries to advance Food Safety globally. The Conference provides the opportunity to meet and network with industry peers, share knowledge, benefit from though-provoking presentations from internationally reputed industry experts and hear innovative ideas to implement in your workplace.
In this presentation, we share highlights on key takeaways from the SGS Special Session and Breakout Sessions during the GFSC 2015 in Kuala Lumpur, Malaysia.
SGS First Quarter 2024 Sales Update Presentation EN.pdfSGS
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: https://www.sgs.com/en/investors/results
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
SGS 2022 Full Year Results Alternative Performance Measures ReportSGS
This document presents and defines the Group’s alternative performance measures (APMs), not defined by IFRS which are used
to evaluate financial and operational performance. Where relevant, a reconciliation to the information included in our IFRS consolidated
financial statements is presented. Management deems these performance measures as a useful source of information when taking
strategic decisions and managing the operations. These APMs are disclosed in the annual report, the half year report and other external
communications to investors, as well as available under: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Discover our Corporate Sustainability report to get an overview of how we contribute to sustainability, demonstrated by case studies from our operations and services, and a summary of performance.
We've delivered a strong financial performance in 2021, making significant progress on our new strategic plan.
#SGS #SGSGroup #WeAreSGS #FinancialResults
SGS 2021 Full Year Results Alternative Performance MeasuresSGS
We've delivered a strong financial performance in 2021, making significant progress on our new strategic plan.
#SGS #SGSGroup #WeAreSGS #FinancialResults
Learn about our collaboration on a range of innovative circular projects with Dutch Government.
Discussion with three experts on safe construction.
First recycled content declarations for manufacturers.
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
SGS First Quarter 2024 Sales Update Presentation EN.pdfSGS
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: https://www.sgs.com/en/investors/results
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
SGS 2022 Full Year Results Alternative Performance Measures ReportSGS
This document presents and defines the Group’s alternative performance measures (APMs), not defined by IFRS which are used
to evaluate financial and operational performance. Where relevant, a reconciliation to the information included in our IFRS consolidated
financial statements is presented. Management deems these performance measures as a useful source of information when taking
strategic decisions and managing the operations. These APMs are disclosed in the annual report, the half year report and other external
communications to investors, as well as available under: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Discover our Corporate Sustainability report to get an overview of how we contribute to sustainability, demonstrated by case studies from our operations and services, and a summary of performance.
We've delivered a strong financial performance in 2021, making significant progress on our new strategic plan.
#SGS #SGSGroup #WeAreSGS #FinancialResults
SGS 2021 Full Year Results Alternative Performance MeasuresSGS
We've delivered a strong financial performance in 2021, making significant progress on our new strategic plan.
#SGS #SGSGroup #WeAreSGS #FinancialResults
Learn about our collaboration on a range of innovative circular projects with Dutch Government.
Discussion with three experts on safe construction.
First recycled content declarations for manufacturers.
Get the financial highlights and an overview of our performance per business. You can view our financial reports here: www.sgs.com/en/our-company/investor-relations/reports-and-presentations
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
The need to protect crops from pests and damage dates back millennia. Insecticides were first recorded 4,500 years ago, when sulphur was used by the Sumerians to control insects and mites. Mercury, arsenic, tar, copper sulphate, lime, and smoking with fumes have all been tried as a solution to protect valuable crops.
The Food and Agriculture Organisation of the United Nations (FAO) Code of Conduct definition of a pesticide is as follows: ‘Pesticide means any substance or mixture of substances intended for preventing, destroying or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals causing harm during or otherwise interfering with the production, processing, storage, transport, or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs, or which may be administered to animals for the control of insects, arachnids or other pests in or on their bodies’.
‘The term includes substances intended for use as a plant growth regulator, defoliant, desiccant, or agent for thinning fruit or preventing the premature fall of fruit, and substances applied to crops either before or after harvest to protect the commodity from deterioration during storage and transport.’
In the 1940’s these new products were inexpensive, effective and highly lauded: the discovery of DDT’s insecticidal properties won Dr Paul Muller the Nobel Prize in Medicine in 1949. DDT-based pesticides had emerged as the most effective method of controlling pests but their use wasn’t without its problems. ‘The Silent Spring’, written in 1962 by Rachel Carson, laid out the environmental dangers of indiscriminate pesticide use, which prompted a shift in public perception and a rethink by governments on how to control pesticide use worldwide. Notably the book inspired a movement, which ultimately led to a ban on the use of DDT for agricultural purposes.
The end of the 20th and beginning of the 21st century heralded the development of entirely new families of agrochemicals.
Advances in chemistry made these new pesticides safer, more selective and far friendlier to the environment, with usage rates only requiring grams rather than kilograms per hectare to be effective.
Pesticides is an estimated $35 billion industry accounting for more than 2.5 million tonnes of chemicals deposited into the environment annually.
Regulation (EC) No 396/2005 sets out the MRLs for pesticides, which are permitted in plant or animal origin products intended for human or animal consumption. MRLs are established at the legal upper level deemed to have the lowest impact on consumer exposure – quantified by a comprehensive risk assessment of the active substance intake at predetermined intake levels.
Countries in most instances choose to exercise their sovereign right to set their own legally binding MRLs or tolerances. Producers exporting to these countries need to adhere to the specific local requirements in place, which if you are exporting to multiple markets can become difficult to manage.
This is rendered even more complex by the fact that each individual pesticide, (and there are hundreds) has its own acceptable MRL in every country.
Moreover, countries establish different MRLs for the hundreds of different food products that may or may not end up.
The resulting list ends up with literally thousands of MRLs for each individual country, which manufacturers have to consider whenever selling products into a specific region. (And of course if you are selling multiple products to multiple regions the task becomes exponentially harder).
The biggest challenge to any manufacturer selling raw agricultural products and/or processed food around the globe is meeting the challenge of differing regulations concerning MRLs. International guidance on MRLs for specific food items or groups of food are set by the Codex Committee on Pesticide Residues (CCPR) based on scientific advice from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR).
In the next slide we will give an example of the impact that Pesticides can have on the economy.
The setting of MRLs at 0.1ppm by the European Union (EU) on diphenylamine (DPA) but the ongoing use of the chemical at 10ppm by US growers to keep apples fresh while in storage has effectively ‘banned’ US apple exports into the EU. That sounds simple enough until you consider the following…[Go to next slide].
With most US apples being found to have DPA concentrations at an average of 0.4ppm and DPA present on 80% of them (based on the most recent research), the EU ruling effectively blocks a US export trade worth around $1.5 million a year. But it may also have consequences for any manufacturers of products which source US apples in the supply chain as a raw ingredient before a final processed product is successfully entered onto the EU market. That could include anything from apple pie, to cereal/cereal bars and from baby food to cider.
Governments setting MRLs have someway to go before any harmonised approach is implemented worldwide. Therefore it is imperative that companies involved in food and feed goods are proactive and vigilant in understanding and meeting MRL requirements in their chosen markets.
The chemical industry is continually researching and developing ever safer and more effective pesticide alternatives.
This requires everyone in the supply chain to be constantly vigilant and up-to-date on any new pesticides registered and marketed by the chemical industry. And more importantly, to be aware of: i) whether their usage impacts their own supply chain ii) how its usage on products is being viewed by the target local and export market regulators
How and where the pesticide is applied can affect the residue level. For example, pesticides applied to a product to suppress growth in long-term storage generally require multiple applications and can create excess levels of pesticide in the soil.
With supply chains becoming ever more globalised, understanding the national differences in MRLs is key to ensuring speed to market for food manufacturers, traders and retailers.
Expert, trusted and independent third-party pesticides consultancy can help to remove ambiguity and uncertainty around pesticides and MRLs. Testing and verification via state-of-the-art analytical methods for any given pesticide and any given matrix is essential for regulatory compliance. Partnering with a global organization that offers local representation is one of the most efficient and effective ways to access this capability and avoid costly product recalls or product bans, and the subsequent potential for damage to brand reputation.