Marek Piasecki advocates for an anti-framework approach to web development called UDD (Understanding Driven Development). UDD is against using frameworks and other methodologies that dictate application structure. It promotes choosing your own abstractions and tools based on what is needed rather than following a predefined framework. The document provides a case study example of how UDD allows flexibility in choosing abstractions like migrations, models, controllers, and views without constraints of a framework. It emphasizes determining your own optimal structure for a project rather than conforming to prescribed framework conventions.