The UCSF Cancer Center provides personalized cancer treatment and conducts clinical trials to advance progress against cancer. A new cancer research building has opened to facilitate collaborative, interdisciplinary research. The Center brings together leading scientists and physicians to translate discoveries into improved prevention, detection, and treatment matched to individual patients.
This document is a thesis submitted by Olivia Herd to the University of Witwatersrand in fulfillment of the requirements for a Doctor of Philosophy degree. The thesis examines chromosomal radiosensitivity in South African cervical and breast cancer patients using two assays - the G0-micronucleus assay and the γ-H2AX foci assay. The study found increased chromosomal radiosensitivity in cervical cancer patients, with HIV-positive patients showing the highest levels of radiosensitivity. In breast cancer patients, only white patients showed significantly higher radiosensitivity compared to controls. The results highlight how factors like HIV, disease stage, and ethnicity can influence radiosensitivity in the South African context.
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
ABIM Cancer Screening PIM™ Practice Improvement Module Measures Catalogue - A...abimorg
Measures (3) This PIM examines the care you provide to your patients by addressing key processes and outcomes of preventive care based on recommendations of the U.S. Preventive Services Task Force, the National Cancer Institute, the American Cancer Society, and the American College of Radiology.
http://www.abim.org/
The document discusses variation in how radiologists assess breast density on mammograms. In a study of 250 mammograms read by 8 radiologists, there was significant variability, with full agreement on density in only 28% of cases. Radiologists disagreed on the distinction between scattered fibroglandular tissue and heterogeneously dense tissue in about 32% of cases. Standardizing breast density assessment is important for accurately determining cancer risk and recommending appropriate screening.
- The Personalized OncoGenomics (POG) program at the British Columbia Cancer Agency conducted whole-genome analysis on tumors from 100 patients with advanced or incurable cancers to inform treatment decisions.
- Fresh tumor and blood samples were obtained from patients and underwent whole-genome and RNA sequencing. Computational analysis identified potential driver mutations, genes and pathways.
- A multidisciplinary team discussed genomic findings weekly and established guidelines for interpreting and communicating results to integrate them into patient care. Genomic findings were considered actionable in 55 of 78 cases that underwent whole-genome analysis, and motivated treatment changes in 23 cases.
- The experience demonstrated that a multidisciplinary team can implement an approach where whole-genome
1) Kevin Braunschweiger was diagnosed with prostate cancer at age 45 and was more concerned about potential impacts to his sex life than death.
2) Early detection is key for genital-pelvic cancers like prostate and testicular cancer. However, many men delay seeking treatment due to embarrassment or fears over impotence and incontinence from surgery.
3) Braunschweiger opted for brachytherapy seed implantation instead of surgery after learning the procedure had similar effectiveness with less risk of side effects. While surgery offers a higher cure rate, radiation allows additional treatment if the initial treatment fails. Early detection and treatment are important for genital cancers.
A diagnosis of DCIS often brings mixed messages. Is this a real breast cancer? What is the meaning of Stage 0? If this is not life threatening, why are the treatments similar to those recommended for an invasive cancer? Deborah Collyar, founder of Patient Advocates in Research, helps us interpret the new findings that will aid you in navigating this diagnosis.
This document is a thesis submitted by Olivia Herd to the University of Witwatersrand in fulfillment of the requirements for a Doctor of Philosophy degree. The thesis examines chromosomal radiosensitivity in South African cervical and breast cancer patients using two assays - the G0-micronucleus assay and the γ-H2AX foci assay. The study found increased chromosomal radiosensitivity in cervical cancer patients, with HIV-positive patients showing the highest levels of radiosensitivity. In breast cancer patients, only white patients showed significantly higher radiosensitivity compared to controls. The results highlight how factors like HIV, disease stage, and ethnicity can influence radiosensitivity in the South African context.
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
ABIM Cancer Screening PIM™ Practice Improvement Module Measures Catalogue - A...abimorg
Measures (3) This PIM examines the care you provide to your patients by addressing key processes and outcomes of preventive care based on recommendations of the U.S. Preventive Services Task Force, the National Cancer Institute, the American Cancer Society, and the American College of Radiology.
http://www.abim.org/
The document discusses variation in how radiologists assess breast density on mammograms. In a study of 250 mammograms read by 8 radiologists, there was significant variability, with full agreement on density in only 28% of cases. Radiologists disagreed on the distinction between scattered fibroglandular tissue and heterogeneously dense tissue in about 32% of cases. Standardizing breast density assessment is important for accurately determining cancer risk and recommending appropriate screening.
- The Personalized OncoGenomics (POG) program at the British Columbia Cancer Agency conducted whole-genome analysis on tumors from 100 patients with advanced or incurable cancers to inform treatment decisions.
- Fresh tumor and blood samples were obtained from patients and underwent whole-genome and RNA sequencing. Computational analysis identified potential driver mutations, genes and pathways.
- A multidisciplinary team discussed genomic findings weekly and established guidelines for interpreting and communicating results to integrate them into patient care. Genomic findings were considered actionable in 55 of 78 cases that underwent whole-genome analysis, and motivated treatment changes in 23 cases.
- The experience demonstrated that a multidisciplinary team can implement an approach where whole-genome
1) Kevin Braunschweiger was diagnosed with prostate cancer at age 45 and was more concerned about potential impacts to his sex life than death.
2) Early detection is key for genital-pelvic cancers like prostate and testicular cancer. However, many men delay seeking treatment due to embarrassment or fears over impotence and incontinence from surgery.
3) Braunschweiger opted for brachytherapy seed implantation instead of surgery after learning the procedure had similar effectiveness with less risk of side effects. While surgery offers a higher cure rate, radiation allows additional treatment if the initial treatment fails. Early detection and treatment are important for genital cancers.
A diagnosis of DCIS often brings mixed messages. Is this a real breast cancer? What is the meaning of Stage 0? If this is not life threatening, why are the treatments similar to those recommended for an invasive cancer? Deborah Collyar, founder of Patient Advocates in Research, helps us interpret the new findings that will aid you in navigating this diagnosis.
Managing central venous access devices in cancer patients a practice guidelin...Clinica de imagenes
This document provides a summary of a practice guideline for managing central venous access devices (CVADs) in cancer patients. The guideline was developed by reviewing existing literature and clinical practice guidelines to make recommendations on: whether CVADs should be locked with heparin or saline, the volume and strength of locking solution, locking frequency, and type of catheter. The review found limited evidence to directly answer these questions for cancer patients. As such, the guideline aims to standardize CVAD management protocols across cancer care settings based on the best available evidence and expert consensus, in order to improve patient care and outcomes.
1) A study was conducted in rural Tanzania to evaluate options for cervical cancer screening in low-resource settings. Over 300 women were enrolled and tested using the careHPV rapid HPV test and Pap smears.
2) The results found an HPV infection rate of 12.8% among participants. Comparison of careHPV to the Hybrid Capture 2 HPV test showed high agreement.
3) The most common HPV genotypes found were HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, and 58. However, the prevalence of HPV 16 and 18 was much lower than expected, implying lower potential effectiveness of the current HPV vaccines in this population.
Public health agencies can play an important role in increasing cancer screening rates in the United States. Existing infrastructure like the National Breast and Cervical Cancer Early Detection Program provides a foundation but more organized efforts are needed. Public health should develop centralized cancer screening systems using insurance data to identify and remind eligible individuals to get screened. Efforts should also improve follow-up for abnormal results and integrate provider systems to ensure capacity. With health reform expanding insurance coverage, public health has an opportunity to ensure widespread and equitable cancer screening.
This document provides a case study analysis of an observational study on cervical cancer conducted in South Asia. The study aimed to identify what stages of cervical dysplasia would progress to cancer to help design cervical cancer screening guidelines. Over 1000 women participated over 12 years. However, midway another study found that all dysplasia requires treatment, and the researchers continued without treatment. Many women's cancers progressed or spread by the end without treatment provided. Questions are raised about ethics approval given facility limitations, informed consent without disclosing disease progression risk, and continuing the study after learning about treatment needs from another study.
The newsletter provides information on senology apps for mobile devices, collaborations, literature on breast cancer risk factors and treatments, upcoming conferences, and workshop summaries on various cancer types. It also includes an editorial on medications to reduce breast cancer risk, recent advances in hepatitis C treatment, and a call for opinions on sentinel lymph node biopsy guidelines.
The document is the NCCN Clinical Practice Guidelines in Oncology for Pancreatic Adenocarcinoma from 2009. It provides guidelines for the diagnosis, staging, treatment and management of pancreatic cancer. The guidelines are developed by the NCCN Pancreatic Adenocarcinoma Panel and are intended to help clinicians individualize treatment for each patient based on clinical circumstances.
The document provides a resource guide for materials from the NYS DOH Cancer Services Program to promote cancer screening. It includes public education materials on breast, cervical, colorectal, and prostate cancer. It also lists professional development resources for providers, as well as presentations and technical assistance available from CSP staff on cancer screening best practices.
The document provides information about postgraduate studies and PhD projects available at the Garvan Institute of Medical Research. It begins with an introduction to postgraduate studies at Garvan and its partnership with UNSW. It then describes the research divisions and groups at Garvan conducting research in cancer, immunological diseases, diabetes, metabolic diseases, neurological diseases, bone diseases, and bioinformatics. Specific PhD project descriptions are provided for several research groups in areas like cancer cell invasion, pancreatic carcinogenesis, B cell biology, immunology and more. Contact information is provided for supervisors of the different projects.
The document discusses adjuvant chemotherapy for early-stage (T1ab) breast cancer in 2014. It summarizes several retrospective studies that found clinical events occurred in 5-10% of T1abN0 patients who did not receive chemotherapy or HER2-targeted treatment. Events were also observed in treated patients, indicating a need to optimize treatment. Major prognostic factors identified were age, proliferation rate, triple-negative status, and HER2 positivity. The document compares treatment guidelines from NCCN, Saint-Gallen, and French experts, noting differences in their approaches and a need for a more individualized molecular-based strategy.
Additional value of prenatal genomic array testing in fetuses with isolated structural ultrasound abnormalities and a normal karyotype: a systematic review of the literature
M.C. de Wit, M.I. Srebniak, L.C.P. Govaerts, D. Van Opstal, R.J.H. Galjaard and A.T.J.I. Go
Link to free access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.12575/abstract
Recent advances in breast surgery include breast conservation surgery in the 1980s, percutaneous needle biopsy in the 1990s, and sentinel node biopsy and oncoplastic surgery in the 2000s. Studies show lumpectomy with radiation therapy results in similar survival rates as mastectomy. Guidelines developed by the Breast Health Global Initiative aim to implement evidence-based, economically feasible recommendations for low and middle income countries. Learning Laboratories are being established to develop and test educational modules based on the guidelines.
This document summarizes some of the key topics and events planned for RSNA 2010. It highlights areas of focus in the scientific program including patient-centered care, dose reduction efforts, emerging technologies, and quantitative imaging. The education program will feature refresher courses, workshops, and exhibits on these topics as well as standardization of results, individualized imaging approaches, and lung and cardiac imaging. A record number of abstracts and exhibits are planned to disseminate the latest research and techniques.
This document provides the definition and classification of acute kidney injury (AKI) put forth by the Kidney Disease: Improving Global Outcomes (KIDGO) group. It defines AKI as an abrupt reduction in kidney function seen within 48 hours that can be identified by an increase in serum creatinine of 0.3 mg/dL or 1.5 times the baseline level. AKI is classified into 3 stages based on the level of increase in serum creatinine and the urine output amount. The definition and staging criteria aim to provide a standardized approach for identifying and classifying AKI severity in clinical practice, research, and public health monitoring.
The documents summarize results from the 22nd Summer Deaflympics held in Sofia, Bulgaria from July 29 - August 1, 2013. They include results from various karate competitions in different age groups and weight classes for males and females. In the overall medal count, Russia won the most medals, with 2 gold medals, 2 silver medals, and 3 bronze medals for a total of 7 medals. Venezuela and Iran both won 3 gold medals each. Turkey won 1 gold medal, 1 silver medal, and 1 bronze medal.
This document provides an overview of atoms and their subatomic particles. It explains that atoms are made up of protons, neutrons, and electrons. Protons have a positive charge, electrons have a negative charge, and neutrons have no charge. The number of protons determines the element, and the number of neutrons contributes to the mass number. The document also discusses the periodic table and how it can be used to find information about elements such as the number of protons, neutrons, and electrons. It includes some example calculations and provides additional online resources for learning more about atomic structure.
Java EE 6 Hands-on Workshop at Dallas Tech Fest 2010Arun Gupta
The document provides an overview of the Java EE 6 Hands-on Workshop being conducted by Arun Gupta. It includes an agenda for the workshop covering topics like Java EE 6 specifications, managed beans, interceptors, servlets, and ease of development features in Java EE 6. The workshop aims to demonstrate how Java EE 6 provides a flexible, extensible and easier to use platform for application development.
Multichannel Fundraising Workshop - Care2, Big Duck, NWFCare2Team
With more communications channels out there, your supporters are getting bombarded with more messages from charities, companies, friends, and family members. So how can you make sure your organization stands out?
In this workshop, Farra Trompeter from Big Duck, Dane Grams from Care2, and Danielle Brigida from National Wildlife Federation, share ways you can build stronger campaigns through multichannel communications, leveraging online communities, embracing social media, and sharing some successful case studies.
Participants will take away:
*Ideas and lessons learned from nonprofit campaign case studies
*Tactics to build your list and use social media
*Ways to integrate best practices into your communications
*Tips to make your campaigns stronger
This document contains a list of initialisms and acronyms from A to G, along with their meanings. Some examples included are 10Q for "Thank You", 24/7 for "24 hours a day, 7 days a week", and ASL for "Age/Sex/Location?". Over 150 initialisms are defined in the list.
Instead of theorizing on what MAY work, get actionable recommendations for your marketing strategy based on tactics that DID work across digital channels like email, Facebook, Twitter and YouTube. Download this informative report and learn how to optimize your social media and email marketing efforts with data-driven findings on 20 leading retail brands.
Here is what you will learn:
-How email marketing boosts social channel engagement by as much as 100%
-What are the most engaging (and alternatively, most utilized) days of week, time of day, campaign format, campaign frequency, and content type
-Why standardizing social engagement provides a more accurate measure of your brand's campaign performance against that of your competitors
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like anxiety and depression.
Managing central venous access devices in cancer patients a practice guidelin...Clinica de imagenes
This document provides a summary of a practice guideline for managing central venous access devices (CVADs) in cancer patients. The guideline was developed by reviewing existing literature and clinical practice guidelines to make recommendations on: whether CVADs should be locked with heparin or saline, the volume and strength of locking solution, locking frequency, and type of catheter. The review found limited evidence to directly answer these questions for cancer patients. As such, the guideline aims to standardize CVAD management protocols across cancer care settings based on the best available evidence and expert consensus, in order to improve patient care and outcomes.
1) A study was conducted in rural Tanzania to evaluate options for cervical cancer screening in low-resource settings. Over 300 women were enrolled and tested using the careHPV rapid HPV test and Pap smears.
2) The results found an HPV infection rate of 12.8% among participants. Comparison of careHPV to the Hybrid Capture 2 HPV test showed high agreement.
3) The most common HPV genotypes found were HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, and 58. However, the prevalence of HPV 16 and 18 was much lower than expected, implying lower potential effectiveness of the current HPV vaccines in this population.
Public health agencies can play an important role in increasing cancer screening rates in the United States. Existing infrastructure like the National Breast and Cervical Cancer Early Detection Program provides a foundation but more organized efforts are needed. Public health should develop centralized cancer screening systems using insurance data to identify and remind eligible individuals to get screened. Efforts should also improve follow-up for abnormal results and integrate provider systems to ensure capacity. With health reform expanding insurance coverage, public health has an opportunity to ensure widespread and equitable cancer screening.
This document provides a case study analysis of an observational study on cervical cancer conducted in South Asia. The study aimed to identify what stages of cervical dysplasia would progress to cancer to help design cervical cancer screening guidelines. Over 1000 women participated over 12 years. However, midway another study found that all dysplasia requires treatment, and the researchers continued without treatment. Many women's cancers progressed or spread by the end without treatment provided. Questions are raised about ethics approval given facility limitations, informed consent without disclosing disease progression risk, and continuing the study after learning about treatment needs from another study.
The newsletter provides information on senology apps for mobile devices, collaborations, literature on breast cancer risk factors and treatments, upcoming conferences, and workshop summaries on various cancer types. It also includes an editorial on medications to reduce breast cancer risk, recent advances in hepatitis C treatment, and a call for opinions on sentinel lymph node biopsy guidelines.
The document is the NCCN Clinical Practice Guidelines in Oncology for Pancreatic Adenocarcinoma from 2009. It provides guidelines for the diagnosis, staging, treatment and management of pancreatic cancer. The guidelines are developed by the NCCN Pancreatic Adenocarcinoma Panel and are intended to help clinicians individualize treatment for each patient based on clinical circumstances.
The document provides a resource guide for materials from the NYS DOH Cancer Services Program to promote cancer screening. It includes public education materials on breast, cervical, colorectal, and prostate cancer. It also lists professional development resources for providers, as well as presentations and technical assistance available from CSP staff on cancer screening best practices.
The document provides information about postgraduate studies and PhD projects available at the Garvan Institute of Medical Research. It begins with an introduction to postgraduate studies at Garvan and its partnership with UNSW. It then describes the research divisions and groups at Garvan conducting research in cancer, immunological diseases, diabetes, metabolic diseases, neurological diseases, bone diseases, and bioinformatics. Specific PhD project descriptions are provided for several research groups in areas like cancer cell invasion, pancreatic carcinogenesis, B cell biology, immunology and more. Contact information is provided for supervisors of the different projects.
The document discusses adjuvant chemotherapy for early-stage (T1ab) breast cancer in 2014. It summarizes several retrospective studies that found clinical events occurred in 5-10% of T1abN0 patients who did not receive chemotherapy or HER2-targeted treatment. Events were also observed in treated patients, indicating a need to optimize treatment. Major prognostic factors identified were age, proliferation rate, triple-negative status, and HER2 positivity. The document compares treatment guidelines from NCCN, Saint-Gallen, and French experts, noting differences in their approaches and a need for a more individualized molecular-based strategy.
Additional value of prenatal genomic array testing in fetuses with isolated structural ultrasound abnormalities and a normal karyotype: a systematic review of the literature
M.C. de Wit, M.I. Srebniak, L.C.P. Govaerts, D. Van Opstal, R.J.H. Galjaard and A.T.J.I. Go
Link to free access article: http://onlinelibrary.wiley.com/doi/10.1002/uog.12575/abstract
Recent advances in breast surgery include breast conservation surgery in the 1980s, percutaneous needle biopsy in the 1990s, and sentinel node biopsy and oncoplastic surgery in the 2000s. Studies show lumpectomy with radiation therapy results in similar survival rates as mastectomy. Guidelines developed by the Breast Health Global Initiative aim to implement evidence-based, economically feasible recommendations for low and middle income countries. Learning Laboratories are being established to develop and test educational modules based on the guidelines.
This document summarizes some of the key topics and events planned for RSNA 2010. It highlights areas of focus in the scientific program including patient-centered care, dose reduction efforts, emerging technologies, and quantitative imaging. The education program will feature refresher courses, workshops, and exhibits on these topics as well as standardization of results, individualized imaging approaches, and lung and cardiac imaging. A record number of abstracts and exhibits are planned to disseminate the latest research and techniques.
This document provides the definition and classification of acute kidney injury (AKI) put forth by the Kidney Disease: Improving Global Outcomes (KIDGO) group. It defines AKI as an abrupt reduction in kidney function seen within 48 hours that can be identified by an increase in serum creatinine of 0.3 mg/dL or 1.5 times the baseline level. AKI is classified into 3 stages based on the level of increase in serum creatinine and the urine output amount. The definition and staging criteria aim to provide a standardized approach for identifying and classifying AKI severity in clinical practice, research, and public health monitoring.
The documents summarize results from the 22nd Summer Deaflympics held in Sofia, Bulgaria from July 29 - August 1, 2013. They include results from various karate competitions in different age groups and weight classes for males and females. In the overall medal count, Russia won the most medals, with 2 gold medals, 2 silver medals, and 3 bronze medals for a total of 7 medals. Venezuela and Iran both won 3 gold medals each. Turkey won 1 gold medal, 1 silver medal, and 1 bronze medal.
This document provides an overview of atoms and their subatomic particles. It explains that atoms are made up of protons, neutrons, and electrons. Protons have a positive charge, electrons have a negative charge, and neutrons have no charge. The number of protons determines the element, and the number of neutrons contributes to the mass number. The document also discusses the periodic table and how it can be used to find information about elements such as the number of protons, neutrons, and electrons. It includes some example calculations and provides additional online resources for learning more about atomic structure.
Java EE 6 Hands-on Workshop at Dallas Tech Fest 2010Arun Gupta
The document provides an overview of the Java EE 6 Hands-on Workshop being conducted by Arun Gupta. It includes an agenda for the workshop covering topics like Java EE 6 specifications, managed beans, interceptors, servlets, and ease of development features in Java EE 6. The workshop aims to demonstrate how Java EE 6 provides a flexible, extensible and easier to use platform for application development.
Multichannel Fundraising Workshop - Care2, Big Duck, NWFCare2Team
With more communications channels out there, your supporters are getting bombarded with more messages from charities, companies, friends, and family members. So how can you make sure your organization stands out?
In this workshop, Farra Trompeter from Big Duck, Dane Grams from Care2, and Danielle Brigida from National Wildlife Federation, share ways you can build stronger campaigns through multichannel communications, leveraging online communities, embracing social media, and sharing some successful case studies.
Participants will take away:
*Ideas and lessons learned from nonprofit campaign case studies
*Tactics to build your list and use social media
*Ways to integrate best practices into your communications
*Tips to make your campaigns stronger
This document contains a list of initialisms and acronyms from A to G, along with their meanings. Some examples included are 10Q for "Thank You", 24/7 for "24 hours a day, 7 days a week", and ASL for "Age/Sex/Location?". Over 150 initialisms are defined in the list.
Instead of theorizing on what MAY work, get actionable recommendations for your marketing strategy based on tactics that DID work across digital channels like email, Facebook, Twitter and YouTube. Download this informative report and learn how to optimize your social media and email marketing efforts with data-driven findings on 20 leading retail brands.
Here is what you will learn:
-How email marketing boosts social channel engagement by as much as 100%
-What are the most engaging (and alternatively, most utilized) days of week, time of day, campaign format, campaign frequency, and content type
-Why standardizing social engagement provides a more accurate measure of your brand's campaign performance against that of your competitors
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like anxiety and depression.
It’s funny how freedom can make us feel containedMagnetic Poetry
The document discusses a series of encounters between a man and a woman on public transportation in Bangalore, India. The man listens to music and engages in philosophical thoughts. On one bus ride, he offers his seat to a woman. They later have brief conversations about love and relationships where the man shares stories and philosophical perspectives. The woman eventually asks to meet for coffee to get the man's advice about whether to move to Chennai with her boyfriend, leading to their first meeting described in the document.
The document describes the author's career journey from studying exercise physiology in West Virginia to realizing her passion for event planning. She discovered her interest in event planning through organizing fundraisers for her sorority. This led her to pursue a degree in media communications at Full Sail University to combine her passions for event planning and music. Since starting the program, she has landed job opportunities in event operations and is collaborating on media projects, believing her degree will open many future possibilities.
Presentation given for TAACCCT grantee Consortium for Healthcare Education Online (CHEO) Faculty Professional Development Workshop. Boulder, Colorado, May 14, 2015.
The document provides an update on the progress and accomplishments of the Nemours Center for Childhood Cancer Research (NCCCR). Key points include:
- NCCCR has established collaborations with other institutions to integrate childhood cancer research efforts and leverage resources to become a national leader.
- Major accomplishments include establishing monthly research translation meetings between clinicians and researchers, and creating one of the few pediatric tumor banks in the US to facilitate biomarker discovery.
- The vision is to develop strategies to advance childhood cancer screening, diagnosis, treatment and prevention, with a focus on identifying biomarkers, developing drug delivery approaches, and discovering new drugs.
An overview of the John Theurer Cancer Center at Hackensack University Medical Center - a top-50 U.S. News & World Report Best Hospitals for Cancer – the only cancer center in New Jersey with this prestigious designation.
To request printed copies of this brochure, please contact aleahing@p4strategy.com.
The document summarizes the state of cancer research in 2010 according to the Campbell Family Cancer Research Institute. Key points include:
- Significant advances have been made in understanding the genetic and epigenetic basis of cancer and tumor behavior. However, cures require strategies to destroy both bulk tumor cells and tumor-initiating cells.
- The immune system plays an important role in preventing tumors, but tumors evade immunity; immunotherapies aim to reactivate anti-tumor immune responses.
- Early detection through improved imaging techniques can increase cure rates for cancers caught at smaller sizes.
The American Cancer Society is committed to finding cures for breast cancer through its extensive research program. It currently funds over 230 grants totaling $82 million to support scientists investigating topics like BRCA genes, weight loss and breast cancer risk, and racial disparities in treatment. Past Society-funded research laid the foundation for treatments like tamoxifen that are saving lives today. The Society will continue its relentless pursuit of answers to save even more lives in the future.
Recent developments in cancer and covid 19tazib rahaman
The document discusses several recent studies on COVID-19. It describes how a study found no link between hypertension drugs and increased COVID-19 risk. It also discusses how a study in Wuhan detected genetic material of the coronavirus in airborne particles, reinforcing the importance of sterilization and ventilation. Additionally, it mentions a new drug candidate identified by Chinese scientists that inhibits a key part of the virus's machinery.
The document summarizes two scientific articles from ScienceDaily about recent discoveries related to cell division and DNA replication that could provide new insights into cancer. The first article discusses a discovery of a protein complex called Ska that helps anchor DNA and distribute it correctly as cells divide. Understanding this complex could help develop new anti-cancer drugs. The second article describes an international study that improves ability to predict hereditary cancer risk by better classifying genetic variants associated with Lynch syndrome. This allows more accurate genetic counseling and preventive measures for at-risk families.
Navigating the cancer maze 7. Professor Rajiv Khanna with Grace GawlerGracieG53
This document promotes the weekly radio show "Navigating the Cancer Maze" hosted by Grace Gawler. This week's guest is Professor Rajiv Khanna, a leading researcher at QIMR Berghofer Medical Research Institute who discusses promising results from world-first brain cancer immunotherapy trials. The show interviews leading cancer researchers, doctors, patients, and caregivers to provide information to help with cancer recovery. Listeners can tune in live or download interviews with experts discussing advances in immuno-therapies, targeted cancer therapies, and integrative approaches to managing cancer symptoms and side effects.
This document discusses several topics related to cancer research and treatment. It begins by explaining that cancer arises from errors in cell replication that can be caused by environmental or lifestyle factors. It then discusses several studies, including one finding that daily multivitamin supplements may reduce cancer risk in older men, and another showing that ovarian cancer screenings are not effective in reducing mortality. The document also discusses how cancer stem cells can fuel tumor growth and how targeting these cells may lead to more effective treatments. Overall, it presents the complexity of cancers and explores new strategies for research based on a deeper understanding of the disease at the cellular level.
This document discusses thyroid cancer and Brooke Burke-Charvet's experience being diagnosed with it in 2012. The main points are:
- Thyroid cancer affects more women than men and Burke-Charvet's cancer was discovered during a routine checkup when she had no symptoms.
- She took two important steps after her diagnosis: researching her condition thoroughly and assembling a strong team of doctors.
- Today she feels great after treatment and wants to help others by sharing her story of survival to encourage early detection.
- Her advice is to not be ruled by fear, empower yourself with knowledge, envision positive outcomes, and find a supportive community.
SciTech Development LLC - Intelligent Technology to Solve Unmet Clinical Needs - Often the difference between success and failure is the dedication and persistence of the executive team. SciTech Development’s principal asset, fenretinide, is guided by a deeply experienced team in the broad portfolio of pharmaceutical development, clinical strategy, and scientific formulation.
The document provides updates from various departments at the Kimmel Cancer Center. It announces new treatments for prostate cancer including high intensity focused ultrasound. It highlights advances in areas like radiation oncology, integrative medicine, and stem cell research. It recognizes support from donors and announces new rankings for cancer care.
Cancer Survivorship with Integrative OncologyBetty Kui
The document discusses the evolution of the definition of cancer survivorship from initially referring to those who survived 5 years post-diagnosis to now including anyone diagnosed with cancer. It provides examples of two cancer patients - Joseph, a pediatric patient diagnosed with osteopetrosis, and Heather, an adult female diagnosed with breast cancer while pregnant - and the specialized survivorship programs available to them. These programs focus on monitoring long-term effects of treatment and promoting overall well-being through screening, education, and support. The availability of such individualized survivorship care reflects an expanded, more optimistic view of cancer patients and survivors.
Crystal Fitzgibbon suffered an acute stroke at age 26 that paralyzed her right side and rendered her unable to speak. She was given the clot-busting drug Tenecteplase, which was being trialled against the standard drug Alteplase. Within 24 hours, Crystal regained movement and speech in what doctors called the "Lazarus effect." Studies showed Tenecteplase helped more patients achieve major neurological improvement within a day compared to Alteplase. The successful trial of Tenecteplase provides hope for more effective stroke treatment.
Best Practices in Cancer Survivorship and Supportive CareAkinAkinsanya
"Early detection, better diagnostic tools, and more effective treatments are resulting in long-term cancer survivorship, with 62% of adults and 77% of pediatric cancer patients now living more than 5 years beyond their initial diagnosis.
While survival rates are rising…according to the National Cancer Institute there are nearly 12 million cancer survivors in the United States. The hurdle now facing many cancer survivors is how to achieve long-term quality of life after treatment has ended. According to the National Action Plan for Cancer Survivorship, fully one-third of survivors say they experience ongoing physical, psychological, or financial consequences of their cancer diagnosis and treatment.
Recognizing the need for a comprehensive approach to long-term survivorship care, many academic medical centers, community hospitals and oncologists in private practices are developing survivorship care programs to manage the ongoing care of their patients. In planning survivorship services, however, we need to delineate survivorship from other periods of care, so we take a pragmatic approach and define survivorship as the period in which patients treated with curative intent have completed their initial therapy and require follow-up care.”
Deciding what information is necessary: do patients with advanced cancer want...Teresa Muñoz Migueláñez
This document summarizes a literature review on communicating prognosis to patients with advanced cancer. The key points are:
1) While diagnosis is usually disclosed, prognosis is often poorly communicated by physicians who are reluctant to disclose details or give estimates.
2) Patients generally want to know their prognosis but preferences vary individually and over time. Barriers to understanding exist on both sides.
3) Regularly asking patients what they want to know and how information should be presented is recommended to ensure their preferences and understanding are addressed.
Associate Professor Phillip Darcy has developed a novel approach to train white blood cells to better detect cancer cells by genetically modifying them to express chimeric antigen receptors that specifically recognize antigens on cancer cells. Testing in mouse models showed the modified white blood cells could effectively eradicate breast, sarcoma, and colon cancer cells without harming normal tissues. A phase I clinical trial is underway at Peter MacCallum Cancer Centre, with initial results showing the modified cells persisting for up to 10 months and homing in on cancer sites to mediate anti-tumor activity with no safety issues. This research aims to develop a new cancer therapy with few side effects compared to conventional treatments like chemotherapy and radiation.
South Carolina Childhood Cancer Research Lab PresentationGoing Places, Inc
Childhood Cancer Research at theMedical University of South CarolinaSeptember 12, 2014 Jacqueline M Kraveka, D.O.Associate ProfessorDirector, Pediatric Oncology Research LaboratoryDepartment of PediatricsDivision of Hematology-Oncology
Evaluation of methods for cervical cancer screening Humphrey Misiri
Cancer is one of the leading causes of death in the world. Among women, cervical cancer) is one of the
deadly cancers in the world. Invasive cervical cancer is AIDS-defining since its presence means that the
patient has AIDS. Hetero-sexual activity is a risk factor of cervical cancer. As all cancers are, cervical cancer
is progressive and so can be prevented if detected in its early stages of development. Several laboratorybased diagnostic tests for screening women for cervical cancer exist. While these tests may be useful,
different tests may be preferred in different localities depending on the availability of resources. Given several
diagnostic tests, before any screening method is recommended for use, it is necessary to compare several
screening methods in order to identify a method which is cost-effective. In this work an attempt is made to
review several laboratory-based diagnostic methods and to explain the procedures for designing an
experiment for identifying a cost-effective method.
[Afr J Health Sci. 2014; 27(4):356-369
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
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5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
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5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Are you looking for a long-lasting solution to your missing tooth?
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Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
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UCSF HDF Cancer Center Newsletter
1. u From the director ~ 2 u Personalized breast treatment ~ 6
u Clinical trials pace progress ~ 3 u Targeting melanoma genes ~ 7
u Cancer research building opens ~ 4
cancer
report
Summer 2009
> Clinical Services
> Perspective When cancer runs in families
Does cancer run in your family? If you or a close family member
has been diagnosed with an early cancer – breast cancer at age
45 or younger, colon cancer at age 50 or younger, prostate cancer
at age 60 or younger, or ovarian cancer at any age – you may want
‘‘ We see ourselves as
pioneers in transformative,
to consider the services offered by the UCSF Cancer Risk Program.
Members of the Cancer Risk Program at UCSF – including genetic
interdisciplinary cancer counselors, oncologists, surgeons, clinical geneticists and primary
research and its translation care physicians – identify and counsel individuals and families at
into improved prevention, high risk for cancers caused by inherited, abnormal genes.
detection and treatment.
Frank McCormick, Director,
UCSF Helen Diller Family
’’ Counselors examine medical histories and the pattern of cancers
within the family tree. When appropriate, they offer testing for spe-
Comprehensive Cancer Center > page 2 cific genetic abnormalities called mutations. Counselors work with
family members to help them make decisions about being tested,
and to develop personal cancer screening and prevention plans. > page 5
1> cancer.ucsf.edu information, visit us at
~ For more > cancer.ucsf.edu
2. > Perspective
From the director
Today, there are more than 11 million research and medical practice. About
US cancer survivors. They are living one-quarter of UCSF’s full-time faculty
proof that science and medicine have members work in cancer research and
made real progress against this most patient care. Based on measures such
feared disease. We are making great as merit-based research funds awarded
strides in developing treatments that through the National Cancer Institute,
offer more than chemotherapy and NCI Comprehensive Cancer Center
radiation therapy. status, the success of our clinical care
programs, and the qualifications and
At the UCSF Helen Diller Family Com-
achievements of our students and resi-
prehensive Cancer Center, we see
dents, I believe the level of excellence we
ourselves as pioneers in transformative,
have achieved – and that we are com-
interdisciplinary cancer research and
mitted to building upon – is unsurpassed.
its translation into improved prevention,
detection and treatment. Twenty years ago, UCSF scientists were
awarded the Nobel Prize for showing
The Cancer Center joins together top
that cancer growth is driven by certain
scientists with exceptional medical
genes that undergo abnormal changes.
practitioners. This culture of interdisci-
Their work opened the floodgates.
plinary teamwork enables us not only
Hundreds of genes that can become
to make key discoveries, but also to
abnormal and foster tumor growth now
Frank McCormick, PhD ensure that this new knowledge leads
have been identified.
to better treatment matched to the
individual patient. We have learned that even tumors of
the same type in different patients may
Discoveries and inventions by UCSF
rely on different, abnormal genes to
faculty already have resulted in the cre-
grow and survive. Some of these ab-
ation of dozens of new companies that
normal genes are proving to be suitable
make better products available for
drug targets.
Cancer Center members are collaborat-
> Our mission ing and consulting with pharmaceutical
The UCSF Helen Diller Family Comprehensive Cancer Center is dedicated
industry partners to identify the most
to conquering cancer worldwide through innovation and education.
promising new drug candidates. These
are being clinically evaluated in patients
stricken by tumors with specific genetic
profiles. We expect that these new
partnerships will result in faster prog-
ress and greater success in making
new drugs available for clinical practice.
2 ~ cancer.ucsf.edu
3. { A Comprehensive Cancer Center }
Any cancer center can call itself compre-
hensive, but the UCSF Helen Diller Family
Comprehensive Cancer Center has earned
that designation from the National Cancer
Institute (NCI). “Comprehensive” signifies
national leadership in advancing cancer
treatment, and in research and education.
It is the highest ranking, awarded through
a rigorous evaluation with approval of
the NCI Cancer Advisory
Board appointed by the
US president. As this news-
letter goes to press, there > Clinical Trials
are 40 NCI-designated
Comprehensive Cancer
Centers nationwide, but only one in Clinical trials pace
progress against cancer
Northern California – the UCSF Helen Diller
Family Comprehensive Cancer Center. u
The percentage of people who survive five years or more fol-
lowing a cancer diagnosis has nearly doubled in the past 40
years. Millions of long-term cancer survivors living full lives
today are a testament to improved treatments. Yet hundreds
At first, some novel treatments may only of thousands still succumb to cancer each year. We still
be available to UCSF patients through have far to go.
clinical trials. Even so, by engaging fully
The development of drugs has played a key role in improv-
in the global communities of biomedical
ing cancer survival. But no new cancer drug is approved
research and health care policy, and by
for standard medical practice without first being tested
educating future generations of research-
through clinical trials in carefully selected patients.
ers and medical caregivers, we aim to
advance medical practice worldwide. Each cancer is different. Tumors rely on any of several bio-
chemical pathways – involving many genes and proteins – to
In these pages, we welcome you to
abnormally survive, grow and spread. Different tumors may
glimpse some of the continuing prog-
be vulnerable to different treatment approaches.
ress we have made in tracking down
and targeting abnormal genes in cancer, The aim is to better know the enemy – and to use the best
in preventing and diagnosing cancers, weapons against each tumor to increase the likelihood of
and in growing the ranks of cancer cancer-free survival for each patient.
survivors. u
“We are designing clinical trials at UCSF that will be more
focused and targeted,” says breast cancer oncologist Pam
Munster, MD, who also is director of early-phase clinical
Frank McCormick, PhD, Director, UCSF Helen Diller
trials for the Cancer Center.
Family Comprehensive Cancer Center
Researchers and physicians at the Cancer Center are lead-
ers in making new discoveries of distinctive tumor profiles.
They are shedding light on the ways in which these tumor > page 4
cancer.ucsf.edu ~3
4. > New Facilities
Helen Diller Family Cancer
Research Building opens
On June 2, 2009, UCSF cel- designed by noted architect
ebrated the opening of the Rafael Viñoly, the five-story
new Helen Diller Family Can- building provides a largely
cer Research Building. The open research space. At full
162,000-square-foot building build-out, it will house 46
now emerges as an integral principal investigators and
part of UCSF Mission Bay, at a total community of 475
the heart of San Francisco’s researchers and staff. Investi-
biggest urban development gators have already taken up
push since the construction residence to begin working
of Golden Gate Park. to identify cancer risks, to
UCSF Mission Bay is a far Mission Bay campus has
explore how cancers arise,
Centrally located at 3rd cry from the abandoned rail quickly become a magnet
and to develop new ideas
Street and Mission Bay yards that covered the site a for biotech development.
for cancer prevention and
Boulevard South, and few short years ago. The
treatment. Plans are also well underway
for this to become the future
> See photos of the new facilities online at cancer.ucsf.edu/diller
Clinical trials from page 3
characteristics might be optimally target- Clinical trials may represent an especial-
ed with new or existing drugs – or com- ly important opportunity for individuals
binations of drugs. Major Cancer Center with advanced cancers who no longer
research programs with this aim engage benefit from standard treatment.
dozens of scientists and physicians, as
well as collaborators from industry who Few take part
work on developing new drugs. Even so, less than 5 percent of cancer
patients nationwide participate in clini-
“We can bring together our scientists
cal trials. As a result, it takes longer to
who work on particular cancer path-
evaluate anti-tumor treatments and to Even patients on standard therapies
ways with scientists from pharmaceuti-
get the best ones into standard practice risk side effects. For drugs still under
cal companies or the National Cancer
to improve cancer outcomes for all the investigation in clinical trials, the risks
Institute who work on drugs that target
patients who might benefit. may not all be known ahead of time.
molecules in those pathways,” Munster
But no trial begins without laboratory,
says. “We want to include in clinical The reasons few participate are complex,
cellular and animal studies on the safety
trials patients who are most likely to Munster says. Some people may be
and cancer-fighting ability of the drug in
benefit – the ones with tumors that we unaware of the opportunity. In addition,
question. Clinical trial researchers and
think will be vulnerable to the treatment.” Munster says, individuals with advanced
sponsors do not begin a study without
disease tend to be too hopeful about
Patients who elect to participate in clini- prior evidence that a new drug will be
the standard of care for their condition,
cal trials have the first chance to benefit better than – or at least as good as –
and to underestimate the potential ben-
from effective new therapy. Opportuni- existing treatments for many patients. u
efits of drug candidates being evaluated
ties to receive the newest treatments
in clinical trials.
are available for patients with many
types of cancers at different stages. > To find cancer clinical trials at UCSF
Call 877/827-3222 (toll-free) or email clinicaltrials@cc.ucsf.edu
4 ~ cancer.ucsf.edu
5. Scientists at the new cancer discoveries that inform think-
research building are well ing about new ways to treat
placed to engage in collabo- all forms of the disease.
rations that will help move
Construction of the building
new discoveries into clinical
began in 2006, thanks to an
applications.
indispensable gift of $35 mil-
The new building allows lion from the Helen Diller Fam-
consolidation of research ily Foundation of the Jewish
programs in brain tumors Community Endowment Fund.
and prostate cancer, as The building is already a hive
well as in population sci- of research activity, and with
ences – a broad field that its beautiful atrium and open
includes epidemiology, design, provides an ideal
chemoprevention, screen- environment that fosters
ing, health communication, collegiality and idea sharing.
behavioral science, health
The building enhances
services, policy, surveillance
home of the first new hos- urgent and emergency care ongoing cancer research
and survivorship research.
pital to be built in the city in and pediatric ambulatory programs at UCSF Mount
It also is the new home of
decades. The 289-bed proj- care facilities, and a women’s Zion and Parnassus, greatly
scientists who make funda-
ect will include a hospital for hospital for specialty care, expanding the existing space
mental discoveries about the
adult cancer surgery patients, with a center for women dedicated to cancer research
biological causes of cancer –
a children’s hospital with and newborns. at UCSF. u
Clinical services from front cover
About 5 percent to 10 percent of cancer But BRCA mutations also increase risks associated with an 80 percent lifetime
cases are due to inherited mutations that for other cancers. Among men, muta- risk for colon cancer. Women with Lynch
run in families. Each member of such a tions confer a 16 percent to 22 percent syndrome also have an elevated risk for
family has a 50-50 chance of inheriting lifetime risk for prostate cancer, usually endometrial and ovarian cancers.
the mutation from an affected parent. occurring before age 65.
UCSF oncologists were among the first
Sadly, men diagnosed with prostate to routinely screen all newly diagnosed
Large benefit
cancer may not suspect that they carry colon cancer patients age 50 and under
“If you can identify older individuals in the
a BRCA mutation until a daughter is with a new pair of lab tests that can be
family who have had cancer at a rela-
diagnosed with advanced-stage breast used to identify tumors that are almost
tively young age, and who carry a muta-
cancer. “It’s very important for men with certainly the result of Lynch syndrome.
tion, then you can make a real difference
prostate cancer to inform their health
for their brothers, sisters and children,” Tests to detect Lynch syndrome gene
care providers about any family his-
says Beth Crawford, director of clinical mutations in carriers before they devel-
tory of breast cancer, ovarian cancer,
services for the Cancer Risk Program. op cancer also are available. If someone
prostate cancer, melanoma or pancre-
is found to carry a Lynch syndrome mu-
One set of inherited cancer genes – atic cancer – and to ask for a referral to
tation, colon cancer screening is recom-
called BRCA genes – is most closely genetic counseling,” Crawford says.
mended, starting at age 22. Physicians
associated with breast and ovarian
Inherited colon cancer most often is use colonoscopy to detect and remove
cancer. Up to 80 percent of women
due to Lynch syndrome, which arises polyps, usually before they have had a
who inherit a BRCA mutation from their
from mutations in any of three related chance to become cancerous. u
mother or father will develop breast
genes – MLH1, MSH2 and MSH6. It is
cancer at some point. Up to 60 percent
will develop ovarian cancer if they have
a mutation in BRCA1; up to 27 percent
> For more information Call 415/885-7779 or (toll-free) 877/747-5422,
if they have a mutation in BRCA2. or visit ucsfhealth.org/cancerriskprogram
cancer.ucsf.edu ~5
6. > Initiatives
Personalized breast cancer treatment
Laura van ’t Veer, PhD, has changed Van ’t Veer was determined to see that
the way physicians look at breast her research did not languish in a lab.
Laura van ’t Veer, PhD
cancer. Tumors differ from each other To make sure that MammaPrint reached
genetically. And thanks to van ’t Veer’s the clinic, she started her own company.
pioneering vision, oncologists now use
Now, in collaboration with researchers Van ’t Veer now has chosen UCSF for a
a new generation of genetic tests to
and physicians at UCSF, van ’t Veer research sabbatical – prized time when
help make treatment decisions.
sees new opportunities to develop ad- dedicated researchers can work free of
Fewer women with low-risk breast can- ditional clinical applications to benefit competing administrative duties.
cer are being treated unnecessarily with breast cancer patients, based on new
She is collaborating with Gray to look
drugs that may have side effects. More knowledge of genetic abnormalities and
for genetic patterns in tumors that can
women with high-risk disease are re- molecular markers in cancer.
help predict the combinations of stan-
ceiving appropriate, aggressive therapy.
Van ’t Veer, who chairs the Division of dard or experimental drugs that may
Diagnostic Oncology at the Netherlands best target each tumor.
Lab on a chip
Cancer Institute, originally came to
Van ’t Veer led the bench-to-bedside Van ’t Veer also is collaborating with
UCSF in 2003 at the invitation of patient
development of the MammaPrint. The Esserman to prepare the next phase of
advocates to speak at an Avon Founda-
MammaPrint is a lab test on a chip. a major, unique clinical trial. During the
tion breast cancer symposium.
It detects patterns of gene activity in course of the study, knowledge of how
samples prepared from breast tumors. early genetic and imaging measure-
More creative time
The various patterns of gene activity ments are associated with treatment re-
During her first UCSF visit, van ’t Veer
detected by the MammaPrint indicate sponses will be used to direct patients
established key connections with leaders
a better or worse likelihood of breast to the treatments that are predicted to
of the Cancer Center’s Breast Oncol-
cancer’s returning despite surgery. work best for them individually.
ogy Program, Joe Gray, PhD, and Laura
Research shows that for early-stage Esserman, MD. Like van ’t Veer, Gray is “The breast cancer program is a good
breast cancer, the MammaPrint is a a leader in developing techniques widely instrument for integrating basic research
more accurate gauge of breast cancer used to probe genes. Esserman leads with patients’ needs, and with the capa-
prognosis than previously established clinical trials that aim to quickly evaluate bility to evaluate new clinical approach-
measures. the effectiveness of treatments for indi- es,” van ’t Veer says. For her, that makes
vidual patients prior to surgery. UCSF a home away from home. u
> To reach our world-class breast care center
The UCSF Carol Franc Buck Breast Care Center provides
specialized services, including individual counseling as
well as support groups that focus on every stage that you
and your family may experience. For information about
services or appointments, call 415/353-7070 or visit
ucsfbreastcarecenter.org.
cancer.ucsf.edu
7. Adil Daud, MD, (far left) and Boris Bastian, MD,
(left) work together, applying new research
knowledge to better match patients to new
treatments for melanomas.
> Partners
Targeting melanoma genes
for treatment success
The most deadly skin cancer, melanoma, is Bastian recently identified a previously unsuspect-
becoming more common. Fortunately, a sea ed genetic abnormality that drives an aggressive
change is at hand in the development of tailored form of melanoma – one that arises within the
treatment to target these tumors. eye. Bastian and Daud now are working with
Alnylam Pharmaceuticals on a clinical trial to
Cancer Center pathologist Boris Bastian, MD,
specifically target the gene culprit with a new type
now has identified distinct genetic abnormalities
of drug. There currently is no effective standard
that distinguish different subtypes of malignant
therapy to treat this eye cancer once it spreads.
melanomas. With this new knowledge, Bastian
is leading efforts to redefine the different forms Similarly, standard therapies do little to improve
of the disease, and he has set the stage for long-term survival of advanced forms of more
the identification and testing of better targeted common melanomas. But Bastian has discov-
treatment. ered that some of these melanomas seem to
rely on an abnormal gene that should make
Bastian’s work also has made it easier to
them vulnerable to an already standard targeted
diagnose melanomas and to distinguish these
therapy, called Gleevec. Gleevec had previously
potentially deadly cancers from harmless moles.
been tried and rejected for melanoma because it
Better yet for patients, Bastian recently teamed failed in most cases.
up with Adil Daud, MD, an oncologist who treats
Now, in early studies by Bastian and others,
skin cancers exclusively. Daud has a wealth of
Gleevec again is being tried to treat patients
experience in designing and leading early-stage
with melanomas driven by this particular genetic
clinical trials of novel therapies. Daud has seen
mutation. Some patients have shown no signs
firsthand how some patients can have remark-
of any remaining cancer after treatment, dem-
able responses to new treatments, even after
onstrating the power of targeted therapy. More
standard therapies have failed them.
studies are in the works.
“We have planned a rationally based panel of
> To learn more about skin cancer clinical trials that take into account the individual
and its prevention characteristics of a given patient’s tumor, to
Visit dermatology.medschool.ucsf.edu/skincancer to match them with the appropriate drug,” Bastian
find out about melanoma, sun protection, self-exams and says. “That’s the vision.” u
our clinics.
cancer.ucsf.edu ~7