This document discusses translational research terminology and clarifies common misconceptions. It defines the 5 stages of translational research from preclinical animal studies to post-marketing regulatory studies. Additionally, it explains the objectives of clinical trials and distinguishes between pharmacokinetics, which describes what the body does to a drug, and pharmacodynamics, which describes what a drug does to the body.

2. •
• There is a misconception about "Translational Research" terminology.
I realized that terms used interchangeably but incorrectly as I was
sharing my experience with people about my next opportunity.

3. Translational Research (TR) from bench to bedside
• Translational Research 0 (TR0): Wet lab-bench work, drug discovery
and Animal Studies (PRECLINICAL STUDY- Early Development)
• TR1: First in Human Studies (Phase 1) and Proof of concept Study
(Phase2), Even though they are in human but not proven to be use to
in human
• TR2: Phase 3, example Drug Efficacy during development of a drug
• TR3: Regulatory Studies required by regulatory bodies like FDA. The
results from the Phase 3 studies used.
• TR4: Phase 4, Surveillance-Post-marketing Studies

4. Technology Transfer to Improve Human Health
Novel technologies potential to improve human health integrating
scientific development technologies and conducting clinical studies.
* Development phases classified in 5 technologies:
1- Drug
2- Medical Device
3- Biologics
4- Biomarker Analysis Assays
5- Imaging Procedures

5. What is PK and PD: How do they relate to each other?
Pharmakokinetics (PK):
• What the human body does to the body
Pharmacodynamics (PD):
• What a drug does to the human body

6. Objectives of a Clinical Trial
We may have 3 Types of Clinical Trial Objectives:
1. Ideal Health/ Primordial Intervention/Healthy
2. Primary Prevention/ Risk Factors/Acute
3. Secondary Prevention/ Disease to treat disease/Chronic