Topic 5 1. Explain the concepts of linkage disequilibrium and haplotype blocks and discuss why they are useful in human population genetics. 2. Explain how the Hardy-Weinberg distributions helps determine the risk of transmitting a disease to offspring. How is this prediction altered by when there is mating among close relatives 3. Discuss the concept of mutation-selection balance and why it is different for autosomal vs recessive disease mutations. 4. Discuss why researchers investigate human protein-coding genetic variation and some of the important outcomes of the large-scale human exome sequencing project.