To determine the mechanism by which N-WASp mediates activation by Cdc4.pdf
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To determine the mechanism by which N-WASp mediates activation by Cdc42, actin polymerization was measured in the presence of purified components. In the presence of the Arp2/3 complex (ARP), N-WASp stimulates actin polymerization substantially over ARP or N- WASp alone, but not nearly so dramatically as the C-terminal segment of N-WASp that contains just the verprolin (V), cofilin (C), and acidic (A) domains (VCA) (Panel A Below). To account for the difference between N-WASp and its C-terminal VCA segment, N-WASp and ARP were mixed with combinations of Cdc42-GTPS and vesicles containing PIP2 [PI(4,5)P2] (Panel B Below). What is required for full-length N-WASp to stimulate actin polymerization as efficiently as its C- terminal VCA segment? Explain your reasoning..
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![To determine the mechanism by which N-WASp mediates activation by Cdc42, actin
polymerization was measured in the presence of purified components. In the presence of the
Arp2/3 complex (ARP), N-WASp stimulates actin polymerization substantially over ARP or N-
WASp alone, but not nearly so dramatically as the C-terminal segment of N-WASp that contains
just the verprolin (V), cofilin (C), and acidic (A) domains (VCA) (Panel A Below). To account
for the difference between N-WASp and its C-terminal VCA segment, N-WASp and ARP were
mixed with combinations of Cdc42-GTPS and vesicles containing PIP2 [PI(4,5)P2] (Panel B
Below).
What is required for full-length N-WASp to stimulate actin polymerization as efficiently as its C-
terminal VCA segment? Explain your reasoning.](https://image.slidesharecdn.com/todeterminethemechanismbywhichn-waspmediatesactivationbycdc4-230310054930-53cfb201/85/To-determine-the-mechanism-by-which-N-WASp-mediates-activation-by-Cdc4-pdf-1-320.jpg)
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dark soil and dark rock with Absorption and Reflection? - Dark colored things are Absorbers and
Reflectors What is the relationship between light colored things such as ice and snow with
Absorption and Reflection? - Light colored things are Absorbers and Reflectors 3 - Scattered
Define Albedo What is the relationship between Albedo and dark colored things and light
colored things?.
This year Luke has calculated his gross tax liability at $1-900- Luke.pdf
This year Luke has calculated his gross tax liability at $1,900. Luke is entitled to a $2,550
nonrefundable personal tax credit, a $1,575 business tax credit, and a $650 refundable personal
tax credit. In addition, Luke has had $2,425 of income taxes withheld from his salary.
What is Luke's net tax due or refund?
Note: Input the amount as a positive value..
This Scottish economist was highly critical of the Mercantilists- A-Ad.pdf
This Scottish economist was highly critical of the Mercantilists:
A.Adam Smith
B.John Maynard Keynes
C.Joseph Schumpeter
D.Paul Volcker
If the value of goods and services a country buys from foreigners is more than the value of goods
and services it sells to foreigners, that country is said to have a:
A.Trade deficit
B.Trade surplus
C.Inflationary trend
D.Deadweight loss.
This map shows the location and size of earthquakes in and around Turk.pdf
This map shows the location and size of earthquakes in and around Turkey since 1990, based on
data from the US Geological Survey. Note that large earthquakes have occurred along the North
and East Anatolian Faults. What type of fault are these two?
A. thrust
B. peninsular
C. subduction zone
D. strike-slip
E. nomal
Magnitudes of major earthquakes since 1900 Includes earthquakes snce 19 U that are classitied
as sgnticant earthquakes by the INational Centers tor Environmental Information based on a
series of criteria including deaths, damage and magnitude..
This medieval social- cultural- and economic movement that involved de.pdf
This medieval social, cultural, and economic movement that involved developments in
philosophy, art, architecture, and music is often attributed as catalyzing the Reformation. The
Romanesque Era The Renaissance The Enlightenment the Bronze Age TRUE or FALSE:
Environmental science seeks to apply the knowledge gained from observations and experiments
to inform resulting actions and develop technologies with the ultimate goal of generating positive
change. True False 2 pts Question 2 Which of the following are part of our biological
environment on Earth? Select all that apply. Humans Vegetation Lipids Oxygen Rocks Water
Suniight Microbes.
This map shows a summary of earthquakes that occurred across the globe.pdf
This map shows a summary of earthquakes that occurred across the globe in 2019. A few
particular quakes are labelled. What is geologcially significant about the overall distribution (or
pattern) of the earthquakes?
A. their distribution shows the boundaries of the tectonic plates
B. earthquakes occur in the oceans and on the continents
C. earthquakes occur in curves
D. earthquakes occur everywhere
E. earthquakes do not occur in North America except along the west coast
Emergency Response Coordination Centre (ERCC) - DG ECHO Daily Map |20/01/2020
Earthquakes Global Overview 2019 European.
This map from the USGS' Earthquake Hazards Program website shows earth.pdf
This map from the USGS' Earthquake Hazards Program website shows earthquakes in Ohio
since 1900. What is the likely cause of these quakes?
A. recent breakup of the mid-continent
B. moutain building in Ohio
C. reactivation of old faults
D. movement of faults along the Western Ohio Subduction Zone
Detroit Lake St anapolis A cincirgati.
Things wrong with my code- 1- The notes do not play when i press down.pdf
Things wrong with my code:
1. The notes do not play when i press down the key on keyboard or the mouse.
2. The premade songs in the backend do not show up or play in the dropdown
3. The recordings do not go to the file when you save them.
// Wait for the DOM to finish loading
document.addEventListener("DOMContentLoaded", () => {
// Create a new synthesizer object from Tone.js
const synth = new Tone.Synth().toDestination();
// Define the mappings between keyboard keys and notes
const keyNoteMappings = {
"a": "C4", "w": "C#4", "s": "D4", "e": "D#4", "d": "E4",
"f": "F4", "t": "F#4", "g": "G4", "y": "G#4", "h": "A4",
"u": "Bb4", "j": "B4", "k": "C5", "o": "C#5", "l": "D5",
"p": "D#5", ";": "E5"
};
// Add event listeners to each keyboard key
const keys = document.querySelectorAll(".keyboard button");
keys.forEach(key => {
// When the key is pressed, play the corresponding note
key.addEventListener("mousedown", () => {
const note = keyNoteMappings[key.textContent.trim().toLowerCase()];
synth.triggerAttack(note);
});
// When the key is released, stop playing the note
key.addEventListener("mouseup", () => {
const note = keyNoteMappings[key.textContent.trim().toLowerCase()];
synth.triggerRelease(note);
});
});
// Get a reference to the tune dropdown, tune button, and recording buttons
const tuneDropdown = document.querySelector("#tune-dropdown");
const tuneButton = document.querySelector("#tunebtn");
const recordButton = document.querySelector("#recordbtn");
const stopButton = document.querySelector("#stopbtn");
const saveButton = document.querySelector("#savebtn");
const tuneNameInput = document.querySelector("#tuneNameInput");
// Load the list of available tunes from the server and populate the dropdown
axios.get("http://localhost:3000/api/v1/tunes/").then(response => {
const tunes = response.data;
tunes.forEach(tune => {
const option = document.createElement("option");
option.value = tune.name;
option.textContent = tune.name;
tuneDropdown.appendChild(option);
});
}).catch(error => {
console.error("Failed to load tunes:", error);
});
// Add a click event listener to the tune button
tuneButton.addEventListener("click", () => {
const selectedTune = tuneDropdown.value;
if (!selectedTune) {
alert("Please select a tune first.");
return;
}
axios.get("http://localhost:3000/api/v1/tunes/${selectedTune}").then(response => {
const tune = response.data;
// Play each note in the tune with a slight delay between them
tune.notes.forEach((note, index) => {
setTimeout(() => {
synth.triggerAttackRelease(note.note, note.duration);
}, index * note.duration);
});
}).catch(error => {
console.error(`Failed to load tune "${selectedTune}":`, error);
});
});
// Define variables for recording a new tune
let recordedNotes = [];
let recordingStartTime = null;
// Define a function for starting a new recording
function startRecording() {
recordedNotes = [];
recordingStartTime = Date.now();
recordButton.disabled = true;
stopButton.disabled = false;
}
// Define a function for sto.
This is my code- #include -llvm-IR-LegacyPassManager-h- #include -llv.pdf
This is my code:
#include "llvm/IR/LegacyPassManager.h"
#include "llvm/Passes/PassPlugin.h"
#include "llvm/Passes/PassBuilder.h"
#include "llvm/IR/PassManager.h"
#include "llvm/IR/Instructions.h"
#include "llvm/ADT/BitVector.h"
#include <unordered_map>
#include <queue>
using namespace std;
using namespace llvm;
namespace {
struct LivenessInfo {
BitVector liveIn;
BitVector liveOut;
};
// This method implements what the pass does
void visitor(Function &F){
string func_name = "main";
errs() << "Liveness analysis for function: " << F.getName() << "\n";
// Process each basic block in the function and initialize the live-out and live-in sets
unordered_map<BasicBlock*, LivenessInfo> blockInfo;
BitVector initialLiveOut(F.arg_size() + F.getBasicBlockList().size(), false);
for (auto& basic_block : F) {
LivenessInfo info;
info.liveOut = initialLiveOut;
info.liveIn.resize(F.arg_size() + F.getBasicBlockList().size(), false); // initialize live-in set to
empty
blockInfo[&basic_block] = info;
}
// Creates a worklist of basic blocks to process, starting with the exit block
queue<BasicBlock*> worklist;
auto exitBlock = &F.back();
auto& exitInfo = blockInfo[exitBlock];
worklist.push(exitBlock);
exitInfo.liveOut = BitVector(initialLiveOut.size(), false); // initialize live-out set for exit block to
empty
// Compute the live-out set for each basic block
while (!worklist.empty()) {
auto block = worklist.front();
worklist.pop();
// Compute the live-out set by taking the union of the live-in sets of successors
auto& info = blockInfo[block];
for (auto it = succ_begin(block); it != succ_end(block); ++it) {
auto& succInfo = blockInfo[*it];
info.liveOut |= succInfo.liveIn;
}
// Compute the live-in set based on the live-out set and the instructions in the block
BitVector liveIn(info.liveOut);
for (auto it = block->rbegin(); it != block->rend(); ++it) {
auto inst = &*it;
// Remove variables defined by the instruction from the live-in set
if (auto store = dyn_cast<StoreInst>(inst)) {
auto var = store->getPointerOperand();
size_t varIndex = F.arg_size() + var->getName().substr(1).getAsInteger(10, varIndex);
liveIn.reset(varIndex);
}
// Add variables used by the instruction to the live-in set
for (auto op = inst->op_begin(); op != inst->op_end(); ++op) {
if (auto var = dyn_cast<Instruction>(*op)) {
size_t varIndex = F.arg_size() + var->getName().substr(1).getAsInteger(10, varIndex);
liveIn.set(varIndex);
}
}
}
// Update the live-in set for the current block
info.liveIn = liveIn;
// Add the predecessors of the block to the worklist, if not already processed
for (auto it = pred_begin(block); it != pred_end(block); ++it) {
auto predBlock = *it;
if (blockInfo[predBlock].liveOut != liveIn) {
worklist.push(predBlock);
}
}
}
// Print the live-in and live-out sets for each basic block
for (auto& basic_block : F) {
errs() << "-----" << basic_block.getName() << "-----" << "\n";
auto& info = blockInfo[&basic_block];
errs() << "UEVAR: ";
for (int i = 0; i < F.arg_size(); i++) {
if (inf.
This chemical provides the body with energy a- Electro-energizing fusi.pdf
This chemical provides the body with energy
a.
Electro-energizing fusion
b.
Pituitary
c.
Andrenal chemical
d.
Adrenaline
Environmental factors include ALL of the following EXCEPT
a.
Work place
b.
Food
c.
Air
d.
DNA
.
This is computer network class Select the statement that is correct- D.pdf
This is computer network class
Select the statement that is correct. Demultiplexing is used to direct incoming packets to the
correct process. Since UDP is a "connectionless" protocol, it is possible for requests to go to the
wrong socket. If the network is having a lot of congestion, then the application can switch
between TCP and UDP dynamically to adjust for this. Demultiplexing is needed only when you
have multiple instances of the same application running on a host machine. Question 2 ( 2
points) Saved Why does DNS use UDP rather than TCP? Deverlopers assume that since the
application requests cannot run until DNS happens first, then it is okay to make it wait for the
services to provide for reliability. DNS requests are so frequent, and have to happen quickly, we
don't want to add extra time for the services provided by TCP. To ensure that we get the mapping
without any errors. DNS can tolerate some erros..
This assignment and the next (#5) involve design and development of a.pdf
This assignment and the next (#5) involve design and development of a sequential
non contiguous and dynamic datastructure called LinkedList. A linked list object is
a container consisting of connected ListNode objects. As before, we are not going
to use pre-fabricated classes from the c++ library, but construct the LinkedList
ADT from scratch.
The first step is construction and testing of the ListNode class. A ListNode object
contains a data field and a pointer to the next ListNode object (note the recursive
definition).
#This assignment requires you to
1. Read the Assignment 4 Notes
2. Watch the Assignment 4 Support video
3. Implement the following methods of the ListNode class
-custom constructor
-setters for next pointer and data
4. Implement the insert and remove method in the main program
5. Scan the given template to find the above //TODO and implement the code
needed
//TODO in ListNodecpp.h file
public: ListNode(T idata, ListNode<T> * newNext);
public: void setNext(ListNode<T> * newNext);
public: void setData(T newData);
// TODO in main program
void remove(ListNode<int> * &front,int value)
void insert(ListNode<int> * &front,int value)
# The driver is given ListNodeMain.cpp is given to you that does the following
tests
1. Declares a pointer called front to point to a ListNode of datatype integer
2. Constructs four ListNodes with data 1,2,4 and adds them to form a linked
list.
3. Inserts ListNode with data 3 to the list
4. Removes node 1 and adds it back to test removing and adding the first
element
5. Removes node 3 to test removing a middle node
6. Removes node 4 to test removing the last node
7. Attempt to remove a non existent node
8. Remove all existing nodes to empty the list
9. Insert node 4 and then node 1 to test if insertions preserve order
10.Print the list
Main.cpp
#include <iostream>
#include "ListNodecpp.h"
// REMEMBER each ListNode has two parts : a data field
// and an address field. The address is either null or points to the next node
//in the chain
//Requires: integer value for searching, address of front
//Effects: traverses the list node chain starting from front until the end comparing search value
with listnode getData. Returns the original search value if found, if not adds +1 to indicate not
found
//Modifies: Nothing
int search(ListNode<int> * front, int value);
//Requires: integer value for inserting, address of front
//Effects: creates a new ListNode with value and inserts in proper position (increasing order)in
the chain. If chain is empty, adds to the beginning
//Modifies: front, if node is added at the beginning.
//Also changes the next pointer of the previous node to point to the
//newly inserted list node. the next pointer of the newly inserted pointer
//points to what was the next of the previous node.
//This way both previous and current links are adjusted
//******** NOTE the use of & in passing pointer to front as parameter -
// Why do you think this is needed ?**********
void insert(ListNode<int> * &fr.
These structures are formed in similar ways during embryonic developme.pdf
These structures are formed in similar ways during embryonic development and share like
arrangements; however they have somewhat different forms and functions. They are called
homologous structures. Fill in the blanks below with the correct letter: Take Quiz Exit Human
Cheetah (Cat) Humerus Radius Uina Carpals Metacarpals Phalanges Questio 2 2 pts Take Quiz
Exit Whale Bat.
Think of a time you had an infectious disease- Describe the disease (s.pdf
Think of a time you had an infectious disease. Describe the disease (such as which body systems
were affected; you do NOT need the actual pathogen). Include any signs or symptoms of the
illness and make sure you group signs and symptoms appropriately as learned in Chapter 13.
Please do not pick an infectious disease that you would consider of personal nature.
There is a longstanding conundrum in biological research and biotechno.pdf
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CAN do something, is it right to do it? In other words, how do we determine whether a technique
is moral? In the video clip about Henrietta Lacks, we can see this illustrated in that one woman's
cells were taken without her knowledge or permission and used for technological and medical
purposes. Was this right? Why or why not? What other instances of potential moral conflict are
there regarding biotechnology?.
There are several network threats and vulnerabilities- These threats c.pdf
There are several network threats and vulnerabilities. These threats can be from physical level
threats to data level threats. Write a paper discussing the different threats we can encounter, and
how we can protect our network from them. Be sure to include specific vulnerabilities and the
security policies and software/hardware needed to create a secure network. Include a drawing if
you wish. Please do not copy and paste information already on Chegg..
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This Scottish economist was highly critical of the Mercantilists- A-Ad.pdf
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