Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
This document provides an overview of Tiziana Life Sciences and its innovative platform technologies for oral, nasal, and inhalation administration of monoclonal antibodies. Some key points:
- Tiziana is developing oral and nasal formulations of the fully human anti-CD3 monoclonal antibody Foralumab for conditions like Crohn's disease and progressive multiple sclerosis.
- They are also developing an inhalable formulation of an anti-IL-6 receptor monoclonal antibody for treatment of COVID-19 patients, allowing direct delivery to the lungs.
- The company's technologies aim to transform antibody delivery from intravenous to more patient-friendly oral, nasal, and inhalation routes.
Tiziana Life Sciences (NASDAQ: TLSA) Investor Presentation - July 20th 2020RedChip Companies, Inc.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Tiziana Life Sciences is a dual-listed clinical stage biotechnology company focused on the discovery and development of novel molecules to treat human disease in oncology and immunology. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Foralumab is the only fully human anti-CD3 monoclonal antibody in clinical development in the world. This Phase 2 compound has potential application in a wide range of autoimmune and inflammatory diseases, such as nonalcoholic steatohepatitis (NASH), ulcerative colitis, multiple sclerosis, type-1 diabetes (T1D), Crohn's disease, psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Aptorum Group Limited (NASDAQ: APM) is a pharmaceutical company dedicated to
developing and commercializing novel therapeutics to tackle unmet medical needs.
Aptorum's current drug pipeline includes indications in orphan diseases, infectious
diseases, and metabolic diseases. In 2021, the company plans to bring two candidates to
clinical trials. Aptorum’s Smart-ACT™ platform is designed to bring an average of three
drug candidates for orphan diseases to clinical trials every 12-18 months. The company is
now preparing to launch a dietary supplement for women undergoing menopause and
experiencing related symptoms, including osteoporosis. Targeting a global woman’s health
supplement market that is expected to reach $17 billion in 2025, Aptorum is expected to
generate near-term revenue with significant long-term growth potential.
HR Compliance & Insurance Benefit Perspectives: What Employers Should Be Awar...Rea & Associates
Guidelines for employees are constantly changing but it’s important that businesses stay on top of mandates and regulations. What risks should organizations be informed about? Is your organization able to have varied insurance premiums for vaccinated vs. non-vaccinated employees?
Join Rea & Associates and Huntington Insurance for a deep dive into best practices for exposures, insurance perspectives, and vaccine mandates and regulations.
Tiziana Life Sciences provides an update on their clinical pipeline, including completing a study of nasally administered Foralumab in COVID-19 patients that showed positive responses, initiating several phase 2 trials with Foralumab and Milciclib, and executing an agreement with Precision Biosciences to use Foralumab to improve CAR-T cell therapy outcomes for cancer treatment. The company is developing oral and intranasal formulations of antibodies to enable local tissue delivery and reduce costs and side effects compared to IV administration. Milciclib is advancing in clinical trials as a potential treatment for cancers like hepatocellular carcinoma and KRAS-mutated
Immuron is presenting an overview of their company and investment opportunities. They have a unique oral immunotherapy platform targeting the microbiome and inflammation with potential in various indications. Their lead program is in NASH (non-alcoholic steatohepatitis), where their drug IMM-124E has shown potential in preclinical and clinical studies to reduce liver inflammation and fibrosis through its anti-LPS and regulatory T-cell promoting properties. They are also developing a vaccine against C. difficile and have an approved traveler's diarrhea drug called Travelan that is generating revenues. Immuron believes they are significantly undervalued given their pipeline, which includes programs targeting large markets like NASH estimated at $35-40 billion by
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
This document provides an overview of Tiziana Life Sciences and its innovative platform technologies for oral, nasal, and inhalation administration of monoclonal antibodies. Some key points:
- Tiziana is developing oral and nasal formulations of the fully human anti-CD3 monoclonal antibody Foralumab for conditions like Crohn's disease and progressive multiple sclerosis.
- They are also developing an inhalable formulation of an anti-IL-6 receptor monoclonal antibody for treatment of COVID-19 patients, allowing direct delivery to the lungs.
- The company's technologies aim to transform antibody delivery from intravenous to more patient-friendly oral, nasal, and inhalation routes.
Tiziana Life Sciences (NASDAQ: TLSA) Investor Presentation - July 20th 2020RedChip Companies, Inc.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Tiziana Life Sciences is a dual-listed clinical stage biotechnology company focused on the discovery and development of novel molecules to treat human disease in oncology and immunology. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Foralumab is the only fully human anti-CD3 monoclonal antibody in clinical development in the world. This Phase 2 compound has potential application in a wide range of autoimmune and inflammatory diseases, such as nonalcoholic steatohepatitis (NASH), ulcerative colitis, multiple sclerosis, type-1 diabetes (T1D), Crohn's disease, psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Aptorum Group Limited (NASDAQ: APM) is a pharmaceutical company dedicated to
developing and commercializing novel therapeutics to tackle unmet medical needs.
Aptorum's current drug pipeline includes indications in orphan diseases, infectious
diseases, and metabolic diseases. In 2021, the company plans to bring two candidates to
clinical trials. Aptorum’s Smart-ACT™ platform is designed to bring an average of three
drug candidates for orphan diseases to clinical trials every 12-18 months. The company is
now preparing to launch a dietary supplement for women undergoing menopause and
experiencing related symptoms, including osteoporosis. Targeting a global woman’s health
supplement market that is expected to reach $17 billion in 2025, Aptorum is expected to
generate near-term revenue with significant long-term growth potential.
HR Compliance & Insurance Benefit Perspectives: What Employers Should Be Awar...Rea & Associates
Guidelines for employees are constantly changing but it’s important that businesses stay on top of mandates and regulations. What risks should organizations be informed about? Is your organization able to have varied insurance premiums for vaccinated vs. non-vaccinated employees?
Join Rea & Associates and Huntington Insurance for a deep dive into best practices for exposures, insurance perspectives, and vaccine mandates and regulations.
Tiziana Life Sciences provides an update on their clinical pipeline, including completing a study of nasally administered Foralumab in COVID-19 patients that showed positive responses, initiating several phase 2 trials with Foralumab and Milciclib, and executing an agreement with Precision Biosciences to use Foralumab to improve CAR-T cell therapy outcomes for cancer treatment. The company is developing oral and intranasal formulations of antibodies to enable local tissue delivery and reduce costs and side effects compared to IV administration. Milciclib is advancing in clinical trials as a potential treatment for cancers like hepatocellular carcinoma and KRAS-mutated
Immuron is presenting an overview of their company and investment opportunities. They have a unique oral immunotherapy platform targeting the microbiome and inflammation with potential in various indications. Their lead program is in NASH (non-alcoholic steatohepatitis), where their drug IMM-124E has shown potential in preclinical and clinical studies to reduce liver inflammation and fibrosis through its anti-LPS and regulatory T-cell promoting properties. They are also developing a vaccine against C. difficile and have an approved traveler's diarrhea drug called Travelan that is generating revenues. Immuron believes they are significantly undervalued given their pipeline, which includes programs targeting large markets like NASH estimated at $35-40 billion by
Tiziana Life Sciences presented an overview of their transformational immunotherapy platform enabling alternative routes of administration. Their proprietary technologies allow for oral, nasal, and inhalation delivery of antibodies, which currently require IV administration. They highlighted clinical progress including trials of their lead asset foralumab administered intranasally for progressive MS and COVID-19. Results demonstrated safety and positive clinical responses. Tiziana is also developing other pipeline assets and expanding their management team and scientific advisory board.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
1) Imugene is developing B-cell peptide cancer immunotherapy vaccines targeting the HER-2 receptor, which is the target of Roche's $6.4 billion breast cancer drug Herceptin.
2) Imugene has completed a Phase 1 clinical trial of its lead HER-Vaxx vaccine in HER-2 positive breast cancer patients, and plans to begin a Phase 1b/2 gastric cancer trial in early 2016.
3) HER-Vaxx induces polyclonal antibody responses against HER-2, unlike monoclonal antibodies, and has the potential to provide long-lasting immunity through immune memory activation.
Experiences from an IPO at AIM, Juho Jalkanen Business Turku
- Faron Pharmaceuticals conducted an IPO on the London AIM market in November 2015, raising €14.2 million to fund their phase III clinical trial of Traumakine for the treatment of Acute Respiratory Distress Syndrome.
- Traumakine has shown promising results in earlier UK clinical trials, including an 81% reduction in mortality. Their phase III trial is ongoing across Europe.
- Faron is also developing an immunotherapy called Clevegen to target tumour-associated macrophages and reduce immune suppression of cancers.
Immuron Ltd is an Australian biopharmaceutical company focused on immunotherapy using dairy-derived antibody products for humans. Immuron has a unique and versatile technology platform that is capable of generating a wide range of products, all with a high safety profile. The versatility of Immuron’s platform technology enables the development of medicines that target a large range of medical needs, including infectious diseases, immune mediated disorders, and cancers. The versatility is also a function of the dairy origin of Immuron’s antibodies, which enables Immuon to commercialize its platform derived products through a range of regulatory pathways, including prescription (Rx), medical foods, over-the-counter (OTC) medicines, and dietary supplements. The Company has received clearance from the FDA to commence a Phase IIb clinical trial for its NASH product (IMM-124E), a potential blockbuster, in less than three years from commencing its NASH R&D program. Additionally, Immuron has one marketed product (Travelan, for the prevention of travelers’ diarrhea) and a pipeline of products at various stages of clinical and earlier development.
Immuron is presenting an overview of their company and investment opportunities. They have a unique oral immunotherapy platform targeting the microbiome and inflammation with potential in various indications. Their lead program is in NASH (non-alcoholic steatohepatitis), where their drug IMM-124E has shown in preclinical and clinical trials to reduce liver inflammation and fibrosis by binding to LPS (bacterial endotoxin) and promoting regulatory T-cells. Phase 2 trials in NASH are ongoing with results expected in late 2016 to early 2017. Immuron is also developing a vaccine for C. difficile and generates revenues from their traveler's diarrhea drug Travelan. They highlight the significant commercial potential of NASH which is estimated
ANGLE shares investor evening 15 April 2015ANGLE plc
ANGLE has developed a liquid biopsy system called Parsortix that can isolate circulating tumor cells from blood samples in a non-invasive manner. Early clinical studies have shown the system to have unprecedented sensitivity and specificity in detecting ovarian cancer. ANGLE is working with key opinion leaders to validate Parsortix and develop clinical applications in other cancers that could lead to regulatory approval and access to multi-billion dollar clinical markets.
Liquid biopsy from a simple blood test enabling personalised cancer care | Sh...ANGLE plc
Liquid biopsy from a simple blood test is enabling personalised cancer care. The Parsortix system from ANGLE can harvest cancer cells from blood (liquid biopsy) in a non-invasive and repeatable way. This provides a new approach to obtaining cancer cells for analysis compared to traditional tumour biopsies. Key opinion leaders have evaluated the Parsortix system and found that it captures all types of cancer cells with high purity in an easy to use process, making it well suited for clinical applications in personalised cancer care.
Presentation 2 July 2015: Proactive Investors Forum ANGLE plc
ANGLE presented on their Parsortix liquid biopsy system, a non-invasive method to capture and harvest circulating tumor cells from blood to enable personalized cancer care. Their system has shown promising results in early clinical studies and key opinion leader evaluations, and ANGLE outlined their commercialization strategy focused on research use sales and the first clinical application in ovarian cancer triage.
- Liquid biopsy from a simple blood test enables personalized cancer care by harvesting rare cancer cells from blood using ANGLE's patented Parsortix system.
- The Parsortix system captures circulating tumor cells shed from primary tumors with unprecedented sensitivity and specificity, enabling non-invasive analysis and repeat testing over time for personalized treatment.
- ANGLE aims to partner with established diagnostic companies to accelerate global distribution of the Parsortix system and make liquid biopsy available for improving cancer care and reducing healthcare costs.
Sanofi reported strong Q1 2023 results, with sales growth of 5.5% overall. The Specialty Care unit grew 18.3% driven by Dupixent sales increasing 39.7%. Dupixent continues to see strong demand globally. Vaccines sales grew 15.2% from COVID contracts and travel/booster vaccine recovery. R&D advancements included positive Dupixent COPD data and upcoming events for fitusiran and tolebrutinib. Financial guidance and outlook will be provided later in the year.
Sanofi reported strong Q1 2023 results, with specialty care sales up 18.3% driven by Dupixent growth of 39.7%. Vaccines sales also grew 15.2% from COVID contracts and travel vaccine recovery. R&D updates included positive Dupixent COPD data and promising early immunology assets. The document provided financial and business performance summaries for Q1 2023 and outlook.
Aptorum Group Limited (NASDAQ: APM) is a pharmaceutical company dedicated to developing and commercializing novel therapeutics to tackle unmet medical needs. Aptorum's current drug pipeline includes indications in orphan diseases, infectious diseases, and metabolic diseases. The Company launched two new clinical trials in 2021. Aptorum’s Smart-ACT™ platform is designed to bring an average of three drug candidates for orphan diseases to clinical trials every 12-18 months. The Company is now preparing to launch a dietary supplement for women undergoing menopause and experiencing related symptoms, including osteoporosis. Targeting a global woman’s health supplement market that is expected to reach $17 billion in 2025, Aptorum is expected to generate near-term revenue with significant long-term growth potential.
Dupilumab is an investigational monoclonal antibody that targets IL-4 and IL-13, key drivers of the type 2 inflammatory response in atopic dermatitis (AD). Two phase 3 clinical trials, SOLO 1 and SOLO 2, evaluated the efficacy and safety of dupilumab in adults with moderate-to-severe AD. The results from these trials showed that dupilumab monotherapy significantly improved measures of disease severity such as EASI, IGA, and pruritus scores compared to placebo. Treatment with dupilumab also led to rapid and significant improvements in skin clearance and quality of life measures. The safety profile observed was generally consistent with the mechanism of action and the patient population.
1) Marker Therapeutics is developing a multi-tumor associated antigen (MultiTAA) T cell therapy approach that targets multiple tumor antigens to address limitations of current CAR T and TCR therapies such as relapse due to antigen escape.
2) In clinical trials to date involving over 50 lymphoma patients, MultiTAA T cell therapy has shown durable complete responses in over 50% of patients with active lymphoma with no serious adverse events or cytokine release syndrome observed.
3) For patients treated while in remission, over 80% have maintained a continued complete response for durations ranging from 3 to 37 months to date.
This document discusses Ruthigen, Inc., a drug development company focused on developing RUT58-60, a hypochlorous acid-based drug candidate for invasive use. RUT58-60 aims to improve patient outcomes for invasive procedures by reducing post-surgical infections in a more effective way than current standard of care antibiotics. Published studies on Microcyn, another hypochlorous acid-based product, show promise in reducing infection rates for diabetic foot ulcers and coronary artery bypass graft surgery wounds. If successful, RUT58-60 could help hospitals reduce costs by shortening patient stays and lowering readmission rates for post-surgical infections.
Blue Horizon International AG was formed in 2017 to commercialize stem cell technology and regenerative medicine. It has established stem cell manufacturing and treatment procedures through its clinics in Slovakia, Jamaica, and partnerships in China. The company aims to treat a wide range of diseases like stroke, Alzheimer's, diabetes, heart disease, and arthritis using stem cells without drugs or surgery. Financial projections estimate revenues growing from $617,980 in 2020 to $23.7 million in 2024 as more clinics are launched globally.
Better Choice Company (OTCQB: BTTR) is a rapidly growing animal health and wellness company committed to leading the industry shift toward pet products and services that help dogs and cats live healthier, happier and longer lives. Better Choice takes an alternative, nutrition-based approach to animal health relative to conventional dog and cat food offerings, and positions its portfolio of brands to benefit from the mainstream trends of growing pet humanization and consumer focus on health and wellness. The Company has a demonstrated, multi-decade track record of success selling trusted animal health and wellness products, and leverage its established digital footprint to provide pet parents with the knowledge to make informed decisions about their pet’s health. Better Choice sells the majority of its dog food, cat food and treats under the Halo and TruDog brands, which are focused, respectively, on providing sustainably sourced kibble and canned food derived from real whole meat, and minimally processed raw-diet dog food and treats.
Annovis Bio (NYSE American: ANVS) is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing Phase 2a study in AD patients and plans to commence a second Phase 2a study in PD patients. Learn more at ANVSinfo.com.
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Tiziana Life Sciences presented an overview of their transformational immunotherapy platform enabling alternative routes of administration. Their proprietary technologies allow for oral, nasal, and inhalation delivery of antibodies, which currently require IV administration. They highlighted clinical progress including trials of their lead asset foralumab administered intranasally for progressive MS and COVID-19. Results demonstrated safety and positive clinical responses. Tiziana is also developing other pipeline assets and expanding their management team and scientific advisory board.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
Tiziana Life Sciences (NASDAQ: TLSA) is a dual-listed clinical stage company developing targeted therapeutics to transform treatment of liver diseases, inflammatory diseases, and cancer. Our clinical pipeline includes drug assets for Crohn's, and hepatocellular carcinoma. Tiziana’s two lead drug candidates, Foralumab and Milciclib, uniquely target the root cause of diseases with large unmet needs in multibillion-dollar markets. Tiziana is accelerating development of anti-IL6 receptor monoclonal antibody (mAb) for treatment of COVID-19 lung inflammation. Tiziana is a market leader in the invention of proprietary technology for oral, nasal and inhaled formulation to transform immunotherapies with Monoclonal Antibodies currently administered intravenously. Also, Tiziana has a robust and growing patent portfolio.
1) Imugene is developing B-cell peptide cancer immunotherapy vaccines targeting the HER-2 receptor, which is the target of Roche's $6.4 billion breast cancer drug Herceptin.
2) Imugene has completed a Phase 1 clinical trial of its lead HER-Vaxx vaccine in HER-2 positive breast cancer patients, and plans to begin a Phase 1b/2 gastric cancer trial in early 2016.
3) HER-Vaxx induces polyclonal antibody responses against HER-2, unlike monoclonal antibodies, and has the potential to provide long-lasting immunity through immune memory activation.
Experiences from an IPO at AIM, Juho Jalkanen Business Turku
- Faron Pharmaceuticals conducted an IPO on the London AIM market in November 2015, raising €14.2 million to fund their phase III clinical trial of Traumakine for the treatment of Acute Respiratory Distress Syndrome.
- Traumakine has shown promising results in earlier UK clinical trials, including an 81% reduction in mortality. Their phase III trial is ongoing across Europe.
- Faron is also developing an immunotherapy called Clevegen to target tumour-associated macrophages and reduce immune suppression of cancers.
Immuron Ltd is an Australian biopharmaceutical company focused on immunotherapy using dairy-derived antibody products for humans. Immuron has a unique and versatile technology platform that is capable of generating a wide range of products, all with a high safety profile. The versatility of Immuron’s platform technology enables the development of medicines that target a large range of medical needs, including infectious diseases, immune mediated disorders, and cancers. The versatility is also a function of the dairy origin of Immuron’s antibodies, which enables Immuon to commercialize its platform derived products through a range of regulatory pathways, including prescription (Rx), medical foods, over-the-counter (OTC) medicines, and dietary supplements. The Company has received clearance from the FDA to commence a Phase IIb clinical trial for its NASH product (IMM-124E), a potential blockbuster, in less than three years from commencing its NASH R&D program. Additionally, Immuron has one marketed product (Travelan, for the prevention of travelers’ diarrhea) and a pipeline of products at various stages of clinical and earlier development.
Immuron is presenting an overview of their company and investment opportunities. They have a unique oral immunotherapy platform targeting the microbiome and inflammation with potential in various indications. Their lead program is in NASH (non-alcoholic steatohepatitis), where their drug IMM-124E has shown in preclinical and clinical trials to reduce liver inflammation and fibrosis by binding to LPS (bacterial endotoxin) and promoting regulatory T-cells. Phase 2 trials in NASH are ongoing with results expected in late 2016 to early 2017. Immuron is also developing a vaccine for C. difficile and generates revenues from their traveler's diarrhea drug Travelan. They highlight the significant commercial potential of NASH which is estimated
ANGLE shares investor evening 15 April 2015ANGLE plc
ANGLE has developed a liquid biopsy system called Parsortix that can isolate circulating tumor cells from blood samples in a non-invasive manner. Early clinical studies have shown the system to have unprecedented sensitivity and specificity in detecting ovarian cancer. ANGLE is working with key opinion leaders to validate Parsortix and develop clinical applications in other cancers that could lead to regulatory approval and access to multi-billion dollar clinical markets.
Liquid biopsy from a simple blood test enabling personalised cancer care | Sh...ANGLE plc
Liquid biopsy from a simple blood test is enabling personalised cancer care. The Parsortix system from ANGLE can harvest cancer cells from blood (liquid biopsy) in a non-invasive and repeatable way. This provides a new approach to obtaining cancer cells for analysis compared to traditional tumour biopsies. Key opinion leaders have evaluated the Parsortix system and found that it captures all types of cancer cells with high purity in an easy to use process, making it well suited for clinical applications in personalised cancer care.
Presentation 2 July 2015: Proactive Investors Forum ANGLE plc
ANGLE presented on their Parsortix liquid biopsy system, a non-invasive method to capture and harvest circulating tumor cells from blood to enable personalized cancer care. Their system has shown promising results in early clinical studies and key opinion leader evaluations, and ANGLE outlined their commercialization strategy focused on research use sales and the first clinical application in ovarian cancer triage.
- Liquid biopsy from a simple blood test enables personalized cancer care by harvesting rare cancer cells from blood using ANGLE's patented Parsortix system.
- The Parsortix system captures circulating tumor cells shed from primary tumors with unprecedented sensitivity and specificity, enabling non-invasive analysis and repeat testing over time for personalized treatment.
- ANGLE aims to partner with established diagnostic companies to accelerate global distribution of the Parsortix system and make liquid biopsy available for improving cancer care and reducing healthcare costs.
Sanofi reported strong Q1 2023 results, with sales growth of 5.5% overall. The Specialty Care unit grew 18.3% driven by Dupixent sales increasing 39.7%. Dupixent continues to see strong demand globally. Vaccines sales grew 15.2% from COVID contracts and travel/booster vaccine recovery. R&D advancements included positive Dupixent COPD data and upcoming events for fitusiran and tolebrutinib. Financial guidance and outlook will be provided later in the year.
Sanofi reported strong Q1 2023 results, with specialty care sales up 18.3% driven by Dupixent growth of 39.7%. Vaccines sales also grew 15.2% from COVID contracts and travel vaccine recovery. R&D updates included positive Dupixent COPD data and promising early immunology assets. The document provided financial and business performance summaries for Q1 2023 and outlook.
Aptorum Group Limited (NASDAQ: APM) is a pharmaceutical company dedicated to developing and commercializing novel therapeutics to tackle unmet medical needs. Aptorum's current drug pipeline includes indications in orphan diseases, infectious diseases, and metabolic diseases. The Company launched two new clinical trials in 2021. Aptorum’s Smart-ACT™ platform is designed to bring an average of three drug candidates for orphan diseases to clinical trials every 12-18 months. The Company is now preparing to launch a dietary supplement for women undergoing menopause and experiencing related symptoms, including osteoporosis. Targeting a global woman’s health supplement market that is expected to reach $17 billion in 2025, Aptorum is expected to generate near-term revenue with significant long-term growth potential.
Dupilumab is an investigational monoclonal antibody that targets IL-4 and IL-13, key drivers of the type 2 inflammatory response in atopic dermatitis (AD). Two phase 3 clinical trials, SOLO 1 and SOLO 2, evaluated the efficacy and safety of dupilumab in adults with moderate-to-severe AD. The results from these trials showed that dupilumab monotherapy significantly improved measures of disease severity such as EASI, IGA, and pruritus scores compared to placebo. Treatment with dupilumab also led to rapid and significant improvements in skin clearance and quality of life measures. The safety profile observed was generally consistent with the mechanism of action and the patient population.
1) Marker Therapeutics is developing a multi-tumor associated antigen (MultiTAA) T cell therapy approach that targets multiple tumor antigens to address limitations of current CAR T and TCR therapies such as relapse due to antigen escape.
2) In clinical trials to date involving over 50 lymphoma patients, MultiTAA T cell therapy has shown durable complete responses in over 50% of patients with active lymphoma with no serious adverse events or cytokine release syndrome observed.
3) For patients treated while in remission, over 80% have maintained a continued complete response for durations ranging from 3 to 37 months to date.
This document discusses Ruthigen, Inc., a drug development company focused on developing RUT58-60, a hypochlorous acid-based drug candidate for invasive use. RUT58-60 aims to improve patient outcomes for invasive procedures by reducing post-surgical infections in a more effective way than current standard of care antibiotics. Published studies on Microcyn, another hypochlorous acid-based product, show promise in reducing infection rates for diabetic foot ulcers and coronary artery bypass graft surgery wounds. If successful, RUT58-60 could help hospitals reduce costs by shortening patient stays and lowering readmission rates for post-surgical infections.
Blue Horizon International AG was formed in 2017 to commercialize stem cell technology and regenerative medicine. It has established stem cell manufacturing and treatment procedures through its clinics in Slovakia, Jamaica, and partnerships in China. The company aims to treat a wide range of diseases like stroke, Alzheimer's, diabetes, heart disease, and arthritis using stem cells without drugs or surgery. Financial projections estimate revenues growing from $617,980 in 2020 to $23.7 million in 2024 as more clinics are launched globally.
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2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Tiziana Life Sciences (NASDAQ: TLSA) Investor Presentation
1. An Innovative Platform in Oral, Nasal and Inhalation
for Monoclonal Antibody Administration
Differentiated Treatment Approaches for Crohn’s
Disease, COVID-19, Autoimmune Disease and
Hepatocellular Carcinoma
A p r i l 2 0 2 0
C o r p o r a t e P r e s e n t a t i o n
NASDAQ: TLSA AIM: TILShttps://www.tizianalifesciences.com/
2. DISCLAIMER AND FORWARD LOOKING STATEMENTS
The content of this presentation has been prepared for the purpose of providing general information about, and an overview of, the Company and its business. It is not intended to be a
complete review of all matters concerning the Company and nor has it been independently verified. Whilst the presentation has been prepared in good faith and the Company has taken all
reasonable care to ensure the information and facts contained in this presentation are accurate and up-to-date, it does not make any representation or warranty, express or implied, as to
the accuracy or completeness of any information included in this presentation. Neither the Company nor any of its directors, officers, employees or agents shall be liable for any loss arising
directly or indirectly from the use of or reliance upon this presentation or in relation to the adequacy, accuracy, completeness or reasonableness of the information it contains. All and any
such liability is expressly excluded to the fullest extent permitted by law. The information in this presentation is subject to updating, completion, revision, further verification and
amendment without notice.
This presentation does not constitute or form part of any offer for sale or solicitation of any offer to buy or subscribe for any securities including ordinary shares in the Company nor does it
constitute an invitation or inducement to engage in investment activity in relation to any securities, including the ordinary shares of the Company. It does not purport to contain information
that shall form the basis of or be relied upon in making such investment decisions. If you require any advice, please consult with a professional financial adviser. All investments are subject to
risk. The value of securities may go down as well as up. Past performance cannot be relied on as a guide for future performance.
This presentation may contain certain forward-looking statements concerning the financial condition, results of operations and businesses of the Company. All statements other than
statements of historical fact are, or may be deemed to be, forward-looking statements. Forward-looking statements are statements of future expectations that are based on management’s
current expectations and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance or events to differ materially from those
expressed or implied in these statements. All forward-looking statements contained in this presentation are expressly qualified in their entirety by the cautionary statements contained or
referred to in this section. You should not place undue reliance on forward-looking statements. Each forward-looking statement speaks only as of the date of this presentation. The
Company does not undertake any obligation to publicly update or revise any forward-looking statement as a result of new information, future events or other information. In light of these
risks, results could differ materially from those stated, implied or inferred from the forward-looking statements contained in this presentation.
In the UK, this presentation has not been approved by an authorised person and is being distributed on the basis that each person in the UK to whom it is issued is reasonably believed to be
such a person as is described in Article 19 (investment professionals) or Article 49 (high net worth companies, unincorporated associations etc.) of the Financial Services and Markets Act
2000 (Financial Promotion) Order 2005 (SI 2005/1529) or are persons to whom an invitation or inducement to engage in investment activity (within the meaning of section 21 of the Financial
Services and Markets Act 2000) in connection with the issue or sale of any securities may otherwise lawfully be communicated or caused to be communicated. Persons who do not fall within
such descriptions may not act upon the information contained in this presentation.
2
3. 33
EXECUTIVE TEAM
Key Strengths of the
Management Team
• Successful track record in
biotechnology ‘Bench to
Market’
• Proven industry leadership
• Strong entrepreneurial success
in Biotechnology deals
• Co-founder , EVP & CSO of Synergy
Pharmaceuticals, NASDAQ: SGYP
• The pioneer of GC-C agonist technology
• Inventor of TRULANCE® approved for
Chronic constipation and IBS-C
• VP, Callisto Pharmaceuticals
• Group Leader, Monsanto Co.
Kunwar Shailubhai PhD,
MBA
CEO & CSO
Executive Director
• Former Group Finance Director at
Pharmentis, a Teva Ratiopharm spin-off
• Former Executive Director at Walgreen
Boots, Snia, Accenture and FIAT Group
• MBA, Bocconi University, Milan
• Corporate Finance, London Business
School
Tiziano Lazzaretti, MBA
Chief Financial Officer
• Proven track record & experience in
financing biotechnology companies
• Founder and chairman of two biotech
companies with market cap over $2 B
• Inhibitex sale $2.5 B
• Synergy / Trovagene / Gensignia / Rasna /
Contravir / Siga Technologies
• MBA, Stern School of Business, NY, US.
Gabriele Cerrone, MBA
Executive Chairman
• Career as an executive in the banking and
corporate finance sector and director of
publicly listed companies
• Kredietbank N.V., Citibank, Generale Bank
NL, CEO of Fortis Investment Management
• Chairman of Bank Oyens & van Eeghen,
Partner at Redi & Partners
Willy Simon
Non-Executive Director
BOARD OF DIRECTORS
4. SCIENTIFIC ADVISORY COMMITTEE
Howard Weiner, MD
Professor of Neurology at Harvard Med
Director and Founder of the Partners MS Center and Co-Director of the
Ann Romney Center for Neurologic Diseases
Pioneered investigation of the mucosal immune system for the
treatment of autoimmune and other diseases
Napoleone Ferrara MD
Inventor of Avastin® ($6.67Bn/yr)*; 2010 Lasker Award
Senior Deputy Director Basic Sciences, Moores Cancer Center, UC
San Diego
Distinguished Prof of Pathology, School of Medicine, UC San Diego
Kevin Herold, MD
Professor of Immunobiology and Medicine and Deputy Director, Yale
Center for Clinical Investigation
Director of the Yale Diabetes Center and Director of the TrialNet
Center at Yale
Expert in autoimmune diseases and anti-CD3 monoclonal antibody
therapies
Arun Sanyal MD
Charles Caravati Distinguished Professor and Chair, Division of
Gastroenterology, Hepatology and Nutrition at Virginia
Commonwealth University School of Medicine
Leader in the field of liver diseases
Angelo Sangiovanni, MD
Adjunct Professor of Gastroenterology at the University of Milan
Leader in liver disease and gastroenterology
Awarded Best Scientific Publication in clinical Hepatology in Italy
Fabio Piscaglia, MD
Associate Professor, Medical and Surgical Sciences at the University
of Bologna
Leader in liver diseases and transplantation
2017 Winner of a National Institute of Health (NIH) of United States of
America grant
Erica Villa, MD
Professor and Chief GI Unit
Chairman of the Department of Internal Medicine
Universitaria di Modena, Policlinico, Modena, Italy
Leader in Clinical Hepatology and Translational Medicine
4
5. • Transformational platform technologies: Proprietary oral, nasal and inhaled formulation
technologies to transform immunotherapies with Monoclonal Antibodies (‘mAbs’) currently
administered intravenously
• Oral immunotherapy for Crohn’s Disease (CD): Phase 2 clinical study with orally administered
Foralumab, a fully human anti-CD3 mAb: Anticipated completion date Q2, 2021
• Proprietary Inhalation formulation of fully human anti-IL6 receptor mAb for direct delivery in lungs
lungs for treatment of COVID-19 patients. Lungs are the primary site for COVID-19 infection and
and progression. Thus, direct delivery of anti-IL6R (TZLS-501) mAb to lungs is expected to provide
immediate relief to COVID-19 patients
• Nasal treatment for progressive multiple sclerosis (pro-MS): Phase 2 clinical study with nasally
administered Foralumab: Anticipated completion date Q2, 2021.
• Innovative Approach: Nasally administered Foralumab upregulates T regulatory cells (Tregs) that are
capable of crossing ‘Blood Brain Barrier’ to suppress inflammation in brain commonly associated
Neurodegenerative diseases such as, Multiple Sclerosis, Alzheimer and Lupus (systemic lupus
erythematosus)
• Broad-spectrum treatment for hepatocellular carcinoma (HCC): Milciclib, a pan-CDK (cyclin
dependent kinase) inhibitor, successfully completed phase 2 clinical trial in advanced HCC patients
• Orphan Drug Designation for Milciclib: Granted in US and EU for treatment of thymic
carcinoma/thymoma (TC/T)
5
Orphan Drug Designation: Met primary
and secondary endpoints in 2 separate
Phase 2 trials in TC/T
Phase 2a in sorafenib-resistant HCC
patients completed
Milciclib seems to outperform
Standard of care
Oral Trial: FDA approved IND
Phase 1 oral trial completed
Phase 2 oral in CD by Q2, 2021
Nasal Trial: Phase 2 starting shortly
Phase 1 trial completed
Phase 2 data in pro-MS by Q2, 2021
5
Inhalant Trial: Preclinical
Trial to commence investigating direct
delivery of anti-IL6R mAb to the lungs
using a portable inhaler
INVESTMENT HIGHLIGHTS Foralumab
TZLS-501 (Anti-IL6R)
Milciclib
6. platform enables…
A REVOLUTIONARY PLATFORM
Costly Infusion
Poor patient compliance
Higher toxicity
Systemic treatment to affect
whole body
Infusion related side effects
TODAY’S ANTIBODY ADMINISTRATION
OPTIONS ARE MOSTLY I.V.
Antibodies (mAbs) reformulated
for oral administration
Antibodies (mAbs) reformulated for
nasal administration
Ease of use
Superior compliance
Topical action in gut
Minimized toxicity
Take home Rx
No costly infusion
PATIENT &
PROVIDER BENEFITS
THE LARGE MARKET
OPPORTUNITY
Market opportunity for
mAb therapeutics is
greater than
$86
BILLION
6 6
SWITCH ANTIBODY ADMINSTRATION FROM INTRAVENOUS
TO ORAL, NASAL AND INHALED ROUTES
TZLS- 501 Anti- IL6R- delivery of anti-IL-6R
mAb to the lungs using a portable inhaler
7. DISCOVERY
LEAD
OPTIMIZATION
PRE-CLINICAL IND PHASE 1 PHASE 2 PHASE 3
DEVELOPMENT PIPELINE
PHASE 2 TO
BEGIN
Nasal Trial
Pro-MS
PHASE 2 TO
BEGIN
Oral trial in
Crohn’s Disease
7 7
Milciclib + Gemcitabine in refractory solid tumors
Potential Adjuvant Treatment
HCC monotherapy
Sorafenib Resistant Patient
HCC combination with a Tyrosine Kinase Inhibitor
Potentially for synergism
Intranasal formulation for Neurodegenerative disease
Nasal Administration
Enteric coated capsules
Oral Administration for CD and NASH
Crohn’s disease
I.V. Administration – Conducted by Novimmune
Starting Phase 2 shortly
Starting Phase 2 shortly
COVID – 19
investigating direct delivery of anti-IL-6R
to the lungs using a portable inhaler
Clinical Studies to begin shortly
Foralumab
TZLS-501
(Anti-IL6R)
Milciclib
PRECLINICAL
STUDIES
ANTI-IL6R
INHALER
PHASE 2a
COMPLETE
HCC Oral
Monotherapy
Foralumab
TZLS-501
(Anti-IL6R)
Milciclib
8. 8
P L A T F O R M
T E C H O L O G I E S
ORAL ADMINISTRATION
Successfully completed Phase 1 trial with
orally administered Foralumab
Phase 2 trial in Crohn’s Disease to start shortly
8
A BIOTECHNOLOGY PLATFORM ENABLING
ORAL, NASAL & INHALATION
ADMINISTRATION OF MONOCLONAL
ANTIBODIES
NASAL ADMINISTRATION
Phase 1 trial completed for related neurodegenerative
diseases such as Progressive Multiple Sclerosis (Pro-MS) .
Phase 2 trial in Pro-MS to start shortly.
INHALATION ADMINISTRATION
Preclinical Studies Ongoing
Trial to commence investigating direct delivery of anti-
IL6R mAb to the lungs using a portable inhaler
9. OKT3
MUROMONAB
CHAGLYCD3
OTELIXIZUMAB
NUVION
VISILIZUMAB
HOKT31(ALA-ALA)
TEPLIZUMAB FORALUMAB
IgG2a IgG1
*Agly
IgG2
*AA
IgG2
*AA
IgG1
*AE
Fully Mouse Chimeric & Humanized Humanized Humanized Fully Human
THE ONLY FULLY HUMAN ANTI-CD3 MAB IN CLINICAL TRIALS
Approved by the FDA for solid
organ transplantation
immuno-suppression
9
CD3-SPECIFIC MONOCLONAL ANTIBODIES IN CLINICAL DEVELOPMENT
Oral and Nasal Administration
Market Opportunities
Tiziana’s platform of oral and nasal
mAbs administration potentially enhances
efficacy and reduces toxicity
Foralumab is unique: functionally equivalent to OKT3 with minimal immune reactions when administered IV
10. Patent covers Foralumab and other mAbs
ANTI-CD3 ANTIBODY FORMULATIONS
Applicant(s): Tiziana Life Sciences PLC
Inventor(s): SHAILUBHAI, Kunwar
US Non-Provisional Patent Application
No.:62/380,652, filed August 29, 2016
PCT Application
PCT/US2017/049211, filed, Aug 29, 2017
Patent estate
Exclusive license for
composition of matter
Composition of matter patent for oral
and nasal formulation
Additional patent applications pending
Oral formulation technology applicable to
other mAbs
Targets: Crohn’s Disease and NASH
Nasal administration of Foralumab
Proof-of-concept demonstrated in
animal studies
Phase 1 study for neurodegenerative
diseases at Brigham and Women’s
Hospital, Harvard Medical School;
completed and well-tolerated up to 250
µg
Positive Top line data received August
2019, CSR in preparation
In-licensed nasal delivery technology
from Brigham and Women’s Hospital,
Harvard Medical School
Targets: Pro-MS and Alzheimer
ORAL AND NASAL FORMULATION PATENTS PENDING
10
11. Phase 1 trial conducted at Brigham and Women’s Hospital
completed July 2019
Dose-ranging, double-blind, placebo-controlled study in healthy
subjects
Foralumab was administered nasally at 10, 50 and 250 µg per day,
consecutively for 5 days using a hand-held spray device
Each dose group consisted of 6 active and 3 placebo
KEY FINDINGS
1. Foralumab was well-tolerated with no drug-related toxicities
2. Immunology marker analysis indicated, that 50-µg dose
the anti-inflammatory cytokine IL-10 and suppressed the pro-
inflammatory cytokine IFN-γ
3. Results suggest stimulation of T regs needed for clinical
PHASE 1 CLINICAL DATA WITH NASALLY ADMINISTERED FORALUMAB
11Press Release Reference: https://ir.tizianalifesciences.com/news-releases/news-release-details/tiziana-life-sci-plc-phase-1-clinical-data
12. Phase 1 trial conducted at Brigham and Women’s Hospital
completed December 2019
Single ascending dose, double-blind, placebo-controlled study in
healthy subjects
Foralumab administered at 1.25, 2.5 and 5.0 mg/dose as stabilized
powder formulation in enteric-coated capsules
No apparent toxicity up to 5 mg
KEY FINDINGS
1. Well-tolerated at all doses tested
2. No drug-related safety issues observed
3. Toxicities associated with IV administration of anti-CD3 mAbs
observed
PHASE 1 CLINICAL DATA WITH ORALLY ADMINISTERED FORALUMAB
12
Press Release Reference: https://ir.tizianalifesciences.com/news-releases/news-release-details/tiziana-life-sci-plc-further-re-foralumab-phase-1-trial
13. Conducted by Dr. Scott Snapper at Harvard Medical School
Determined the immunologic effects and safety of orally delivered anti-CD3
antibody in patients with moderate-to-severe ulcerative colitis (UC)
Six subjects received oral OKT3
* Boden, E. K., Canavan,J. B., Moran, C. J., McCann, K., Dunn, W. A., Farraye, F. A., Ananthakrishnan, A. N., Yajnik, V., Gandhi, R., Nguyen, D. D.,
Bhan, A. K., Weiner, H. L., Korzenik, J. R., Snapper, S. B. Immunologic alterations associated with oral delivery of anti-CD3 (OKT3) monoclonal
antibodies in patients with moderate-to-severe ulcerative colitis. Crohn's & Colitis 360 (2019). 183: 240-246.
KEY FINDINGS
1. The biologic response to treatment with oral anti-CD3 were increased proliferation
anti-inflammatory gene expression profile in peripheral blood mononuclear cells
2. 3 of 6 patients had a clinical response including one patient in clinical remission
3. Treatment was well-tolerated with no serious treatment-related adverse events
THE CONCEPT FOR ORAL ADMINISTRATION WITH ANTI-CD3 MAB
IS VALIDATED WITH CLINICAL DATA IN ULCERATIVE COLITIS
13
14. OKT3, a murine mAb, was withdrawn from the market due to severe side effects
Foralumab is a fully human anti-CD3 mAb with minimal side effects
STUDY DESIGN SAFETY IMMUNOLOGICAL EFFICACY BIOMARKERS
36 subjects with NASH and
type II diabetes
Randomized, single-blinded,
placebo-controlled
9 per group, not powered for
statistical significance
0.2, 1.0, 5.0 mg or placebo
daily for 30 days
Primary endpoints: safety and
trends in immunomodulation
Secondary endpoint:
indication or trend of efficacy
through biomarkers
Follow up: Days 0, 14, 30, 60
Hadassah Medical Center,
Jerusalem Israel
Well tolerated by all patients in
all groups
No systemic drug-related
adverse events
No changes in vital signs,
serum biochemistry and
hematological parameters
during treatment or follow-up
periods (30-days post-
treatment)
No changes in lymphocyte and
CD+ cell counts
No changes in weight or BMI or
HbA1C lipid GLP-1, or CRP
levels in any of the groups
Increases inTreg markers
consistent with induction of
Tregs
Anti-inflammatory markers ↑
CD4+CD25+LAP+Treg cells,
TGFβ↑
Positive trends, some of which
were statistically significant
AST ↓ – liver enzyme indicating
reduced liver inflammation
Glucose ↓ – favorable for
subjects with type-2 diabetes
Insulin ↓ – favorable for
subjects with type-2 diabetes
14
ORAL TREATMENT WITH MURINE ANTI-CD3 (OKT3) EFFECTIVE IN A PHASE 2 TRIAL WITH NASH1
Sources:1)Lalazar, G., Mizrahi, M., Turgeman, I., Adar, T., Ya’Acov, A. B., Shabat, Y., . . . Ilan, Y. (2015). Oral Administration of OKT3 MAb
to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-
Controlled Trial. Journal of Clinical Immunology, 35(4), 399-407.
PROOF-OF-CONCEPT IN NASH PATIENTS
15. Applicant:Tiziana Life Sciences PLC
Inventors: Gabriele Cerrone and Kunwar Shailubhai
• Excessive levels of circulating IL6 is the major cause of COVID-19 progression.
Thus depletion of circulating IL6 is an attractive approach to provide
immediate relief to patients with COVID-19
• TZLS-501 (formerly NI-1201) a fully human anti-IL-6 receptor mAb was
acquired from Novimmune in 2017 and currently under license from BMS
• Binds to both the membrane-bound and soluble forms of the IL6R and
depletes circulating levels of the IL-6 in the blood
• Anti IL-6R mAb Patent application covers
Use of antibody for immediate treatment of COVID-19 patient
Delivery via aerosol formulation by an inhaler or nebulizer, which can be
easy to use for children and elderly people
Administration as aerosol formulation by an inhaler/nebulizer either
alone or in combination with intravenous administration
PATENT APPLICATION FILED FOR COMPOSITION AND METHOD OF USE OF
ANTI-IL-6R MONOCLONAL ANTIBODIES FOR TREATMENT OF COVID-19
15
16. THERAPEUTIC OPTIONS DURING PROGRESSION OF COVID-19
Death
Time Course
ProgressionofCOVID-19
Viral Infection Viral Proliferation
Hyperinflammation in lungs
Cytokine Storm (IL-6 & TNF-a)
Lung damage
Antiviral Treatment Anti-inflammatory Treatment
A combination of anti-viral & anti-inflammatory drugs might be better therapeutic option
16
17. 17
A PAN-CDK INHIBITOR FOR TREATMENT OF
HEPATOCELLULAR CARCINOMA AND SOLID
TUMORS
HCC is a complex and heterogenous
cancer associated with multiple etiological
factors
17
NASH
Newer treatment approach with broad-spectrum
action is needed to address heterogeneity of HCC
18. 18
SMALL MOLECULE PAN-CDK INHIBITOR
• Complex heterogeneity in HCC due to multiple
etiological agents; Need for broad-spectrum approach
• Orally-bioavailable small molecule with potent anti-
tumor activity in a wide range of animal models
Inhibitor of kinases associated with cancer cell growth
including CDK1, CDK2, CDK4 CDK5, CDK7 and src-family
kinases
Inhibits signaling pathways for hepato-carcinogenesis
Well tolerated in 316 patients
Improved toxicity profile over the current standard of
care anticipated
A drug with completely differentiated MOA and long-term safety
19. 19
CLINICAL DATA FROM MILCICLIB
Trial design: Oral administration (100 mg/day, consecutive 4 days a week in a 4-week cycle). Total patients 30 to
be enrolled. Duration 6 months
Primary end point: safety
Secondary end points: PFS, ORR & TTP
Exploratory: AFP and miRNA profiling
Compassionate use: Upon request of patients with EC approval
Trial complete: Data from 28 out of 31 evaluable sorafenib-resistant HCC patients
14 patients completed treatment as per protocol
Nine approved for compassionate use. Seven patients completed
9, 9, 10, 11, 13, 13 and 16 months, respectively.
No drug related deaths in the trial
Treatment was well-tolerated
Adverse events were manageable
Time to progression 5.9 months out of 6 months duration of trial
Stabilized Disease (SD) 61%
Clinical Benefit Response 64%
PHASE 2A TRIAL IN SORAFENIB-RESISTANT HCC PATIENTS
Two patients currently continuing
compassionate use. Ongoing
treatment at 18 months.
20. 20
• Superior assay based on a stemness
signature genes for early prediction of
ER+/HER2- recurrence of breast cancer
• Side-by-side comparison with samples
(n=818) from the Trans-ATAC cohort
indicated superior prognostic value of
StemPrinter assay over Oncotype DX assay
P L A T F O R M
T E C H O L O G I E S
20
Best-in-class genomic signature for prognosis of
early and late recurrence of ER+/HER2- breast
cancer patients in early stage
21. 21
1. Comparison of StemPrintER, a Novel Biology-based Genomic Predictor of Distant Recurrence in Breast
Cancer, with Oncotype DX in the TransATAC cohort, shows that StemPrintER:
• Significantly (p<0.0001) stratifies high vs. low risk groups when adjusted for clinical parameters as expressed by
clinical treatment scores (CTS)
• Outperforms Oncotype DX in 10-year risk prediction in more than 800 ER+/HER2- postmenopausal breast
cancer patients, including lymph node-negative (N0) and 1 to 3 lymph node-positive (N1-3) patients
• Adds more prognostic information than Oncotype DX on the top of clinical parameters as expressed by clinical
treatment scores (CTS)
2. Integration of the stem cell biology-based genomic tool, StemPrintER, with clinicopathological parameters for
the prediction of distant recurrence in ER+/HER2- breast cancer patients
• Demonstrates that the next-generation StemPrintER Risk Score (SPARE) model is:
- approximately 20% superior to the traditional clinicopathological parameters, as expressed by the CTS, in
providing
prognostic information in more than 1,800 ER+/HER2- patients analyzed;
- up to 40-50% more accurate in lymph node-negative (N0) and 1 to 3 lymph node-positive (N1-3) patients.
• Investigators found that SPARE added substantial prognostic information to CTS, but the inverse was not
proven to be the case.
Two Posters Presented at ASCO2020
22. FAMILY SUBJECT PRIORITY STATUS EXPIRES JURISDICTION
TZLS-401
Methods of Use (Autoimmune or
Inflammatory diseases and disorders) 2004 Issued 2025
Australia, Canada, China, Hong Kong, Israel, Japan, Mexico, Norway, Singapore, South Africa, Ukraine,
Armenia, Austria, Azerbaijan, Belgium, Belarus, Switzerland, Germany, Denmark, Spain, France, United
Kingdom, Ireland, Italy, Kyrgyzstan, Kazakhstan, Luxembourg, Moldova, Netherlands, Portugal, Russian
Federation, Sweden, Tajikistan, Turkmenistan,
Composition and methods of use 2004 Issued/ Pending 2025
US, Armenia, Australia, Austria, Azerbaijan, Belarus, Brazil, Canada, China, Denmark, France, Germany,
Hong Kong, India, Israel, Italy, Japan, Kazakhstan, Kyrgyzstan, Mexico, Moldova, Netherlands, Norway,
Republic of Korea, Russian Federation, Singapore, South Africa, Spain, Switzerland, Tajikistan,
Turkmenistan, and Ukraine Pending: Japan (divisional), Singapore (divisional), US (divisional)
Methods of Use (In combination
with anti-IL-6/IL-6R antibodies) 2011 Pending 2032 US
Formulations and dosing regimen 2016 Pending 2037 US (allowed), Australia, Canada, China, Europe, Hong Kong, Israel, Japan
Methods of Use (CNS disorders) 2017 Pending 2038 National
Methods of Use
(gastrointestinal/autoimmune/inflammatory) 2018 Pending 2039 PCT
TZLS-201
Composition of matter, methods of
use, process of manufacturing 2003 Issued/ Pending 2024
US, Europe, Eurasia, Africa, Algeria, Argentina, Australia, Barbados, Bosnia & Herzegovina, Canada,
Colombia, Costa Rica, Croatia, Cuba, Ecuador, Georgia, Iceland, India, Indonesia, Israel, Japan, Korea,
Kosovo, Malaysia, Mexico, Mongolia, Montenegro, New Zealand, Nicaragua, Norway, Pakistan, Philippines,
Serbia, Singapore, South Africa, Sri Lanka, Taiwan, Tunisia, Ukraine, Uzbekistan, Vietnam. Pending: US,
Brazil, Egypt, Thailand, Trinidad & Tobago, Venezuela
Methods of use (multiple indications) 2008; 2009 Issued 2029; 2030 US, EU, China, Hong Kong, Japan
Methods of use (combination
therapies with cytotoxics) 2008; 2009 Issued 2029; 2030 US, EU, China, Hong Kong, Japan
Compositions of related entities, formulations
and methods of treatment 2009 Issued 2030 US, EU, China, Hong Kong, Japan
Methods of use (combination therapies
with therapeutic antibodies) 2006 Issued 2027 US, EU, China, Japan
Formulations of Milciclib and therapeutic combinations of
the same for use in the
treatment of cancer
2017 Pending 2038 US, PCT
Composition of Matter and
Methods of use
Composition of Matter and
Methods of use (Inhalation)
2009
2020
Issued/ Pending
Pending
2029
US, Austria, Australia, Belgium, Canada, China, Denmark, France, Germany, India, Ireland, Italy, Japan
Luxembourg, Mexico, Netherland, Spain, Sweden, Switzerlandand UK. Pending: US (divisional), Japan
(divisional)
US Provisional
INTELLECTUAL PROPERTY PORTFOLIO
22
Foralumab
Milciclib
TZLS-501
(Anti-IL6R)
23. UPCOMING CATALYSTS
GROWTHOBJECTIVES
PRODUCT ACTION/OBJECTIVE
TARGET
DATE
Phase 2 trial with orally administered Foralumab in Crohn’s Disease
patients anticipated completion
Q2, 2021
Phase 2 trial with nasally administered Foralumab in progressive multiple
sclerosis (pro-MS) patients anticipated completion
Q2, 2021
Development of inhalation technology to deliver stable aerosols directly in
lungs.
Initiate Phase 2b in HCC patients with Milciclib in combination
with aTKI.
Q2, 2021
Q2, 2021
23
Foralumab
Foralumab
TZLS-501
(Anti-IL6R)
Milciclib
24. CAPITAL STRUCTURE
Ordinary Issued Shares 160,766,884
Warrants 5,696,953
Options 15,909,403
Fully Diluted Shares 182,373,240*
24
ADS EQUIVALENT*
Ordinary Issued Shares 32,153,377
Warrants 1,139,391
Options 3,181,881
Fully Diluted Shares 36,474,649
*Information prepared as of April 27, 2020. 1 ADS represents 5 ordinary shares.
The company is contemplating/planning to migrate to Bermuda in the second quarter which will enable it to de-list from AIM, eliminate its ADR program and have
Bermuda common shares instead listed on Nasdaq.
25. CONTACT US
US Headquarters
Tiziana Life Sciences Inc
420 Lexington Avenue Suite 2525
New York, NY 10170
Research and Development Center
Tiziana Life Sciences Inc
Pennsylvania Biotechnology Center of Bucks County
3805 Old Easton RD
Doylestown, PA 18902-8400
UK Headquarters
Tiziana Life Sciences plc
55 Park Lane
London W1K 1NA
United Kingdom
+ 1 (267) 982 9785
mpreiss@tizianalifesciences.com
+44 7769 88 4020
hmalik@tizianalifesciences.com
www.tizianalifesciences.com
NASDAQ: TLSA AIM: TILS
An Innovative Platform in Oral, Nasal and Inhalation for
Monoclonal Antibody Administration
Differentiated Treatment Approaches for COVID-19,
Autoimmune Disease and Hepatocellular Carcinoma
Foralumab TZLS-501
(Anti-IL6R)
Milciclib
26. 26
CLINICAL DATA SUGGEST MILCICLIB
OVERCOMES GEMCITABINE RESISTANCE
KEY FINDINGS FROM PHASE 1 STUDY
1. Milciclib well-tolerated with manageable side
in patients with refractory solid tumors
2. Oral treatment in combination with gemcitabine
demonstrated clinical activity in patients who
non-responder to existing chemotherapeutic
3. Recommended Phase 2 dose (RPD) found to be
80mg/m2/day for milciclib and 1000mg/m2/day
gemcitabine
4. Overall response rate was 36%
5. Results suggest further evaluation in other solid
cancers either as monotherapy or combo-therapy
PATIENTS RAPIDLY ACQUIRE RESISTANCE TOWARDS CHEMOTHERAPIES
Phase 1 Dose-Escalation Study of Milciclib in
Combination with Gemcitabine in Patients with
Refractory Solid Tumors*
Swimmerplot showing treatment duration. Tumor type was indicated for patients having a
prolonged stable disease or a partial response. M Milciclib; G gemcitabine.
* Cancer Chemotherapy and Pharmacology, June 2017, 79(6), 1257-1265
27. PANETH CELL
Dendritic cells
M CELL
INTESTINAL
EPITHELIAL
CELLS
Lymphoid
follicle
Mesenteric
lymph node
Treg cell
induction
Site-targeted
Immunomodulation
Gut Lumen
INNATE IMMUNE SYSTEM
Macrophages
NKT cells
Intraepithelial
lymphocytes
NOVEL APPROACH FOR SITE-TARGETED IMMUNOMODULATION
HOW DOES OUR PLATFORM TECHNOLOGY WORK?
Lamina Propria
27