The thoracic duct is the largest lymphatic vessel that extends from the upper abdomen to the lower neck. It begins near the 12th thoracic vertebrae and ascends through the posterior mediastinum before passing into the superior mediastinum. In the neck, it opens at the junction of the left subclavian and left internal jugular veins. It receives lymph from the lower body and left side of the body above the diaphragm. Obstruction or injury to the thoracic duct can lead to conditions such as chylothorax.