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UNIVERSITY OF NANTES
UFR PHARMACEUTICAL AND BIOLOGICAL SCIENCES
____________________________________________________________________________________________________
YEAR 2014 N°
THESIS
For the
STATE DIPLOMA
OF DOCTOR OF PHARMACY
by
Olivier ANGIBAUD
-----------------------------------------
Presented and supported publicly November 17th, 2014
Interactions between antiretroviral treatment
and recreational drugs
Président : Pr Yves-François POUCHUS, Professor of Botany and Mycology
Jury members: Pr Alain PINEAU, Professor de Toxicology, Hygiene et First Aid
Mr Igor DOMINGUEZ, Doctor of pharmacy, Pharmacy Owner
UNIVERSITY OF NANTES Year of the presentation
2014
___________________________________________________________________________
Full Name : Olivier Isaac Marc Angibaud
Thesis title : Interactions between antiretroviral treatment and recreational drugs.
___________________________________________________________________________
Abstract :
For over thirty years, HIV infection has continued to prevail in all regions of the world.
Despite medical advances, we are still not able to eradicate the phenomenon. The
number of infections and deaths from the disease continues to increase. There is also a
prevalent use of illegal drugs. Historical data shows the existence of a link between new
infections of the virus and the use of psychotropic substances. In some patients,
dangerous interactions between treatments and recreational drugs were observed,
including fatalities.
These drugs may be responsible not only for adherence issues but also for HIV
treatment failures. Not enough research on the phenomenon exists, despite its
importance.
Science, including toxicology, has revealed and prevented some of the dangerous
interactions. In this thesis, data will be presented to show how the interactions may
occur and how they can be prevented.
KEY WORDS HIV, RECREATIONAL DRUGS, HIV THERAPIES, ANTIRETROVIRAL DRUGS,
INTERACTIONS, TOXICOLOGY
___________________________________________________________________________
JURY
PRESIDENT : Pr Yves-François POUCHUS, Professor of botanic and mycology
Pharmacy school of Nantes
ASSESSORS : Pr Alain PINEAU, Professor of toxicology, Hygiena et secourism
Pharmacy school of Nantes
Mr Igor DOMINGUEZ, Doctor of pharmacy, Pharmacy owner
26 rue du temple, 75004 Paris
___________________________________________________________________________
Author’s adress : Olivier ANGIBAUD
383 Stockton ave, San Jose, CA 95126

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THESIS ENGLISH PRESENTATION

  • 1. UNIVERSITY OF NANTES UFR PHARMACEUTICAL AND BIOLOGICAL SCIENCES ____________________________________________________________________________________________________ YEAR 2014 N° THESIS For the STATE DIPLOMA OF DOCTOR OF PHARMACY by Olivier ANGIBAUD ----------------------------------------- Presented and supported publicly November 17th, 2014 Interactions between antiretroviral treatment and recreational drugs Président : Pr Yves-François POUCHUS, Professor of Botany and Mycology Jury members: Pr Alain PINEAU, Professor de Toxicology, Hygiene et First Aid Mr Igor DOMINGUEZ, Doctor of pharmacy, Pharmacy Owner
  • 2. UNIVERSITY OF NANTES Year of the presentation 2014 ___________________________________________________________________________ Full Name : Olivier Isaac Marc Angibaud Thesis title : Interactions between antiretroviral treatment and recreational drugs. ___________________________________________________________________________ Abstract : For over thirty years, HIV infection has continued to prevail in all regions of the world. Despite medical advances, we are still not able to eradicate the phenomenon. The number of infections and deaths from the disease continues to increase. There is also a prevalent use of illegal drugs. Historical data shows the existence of a link between new infections of the virus and the use of psychotropic substances. In some patients, dangerous interactions between treatments and recreational drugs were observed, including fatalities. These drugs may be responsible not only for adherence issues but also for HIV treatment failures. Not enough research on the phenomenon exists, despite its importance. Science, including toxicology, has revealed and prevented some of the dangerous interactions. In this thesis, data will be presented to show how the interactions may occur and how they can be prevented. KEY WORDS HIV, RECREATIONAL DRUGS, HIV THERAPIES, ANTIRETROVIRAL DRUGS, INTERACTIONS, TOXICOLOGY ___________________________________________________________________________ JURY PRESIDENT : Pr Yves-François POUCHUS, Professor of botanic and mycology Pharmacy school of Nantes ASSESSORS : Pr Alain PINEAU, Professor of toxicology, Hygiena et secourism Pharmacy school of Nantes Mr Igor DOMINGUEZ, Doctor of pharmacy, Pharmacy owner 26 rue du temple, 75004 Paris ___________________________________________________________________________ Author’s adress : Olivier ANGIBAUD 383 Stockton ave, San Jose, CA 95126