The document discusses different conceptions of democracy and the role of media and propaganda. It summarizes that some theorists view democracy as the public being barred from managing their own affairs and information being strictly controlled. Another view is that the public should have means to participate and access open information. The document outlines how early 20th century US government propaganda successfully turned public opinion to support entering WWI. This taught leaders that propaganda supported by elites can influence people. Some theorists then argued that a small group of "responsible men" understand the public interest better than the "bewildered herd" of citizens. They believe democracy works by the public occasionally choosing leaders, but otherwise being distracted spectators. The document critiques this view that the
The document discusses different conceptions of democracy and the role of media and propaganda. It summarizes that some theorists argue democracy requires a "bewildered herd" of citizens who are spectators rather than participants in decision making, which is left to an elite "specialized class". The successes of Woodrow Wilson's Creel Commission in manipulating public opinion through propaganda showed how the public could be influenced en masse. Some theorists like Walter Lippmann argued this system of "manufacturing consent" was necessary, as the interests of the majority elude them and are best determined by experts. Propaganda was thus seen as important in democracies to keep the public distracted while an elite few make decisions.
This document summarizes the evolution of the concept of "civil society" and its influence on international aid policy. It discusses how civil society was originally equivalent to political society or the state, but began to take on new meanings from the 17th century onward to refer to a sphere separate from the state. By the late 20th century, aid policy promoted support for NGOs and local civil society as a way to promote democracy, but this conceptualization of civil society as opposing the state fails to consider issues like ethnicity and risks further polarizing divided societies.
This document provides an overview and summary of the book "Decentralized Globalization: Free Markets, U.S. Foundations, and The Rise of Civil and Civic Society from Rockefeller's Latin America to Soros' Eastern Europe". It discusses 10 main goals of the book, including distinguishing between "gradual" and "fast-track" globalization, defining civic society and its relationship to civil society, examining the role of US philanthropy and free markets in facilitating globalization, and comparing case studies of Mexico and Romania as they modernized. The summary seeks to clarify concepts around non-profit organizations, civic engagement, and how the US model has influenced globalization.
Feminist Economics, Finance, and the CommonsConor McCabe
The document discusses the history of capitalism and its relationship to non-capitalist systems. It argues that capitalism in the past only occupied a small part of the economy and existed alongside much larger non-capitalist systems. It also discusses Fernand Braudel's distinction between the economy, capitalism, and a lowest non-economic stratum. The document advocates understanding capitalism in relation to the surrounding non-capitalist context from which it was defined.
This document discusses the role of civil society in foreign policymaking. It makes three key points:
1) Globalization has diminished the power of nation-states and increased the influence of civil society organizations in daily life and policymaking.
2) Civil society plays a pivotal role in bringing attention to issues like poverty, human rights, and the environment in both local communities and international forums.
3) For foreign policy to effectively address global challenges, a new conceptual framework is needed that shifts power to civil society and its representation of local interests in policy decisions.
This document introduces a special issue on identity politics that aims to intervene in debates around the relationship between class politics and identity politics. It argues that the opposition between these two is a constructed divide that has been effectively used by the right. The issue seeks to move beyond this divide by embracing the complexity of identity under capitalism and recognizing both the necessity of organizing around identity and ultimately abolishing socially constructed identity categories along with capitalism. It summarizes debates around the rise of identity politics in relation to neoliberalism and argues that identity politics has been understood by some Marxists as manifesting neoliberal logic by focusing on competition and representation within existing power structures rather than challenging capitalism. The introduction calls for understanding identities like race not just as modal
In human history, all struggles against oppression have always been directed against a clearly identified enemy, be it people, governments or social classes. In the past, the forces opposing the dominant oppressive power fought to conquer the State through which the power passed to be exercised in order to change the political, economic and social reality in which they lived. This is how social revolutions and national independence in many countries of the world happened. In the past, it was easier to mobilize a social class or an entire people against a clearly identified enemy oppressor. In the contemporary era, with the modern totalitarianism, the oppressive enemy is fragmented and acts openly and also subliminally on people's minds.
The document discusses different conceptions of democracy and the role of media and propaganda. It summarizes that some theorists view democracy as the public being barred from managing their own affairs and information being strictly controlled. Another view is that the public should have means to participate and access open information. The document outlines how early 20th century US government propaganda successfully turned public opinion to support entering WWI. This taught leaders that propaganda supported by elites can influence people. Some theorists then argued that a small group of "responsible men" understand the public interest better than the "bewildered herd" of citizens. They believe democracy works by the public occasionally choosing leaders, but otherwise being distracted spectators. The document critiques this view that the
The document discusses different conceptions of democracy and the role of media and propaganda. It summarizes that some theorists argue democracy requires a "bewildered herd" of citizens who are spectators rather than participants in decision making, which is left to an elite "specialized class". The successes of Woodrow Wilson's Creel Commission in manipulating public opinion through propaganda showed how the public could be influenced en masse. Some theorists like Walter Lippmann argued this system of "manufacturing consent" was necessary, as the interests of the majority elude them and are best determined by experts. Propaganda was thus seen as important in democracies to keep the public distracted while an elite few make decisions.
This document summarizes the evolution of the concept of "civil society" and its influence on international aid policy. It discusses how civil society was originally equivalent to political society or the state, but began to take on new meanings from the 17th century onward to refer to a sphere separate from the state. By the late 20th century, aid policy promoted support for NGOs and local civil society as a way to promote democracy, but this conceptualization of civil society as opposing the state fails to consider issues like ethnicity and risks further polarizing divided societies.
This document provides an overview and summary of the book "Decentralized Globalization: Free Markets, U.S. Foundations, and The Rise of Civil and Civic Society from Rockefeller's Latin America to Soros' Eastern Europe". It discusses 10 main goals of the book, including distinguishing between "gradual" and "fast-track" globalization, defining civic society and its relationship to civil society, examining the role of US philanthropy and free markets in facilitating globalization, and comparing case studies of Mexico and Romania as they modernized. The summary seeks to clarify concepts around non-profit organizations, civic engagement, and how the US model has influenced globalization.
Feminist Economics, Finance, and the CommonsConor McCabe
The document discusses the history of capitalism and its relationship to non-capitalist systems. It argues that capitalism in the past only occupied a small part of the economy and existed alongside much larger non-capitalist systems. It also discusses Fernand Braudel's distinction between the economy, capitalism, and a lowest non-economic stratum. The document advocates understanding capitalism in relation to the surrounding non-capitalist context from which it was defined.
This document discusses the role of civil society in foreign policymaking. It makes three key points:
1) Globalization has diminished the power of nation-states and increased the influence of civil society organizations in daily life and policymaking.
2) Civil society plays a pivotal role in bringing attention to issues like poverty, human rights, and the environment in both local communities and international forums.
3) For foreign policy to effectively address global challenges, a new conceptual framework is needed that shifts power to civil society and its representation of local interests in policy decisions.
This document introduces a special issue on identity politics that aims to intervene in debates around the relationship between class politics and identity politics. It argues that the opposition between these two is a constructed divide that has been effectively used by the right. The issue seeks to move beyond this divide by embracing the complexity of identity under capitalism and recognizing both the necessity of organizing around identity and ultimately abolishing socially constructed identity categories along with capitalism. It summarizes debates around the rise of identity politics in relation to neoliberalism and argues that identity politics has been understood by some Marxists as manifesting neoliberal logic by focusing on competition and representation within existing power structures rather than challenging capitalism. The introduction calls for understanding identities like race not just as modal
In human history, all struggles against oppression have always been directed against a clearly identified enemy, be it people, governments or social classes. In the past, the forces opposing the dominant oppressive power fought to conquer the State through which the power passed to be exercised in order to change the political, economic and social reality in which they lived. This is how social revolutions and national independence in many countries of the world happened. In the past, it was easier to mobilize a social class or an entire people against a clearly identified enemy oppressor. In the contemporary era, with the modern totalitarianism, the oppressive enemy is fragmented and acts openly and also subliminally on people's minds.
1Anarchism Its Aims and PurposesAnarchism versus econ.docxaulasnilda
1
Anarchism: Its Aims and Purposes
Anarchism versus economic monopoly and state power; Forerunners of modern Anarchism; William Godwin and
his work on Political Justice; P.J. Proudhon and his ideas of political and economic decentralisation; Max Stirner's
work, The Ego and Its Own; M. Bakunin the Collectivist and founder of the Anarchist movement; P. Kropotkin the
exponent of Anarchist Communism and the philosophy of Mutual Aid; Anarchism and revolution; Anarchism a
synthesis of Socialism and Liberalism; Anarchism versus economic materialism and Dictatorship; Anarchism and
the state; Anarchism a tendency of history; Freedom and culture.
Anarchism is a definite intellectual current in the life of our times, whose adherents advocate the abolition of
economic monopolies and of all political and social coercive institutions within society. In place of the present
capitalistic economic order Anarchists would have a free association of all productive forces based upon co-
operative labour, which would have as its sole purpose the satisfying of the necessary requirements of every
member of society, and would no longer have in view the special interest of privileged minorities within the social
union. In place of the present state organisation with their lifeless machinery of political and bureaucratic
institutions Anarchists desire a federation of free communities which shall be bound to one another by their
common economic and social interest and shall arrange their affairs by mutual agreement and free contract.
Anyone who studies at all profoundly the economic and social development of the present social system will easily
recognise that these objectives do not spring from the Utopian ideas of a few imaginative innovators, but that they
are the logical outcome of a thorough examination of the present-day social maladjustments, which with every new
phase of the existing social conditions manifest themselves more plainly and more unwholesomely. Modern
onopoly, capitalism and the totalitarian state are merely the last terms in a development which could culminate in
no other results.
The portentous development of our present economic system, leading to a mighty accumulation of social wealth in
the hands of privileged minorities and to a continuous impoverishment of the great masses of the people, prepared
the way for the present political and social reaction. and befriended it in every way. It sacrificed the general interest
of human society to the private interest of individuals, and thus systematically undermined the relationship between
man and man. People forgot that industry is not an end in itself, but should only be a means to ensure to man his
material subsistence and to make accessible to him the blessings of a higher intellectual culture. Where industry is
everything and man is nothing begins the realm of a ruthless economic despotism whose workings are no less
disastrous than those of any political despotism. The two mutually augment o ...
This document summarizes Peter Dahlgren's presentation on the contingencies of political participation via social media. Some key points:
1) Dahlgren argues that political participation through social media is shaped by various contingencies including political economy, technology, and socio-cultural patterns. These factors both enable and constrain online participation.
2) He examines how the commercial logic and data collection practices of major tech companies like Google and Facebook can undermine democracy by collecting personal information without transparency and sluicing users towards certain sites.
3) Socio-cultural currents online often promote individualized consumerism and entertainment over political engagement, which can subvert alternative politics and civic participation. Navigating these
This document summarizes and analyzes recent protest movements in Portugal and Brazil from 2011-2013. It argues that these movements reflect tensions among a growing middle class faced with precarious employment and declining rights and opportunities. Data is presented showing rising inequality in Portugal, and the situation in Brazil is examined in light of recomposing working class conditions. The social composition of protesters is analyzed based on surveys conducted during this period. Key factors seen as fueling the protests include the fragmentation of paid work, rising precarious employment, and ineffective public policies exacerbating social conflict.
This text analyzes recent protest movements in Portugal and Brazil from 2011-2013. It argues that these movements reflect tensions among the middle class where youth and precarious employment play a key role. It presents data on inequality in Portugal to show how the movements protested the suppression of rights and worsening working conditions. The situation in Brazil is examined in light of changing working class conditions and the constraints of Brazil's development model. The text aims to understand the social composition of the protesters based on surveys conducted during this period.
This document provides an overview of libertarian theory according to a graduate student. It defines key libertarian concepts such as individualism, individual rights, spontaneous order, limited government, and free markets. It discusses the historical roots of libertarianism in 18th century liberal economics and figures like Thomas Paine. It also outlines the development of marginalist economics and key libertarian thinkers and organizations that helped spread libertarian ideas, such as the Foundation for Economic Education.
From the Logic of the Particular to the Plea of Minority: A Philosophical App...AJHSSR Journal
ABSTRACT: The problem of minorities1
is one of the constancies that is more and more being highlighted
notably in the battling field of the social, economic, political, cultural and the military. But giving the diverse
angles from which we may want to draw the question of minority2
, or better still, make it elastic, there is a high
risk of ignoring the fact that the latter is above all a philosophical problem. The struggle for the emancipation of
minorities cannot be purely legal or moral; it must be rooted in a broader conception of man and the cosmos.
This is the point of view defended by John Stuart Mill and some English authors. More precisely, he appeals for
an argument which requires a revision of logic in connection with their revision of the cosmology, a revision
which prepares what Wilhelm Windelband will later refer to as “idiological” logic. This article aims at showing
that, faced with complex situations, generalized definition covers within it some frustrations giving that the
world is first and foremost an agglomeration of private lives. But, can we thus value individuals and socialgroups, without at the same time absolving the notion of private life and without a transcendental negation of
values? Furthermore, should one of these arguments in favor of minority base the acceptance of all minorities?
Besides, is it not pertinent we differentiate between objective minority (women, racial, Disabled) that can make
a consensus, and a subjective minority (L.G.B.T.) whose acceptance can be problematic?
KEYWORDS:“Idiological” logic, minority, objective minority, subjective minority, liberalism.
Using individual data on voting and political parties manifestos in European coun- tries, we empirically characterize the drivers of voting for populist parties (the demand side) as well as the presence of populist parties (the supply side). We show that the economic insecurity drivers of the demand of populism are significant, especially when considering the key interactions with turnout incentives, neglected in previous studies. Once turnout effects are taken into account, economic insecurity drives consensus to populist policies directly and through indirect negative effects on trust and attitudes towards immigrants. On the supply side, populist parties are more likely to emerge when countries are faced with a systemic crisis of economic security. The orientation choice of populist parties, i.e., whether they arise on left or right of the political spec- trum, is determined by the availability of political space. The typical mainstream parties response is to reduce the distance of their platform from that of successful populist entrants, amplifying the aggregate supply of populist policies.
This document provides a summary of a research paper about the foreign policy positions of five populist parties in Western Europe, including three right-wing parties (Front National, FPÖ, PVV) and two left-wing parties (Die Linke, SP). It finds that these populist parties share a critique of modernization and globalization processes and a desire to uphold more unitary visions of society. Their foreign policy positions generally oppose the erosion of national sovereignty and embrace nationalist stances, while left-wing parties also support anti-imperialist stances. The document analyzes their positions on transatlantic relations, EU-Russia relations, the Middle East, and global economic issues.
Write a scholarly paper in which you apply the concepts of epide.docxarnoldmeredith47041
This document provides requirements for an epidemiology paper that analyzes a communicable disease. Students must choose a communicable disease, describe it thoroughly including causes, transmission, symptoms, treatment and complications. They must discuss the population most affected by the disease and the determinants of health related to it. Students must also identify the epidemiologic triad of host, agent, and environmental factors for the disease and discuss the role of public health nurses in finding, reporting, collecting, analyzing data, and following up on the disease. The paper requires a minimum of three references and 1250 words in APA format.
Write a S.M.A.R.T. goal to improve the Habit 5 Seek First to .docxarnoldmeredith47041
This document outlines a goal to improve the ability to seek first to understand others rather than be understood according to Habit 5. The author acknowledges they are able to communicate but struggles with listening skills. The goal is to practice actively listening and understanding what people are saying rather than being focused on themselves.
Write a Risk Management Plan for a School FacilityInclude th.docxarnoldmeredith47041
Write a Risk Management Plan for a School Facility
Include the following topics listed below
Write at least one page per topic, double spaced, Times Roman, Font Size 12
Provide References.
Use the APA Format
·
Personnel Management
·
Indemnification Waiver
·
General Supervisory Practices
·
Crowd Management Plan
.
Write a review that 750 - 1000 words in length about one chapter in .docxarnoldmeredith47041
Write a review that 750 - 1000 words in length about one chapter in the Niebuhr textbook. Half will be a summary and half will be the student’s personal reflection. The reflection should include points that the student agrees and disagrees with Niebuhr about and why.
Niebuhr, H. Richard. (2001).
Christ and Culture
. New York: Harper and Row.
.
write a resume using the example belowCONTACT INFOFirs.docxarnoldmeredith47041
write a resume using the example below
CONTACT INFO
First and Last Name
City, State (Optional) | Best Phone Number to Reach You | Appropriate Email Address
SUMMARY OF QUALIFICATIONS
· 3-5 sentences describing why you would be a great fit for the position.
· Describe your relevant accomplishments, strengths, knowledge, experience, skillsets, and languages.
· This is the “preview to the movie.” Highlight your best qualifications so they choose to read the rest of the resume.
· Use bullet points to distinguish each sentence if more aesthetically pleasing.
PROFESSIONAL EXPERIENCE
· List jobs you have held in the past 10 years; only list older jobs if they are directly related to desired job.
· Do NOT list a job if you worked at a place of employment for less than 3 months.
· If you have some jobs that are related to your desired position/field and others that are not, only list the related jobs in this section. Create an “Additional Work History” section at the end of the resume for the non-related jobs.
· Use bullet points to list achievements, results, recognitions, and duties for each job.
Company Name - City, State
Job Title
Start Year - End Year or Present
3-5 achievements, results, recognitions, and duties
INTERNSHIP / EXTERNSHIP / CLINICAL EXPERIENCE
· This section should take priority over others unless you have previous work history in exact field.
Company Name - City, State
Title or Role
Month Year - Month Year
2-3 Main Responsibilities/Duties
CERTIFICATIONS and LICENSURES
Name of Certification/License
Issuing Company or Organization
Certification/License Number
Expiration Month Year
EDUCATION
· Only include schools that you received a degree or relevant certifications from, or are currently attending.
· Do NOT include your high school.
School Name - City, State
Major/Area of Study
Degree Earned
Graduation Year/Estimated Graduation Month Year
CORE COMPETENCIES
· List 6-9 competencies, skills, traits, and/or areas of proficiency that directly relate to the job.
· Utilize the job description to find the types of preferred and/or required skills and traits.
· This is a great area to match keywords from the job description that may not otherwise be easily listed in your resume.
· Use bullet points and columns to make this section more aesthetically pleasing and organized.
RELEVANT COURSEWORK
· List the core courses you have already completed and are currently in.
· Use bullet points to list each course.
VOLUNTEER WORK / AFFILIATIONS
Organization
City, State
example of resume
SHARKLY BRUCE, COTA/L
Amity Island, FL | (975) 206-1120 |
[email protected]
SUMMARY OF QUALIFICATIONS
· Certified Occupational Therapy Assistant with two 8-week rotations of Level II OTA fieldwork, as well as 3 years of previous healthcare experience in a hospital setting.
· Extensive direct care experience assisting patients after treatment of traumatic wounds from local wildlife attacks.
· Proven track record o.
Write a resume and cover letter for the following positionOnline.docxarnoldmeredith47041
Write a resume and cover letter for the following position
Online Marketing Strategist
Riverside, CA 92507
Full-time, Contract
Raincross is seeking a full time marketing rockstar to manage client accounts, devise and implement strategies and craft winning content daily. Candidates must be extremely motivated, possess excellent research and writing skills and pay very close attention to detail.
Requirements
Master the art of creating content: blog articles, updates on social sites, press releases, infographics (or at least the concepts behind them for our design team to create) are all part of the ideal candidates daily tasks
Research and analyze the latest data to uncover gaps; stay up to date on the latest trends and be quick enough to jump on them before they pass
Convert through compelling CTA’s: Create copy for signage, newsletters, email campaigns, online promotions, ads, etc to help brand reach their goals
A/B test: Do you know what works and what doesn’t?
Craft brand strategies: Figure out what they’re doing right, what they’re doing wrong and create strategies to implement. Research to include competitor marketing, trends, etc. Come up with creative new ways to help clients grow and become more successful
Social advertising: Run ads on Facebook, Instagram, Twitter, LinkedIn and any other social platform that allows us to
Responsibilities
Bachelors Degree in Communications, Marketing or similar
Excellent written and verbal communication and customer service skills
Must take initiative, possess creativity, be hands on and a team player
Should be open-minded, a fast learner, enthusiastic, and adaptable
Experience in writing, copy-writing, researching trends, analyzing data, a/b testing, brand strategies and running social ads and campaigns a huge plus
.
Write a response to the peers post based on the readings. Origi.docxarnoldmeredith47041
Write a response to the peer's post based on the readings.
Original Prompt:
Compare Carroll's strategies for creating sound in
Jabberwocky
with those used by Swenson in
A Nosty
Fright.
Pay attention to connotative and denotative meanings of the words and how the poet plays with sound.
Edilzon Ramirez
Response to Prompt:
In both poems there is a common element. And that is a wordplay to make nonsense poetry. The effect of this, is that we must think more in depth to figure out the real meaning behind the works of literature. In Jabberwocky, the writer begins by setting up the mood giving us the background of the events that are about to occur. The use of exclamation marks throughout the poem afterwards, are what in my opinion, give it the sound. For example, “O frabjous day! Callooh! Callay!” suggests sort of a proud/relived cry. Which is furthered backed up by the whimsical words that have a positive connation to them due to the slaying of the jabberwocky, who terrorized the people.
While in “A Nosty Fright” another poem with nonsense words or portmanteau the mood is sad, and it only becomes gloomier. Like Miss Brill, the poet describes things together, in the first stanza “roldengod and the soneyhuckle” and jumps to a lonely chipmunk, suggesting that it has lost its companion. There is hope for it when it meets the grasshopper. Ultimately, it comes to an end “Here we part,” said the hassgropper. “Pere we hart,” mipchunk, too”. All hope is lost for the chipmunk and is waiting for the winter to come. This symbolizes death because during the months of October, November, and December many mammals including the chipmunks hibernate and its almost like it wanted to go to sleep permanently remarking things like “Will it ever be morning, Nofember virst”.
Some say, that the chipmunk is a representation of the author and her sexuality. She like the chipmunk, was alone and the typhoon that was mentioned earlier, was her losing her mind. The words and the sounds they make, further makes this evident because it is gibberish written by someone who is broken.
(Your response to your peer should add or extend the point given by your peer.)
.
Write a response to the following prompt.Analyze the characteriz.docxarnoldmeredith47041
Write a response to the following prompt.
Analyze the characterization Shakespeare employed in
Julius Caesar
, paying particular attention to the role of women. (50 pts) Remember, as you write, to use the language of characterization as we have discussed in class.
.
Write a response to a peers post that adds or extends to the discus.docxarnoldmeredith47041
Write a response to a peer's post that adds or extends to the discussion point of your peer by Friday 07/24/2020.
This week's discussion prompt:
Explain how Faith in "Young Goodman Brown," Georgiana in "The Birthmark," and Elizabeth in "The Black Minister's Veil" are use to reveal some truth about the central male characters in each story. Describe the similarities that you see among these women characters.
Peer's Post:
-Emily Seide
In each of the three short stories, the female characters play a large role in the character development of the three male protagonists (Goodman, Aylmer, and Hooper). Throughout each story, the women leave a lasting impact on their significant other’s mentality of the world and perception of others. In “Young Goodman Brown”, Brown is faced with troubling sights that make him alter his point of view on his town and the townspeople. Brown was introduced to the true form of some nasty people, including his wife, Faith. When he returns home the next morning from a place of sinister evil, his encounter with Faith and his townspeople has made him a hardcore skeptic of anyone and everyone around him. Goodman Brown never trusted a soul after that night because he was forced to believe that evil resides in everyone. In “The Birthmark”, Aylmer goes insane trying to remove his wife, Georgiana’s, birthmark. Even after hearing how beautiful and well liked she is, Georgiana agrees to get her birthmark removed. Rather than seeing this as a perfect part of her, Aylmer sees the birthmark as a flaw that gives her an imperfect complexion. Later in the story, as the birthmark fades and she wakes up, she states that he should’ve admired what he had in the first place, then dies. This made Aylmer realize that he took time for granted, and now he lives a life without Georgiana due to his impatience with her already beautiful complexion. And finally, in “The Minister’s Black Veil”, Reverend Hooper consistently wears a black veil that covers the majority of his face. Several people were afraid and intimidated by it, except for his fiancée, Elizabeth. After further questioning, she begins to fear the veil due to what it symbolizes- the sin in all human beings. Hooper’s plea for Elizabeth to stay reveals the extent of which he is willing to sacrifice, and the decision for him to continue to wear the veil reveals great sorrow; “Do not leave me in this miserable obscurity forever!” (Hawthorne, 36). In each of the short stories, each female character, always a love interest, is first skeptical of the main character’s choice of actions, then later comply. In each short story, a life lesson is learned for each male character.
Readings are attached!
.
Write a response mini-essay of at least 150 to 300 words on the dis.docxarnoldmeredith47041
Write a response mini-essay of at least 150 to 300 words on the discussion topic identified below. Take a position and defend it. (Specify a thesis and support it very briefly with evidence)
The response essay should provide one example from the contemporary world to support your
Position. Ideally you have a source reference for your example. You must have a source reference if you
Refer to any material which is neither common knowledge nor personal experience. essay should be typed using
APA style
feature with a title page and list of references if any are used.
Topic:
Technology changes education
Postman argues that television technology substantively changes aspects of culture such as news, politics, religion, and education in ways that suit the technology, not the human culture that uses the technology. It is a point others have made as well, though it is still contested by many other philosophers and social critics. One excellent example of technological change is on-line course delivery. While there are some who say that the new medium does not provide an education, others (such as your instructor) believe they can accomplish a better education in some subject areas. What have you noticed? What differences are there in on-line education that are due to the way it is technologically mediated? What differences do they make in the education you are receiving? Do you think this is a better or worse education? Why might your instructor think it can be better (and not just because he manages the class while in his pajamas)?
.
Write a response for each document.Instructions Your post sho.docxarnoldmeredith47041
Write a response for each document.
Instructions:
Your post should be a thoughtful response and should include outside reference material from the internet or primary literature. That reference should be referred to specifically with an in-text citation (author, year) and your post should have a bibliography with those outside sources you used cited in APA format.
.
write a resonse paper mla styleHAIRHair deeply affects people,.docxarnoldmeredith47041
write a resonse paper mla style
HAIR
Hair deeply affects people, can transfigure or repulse them. Symbolic of life, hair bolts from our head. Like the earth, it can be harvested, but it will rise again. We can change its color and texture when the mood strikes us, but in time it will return to its original form, just as Nature will in time turn our precisely laid-out cities into a weed-way. Giving one's lover a lock of hair to wear in a small locket [3] around his neck used to be a moving and tender gesture, but also a dangerous one, since to spell-casters, magicians, voodoo-ers, and necromancers of all sorts, a tuft of someone's hair could be used to cast a spell against them. In a variation on this theme, a medieval knight wore a lock of his lady's pubic hair into battle. Since one of the arch-tenets of courtly love was secrecy, choosing this tiny memento instead of a lock of hair from her head may have been more of a practical choice than a philosophical one, but it still symbolized her life-force, which he was carrying with him. Ancient male leaders wore long flowing tresses as a sign of virility (in fact,
"kaiser" and "tsar" both mean "long-haired"
). In the biblical story of Samson, the hero's loss of hair brings on his weakness and downfall, just as it did for the hero Gilgamesh before him. In Europe in more recent times, women who collaborated with the enemy in World War II were humiliated by having their hair cut short. Among some orthodox Jews, a young woman must cut off her hair when she marries, lest her husband find her too attractive and wish to have sex with her out of desire rather than for procreation. Rastafarians regard their dreadlocks as "high-tension cables to heaven." These days, to shock the bourgeoisie and establish their own identity, as every generation must, many young men and women wear their hair as freeform sculpture, with lacquered spikes, close-cropped patterns that resemble a formal garden maze, and colors borrowed from an aviary or spray-painted alley. The first time a student walked into my classroom wearing a "blue jay," it did startle me. Royal-blue slabs of hair were brushed and sprayed straight up along the sides of his head, a long jelly roll of white hair fell forward over his eyebrows, and the back was shiny black, brushed straight up and plastered close to the head. I didn't dislike it, it just seemed like a lot to fuss with each day. I'm sure my grandmother felt that way about my mother's "beehive," and I know my mother feels that way about the curly weather system which is my own mane of long thick hair. One's hairstyle can be the badge of a group, as we've always known -- look at the military's crew cut, or the hairstyles worn by some nuns and monks. In the sixties, wearing long hair, especially if you were a man, often fetched a vitriolic outburst from parents, which is why the musical Hair summed up a generation so beautifully. The police, who seemed so clean-cut and cropped then, were succee.
Write a response about the topic in the reading (see attached) and m.docxarnoldmeredith47041
Write a response about the topic in the reading (see attached) and make sure you include the following:
1. Brief summary of the reading
2. What was intersting?
3. The main points highlighted and what do you think of the reading?
( 2 page response)
.
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Anarchism: Its Aims and Purposes
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Anarchism is a definite intellectual current in the life of our times, whose adherents advocate the abolition of
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Using individual data on voting and political parties manifestos in European coun- tries, we empirically characterize the drivers of voting for populist parties (the demand side) as well as the presence of populist parties (the supply side). We show that the economic insecurity drivers of the demand of populism are significant, especially when considering the key interactions with turnout incentives, neglected in previous studies. Once turnout effects are taken into account, economic insecurity drives consensus to populist policies directly and through indirect negative effects on trust and attitudes towards immigrants. On the supply side, populist parties are more likely to emerge when countries are faced with a systemic crisis of economic security. The orientation choice of populist parties, i.e., whether they arise on left or right of the political spec- trum, is determined by the availability of political space. The typical mainstream parties response is to reduce the distance of their platform from that of successful populist entrants, amplifying the aggregate supply of populist policies.
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Write a Risk Management Plan for a School FacilityInclude th.docxarnoldmeredith47041
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Write at least one page per topic, double spaced, Times Roman, Font Size 12
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Use the APA Format
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Personnel Management
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Indemnification Waiver
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General Supervisory Practices
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Crowd Management Plan
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Christ and Culture
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write a resume using the example belowCONTACT INFOFirs.docxarnoldmeredith47041
write a resume using the example below
CONTACT INFO
First and Last Name
City, State (Optional) | Best Phone Number to Reach You | Appropriate Email Address
SUMMARY OF QUALIFICATIONS
· 3-5 sentences describing why you would be a great fit for the position.
· Describe your relevant accomplishments, strengths, knowledge, experience, skillsets, and languages.
· This is the “preview to the movie.” Highlight your best qualifications so they choose to read the rest of the resume.
· Use bullet points to distinguish each sentence if more aesthetically pleasing.
PROFESSIONAL EXPERIENCE
· List jobs you have held in the past 10 years; only list older jobs if they are directly related to desired job.
· Do NOT list a job if you worked at a place of employment for less than 3 months.
· If you have some jobs that are related to your desired position/field and others that are not, only list the related jobs in this section. Create an “Additional Work History” section at the end of the resume for the non-related jobs.
· Use bullet points to list achievements, results, recognitions, and duties for each job.
Company Name - City, State
Job Title
Start Year - End Year or Present
3-5 achievements, results, recognitions, and duties
INTERNSHIP / EXTERNSHIP / CLINICAL EXPERIENCE
· This section should take priority over others unless you have previous work history in exact field.
Company Name - City, State
Title or Role
Month Year - Month Year
2-3 Main Responsibilities/Duties
CERTIFICATIONS and LICENSURES
Name of Certification/License
Issuing Company or Organization
Certification/License Number
Expiration Month Year
EDUCATION
· Only include schools that you received a degree or relevant certifications from, or are currently attending.
· Do NOT include your high school.
School Name - City, State
Major/Area of Study
Degree Earned
Graduation Year/Estimated Graduation Month Year
CORE COMPETENCIES
· List 6-9 competencies, skills, traits, and/or areas of proficiency that directly relate to the job.
· Utilize the job description to find the types of preferred and/or required skills and traits.
· This is a great area to match keywords from the job description that may not otherwise be easily listed in your resume.
· Use bullet points and columns to make this section more aesthetically pleasing and organized.
RELEVANT COURSEWORK
· List the core courses you have already completed and are currently in.
· Use bullet points to list each course.
VOLUNTEER WORK / AFFILIATIONS
Organization
City, State
example of resume
SHARKLY BRUCE, COTA/L
Amity Island, FL | (975) 206-1120 |
[email protected]
SUMMARY OF QUALIFICATIONS
· Certified Occupational Therapy Assistant with two 8-week rotations of Level II OTA fieldwork, as well as 3 years of previous healthcare experience in a hospital setting.
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Write a resume and cover letter for the following position
Online Marketing Strategist
Riverside, CA 92507
Full-time, Contract
Raincross is seeking a full time marketing rockstar to manage client accounts, devise and implement strategies and craft winning content daily. Candidates must be extremely motivated, possess excellent research and writing skills and pay very close attention to detail.
Requirements
Master the art of creating content: blog articles, updates on social sites, press releases, infographics (or at least the concepts behind them for our design team to create) are all part of the ideal candidates daily tasks
Research and analyze the latest data to uncover gaps; stay up to date on the latest trends and be quick enough to jump on them before they pass
Convert through compelling CTA’s: Create copy for signage, newsletters, email campaigns, online promotions, ads, etc to help brand reach their goals
A/B test: Do you know what works and what doesn’t?
Craft brand strategies: Figure out what they’re doing right, what they’re doing wrong and create strategies to implement. Research to include competitor marketing, trends, etc. Come up with creative new ways to help clients grow and become more successful
Social advertising: Run ads on Facebook, Instagram, Twitter, LinkedIn and any other social platform that allows us to
Responsibilities
Bachelors Degree in Communications, Marketing or similar
Excellent written and verbal communication and customer service skills
Must take initiative, possess creativity, be hands on and a team player
Should be open-minded, a fast learner, enthusiastic, and adaptable
Experience in writing, copy-writing, researching trends, analyzing data, a/b testing, brand strategies and running social ads and campaigns a huge plus
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Write a response to the peers post based on the readings. Origi.docxarnoldmeredith47041
Write a response to the peer's post based on the readings.
Original Prompt:
Compare Carroll's strategies for creating sound in
Jabberwocky
with those used by Swenson in
A Nosty
Fright.
Pay attention to connotative and denotative meanings of the words and how the poet plays with sound.
Edilzon Ramirez
Response to Prompt:
In both poems there is a common element. And that is a wordplay to make nonsense poetry. The effect of this, is that we must think more in depth to figure out the real meaning behind the works of literature. In Jabberwocky, the writer begins by setting up the mood giving us the background of the events that are about to occur. The use of exclamation marks throughout the poem afterwards, are what in my opinion, give it the sound. For example, “O frabjous day! Callooh! Callay!” suggests sort of a proud/relived cry. Which is furthered backed up by the whimsical words that have a positive connation to them due to the slaying of the jabberwocky, who terrorized the people.
While in “A Nosty Fright” another poem with nonsense words or portmanteau the mood is sad, and it only becomes gloomier. Like Miss Brill, the poet describes things together, in the first stanza “roldengod and the soneyhuckle” and jumps to a lonely chipmunk, suggesting that it has lost its companion. There is hope for it when it meets the grasshopper. Ultimately, it comes to an end “Here we part,” said the hassgropper. “Pere we hart,” mipchunk, too”. All hope is lost for the chipmunk and is waiting for the winter to come. This symbolizes death because during the months of October, November, and December many mammals including the chipmunks hibernate and its almost like it wanted to go to sleep permanently remarking things like “Will it ever be morning, Nofember virst”.
Some say, that the chipmunk is a representation of the author and her sexuality. She like the chipmunk, was alone and the typhoon that was mentioned earlier, was her losing her mind. The words and the sounds they make, further makes this evident because it is gibberish written by someone who is broken.
(Your response to your peer should add or extend the point given by your peer.)
.
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Write a response to the following prompt.
Analyze the characterization Shakespeare employed in
Julius Caesar
, paying particular attention to the role of women. (50 pts) Remember, as you write, to use the language of characterization as we have discussed in class.
.
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Write a response to a peer's post that adds or extends to the discussion point of your peer by Friday 07/24/2020.
This week's discussion prompt:
Explain how Faith in "Young Goodman Brown," Georgiana in "The Birthmark," and Elizabeth in "The Black Minister's Veil" are use to reveal some truth about the central male characters in each story. Describe the similarities that you see among these women characters.
Peer's Post:
-Emily Seide
In each of the three short stories, the female characters play a large role in the character development of the three male protagonists (Goodman, Aylmer, and Hooper). Throughout each story, the women leave a lasting impact on their significant other’s mentality of the world and perception of others. In “Young Goodman Brown”, Brown is faced with troubling sights that make him alter his point of view on his town and the townspeople. Brown was introduced to the true form of some nasty people, including his wife, Faith. When he returns home the next morning from a place of sinister evil, his encounter with Faith and his townspeople has made him a hardcore skeptic of anyone and everyone around him. Goodman Brown never trusted a soul after that night because he was forced to believe that evil resides in everyone. In “The Birthmark”, Aylmer goes insane trying to remove his wife, Georgiana’s, birthmark. Even after hearing how beautiful and well liked she is, Georgiana agrees to get her birthmark removed. Rather than seeing this as a perfect part of her, Aylmer sees the birthmark as a flaw that gives her an imperfect complexion. Later in the story, as the birthmark fades and she wakes up, she states that he should’ve admired what he had in the first place, then dies. This made Aylmer realize that he took time for granted, and now he lives a life without Georgiana due to his impatience with her already beautiful complexion. And finally, in “The Minister’s Black Veil”, Reverend Hooper consistently wears a black veil that covers the majority of his face. Several people were afraid and intimidated by it, except for his fiancée, Elizabeth. After further questioning, she begins to fear the veil due to what it symbolizes- the sin in all human beings. Hooper’s plea for Elizabeth to stay reveals the extent of which he is willing to sacrifice, and the decision for him to continue to wear the veil reveals great sorrow; “Do not leave me in this miserable obscurity forever!” (Hawthorne, 36). In each of the short stories, each female character, always a love interest, is first skeptical of the main character’s choice of actions, then later comply. In each short story, a life lesson is learned for each male character.
Readings are attached!
.
Write a response mini-essay of at least 150 to 300 words on the dis.docxarnoldmeredith47041
Write a response mini-essay of at least 150 to 300 words on the discussion topic identified below. Take a position and defend it. (Specify a thesis and support it very briefly with evidence)
The response essay should provide one example from the contemporary world to support your
Position. Ideally you have a source reference for your example. You must have a source reference if you
Refer to any material which is neither common knowledge nor personal experience. essay should be typed using
APA style
feature with a title page and list of references if any are used.
Topic:
Technology changes education
Postman argues that television technology substantively changes aspects of culture such as news, politics, religion, and education in ways that suit the technology, not the human culture that uses the technology. It is a point others have made as well, though it is still contested by many other philosophers and social critics. One excellent example of technological change is on-line course delivery. While there are some who say that the new medium does not provide an education, others (such as your instructor) believe they can accomplish a better education in some subject areas. What have you noticed? What differences are there in on-line education that are due to the way it is technologically mediated? What differences do they make in the education you are receiving? Do you think this is a better or worse education? Why might your instructor think it can be better (and not just because he manages the class while in his pajamas)?
.
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Write a response for each document.
Instructions:
Your post should be a thoughtful response and should include outside reference material from the internet or primary literature. That reference should be referred to specifically with an in-text citation (author, year) and your post should have a bibliography with those outside sources you used cited in APA format.
.
write a resonse paper mla styleHAIRHair deeply affects people,.docxarnoldmeredith47041
write a resonse paper mla style
HAIR
Hair deeply affects people, can transfigure or repulse them. Symbolic of life, hair bolts from our head. Like the earth, it can be harvested, but it will rise again. We can change its color and texture when the mood strikes us, but in time it will return to its original form, just as Nature will in time turn our precisely laid-out cities into a weed-way. Giving one's lover a lock of hair to wear in a small locket [3] around his neck used to be a moving and tender gesture, but also a dangerous one, since to spell-casters, magicians, voodoo-ers, and necromancers of all sorts, a tuft of someone's hair could be used to cast a spell against them. In a variation on this theme, a medieval knight wore a lock of his lady's pubic hair into battle. Since one of the arch-tenets of courtly love was secrecy, choosing this tiny memento instead of a lock of hair from her head may have been more of a practical choice than a philosophical one, but it still symbolized her life-force, which he was carrying with him. Ancient male leaders wore long flowing tresses as a sign of virility (in fact,
"kaiser" and "tsar" both mean "long-haired"
). In the biblical story of Samson, the hero's loss of hair brings on his weakness and downfall, just as it did for the hero Gilgamesh before him. In Europe in more recent times, women who collaborated with the enemy in World War II were humiliated by having their hair cut short. Among some orthodox Jews, a young woman must cut off her hair when she marries, lest her husband find her too attractive and wish to have sex with her out of desire rather than for procreation. Rastafarians regard their dreadlocks as "high-tension cables to heaven." These days, to shock the bourgeoisie and establish their own identity, as every generation must, many young men and women wear their hair as freeform sculpture, with lacquered spikes, close-cropped patterns that resemble a formal garden maze, and colors borrowed from an aviary or spray-painted alley. The first time a student walked into my classroom wearing a "blue jay," it did startle me. Royal-blue slabs of hair were brushed and sprayed straight up along the sides of his head, a long jelly roll of white hair fell forward over his eyebrows, and the back was shiny black, brushed straight up and plastered close to the head. I didn't dislike it, it just seemed like a lot to fuss with each day. I'm sure my grandmother felt that way about my mother's "beehive," and I know my mother feels that way about the curly weather system which is my own mane of long thick hair. One's hairstyle can be the badge of a group, as we've always known -- look at the military's crew cut, or the hairstyles worn by some nuns and monks. In the sixties, wearing long hair, especially if you were a man, often fetched a vitriolic outburst from parents, which is why the musical Hair summed up a generation so beautifully. The police, who seemed so clean-cut and cropped then, were succee.
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Write a response about the topic in the reading (see attached) and make sure you include the following:
1. Brief summary of the reading
2. What was intersting?
3. The main points highlighted and what do you think of the reading?
( 2 page response)
.
Write a research report based on a hypothetical research study. Con.docxarnoldmeredith47041
Write a research report based on a hypothetical research study. Conducting research and writing a report is common practice for many students and practitioners in any of the behavioral sciences fields.
A research report, which is based on scientific method, is typically composed of the different sections listed below:
Introduction:
The introduction states a specific hypothesis and how that hypothesis was derived by connecting it to previous research.
Methods:
The methods section describes the details of how the hypothesis was tested and clarifies why the study was conducted in that particular way.
Results:
The results section is where the raw uninterpreted data is presented.
Discussion:
The discussion section is where an argument is presented on whether or not the data supports the hypothesis, the possible implications and limitations of the study, as well as possible future directions for this type of research.
Together, these sections should tell the reader what was done, how it was done, and what was learned through the research. You will create a research report based on a
hypothetical
problem, sample, results, and literature review. Organize your data by creating meaningful sections within your report. Make sure that you:
Apply key concepts of inferential hypothesis tests.
Interpret the research findings of the study.
Examine the assumptions and limitations of inferential tests.
Develop a practical application of the research principles covered in this course.
Focus of the Research Report
To begin, create a hypothetical research study (you do not have to carry out the study; you will just have to describe it) that is based on the three pieces of information listed below. Once you have your hypothetical study created, write a three- to four-page research report (excluding title and reference pages) that outlines the study. You are encouraged to be creative with your research study, but be sure to follow the format outlined below and adhere to APA formatting as outlined in the Ashford Writing Center.
Your hypothetical research study should be based on the following information:
Recent research has indicated that eating chocolate can improve memory. Jones and Wilson (2011) found that eating chocolate two hours before taking math tests improved scores significantly. Wong, Hideki, Anderson, and Skaarsgard (2009) found that women are better than men on memory tests after eating chocolate.
There were 50 men and 50 women who were randomly selected from a larger population.
A
t
-test was conducted to compare men and women’s performance on an assessment after eating chocolate. The results showed an independent
t
-test value of
t
.05(99) = 3.43;
p
< .05
Your research study must contain the following:
Title Page
Title of your report
Your name
The course
Instructor
Date
Introduction
Introduce the research topic, explain why it is important, and present the purpose of the paper and the resea.
Write a Research Paper with the topic Pregnancy in the adolesce.docxarnoldmeredith47041
Write a Research Paper with the topic: Pregnancy in the adolescent life.
The conditions are:
APA format
Double space
One inch margin on all sides
All paragraph in the body are indented
The title is centered on the page with your name and school institution
Paragraph 2, 3, and 4 need another inch more
All pages should be numbered and with citation
Apart of the Research paper write the topic sentence (a question or a statement) & the THESIS of the Research Paper. Write 3 citations for your Research Paper.
.
Write a Research Paper with the topic Autism a major problem. T.docxarnoldmeredith47041
Write a Research Paper with the topic: Autism a major problem.
The conditions are:
APA format
Double space
One inch margin on all sides
All paragraph in the body are indented
The title is centered on the page with your name and school institution
Paragraph 2, 3, and 4 need another inch more
All pages should be numbered and with citation
Apart of the Research paper write the topic sentence (a question or a statement) & the THESIS of the Research Paper.
Write 3 citations for your Research Paper.
.
Write a research paper that explains how Information Technology (IT).docxarnoldmeredith47041
Write a research paper that explains how Information Technology (IT) promotes getting people who are affected by policies involved in the policy-making process. Cite specific examples.
1000- 1200 words APA format and
Create a powerpoint presentation using 5 slides on the main points covered in your research paper. You may use a title slide and a reference slide.
Please find the attached text book.
.
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Write a research paper outlining possible career paths in the field of Human Resources Management (HRM) and based upon independent research discuss how different organizations might develop and implement a strategic HRM plan.
Research Paper Instructions:
IMPORTANT!!
Submit your work as an MS WORD ATTACHMENT in either a .doc, .docx, or .rtf format.
Please support your ideas, arguments, and opinions with independent research, include at least three (3) supporting references or sources (NOT Wikipedia, unknown, or anonymous sources), format your work in proper APA format, include a cover page, an abstract, an introduction and a labeled conclusion in accordance with the course rubric, a minimum of 3 FULL pages of written content, and a reference section. Double space all work and cite all listed references properly in text in accordance with the 6th edition of the APA manual, chapters 6 & 7.
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Write a Research paper on the Legal issues associated with pentestin.docxarnoldmeredith47041
Write a Research paper on the Legal issues associated with pentesting.
Paper Specifics
3000 words (not counting citations)
APA format
Max team size of two
Minimum 5 academic sources
Provides clear summary and introduction to project scope; includes coherent discussion of key concepts, principles, and problem statement; develops clear context between project tasks and performing security testing in a virtual environment
Provides a thorough and concise summary of the project by listing the purpose and results of each test conducted; or research summary; clearly links the results with recommendations/research, which are supported by test data and external references
.
Write a research paper on one of the following topics .docxarnoldmeredith47041
Write a research paper on
one
of the following topics:
1. What are the effects of corruption on capitalism and foreign investment? (Unit II)
Be sure to include at least the following points in your paper:
What are the types of corruption?
What are effects of corruption on MNCs?
How can MNCs deal effectively with these problems?
2. How can MNCs effectively negotiate with local employees, local suppliers, and local governments in the Middle East? (Unit IV)
Be sure to include at least the following points in your paper:
What are some examples of negotiation cases in the Middle East?
How do MNCs use negotiation to solve problems?
What roles do different cultures have in negotiation?
3. Discuss the problems MNCs face when assigning expatriates to an Eastern European country and how they should support the expatriates. (Unit VII)
Be sure to include at least the following points in your paper:
What are problems for international assignments in Eastern Europe?
What are solutions for the problems?
What are strategies MNCs can implement to support their expatriates?
Directions:
The paper should be at least 750 words in length.
You are required to use a minimum of three scholarly sources for the paper.
All sources used must be referenced; paraphrased and quoted material must have accompanying APA citations.
.
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.pptHenry Hollis
The History of NZ 1870-1900.
Making of a Nation.
From the NZ Wars to Liberals,
Richard Seddon, George Grey,
Social Laboratory, New Zealand,
Confiscations, Kotahitanga, Kingitanga, Parliament, Suffrage, Repudiation, Economic Change, Agriculture, Gold Mining, Timber, Flax, Sheep, Dairying,
A Free 200-Page eBook ~ Brain and Mind Exercise.pptxOH TEIK BIN
(A Free eBook comprising 3 Sets of Presentation of a selection of Puzzles, Brain Teasers and Thinking Problems to exercise both the mind and the Right and Left Brain. To help keep the mind and brain fit and healthy. Good for both the young and old alike.
Answers are given for all the puzzles and problems.)
With Metta,
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The Uses of NeoliberalismJames FergusonDepartment of Ant.docx
1. The Uses of Neoliberalism
James Ferguson
Department of Anthropology, Stanford University;
[email protected]
Abstract: The term “neoliberalism” has come to be used in a
wide variety of partly overlapping
and partly contradictory ways. This essay seeks to clarify some
of the analytical and political
work that the term does in its different usages. It then goes on
to suggest that making an analytical
distinction between neoliberal “arts of government” and the
class-based ideological “project”
of neoliberalism can allow us to identify some surprising (and
perhaps hopeful) new forms of
politics that illustrate how fundamentally polyvalent neoliberal
mechanisms of government can
be. A range of empirical examples are discussed, mostly coming
from my recent work on social
policy and anti-poverty politics in southern Africa.
Keywords: neoliberalism, governmentality, South Africa, basic
income, poverty
In thinking about the rapidly expanding literature on
neoliberalism, I
am struck by how much of the critical scholarship on topic
arrives
in the end at the very same conclusion—a conclusion that might
be
expressed in its simplest form as: “neoliberalism is bad for poor
2. and
working people, therefore we must oppose it.” It is not that I
disagree
with this conclusion. On the contrary. But I sometimes wonder
why I
should bother to read one after another extended scholarly
analysis only
to reach, again and again, such an unsurprising conclusion.
This problem in recent progressive scholarship strikes me as
related
to a parallel problem in progressive politics more broadly. For
over
the last couple of decades, what we call “the Left” has come to
be
organized, in large part, around a project of resisting and
refusing
harmful new developments in the world. This is understandable,
since
so many new developments have indeed been highly
objectionable. But
it has left us with a politics largely defined by negation and
disdain,
and centered on what I will call “the antis.” Anti-globalization,
anti-
neoliberalism, anti-privatization, anti-imperialism, anti-Bush,
perhaps
even anti-capitalism—but always “anti”, not “pro”. This is good
enough,
perhaps, if one’s political goal is simply to denounce “the
system” and to
decry its current tendencies. And, indeed, some seem satisfied
with such
a politics. In my own disciplines of anthropology and African
Studies,
for instance, studies of state and development tend, with
4. treat government as the simple expression of power or
domination—
the implication apparently being that it is politically
objectionable that
people should be governed at all. But any realistic sort of
progressive
politics that would seek a serious answer to the question “what
do
we want?” will have to involve an exploration of the
contemporary
possibilities for developing genuinely progressive arts of
government.
In his 1979 lectures on neoliberalism (2008), Michel Foucault
famously spoke of the “absence of a socialist art of
government”, and the
historic failure of the left to develop an “autonomous
governmentality”
comparable to liberalism. Stated as starkly as this, the point is
no doubt
debatable. Various forms of democratic socialism and social
democracy
(including but not limited to the German case treated in the
lectures) may
perhaps leave us with a richer trove of governmental arts than
Foucault’s
very schematic account acknowledged, and the diverse histories
of
“unhappy symbiosis” of socialism with liberalism that he
referred to
parenthetically (2008:94n) may well have a greater originality
than
his analysis allowed. But what seems less open to dispute is that
any
program for governing from the left today faces an obstacle that
we
6. 168 Antipode
much of the rest of the world, as Mike Davis (2007) has
recently pointed
out in his usual alarmist style. The twentieth-century social
democracies,
on the other hand (and still more so the state socialist regimes),
were
built on the putatively universal figure of “the worker”. The
Keynesian
welfare state, as we know, was founded on a pact between
capital and
organized labor, and the domain we have come to know as “the
social”
was constructed on the foundation of the able-bodied worker.
Indeed, the
list of those requiring “social” intervention (the elderly, the
infirm, the
child, the disabled, the dependent reproductive woman) sketches
a kind
of photographic negative of the figure of the wage-earning man.
Today,
however, the question of social assistance is transformed in
societies
where young, able-bodied men look in vain for work, and are as
much
in need of assistance as everyone else. A compact between
capital
and labor, meanwhile, even were it politically possible, risks
leaving
out most of the population. New approaches to distribution, and
new
approaches to the question of social assistance, will need to be
7. based
on a fundamental rethinking that gives a new prominence to
those hard-
to-categorize urban improvisers who have for so long been
relegated to
the margins both of society, and of social analysis.
The second challenge to progressive thought and politics that I
would
like to identify is the rise of what we might call transnational
forms of
government, and particularly of the philanthropic funding of
what we
used to call “the social”. Much has been written about the
governmental
role played by international organizations like the IMF and the
World Bank. But the last couple of decades have also seen an
explosion
in de facto government carried out by an extraordinary swarm of
NGOs,
voluntary organizations, and private foundations. The Gates
Foundation
in Mozambique, to take just one example,1 is carrying out a
wide range
of projects (in health, hygiene, education, sanitation, etc) that
looks
something like the twentieth century “social” of the social
welfare state.
But there is obviously a very different relation to the nation-
state here,
and to the national political arena. Social policy and nation-
state are, to
a very significant degree, decoupled, and we are only beginning
to find
ways to think about this.
9. would count as progressive politics here?
One response here—understandable in the wake of the
neoliberal
restructuring of recent decades—is to call for the reinstating of
old-style
developmental states, effectively undoing the neoliberal
transformations
of the 1980s and 1990s and going back to the 1970s. I am
skeptical
that this is an adequate response—partly because the supposedly
developmental states I know from the 1970s in Africa were
pretty
awful, and partly because I doubt that you can run history
backward
(as if you could just hit the rewind button and try again). The
world
has changed, and simply re-asserting Third World sovereignty
will
not get us very far in dealing with a fundamentally reconfigured
politico-spatial world order. Imperialism is undoubtedly alive
and
well. But I don’t think we have a good analysis of, say, the
Gates
Foundation, or the Soros Foundation, if we see them simply as
the
imperial tools of the global rich, undermining the sovereignty of
African
governments. It is much more complicated than that—and
perhaps
also more hopeful. Can we find ways of thinking creatively
about the
progressive possibilities (and not only the reactionary dangers)
of this
new terrain of transnational organization of funds, energies, and
affect?
10. Can we imagine new “arts of government” that might take
advantage of
(rather than simply denouncing or resisting) recent
transformations in
the spatial organization of government and social assistance?
Most broadly, can we engage with these new configurations of
governmental power in a way that goes beyond the politics of
denunciation, the politics of the “anti”? Can we develop new
ways
of thinking through the problem of government that are
genuinely
progressive, but that don’t take for granted the absolute solidity
or
centrality of those two figures of twentieth-century left common
sense:
the worker and the nation-state?
It is here that we have to look more carefully at the “arts of
government” that have so radically reconfigured the world in
the last few
decades, and I think we have to come up with something more
interesting
to say about them than just that we’re against them. With
respect to
poverty and social policy, for instance (my particular interest
here), it is
simply not the case (as is often suggested) that neoliberal
government
ignores poverty, or leaves it to “the market”. (Later in this
essay, I
will discuss a range of welfare-like interventions and social
payments
that coexist with—and may, in fact, be necessary complements
to—
neoliberal economic models.) At the same time, there is
12. “uses” in
the literal sense of semantic usage, as the wide variation in the
way
the term is used forces some clarification before we can begin
to ask
some new questions that might bring to light the surprising
affinity of
some aspects of what we call “neoliberalism” with certain forms
of
progressive politics.
As even a cursory inspection reveals, there is huge variation in
the
way the word, “neoliberalism” is used in contemporary
scholarship. In
perhaps the strictest sense, neoliberalism refers to a
macroeconomic
doctrine (and is, in this sense, a true “-ism”). The key elements
of
the doctrine are variously described, but always include a
valorization
of private enterprise and suspicion of the state, along with what
is
sometimes called “free-market fetishism” and the advocacy of
tariff
elimination, currency deregulation, and the deployment of
“enterprise
models” that would allow the state itself to be “run like a
business”.
(See Peck 2008 for an illuminating review of the rise and
dissemination
of this doctrine.)
A related usage would have “neoliberalism” refer to a regime of
policies and practices associated with or claiming fealty to the
doctrine
14. the contingencies of democratic politics. This no doubt helps to
account for the otherwise paradoxical fact that a number of
regimes
pursuing undoubtedly neoliberal macroeconomic policies have
also
seen substantial recent rises in social spending (examples
include India,
Brazil, and South Africa, among others). Neoliberal policy is
thus much
more complicated than a reading of neoliberal doctrine might
suggest.
Finally, it is perhaps worth mentioning, if only schematically,
some
other common uses of the term. One is as a sloppy synonym for
capitalism itself, or as a kind of shorthand for the world
economy and
its inequalities. In much current anthropological usage,
“neoliberalism”
appears in this way, as a kind of abstract causal force that
comes
in from outside (much as “the world system” was reckoned to
do at an earlier theoretical moment) to decimate local
livelihoods.
Another, more interesting, usage sees “neoliberalism” as the
name
of a broad, global cultural formation characteristic of a new era
of
“millennial capitalism”—a kind of global meta-culture,
characteristic
of our newly de-regulated, insecure, and speculative times (eg
Comaroff
and Comaroff 2000). And finally, “neoliberalism” can be
indexed to a
sort of “rationality” in the Foucauldian sense, linked less to
economic
15. dogmas or class projects than to specific mechanisms of
government,
and recognizable modes of creating subjects. (I will have more
to say
about this last usage shortly.)
It is, then, possible to identify many quite distinct referents for
the
same widely used term. This has some obvious dangers, of
course. There
is plainly a danger of simple confusion, since the meaning of
the term
can slip in the course of an argument being passed from author
to reader
(or, indeed, even in the course of an argument made by a single
author).
There is also another danger, only slightly less obvious, which
is that
such an all-encompassing entity can easily come to appear as a
kind
of gigantic, all-powerful first cause (as categories like
“Modernity” or
“Capitalism” have done before it)—that malevolent force that
causes
everything else to happen. This yields empty analysis (since to
say
that all our problems are caused by “neoliberalism” is really not
to say
much), and may also lead to an ineffectual politics—since all
one can do
with such a gigantic, malevolent “thing” as “neoliberalism”
conceived
in this way is to denounce it. (And that, the evidence suggests,
doesn’t
seem to do much good).
17. confusing
the different meanings, the word can be an occasion for
reflecting on how
the rather different things to which it refers may be related. In
particular,
I would like to use this confusing, conflating word as an
occasion for
thinking about the relation between the following two things:
First, we may consider the new governmental rationalities that
emerged through the Thatcher–Reagan assaults on the North
Atlantic,
post-war welfare state. Key here was the deployment of market
mechanisms and “enterprise” models to reform government,
restructure
the state, and pioneer new modes of government and
subjectification.
(See, eg, Barry, Osborne and Rose 1996; Rose 1999; Cruikshank
1999;
Miller and Rose 2008.) There is a clear analysis in this
literature of
what it is that distinguishes “neoliberalism” from liberalism.
Liberalism,
in this account, was always about finding the right balance
between
two spheres understood as properly distinct, if always related:
state
and market, public and private, the realm of the king and the
proper
domain of the merchant. Neoliberalism, in contrast, puts
governmental
mechanisms developed in the private sphere to work within the
state
itself, so that even core functions of the state are either
subcontracted
out to private providers, or run (as the saying has it) “like a
18. business”.
The question of what should be public and what private
becomes blurred,
as the state itself increasingly organizes itself around “profit
centers”,
“enterprise models”, and so on. Rather than shifting the line
between
state and market, then, neoliberalism in this account involved
the
deployment of new, market-based techniques of government
within the
terrain of the state itself. At the same time, new constructions
of “active”
and “responsible” citizens and communities are deployed to
produce
governmental results that do not depend on direct state
intervention.
The “responsibilized” citizen comes to operate as a miniature
firm,
responding to incentives, rationally assessing risks, and
prudently
choosing from among different courses of action.
Against this understanding of the neoliberal, consider what we
might call neoliberalism in the African sense. Here,
neoliberalism has
meant first of all the policy measures that were forced on
African
states in the 1980s by banks and international lending agencies,
under
the name of “structural adjustment”. Reforms focused on
removing
tariffs, deregulating currency markets, and removing the state
from
production and distribution (via dismantling of state marketing
boards
20. government
versus a crude battering open of Third World markets).
But bringing these two different referents together can be more
interesting, if we don’t just equate them, but instead reflect on
the conceptual themes they share (broadly, a technical reliance
on
market mechanisms coupled with an ideological valorization of
“private
enterprise” and a suspicion of the state), and use such a
reflection
to ask if the new “arts of government” developed within First
World
neoliberalism might take on new life in other contexts, in the
process
opening up new political possibilities.
Can we on the left do what the right has, in recent decades,
done
so successfully, that is, to develop new modes and mechanisms
of
government? And (perhaps more provocatively) are the
neoliberal “arts
of government” that have transformed the way that states work
in so
many places around the world inherently and necessarily
conservative,
or can they be put to different uses? To ask such questions
requires us
to be willing at least to imagine the possibility of a truly
progressive
politics that would also draw on governmental mechanisms that
we have
become used to terming “neoliberal”.
I have been led to these questions by my current interest in anti-
22. problems
in the way you see best”. In contrast to older forms of “welfare”
assistance, the claim is that such grants rely on poor people’s
own
ability to solve their own problems, without imposing the
policing,
paternalism, and surveillance of the traditional welfare state.
More
broadly, similar new lines of thought are calling for an
increased role
for direct cash transfers in many forms of social and
humanitarian
policy (eg famine relief, which will be briefly discussed
shortly).
The reasoning here often includes recognizably neoliberal
elements,
including the valorization of market efficiency, individual
choice, and
autonomy; themes of entrepreneurship; and skepticism about the
state
as a service provider. But the politics are avowedly (and, I
think, on
balance, genuinely) “pro-poor” (as the phrase has it). “Pro-
poor” and
neoliberal—it is the strangeness of this conjunction that is of
interest
here. For the sorts of new progressive initiatives I have in mind
seem
to involve not just opposing “the neoliberal project”, but
appropriating
key elements of neoliberal reasoning for different ends. We
can’t think
about this (or even acknowledge its possibility) if we continue
to treat
“neoliberal” simply as a synonym for “evil”. Instead, I suggest
(and
23. this is a deliberate provocation) that some innovative (and
possible
effective) forms of new politics in these times may be showing
us how
fundamentally polyvalent the neoliberal arts of government can
be.
Let me emphasize that to say that certain political initiatives
and
programs borrow from the neoliberal bag of tricks doesn’t mean
that
these political projects are in league with the ideological project
of
neoliberalism (in David Harvey’s sense)—only that they
appropriate
certain characteristic neoliberal “moves” (and I think of these
discursive
and programmatic moves as analogous to the moves one might
make
in a game). These moves are recognizable enough to look
“neoliberal”,
but they can, I suggest, be used for quite different purposes than
that
term usually implies. In this connection, one might think of
statistical
techniques for calculating the probabilities of workplace
injuries. These
were originally developed in the nineteenth century by large
employers
to control costs (Ewald 1986), but they eventually became the
technical
basis for social insurance, and ultimately for the welfare state
(which
brought unprecedented gains to the working class across much
of the
world). Techniques, that is to say, can “migrate” across
25. widening
inequality and very high rates of unemployment, these social
grants
have substantially expanded, and have been instrumental in
holding
together what might otherwise be an explosive situation (a fact
of which
the ANC government appears to be acutely aware). But planners
have
been bothered by the patchy and arbitrary spread of the
coverage, and
the inefficiency and cost of administering a host of cumbersome
and
bureaucratic targeted programs.
It is in this context that proposals emerged for a far-reaching
new
comprehensive system of income support, anchored by a BIG to
be
paid to all South Africans (Department of Social Development
2002).
The idea of a BIG was first put forward by the labor union
federation,
COSATU, in 1998, and it acquired new legitimacy when it was
embraced
in 2002 by a government-appointed committee (the Taylor
Committee)
charged with recommending measures for the rationalization of
the
system of social assistance (see Barchiesi 2007; Department of
Social
Development 2002; Ferguson 2007; Tilton 2005). The proposal
has been
advocated from 2001 onward by a formal coalition of church
groups and
labor, the BIG Coalition).2
27. 176 Antipode
ANC, however, has thus far rejected the plan, though it does
enjoy
support from at least some key players within the party
(including the
Minster for Social Development, Dr Zola Skweyiya).
The BIG campaign is significant not only as an interesting and
potentially progressive policy proposal, but also as an
illustration of
some new ways of thinking about questions of poverty and
welfare that
bring neoliberal themes to bear on the question of social
assistance in
ways that are very different from those we have become
accustomed to
in the last few decades. I begin by acknowledging that the
arguments for
a basic income grant in South Africa have been many sided and
complex,
and they are not reducible to a single logic or rationality
(neoliberal or
otherwise). Older languages of social democracy and solidarity
continue
to have significant currency, and a reading of pro-BIG
documents shows
that traditional welfare-state arguments are regularly deployed.
These
include themes of social solidarity and moral obligation; the
advantages
of social cohesion and dangers of class war; Keynesian
arguments about
stimulating demand; and labor-rights arguments about giving
workers
the security to say no to dangerous and demeaning work.3 Yet
28. these
lines of argument lie side by side with others, which are
markedly
different from social democratic reasoning, and surprisingly
similar
to the neoliberal rationality that we more usually associate with
anti-
welfare discourses. The intermingling of these different themes
speaks
to the complex political struggles around the BIG, which have
been
discussed by others (eg Mattisonn and Seekings 2003; Barchiesi
2007).
My interest here, though, is not in analyzing these politics, but
in
identifying some surprising ways in which certain discursive
“moves”
that we can readily identify as neoliberal are being put to work
in the
service of apparently pro-poor and pro-welfare political
arguments. To
make this process visible, it is useful to pull some of these
neoliberal
“moves” out of the broader mix of BIG arguments so that we
can see the
work that they are doing. (Note that the following is a highly
condensed
summary. For a more detailed analysis that includes citations of
specific
texts, see Ferguson 2007.)
One of the most important themes in arguments in favor of a
BIG
is the idea of “investment in human capital”. A BIG, supporters
say,
would enable poor South Africans to increase their spending on
30. worker whose wages are soaked up by dependents in this way
suffers
from both a disincentive to work, and a drag on his or her
ability
to build up human capital. The “dependency” of absolute
poverty in
this way hurts productivity, and also makes it hard for workers
to
be economically active, to search for better jobs, etc. The
passivity
associated with this predicament, moreover, inhibits
entrepreneurship
and “risk-taking behaviors”. Providing basic income security
for all, it is
claimed, will enable the poor to behave as proper neoliberal
subjects (ie
as entrepreneurs and risk takers); the status quo prevents it, and
promotes
“dependency”. In this way, the BIG would provide not a “safety
net”
(the circus image of old-style welfare as protection against
hazard) but
a “springboard”—a facilitator of risky (but presumably
empowering)
neoliberal flight.
Equally striking is the way that basic income arguments
appropriate
neoliberal critiques of welfare paternalism and put them in the
service of
a pro-welfare argument. Echoing the old Margaret Thatcher
complaint
about the “nanny state” that tries to run everybody’s life in the
name
of the needs of “society”, BIG advocates point out that South
Africa’s
31. existing social assistance system makes moralizing judgments
about
“the undeserving poor”, and requires (at great expense) the
surveillance
and normalization of grant recipients, who are publicly labeled
as such,
and thus potentially stigmatized. In contrast to all this, the BIG
would
be paid to everyone; citizens would access their funds (in the
ideal
scheme) by simply swiping their national identity cards at at
automatic
cash dispenser. They would not need the government to tell
them how
to spend the funds. They would use them (like good rational
actors) in
the way they saw best. There would be no “nanny state”: no
policing of
conduct, no stigmatizing labels, no social workers coming into
homes—
and no costly bureaucracy to sort out who does or doesn’t
qualify. Grant
recipients, in this vision, appear as sensible people who know
their
problems and predicaments better than any bureaucrat could.
The state,
meanwhile, appears as both omnipresent and minimal—
universally
engaged (as a kind of direct provider for each and every citizen)
and
maximally disengaged (taking no real interest in shaping the
conduct
of those under its care, who are seen as knowing their own
needs better
than the state does).
33. may never become the norm that it is in Europe (ibid 2002:154).
The need for assistance, then, is not about being “between jobs”
or
correcting for dips in the business cycle; it is part of a world in
which
many, or even most, people, for the foreseeable future, will lack
formal
sector employment. Social assistance is here radically
decoupled from
expectations of employment, and, indeed, from “insurance”
rationality
altogether. Instead, the Taylor Committee Report re-understands
the
condition of unemployment not as a hazard, but as the normal
condition.
Yet unemployment, in this understanding, need not imply
idleness
or a lack of productivity. On the contrary, in a world where
livelihoods
in the “informal economy” will become increasingly important,
small
expenditures on minimum income support (like the BIG) can
have
big payoffs in enabling and enhancing economic action in that
domain. Social payments, in this optic, are most significant not
as
temporary substitutes for employment, but as a way of
promoting greater
productivity, enterprise, and risk-taking in the “informal”
domain within
which more and more South Africans are expected to make their
living.
I hope to have identified some recognizably neoliberal motifs
35. have in
mind is the increasingly influential argument that hunger is best
dealt
with by boosting the purchasing power of those at risk, rather
than by
distributing in-kind food aid.
The current international food aid system is based on the
subsidized
overproduction of agricultural crops (especially grain) in rich
countries
like the USA. Food aid programs then take this surplus grain
and
transport it to places (largely in Africa) where it is distributed
to
people who are at risk of hunger due to drought, natural
disasters,
political violence, or other sorts of humanitarian emergency.
Critics like
Amartya Sen have long noted the (largely unintended) negative
impacts
of such policies, which tend to depress producer prices for local
farmers,
while damaging local institutions for producing and distributing
food
crops. Once food aid has arrived, local food production may
never
recover. Too often, what was supposed to be a “temporary”
crisis
becomes a long-term decline in food self-sufficiency (see, eg
Sen 1983;
Dreze and Sen 1991).
As an alternative, Sen’s followers have pushed for cash
payments to
be made directly to those at risk of food deficit (either via
36. employment
guarantees, or through direct cash transfers). People with money
in
their pockets, these advocates point out, usually don’t starve.
And cash
support allows famine victims to preserve or restore productive
assets
(eg livestock) in ways that simply supplying a certain number of
calories
does not. What is more, the economic chain of events that is set
in motion
by boosting purchasing power not only avoids the destructive
effects of
food aid, but creates a virtuous cycle, in which market forces
lead to
increased capacity for local production and distribution. A
number of
pilot projects have been launched putting these principles into
practice
in recent years. Among the best known is the Cash for Relief
Programme
in Ethiopia, which used cash payments to enable households
that had
been hit by crop failure to rebuild their assets and regenerate
their
livelihoods, and not only to eat (USAID/OFDA 2004). Another
widely
discussed project has been the Kalomo Social Cash Transfer
Scheme
in Zambia. Here, too, cash took the place of food aid, with the
result
that recipients were able to meet non-nutritional as well as
nutritional
needs, including education, transportation, and health care
(Schubert and
Goldberg 2004). An impressive range of similar projects are
38. of maize meal the next, and so on. Rather than wasting the
money
on frivolous expenditure, advocates insist, recipients generally
apply
their scant cash resources very rationally, and even make canny
small
investments. As one PowerPoint presentation on the Kalomo
project put
it: “The ‘grannies’ turned out to be excellent economists!”
Top-down, state-planned attempts to directly meet nutritional
needs
through trucking in food, in this view, are bound to be clumsy,
inefficient,
and wasteful. Cash transfers, on the other hand, put more
decision-
making power in the hands of those who know their predicament
best—the hunger afflicted—and empower them to use the
flexibility
and efficiency of markets to help solve their own problems.
Unlike
direct food aid, cash transfers can have a catalytic effect on
many
other income-gaining activities, thereby contributing powerfully
to the
“multiple livelihood strategies” that are so important in keeping
the
poorest households afloat.
Such arguments recall Jane Guyer’s (1989) groundbreaking
work on
feeding African cities. Consider, Guyer suggests, how food ends
up
finding its way to consumers’ plates in the vast megacities of
West
Africa such as Lagos. The logistical task of moving thousands
39. of tons
of food each day from thousands of local producers to millions
of urban
consumers would be beyond the organizational capacity of any
state
(to say nothing of the less-than-exemplary Nigerian one). Here,
market
mechanisms, drawing on the power of vast self-organizing
networks,
are very powerful, and very efficient. Such forms of
organization
must appear especially attractive where states lack capacity
(and let
us remember how many progressive dreams in Africa have
crashed on
the rocks of low state capacity).
Why should relying on this sort of mechanism be inherently
right-
wing, or suspect in the eyes of progressives? The answer is, of
course,
not far to find: markets serve only those with purchasing power.
Market-
based solutions are thus likely to be true “solutions” only for
the better-
off, whose needs are so effectively catered to by markets. But
the food
aid example shows a way of redirecting markets toward the
poor, by
intervening not to restrict the market, but to boost purchasing
power.
I have become convinced that (at least in the case of food aid)
this is
probably good public policy. Is it also neoliberal? Perhaps that
is not
the right question. Perhaps we should rather ask: are there
41. entities such
as foundations or international agencies), and all are premised
on the
principle that public policy must play a major redistributive
role. But
they are interventions that create a situation where markets can
arguably
serve progressive ends, in ways that may require us to revise
some of
our prejudices that automatically associate market mechanisms
with the
interests of the well-to-do.
The Point is to Change It!
If we are seeking, as this special issue of Antipode aspires to
do, to link
our critical analyses to the world of grounded political
struggle—not
only to interpret the world in various ways, but also to change
it—then
there is much to be said for focusing, as I have here, on
mundane, real-
world debates around policy and politics, even if doing so
inevitably puts
us on the compromised and reformist terrain of the possible,
rather than
the seductive high ground of revolutionary ideals and utopian
desires.
But I would also insist that there is more at stake in the
examples I
have discussed here than simply a slightly better way to
ameliorate the
miseries of the chronically poor, or a technically superior
method for
relieving the suffering of famine victims.
43. it. So
far, the technocrats’ dreams of relieving poverty through
efficient cash
transfers have attracted little support from actual poor people,
who seem
to find that vision a bit pale and washed out, compared with the
vivid
(if vague) populist promises of jobs and personalistic social
inclusion
long offered by the ANC patronage machine, and lately
personified by
Jacob Zuma (Ferguson forthcoming).
My real interest in the policy proposals discussed here, in fact,
has
little to do with the narrow policy questions to which they seek
to provide
answers. For what is most significant, for my purposes, is not
whether
or not these are good policies, but the way that they illustrate a
process
through which specific governmental devices and modes of
reasoning
that we have become used to associating with a very particular
(and
conservative) political agenda (“neoliberalism”) may be in the
process
of being peeled away from that agenda, and put to very different
uses.
Any progressive who takes seriously the challenge I pointed to
at the
start of this essay, the challenge of developing new progressive
arts of
government, ought to find this turn of events of considerable
interest.
44. As Steven Collier (2005) has recently pointed out, it is
important to
question the assumption that there is, or must be, a neat or
automatic fit
between a hegemonic “neoliberal” political-economic project
(however
that might be characterized), on the one hand, and specific
“neoliberal”
techniques, on the other. Close attention to particular
techniques
(such as the use of quantitative calculation, free choice, and
price
driven by supply and demand) in particular settings (in Collier’s
case,
fiscal and budgetary reform in post-Soviet Russia) shows that
the
relationship between the technical and the political-economic
“is much
more polymorphous and unstable than is assumed in much
critical
geographical work”, and that neoliberal technical mechanisms
are in
fact “deployed in relation to diverse political projects and social
norms”
(2005:2).
As I suggested in referencing the role of statistics and
techniques for
pooling risk in the creation of social democratic welfare states,
social
technologies need not have any essential or eternal loyalty to
the political
formations within which they were first developed. Insurance
rationality
at the end of the nineteenth century had no essential vocation to
provide
46. worked up
out of whole cloth. More often, it involves a kind of bricolage
(Lévi-
Strauss 1966), a piecing together of something new out of
scavenged
parts originally intended for some other purpose. As we pursue
such
a process of improvisatory invention, we might begin by making
an
inventory of the parts available for such tinkering, keeping all
the while
an open mind about how different mechanisms might be put to
work, and
what kinds of purposes they might serve. If we can go beyond
seeing in
“neoliberalism” an evil essence or an automatic unity, and
instead learn
to see a field of specific governmental techniques, we may be
surprised
to find that some of them can be repurposed, and put to work in
the
service of political projects very different from those usually
associated
with that word. If so, we may find that the cabinet of
governmental arts
available to us is a bit less bare than first appeared, and that
some rather
useful little mechanisms may be nearer to hand than we thought.
Endnotes
1 I refer here to the remarkable PhD research now being carried
out by Ramah McKay
(Department of Anthropology, Stanford University).
2 Barchiesi (2007) gives a detailed and illuminating account of
the origins of the BIG
campaign and the Taylor Committee report.
48. Comaroff J and Comaroff J (2000) Millennial capitalism: First
thoughts on a second
coming. Public Culture 12(2):291–343
Cruikshank B (1999) The Will to Empower: Democratic
Citizens and Other Subject.
Ithaca: Cornell University Press
Davis M (2007) Planet of Slums. New York: Verso
Department of Social Development (2002) Transforming the
Present—Protecting the
Future: Report of the Committee of Inquiry into a
Comprehensive System of Social
Security for South Africa. Pretoria: Government Printer
Dreze J and Sen A (1991) Hunger and Public Action. New York:
Oxford University
Press
Ewald F (1986) L’etat Providence. Paris: Bernard Grasset
Farrington J and Slater R (2006) Cash transfers: Panacea for
poverty reduction or money
down the drain? Development Policy Review 24(5):499–511
Ferguson J (2007) Formalities of poverty: Thinking about social
assistance in neoliberal
South Africa. African Studies Review 50(2):71–86
Ferguson J (forthcoming) Declarations of dependence: Labor,
personhood, and welfare
in South Africa
Fiszbein A and Schady N (2009) Conditional Cash Transfers:
Reducing Present and
49. Future Poverty. Washington DC: The World Bank
Foucault M (2008) The Birth of Biopolitics: Lectures at the
College de France, 1978–
1979. Translated by Graham Burchell. New York: Palgrave
MacMillan
Guyer J (ed) (1989) Feeding African Cities: Studies in Regional
Social History.
Manchester: Manchester University Press
Harvey D (2005) A Brief History of Neoliberalism. New York:
Oxford University Press
Harvey P and Holmes R (2007) The Potential for Joint
Programmes for Long-term Cash
Transfers in Unstable Situations: A Report Commissioned by
the Fragile States Team
and the Equity and Rights Team of the UK Department for
International Development.
London: Humanitarian Policy Group, Overseas Development
Institute
Lévi-Strauss C (1966) The Savage Mind. Chicago: University of
Chicago Press
Mattisonn H and Seekings J (2003) The politics of a basic
income grant in South Africa,
1996–2002. In G Standing and M Samson (eds) A Basic Income
Grant for South
Africa (pp 56–76). Cape Town: University of Cape Town Press
Miller P and Rose N (2008) Governing the Present. Malden,
Massachusetts: Polity
Press
Peck J (2008) Remaking laissez-faire. Progress in Human
52. mothers (a 50 percent chance), they inherit the life-threatening
OTC deficiency disease.
Jesse’s mother, however, was not a carrier. Doctors therefore
attributed his OTC deficiency to spontaneous mutations in some
of his liver cells. Hence, his OTC deficiency was mild and his
disease was manageable as long as he stayed on a low-protein
diet and took his medications.
In September 1998, when Jesse was seventeen and living in
Arizona with his father, Paul, and his stepmother, a physician
monitoring his disease at a metabolic clinic informed him and
his father that researchers at the University of Pennsylvania
were working on a clinical trial to see whether they could find a
cure for OTC deficiency. The physician described the trial as
“gene therapy.” The subject of the clinical trial and “gene
therapy” came up again during Jesse’s visit to the metabolic
clinic in April 1999. Both Jesse and Paul were interested in
pursuing it and, since the family was already planning a trip to
New Jersey in June, they agreed to visit the Institute for Human
Gene Therapy (IHGT) at the University of Pennsylvania to see
whether Jesse would be a candidate for the “gene therapy”
clinical trial, which was already under way.
The design of the clinical trial, titled “Recombinant Adenovirus
Gene Transfer in Adults with Partial Ornithine
Transcarbamylase Deficiency,” was relatively simple.
Researchers were engineering an adenovirus (which gives us
colds by working its way into our cells) so it would not
replicate once it invaded the liver cells. Then they inserted good
genes with the OTC capability into the altered virus and infused
the altered virus carrying the good genes into the liver.
Researchers hoped that the healthy genes in the liver would
soon produce enough OTC to overcome the deficiency and
prevent ammonia from building up in the body. At this point
researchers were conducting only a phase I trial, that is, a trial
53. to see how high a load of the OTC gene-bearing viruses they
could safely infuse into people’s livers without causing adverse
reactions.
For the phase I trial they were looking to recruit eighteen adults
who either had some OTC deficiency or who were carriers.
Originally researchers had hoped to try the experiment on
babies suffering from the OTC deficiency, but a well-known
ethicist who was then at the university, Arthur Caplan, had
raised objections to this plan. Caplan argued that the parents of
children dying from OTC deficiency would be so devastated
that many would agree to enroll their child in a clinical trial out
of desperation, and their informed consent would not be truly
voluntary. Moreover, the proposed trial was a phase I study
where the goal was not to evaluate a therapeutic benefit but to
see whether the intervention had unacceptable side effects, a
distinction that desperate parents might not well understand.
Researchers planned to divide the eighteen participants into
groups of three, with two women and one man in each group.
Their plan was to give the three people in the first group a low
dose of the altered virus and then monitor them for side effects
for at least three weeks. If all went well, they would give the
second group of three a higher dose of the altered virus and
monitor them for three weeks, then infuse the third group with
an even higher dose, and so forth. The women would receive the
virus first, and only if the dose did not cause adverse reactions
in them would the researchers give it to the man in the group,
who would be more seriously affected by the OTC deficiency.
Researchers were now nearing the end of the phase I clinical
study; Jesse would be the third member of the sixth group, the
last person to receive the altered virus.
In June 1999 Jesse and his father met with Dr. Steven Raper at
the University of Pennsylvania. Since Jesse turned eighteen that
month, he would be old enough to give voluntary informed
54. consent for the clinical trial. Raper, a surgeon involved with the
gene transfer trial, explained the procedure to him and his
father. He would insert a catheter into the artery leading to
Jesse’s liver and a second one into a vein leading from his liver.
He would put the modified adenovirus with the healthy genes
into the artery leading to the liver. Hopefully the virus with the
genes would invade liver cells and thus deliver the good genes.
A check of the blood in the vein leaving the liver would
indicate how much of the gene-bearing virus remained in the
liver. By measuring the viral input and output researchers could
determine whether the liver was absorbing the virus with the
good genes embedded in it. A week later they would do a needle
biopsy of the liver to confirm the results of the attempted gene
transfer.
Dr. Raper told Jesse that there were risks involved. He would
probably develop some flu-like symptoms after the infusion of
the virus and there was some small chance of hepatitis, which
he said could be treated. There was also a remote possibility
that Jesse might die from the liver biopsy (Dr. Raper told him
that the risk of death from a liver biopsy is about one in ten
thousand). Dr. Raper also made it clear that the clinical trial,
even if it worked as they hoped, would not reverse Jesse’s OTC
deficiency because his immune system would reject the virus
with the healthy genes in a matter of weeks. On the other hand,
if the gene transfer was successful, then it would be a big step
forward toward developing a genetic therapy for babies with the
OTC deficiency as well as for dozens of other genetic diseases
affecting the liver. Both Paul and Jesse agreed to participate if
tests showed that Jesse would be a good candidate for the
clinical trial.
A month later Dr. Mark Batshaw, another one of the physicians
conducting the study, wrote both Paul and Jesse in Arizona
about the clinical trial and then spoke with them by phone.
According to Paul Gelsinger, Dr. Batshaw said that the
55. treatment had worked temporarily in mice, even preventing
death when mice were injected with lethal doses of ammonia.
He also said that there were about twenty-five other liver
disorders affecting five hundred thousand people in the United
States and 12 million worldwide that could be treated with the
same technique if it worked and that a recent human participant
in the study had experienced a 50 percent increase in her ability
to excrete ammonia. In other words, the research was showing
signs of therapeutic value that could benefit millions of people.
This clinched it for Jesse and his father; they considered this
promising news and became excited about participating in the
“genetic therapy” research at IHGT.
The chief investigator in the study was Dr. James Wilson, the
head of the IHGT at the University of Pennsylvania. He had
become interested in developing genetic therapies for liver
diseases after reading about a well-known patient named
Stormie Jones, a young girl whose liver cells had a genetic
mutation that prevented the liver from removing LDL
cholesterol from the blood. This genetic defect allows high
levels of the dangerous LDL cholesterol (the “bad” cholesterol)
to develop in the body, and most patients suffering from it die
prematurely from heart attacks. Stormie was in imminent danger
of dying from very high LDL cholesterol levels when she
received a heart and liver transplant. The transplanted liver
began removing LDL from her blood stream and the healthy
transplanted heart gave her a new lease on life. Wilson began to
think it would be better for patients if a way could be found to
insert normal cells into their liver rather than transplanting a
liver.
In experiments on human participants, which began in 1992,
Wilson and other researchers surgically removed part of the
person’s liver, cultured cells from it in the laboratory, used
retroviruses to convey healthy genes into the DNA of these liver
cells, and then infused the modified cells back into the liver
56. through a catheter in the artery leading to the liver. Eighteen
months after performing the procedure on a twenty-eight-year-
old research subject, Wilson reported in 1994 that the genetic
intervention was safe and had successfully lowered the person’s
LDL level.
Wilson realized, however, that removing cells from a patient,
modifying them in vitro, and then putting them back into the
patient would have limited use in genetic therapy. A more
promising procedure would be the development of what he
called “injectable genes.” Doctors would be able to transfer
healthy genes directly into the body’s liver cells, perhaps by
viruses. If it worked, this would be an in vivo genetic therapy.
In animal experiments, Wilson was actually able to lower the
cholesterol level of rabbits by injecting healthy genes into their
bloodstream.
Wilson soon began working on another genetic disease of liver
cells, the OTC deficiency. He thought he could overcome this
deficiency by using modified viruses to carry healthy cells with
the OTC enzyme directly into the liver so there would be no
need to remove part of the liver and add the genes in the
laboratory. Scientists and biotech companies were watching his
work with great interest. If it worked many people could be
cured of diseases caused by deleterious mutations on the genes
in liver cells and biotech companies could make a lot of money
thanks to patent protection for the engineered viruses that could
reverse the diseases.
Jesse flew to Philadelphia on September 10, 1999. Dr. Raper
inserted the catheters on the following Monday, and a large
dose of the modified virus with the healthy genes flowed into
Jesse’s liver. As expected, Jesse suffered flu-like symptoms that
evening. Soon, however, things got worse. He spiked a high
fever and rapidly deteriorated. Before long he was in a coma, on
a ventilator, and receiving dialysis. Then he needed
57. extracorporeal membrane oxygenation. By Thursday he was so
bloated that his father hardly recognized him. On Friday
morning it was obvious that he had suffered massive brain
damage and that his organs were shutting down. After the
family gathered and a chaplain said a prayer, a doctor withdrew
the life support and Jesse was pronounced dead at 2:30 p.m.
An autopsy failed to identify the cause of the problem that led
to his death. Obviously the infusion of the altered viruses
caused a reaction that killed him, but doctors could not figure
out why. Paul Gelsinger, shocked over the loss of his son,
nonetheless supported the doctors and felt that they had done
the best they could.
The doctors at IHGT promised to conduct a complete
investigation and to inform Paul of everything they discovered.
About two months after Jesse’s funeral, Dr. Wilson, the head of
the Institute and the sponsor and chief investigator of the OTC
deficiency study, flew to Arizona and met with Paul Gelsinger.
He explained that Jesse’s death was totally unexpected and still
remained unexplained. He spoke of how important the work of
his IHGT was, and he sought Paul’s continued support. He
asked Paul to come to a three-day meeting of RAC in December
that would be reviewing the clinical trial. Paul agreed and flew
to Philadelphia where he visited Wilson’s IHGT and then drove
to Bethesda, Maryland, the next day for the RAC meetings.
As the RAC meeting progressed, however, Paul began to see
another side of the clinical trial that took the life of his son. He
heard FDA officials say that Jesse should not have been infused
with the virus because his ammonia level was too high at that
time. Originally candidates with blood ammonia levels of more
than 50 were not considered eligible to participate; later
researchers raised that level to 70. When Jesse arrived in
Philadelphia for the clinical procedure, his blood ammonia level
was 114, and NIH officials said that he should not have been
58. considered eligible for the trial. However, researchers had
lowered his level somewhat with medication before they infused
the virus.
Paul also learned that researchers had failed to report to the
FDA in a timely manner or to inform him and his son that some
earlier participants experienced significant side effects from the
viral infusions. He also learned that the informed consent form
that Jesse signed differed from the one the FDA had approved,
and it in fact omitted the important information that two
monkeys had died in animal studies after being given high doses
of the virus.
Paul now began to think that Jesse had signed the informed
consent form without being well informed about possible side
effects and risks. He also heard that the viral infusions had not
provided any clinically significant therapeutic impact on earlier
participants, something that raised questions in his mind about
Dr. Batshaw’s remarks that one woman achieved a 50 percent
gain in ammonia excretion. Based on that remark, both he and
Jesse had thought the research was showing some sign of
therapeutic advantage. Paul was also upset to learn that
researchers had not provided NIH, which funded the study, or
the FDA, which monitored it, or the IRB at the University that
oversaw it with other information in a timely manner, as was
required by federal regulations.
In remarks to reporters outside the RAC meeting Dr. Wilson
objected to the FDA criticisms. He insisted that no data from
either animal or human studies foretold that Jesse would die;
that the FDA was eventually told of the two participants who
experienced the side effects before Jesse was infused, yet it did
not stop the study; and that the ammonia level in Jesse’s liver
was functioning within the protocol parameters when he was
enrolled in the study three months before his infusion. Wilson,
however, did not respond to criticisms about the informed
59. consent form and he declined to take questions.
On February 14, 2000, the IHGT responded formally to FDA
criticisms and pointed out, among other things, that every
patient did give informed consent for the clinical trial; that the
two monkeys who died were in a genetic experiment for a
different problem, colorectal cancer; and that there was no
evidence that the high ammonia level in Jesse was a cause of his
death. However, these remarks still left important questions
unanswered. Simply because there is a record of informed
consent does not mean that the person actually had all the
information he needed to give informed consent. And the issue
about the two monkeys is not that they received a different gene
for a different problem but that they received a similar viral
vector to transport genes into their bodies. And it is true that
there is no evidence that Jesse’s high ammonia level caused his
death, but the point of the FDA criticism was that the approved
protocol did not allow researchers to infuse the virus into
participants with such high ammonia levels, and researchers are
expected to abide by the approved protocols.
After months of publicly supporting the doctors at the
university and their research despite the loss of his son, Paul
Gelsinger now became their critic and soon sought legal
redress. Before looking at what happened next, we consider the
case from an ethical point of view.
Ethical Analysis
Situational awareness. We are aware of the following facts in
the Gelsinger story:
1. When Jesse was seventeen, both he and his father heard of
some important “gene therapy” research at the University of
Pennsylvania for people suffering from OTC deficiency, a
genetic condition that takes the life of so many afflicted
60. children. He and his father were interested in participating in
the “gene therapy” research because they believed it might save
the lives of babies and might even lead to something down the
road that would help Jesse so he could eat a normal diet and not
need medications to control his condition. When he turned
eighteen, Jesse visited the Institute for Human Gene Therapy at
the University and consented to becoming a participant in the
phase I trial. According to his father, part of his reason was to
do something that would allow development of a genetic
therapy to help prevent future babies from being ravaged by the
deadly disease.
2. Unlike most children with OTC deficiency, Jesse’s disease
was controlled with medications and a low-protein diet.
However, the teenager found taking his medications was a
hassle. He did not always take them on schedule or stay on his
diet, and he suffered occasional relapses. Dealing with his
disease sometimes left him frustrated and angry. At one point,
he actually jumped out of his father’s vehicle in a fit of anger
while it was still moving, and his arm ended up under a wheel.
It is possible that Jesse hoped for a long shot—that enough
progress could be made so a genetic therapy might actually
benefit him by allowing him to go off his medications and enjoy
a normal diet.
3. Dr. James Wilson, chief of Molecular Medicine and Genetics
at the University of Pennsylvania and head of its Institute for
Human Gene Therapy, was a leading researcher in the field of
genetic research on liver diseases. Wilson thought it might be
possible to transfer healthy liver genes into patients.
4. Jesse was the eighteenth and last participant in the phase I
OTC deficiency clinical trial, and he would receive the highest
dose of the viral vector with the healthy genes.
5. NIH funded the clinical trial and the FDA approved it. The
61. FDA provided oversight and required progress reports,
especially about adverse reactions if they occurred. There was
some hesitation when the trial was first proposed because
putting large amounts (trillions) of viruses into people is risky
business. Viruses will trigger, and may overload, the immune
system even though the viruses have been engineered not to
replicate. Actually some earlier participants in the OTC trial did
experience some adverse effects that should have been reported
to the FDA, but the doctors did not inform the Gelsingers of
this.
6. Researchers at the University of Pennsylvania were also
doing animal studies that used adenoviruses to transfer genes.
Two monkeys in one experiment had died and a third became
ill, but the physicians did not inform the Gelsingers of these
deaths.
7. Inserting genes into a person’s body is a major challenge.
Genes are mostly in the nucleus of our cells, and there is much
we do not yet know about the DNA molecule that harbors them.
Viruses have the capability of getting into the DNA of our cells
(an adenovirus is what causes the common cold), so they are
promising vehicles for transferring genes. The trick, of course,
is to render the virus harmless and then use it to transport
healthy genes into the DNA of the cells.
8. Genetic research is more challenging than drug research
because we have to study not only the impact of the agent (the
altered genes) on the body but also the impact of the vehicle we
use to transfer the altered genes into the body. The vehicle, or
“vector” as it is called, is often a virus, and putting massive
doses of viruses into a person’s body even without any altered
genes can trigger or even overwhelm the immune system.
9. The Bayh–Dole Act of 1980 allows universities to patent
their discoveries and then assign patent rights to biotech
62. companies in order to develop the discoveries into commercial
products. The universities like the Bayh–Dole Act because it
allows them to collect license fees and royalties from the
biotech products their researchers develop. Academic
researchers like the act because it allows them an opportunity to
profit from their research by investing in biotech companies that
could support their research and then market what might be
commercially viable. Both the university and Dr. Wilson had
invested in a company known as Genovo, a biotechnology
company that Wilson and others had founded. The university’s
equity share in Genovo was 5 percent and Wilson’s share was
30 percent.
We are also aware of numerous good and bad features in the
case:
1. Clinical trials with human participants are essential for
medical progress, and they have done a tremendous amount of
good. Medical research cannot progress very far without them,
especially when it comes to drugs, medical devices, and genetic
alterations.
2. People who volunteer for clinical trials do so for a number of
reasons. Some are dying and will try anything, some do it for
money (some trials pay the participants) or free health care,
some do it in the hope they will receive therapeutic benefit, and
some do it with a sense of altruism because they want to help
researchers find a cure for diseases that afflict or kill others.
Jesse was not dying and he did not do it for the money. His
father indicated that Jesse had a desire to help find a cure for
the lethal disease that affects babies as well as hope that
researchers might find something that could benefit him. These
motivations are morally sound in a virtue-based ethics that
focuses on flourishing and helping others to flourish.
3. Medical researchers inevitably find themselves enmeshed in
63. numerous conflicts of interest. A major interest of ethical
research is, or should be, protecting human participants from
harm, but numerous other interests can conflict with this. First,
good medical researchers have an intense interest in
accomplishing successful breakthroughs, and this can clash with
their responsibility to protect human participants in research
from harm. Second, researchers often have an interest in
winning recognition for their work and in seeing it published
and accepted, and this can clash with protecting human
participants. Third, medical researchers, especially if they are
trained physicians, often have an interest in finding something
that will help many future patients, and this can clash with
protecting the small number of human participants in their
clinical trials. Fourth, in the more than thirty years since the
1980 Bayh–Dole Act, many researchers and their nonprofit
academic institutions have developed an intense interest in
profiting financially when they develop something with great
commercial value. Obviously the desire to bring a treatment to
market rapidly can clash with the responsibility to protect
carefully the people enrolled in the clinical trials.
4. Researchers had a moral responsibility to provide adequate
and honest information to the Gelsingers when they recruited
Jesse for the clinical trial. They also had a responsibility to
provide timely information about adverse events to the
university IRB, to the NIH, and to the FDA. They also had a
responsibility to adhere strictly to the approved protocols for
the clinical research. Published reports indicate numerous
lapses of their responsibilities in these areas, and this is bad for
the participants in the research and it is bad for clinical trials in
general because people will not volunteer if they think doctors
are acting irresponsibly.
Prudential Reasoning in the Gelsinger Story
Participant’s perspective.Is it morally reasonable for a teenage
64. person in Jesse’s position to agree to enter a clinical trial such
as this? Based on the information he was given and the guidance
of his father, it is hard to fault his decision to enter the trial. He
expected flu-like symptoms that would pass. The informed
consent form also noted that the altered virus could be toxic to
his liver, but he was reassured that this could be treated. His
biggest worry seemed to be the liver biopsy, with its very slight
risk of death. The problem, of course, is that he and his father
did not receive important information about the adverse effects
of the virus transfer in monkeys or in previous participants in
the trial, nor did they receive any concrete information about
the financial arrangements involving Dr. Wilson, the IHDT, and
the University of Pennsylvania. It should be noted that at the
end of the eleven-page informed consent form was a statement
indicating that both Dr. Wilson and the university had
“financial interest in a successful outcome.” The problem, of
course, is that Jesse and his father had no idea what that interest
was or that it involved millions of dollars.
Parent’s perspective. Jesse’s father, Paul, provided a great deal
of guidance and support for his son. It is hard to fault his role
based on the information he was given. Later he pursued legal
action against the researchers, which also is morally reasonable
in a case such as this because the researchers did not disclose
important information and great harm was done: the clinical
trial caused the death of a relatively healthy teenager who had
no need of genetic therapy to control his genetic disease. Paul
has continued to speak and write about the tragedy, and this has
served to call attention to the need to improve patient protection
in clinical trials.
Researchers’ perspective. There are good moral reasons for
doing research with human participants designed to develop
genetic therapies correcting mutations in human liver cells.
Someday genetic research might lead to a significant revolution
in medicine that will help many human beings. It is not morally
65. reasonable, however, for researchers not to meticulously follow
the approved protocols; not to inform prospective participants
of adverse reactions in previous subjects, or of animal deaths in
viral transfers, or of financial arrangements relevant to clinical
research; and not to provide timely information required by the
protocols and by regulations to the NIH, the FDA, and the local
IRB that oversee the clinical trial.
University’s perspective. Officials at the University of
Pennsylvania were aware of some of the conflicts of interest
between Wilson’s work as a university faculty member and his
significant financial stake in Genovo, a company he cofounded
to market the products of his research. In 1994 the university’s
Conflicts of Interest Standing Committee (CISC) had looked
into the conflicts of interest that would exist between Wilson’s
research and the potential for great financial gain for him and
his company that the research could generate. The CISC made
an effort to reduce the potential negative impact of this conflict
by imposing some restrictions on Wilson: he could not sit on
Genovo’s scientific board, he could not be paid for his work as
a consultant for Genovo, and he could not do clinical studies
funded by Genovo. Yet the university allowed Dr. Wilson to
own 30 percent of Genovo stock, and it accepted an equity share
in Genovo for itself. The university also agreed that the IHGT
could accept $4 million a year for five years from Genovo for
genetic research, and in return it allowed Genovo to seek
licenses and patents and to earn profit on future developments
by the IHGT or its researchers. They also agreed to accept
$25,000 a year from Genovo toward the salary of Arthur
Caplan, the well-known bioethicist then at the university.
Professor Caplan was professor of bioethics in the Department
of Molecular and Cellular Engineering, which Dr. Wilson
chaired at that time.
The Aftermath
66. In December 1999 the NIH and the FDA held the hearings in
Bethesda regarding the clinical trial, and Paul Gelsinger
attended. After investigating the circumstances surrounding
Jesse Gelsinger’s death, the NIH reminded all researchers with
similar genetic experiments that federal regulations required
them to report adverse events that occur in the trials. Up to that
point 39 adverse events in genetic experiments had been
reported; after the NIH reminder the number suddenly jumped
to 691! Clearly scientists were routinely disregarding the NIH
reporting regulations.
On January 21, 2000, the FDA shut down all clinical genetic
trials at the University of Pennsylvania due to numerous
regulatory violations.
In August 2000 Targeted Genetics Corporation, a biotech
company, acquired Genovo. Published reports indicate that
Wilson’s equity interest in Genovo brought him $13.5 million in
Targeted Genetics stock and that the university’s equity interest
in the company was worth $1.4 million at the time of the sale.
In September 2000, one year after Jesse died, his family brought
a wrongful death/fraud/intentional misrepresentation lawsuit
against the university, the Children’s National Medical Center
(CNMC) in Washington, the Children’s Hospital of
Philadelphia, doctors Wilson, Raper, Batshaw, and Kelley (the
dean of the medical school), Genovo, and the bioethicist Arthur
Caplan. The suit alleged, among other things, that the informed
consent process was seriously flawed because the defendants
failed to inform Jesse and his family of the risks to him
suggested by the illness and death of the monkeys and failed to
disclose the adverse effects the virus had caused in some earlier
human participants. It also alleged that the defendants failed to
disclose adequately the conflict of interest that existed on the
part of Dr. Wilson and the university due to their financial
interests in seeing Genovo succeed by bringing the viral vector
67. to market as rapidly as possible. The implication of the lawsuit
was that the researchers and the university cut corners in the
clinical trial in their haste to develop what would be a
blockbuster biotech product.
The defendants in the lawsuit decided not to defend their
actions in court. About a month after the lawsuit was filed, they
quickly agreed to settle the case out of court and paid the
Gelsinger family an undisclosed amount of money, estimated by
some reports to be in the neighborhood of $10 million. Both the
FDA and the Justice Department continued their investigations,
In February 2002 the FDA formally notified Dr. Wilson that he
had failed to address adequately numerous issues that the FDA
had raised about the clinical trial, among them:
• The study was not stopped as required by the approved
protocol after some participants developed grade 3 or higher
toxicities.
• Researchers injected the virus into subjects that did not meet
the criteria required by the approved protocol.
• Researchers injected the virus into a male as the second
person in a group of three despite written agreement that the
sequence in each group of three would be two females followed
by one male (males with the disease are more at risk than
female carriers).
• Researchers failed to perform prestudy ammonia tests on three
days and one day before the viral infusion on all participants as
required by the protocol.
• Researchers failed to submit accurate and timely reports to the
IRB. In the annual report to the IRB in August 1997 Dr. Wilson
stated that the first person in the study developed mild anemia
probably because so much blood was drawn and that the next
two participants did not develop anemia after the amount of
blood drawn was reduced. In fact, however, those two
participants actually did develop grade 1 anemias, but this was
68. not reported. In the annual IRB report of August 1998, after the
first ten participants had received the virus, Dr. Wilson stated
that “there have been no significant treatment-related or
procedure-related toxicities,” when in fact a significant adverse
event had occurred on June 25, 1998. Also, the 1998 annual
report did not present a table of adverse events according to the
protocol; this information was not submitted until the 1999
annual report. In the annual report of August 1999 Dr. Wilson
stated: “No serious adverse effects have occurred as a result of
this study.” The FDA alleged this statement is false because the
record shows there were some serious adverse effects, namely,
grade 3 toxicities in six participants.
• The protocol stated that researchers will halt the study if a
single participant develops a grade 3 or higher toxicity, yet they
did not halt the study despite instances of grade 3 toxicities in
dose cohorts 4, 5, and 6.
• Researchers failed to obtain proper informed consent in accord
with federal regulations. The FDA requested that Dr. Wilson
inform participants not to donate blood or gametes, and he
confirmed in writing that he had added that information to the
consent form when in fact this information was not in the
informed consent form. Researchers also failed to inform
potential participants that higher doses of the virus were
associated with DIC (disseminated intravascular coagulation—a
life-threatening generalized bleeding that is hard to stop) in
monkeys and might cause a similar problem for humans. Three
monkeys received viral vectors in late 1998; one received the
same virus vector as the humans and the other two a different
vector, but all three developed DIC. Yet the consent form was
never changed to reflect this important fact, and Jessie did in
fact develop DIC after he received the virus. Researchers also
failed to inform the later participants in the trial that, in
addition to “flu-like symptoms,” they were likely to experience
significant periods of chills, nausea, and vomiting. Moreover,
the protocol said that they would be given only Tylenol for
discomfort when in fact researchers had to use other pain
69. medications to reduce the discomfort participants were
experiencing.
In April 2002 Wilson relinquished his post as director of the
IHGT. In September 2002 Dateline NBC did a program on
Jesse’s death and the family’s search for answers. In February
2003 BBC Two devoted a program to the tragic story.
In February 2005 the US Department of Justice announced a
civil settlement in the case that the department had brought
against the institutions and the researchers involved in the OTC
trial. The Department of Justice had accused the researchers
(Wilson, Raper, and Batshaw) and their institutions (the
University of Pennsylvania and CNMC) of violating the civil
False Claims Act between July 1998 and September 1999 by (1)
submitting false statements and claims on the grant
applications, progress reports, and annual reports submitted to
the NIH; (2) submitting false statements and claims to the FDA,
which was monitoring the research; (3) submitting false
statements to the IRBs, which reviewed the research over a
period of several years; and (4) submitting false statements and
claims that prevented the human research participants from
giving properly informed consent.
In the settlement with the Department of Justice the University
of Pennsylvania agreed to pay a fine of $517,496 and CNMC
agreed to pay a fine of $514,622. The Department of Justice
settlement did not require Dr. Wilson and the other physicians
to pay fines, but it did impose restrictions on their work. Dr.
Wilson, as the sponsor of the FDA-regulated clinical trial paid
for by NIH, had to agree not to participate in research involving
human subjects until he completed training in protecting human
subjects. He also had to accept severe restrictions on his
research with human participants until February 2010. Dr.
Wilson also agreed in the settlement to lecture and write an
article on the lessons learned from the OTC study, and to
70. include statements from the Gelsinger family in the article.
Wilson’s article on lessons learned from OTC trial in which
Jesse Gelsinger died was published online and in print four
years later, in 2009.
Two other physicians involved in the research, Mark Batshaw
and Steven Raper, were also required to complete training in
protecting human subjects, and both had restrictions placed on
their clinical research for three years. As is customary in this
kind of settlement, the accused parties (the two institutions and
the three physicians) did not admit the allegations and
contended that their behavior was at all times lawful and
appropriate.
In January 2008 Dr. Wilson, as the editor-in-chief of the journal
Human Gene Therapy, wrote an editorial on adverse events in
gene transfer trials in which he encouraged “genetic therapy”
organizations to put in place more effective ways for human
participants in clinical trials to have “a full and unbiased
understanding of the risks and benefits of their participation.”
The editorial mentioned the adverse events in the severe
combined immune deficiency (SCID) and arthritis trials
discussed in the next section but did not mention the adverse
events and the death of Jesse Gelsinger in his OTC trial at the
University of Pennsylvania.
In the same issue of Human Gene Therapy, two authors
recommended the appointment of advocates to help people
considering participation in genetic experiments to understand
the risks of genetic research and to advise them whether
participation in a study is truly in their best interest. Yet more
than a participant-advocate was needed in the Gelsinger case.
Jesse needed to know about numerous major problems in his
clinical trial—namely, the failure of researchers to provide
information about the recent monkey deaths; the failure of
researchers to inform him (and the IRBs, the FDA, and the NIH)