This document summarizes 10 studies that examine the relationship between childhood sexual abuse and later substance abuse. Across the studies, several common findings emerged: childhood sexual abuse was associated with earlier initiation and more frequent substance use, particularly of alcohol and drugs; substance use partially mediated the relationship between childhood sexual abuse and later health issues like HIV risk behaviors; and experiences of childhood sexual abuse along with other childhood trauma were correlated with higher rates of substance abuse disorders. The studies highlighted the need for larger and more diverse sample sizes in future research.