This document discusses several examples of problem-based learning (PBL) methods being implemented in medical and health-related education in Portugal. It outlines cases of PBL used in biochemistry, physiology, and pathophysiology courses at the Faculty of Medical Sciences of Lisbon. It also describes analyses comparing PBL to older teaching methods in pathophysiology. Further cases discussed include PBL implementation in courses in technology of health sciences and physiotherapy in occupational therapy.