The DNA content of a diploid cell in the G1 phase of the cell cycle is measured. If this DNA content is X, then the DNA content of the same cell at metaphase of meiosis II would be: Question 22 options: 0.25X 0.5X X 2X 4X 0.25X 0.5X X 2X 4X Solution During meiosis, the chromosome number is halved. This usually occurs for the production of gametes. After fusion of gametes, the original chromosome number as well as total DNA content are restored. Before, meiosis starts, the DNA content is doubled during the S-phase of Interphaseand then the G2 phase comes. During the Interphase, G1 occurs first, then S phase occurs and G2 occurs. DNA replication occurs only during the S-phase. So, if the DNA content was X during the G1 Phase, it will become 2X during S-phase. At the end of Meiosis-2 it will become X. However, at Metaphase2, the chromosomes have aligned themselves at the centre of the cell but not segregated yet. So, DNA content will be the same at Metaphase-2 but it will be halved at the end of Meiosis2. After fusion the original DNA content will remain the same. Therefore, DNA Content will be X at Metaphase2..