1) The AK6 kimberlite in Botswana was discovered in 1969 but considered low interest until improved exploration technologies allowed reexamination in 1998.
2) Advanced exploration from 2005-2006 involved large diameter drilling, sampling, and diamond recovery to evaluate the deposit. This led to an initial inferred resource of 11.6 million carats from 48.5 million tons at 24 carats per hundred tons.
3) Further work including trenching and more drilling was planned to upgrade the resource to the indicated classification required for a bankable feasibility study and potential future mining.
Investor presentation delivered by Impact Minerals' Managing Director Dr Michael Jones, at the Gold Investment Symposium held in Sydney, 8th and 9th October 2014
Deep South Resources Presentation September 2017MomentumPR
TSX-V-DSM, 52 million shares issued; Teck Resources holds 35% of DSM; Board and Management hold 16% of DSM;
Haib Copper Project – world class resource potential:
An existing 2 billion lbs Cu Historical Estimate*, open near surface and at depth; Over 65,000 metres of diamond drilling by 5 mining companies in the last 50 years including 14,000 metres of drilling by Teck in the recent years; Excellent mining jurisdiction – Namibia: Best investment jurisdiction in Africa; politically and economically stable country and Solid infrastructure;
INALProject – Major gold and Lithium potential
Neighboring and along trend to the Kinross Tasiast 21 Moz gold mine; Pegmatites bodies with spodumen over a length of 40 km and 10km width; Strongly under-explored country – Mauritania;
Seasoned and renowned technical management team, experienced board of directors.
Diamond exploration, mining, financing and driving entrepreneurial behaviour.James AH Campbell
A presentation entitled:
"Diamond exploration, mining, financing and driving entrepreneurial behaviour".
to the Antwerp World Diamond Council and Gordon Institute of Business ('GIBS') global seminar entitled "From Mine to Finger. A deep dive into the world of diamonds". 7 February 2024 at GIBS.
Most of the participants are either entrepreneurs in the diamond downstream space or academics from both institutions.
Sokoman Minerals Corp. is a discovery-oriented company with projects in Newfoundland and Labrador, Canada. The company’s primary focus is its portfolio of gold projects: flagship, 100%-owned Moosehead, Crippleback Lake, and East Alder (optioned to Canterra Minerals Corporation) along the Central Newfoundland Gold Belt, and the district-scale Fleur de Lys project in northwestern Newfoundland, that is targeting Dalradian-type orogenic gold mineralization similar to the Curraghinalt and Cavanacaw deposits in Northern Ireland, and Cononish in Scotland. The company has also entered into a strategic alliance (the Alliance) with Benton Resources Inc. through three large-scale joint-venture properties including Grey River Gold, Golden Hope and Kepenkeck on the island of Newfoundland. Sokoman now controls independently and through the Alliance over 150,000 hectares (>6,000 claims – 1,500 sq. km), making it one of the largest landholders in Newfoundland, Canada’s newest and rapidly-emerging gold district. Sokoman also retains an interest in an early-stage antimony/gold project (Startrek) in Newfoundland, optioned to White Metal Resources Inc., and in Labrador, the company has a 100% interest in the Iron Horse (Fe) project that has Direct Shipping Ore (DSO) potential.
Investor presentation delivered by Impact Minerals' Managing Director Dr Michael Jones, at the Gold Investment Symposium held in Sydney, 8th and 9th October 2014
Deep South Resources Presentation September 2017MomentumPR
TSX-V-DSM, 52 million shares issued; Teck Resources holds 35% of DSM; Board and Management hold 16% of DSM;
Haib Copper Project – world class resource potential:
An existing 2 billion lbs Cu Historical Estimate*, open near surface and at depth; Over 65,000 metres of diamond drilling by 5 mining companies in the last 50 years including 14,000 metres of drilling by Teck in the recent years; Excellent mining jurisdiction – Namibia: Best investment jurisdiction in Africa; politically and economically stable country and Solid infrastructure;
INALProject – Major gold and Lithium potential
Neighboring and along trend to the Kinross Tasiast 21 Moz gold mine; Pegmatites bodies with spodumen over a length of 40 km and 10km width; Strongly under-explored country – Mauritania;
Seasoned and renowned technical management team, experienced board of directors.
Diamond exploration, mining, financing and driving entrepreneurial behaviour.James AH Campbell
A presentation entitled:
"Diamond exploration, mining, financing and driving entrepreneurial behaviour".
to the Antwerp World Diamond Council and Gordon Institute of Business ('GIBS') global seminar entitled "From Mine to Finger. A deep dive into the world of diamonds". 7 February 2024 at GIBS.
Most of the participants are either entrepreneurs in the diamond downstream space or academics from both institutions.
Sokoman Minerals Corp. is a discovery-oriented company with projects in Newfoundland and Labrador, Canada. The company’s primary focus is its portfolio of gold projects: flagship, 100%-owned Moosehead, Crippleback Lake, and East Alder (optioned to Canterra Minerals Corporation) along the Central Newfoundland Gold Belt, and the district-scale Fleur de Lys project in northwestern Newfoundland, that is targeting Dalradian-type orogenic gold mineralization similar to the Curraghinalt and Cavanacaw deposits in Northern Ireland, and Cononish in Scotland. The company has also entered into a strategic alliance (the Alliance) with Benton Resources Inc. through three large-scale joint-venture properties including Grey River Gold, Golden Hope and Kepenkeck on the island of Newfoundland. Sokoman now controls independently and through the Alliance over 150,000 hectares (>6,000 claims – 1,500 sq. km), making it one of the largest landholders in Newfoundland, Canada’s newest and rapidly-emerging gold district. Sokoman also retains an interest in an early-stage antimony/gold project (Startrek) in Newfoundland, optioned to White Metal Resources Inc., and in Labrador, the company has a 100% interest in the Iron Horse (Fe) project that has Direct Shipping Ore (DSO) potential.
Investor Presentation delivered by Geopacific Resources' Director Mark Bojanjac, at the Gold Investment Symposium held in Sydney, 8th and 9th October 2014
Sokoman Minerals Corp. is a discovery-oriented company with projects in Newfoundland and Labrador, Canada. The Company's primary focus is its portfolio of gold projects: flagship Moosehead along the Central Newfoundland Gold Belt. The Company is also active on its district-scale Fleur de Lys project in northwestern Newfoundland, which is targeting Dalradian-type orogenic gold mineralization similar to the Curraghinalt and Cavanacaw deposits in Northern Ireland, and Cononish in Scotland.
The Company is actively participating in a strategic alliance with Benton Resources Inc. through three large-scale joint venture properties including Grey River, Golden Hope and Kepenkeck in Newfoundland. Sokoman now controls independently and through the Benton alliance over 150,000 hectares (>6,000 claims – 1,500 sq. km), making it one of the largest landholders in Newfoundland, Canada’s newest and rapidly-emerging gold districts.
The Company also retains an interest in an early-stage antimony/gold project (Startrek) in Newfoundland, optioned to White Metal Resources Inc., the Crippleback Lake (optioned to Trans Canada Gold Corp.) and the East Alder (optioned to Canterra Minerals Corporation) and, the Company has a 100% interest in the Iron Horse (Fe) project in Labrador, that has Direct Shipping Ore (DSO) potential.
About Equitorial Exploration Corp
Equitorial is aggressively developing three 100%-owned, high-potential, lithium projects in North America. The Little
Nahanni Pegmatite Group (LNPG) is a 43-101 compliant, hard rock, lithium property in the NWT. The Tule and Gerlach
Lithium Brine Projects are located in lithium-rich Utah and Nevada within easy reach of the Tesla Gigafactory #1
Objective Capital Rare Earths, Speciality and Minor Metals Investment Summit
Overview of the Tungsten Market and the
challenges of (re)opening the world’s next
tungsten mine
18 March 2010
by Brian Wesson, Woulfe Mining
Sokoman Minerals Corp. is a discovery-oriented company with projects in the province of Newfoundland and Labrador, Canada. The Company’s primary focus is its portfolio of gold projects; flagship, advanced-stage Moosehead, Crippleback Lake (optioned to Trans Canada Gold Corp.) and East Alder (optioned to Canterra Minerals Corporation) along the Central Newfoundland Gold Belt, and the district-scale Fleur de Lys project in northwestern Newfoundland, that is targeting Dalradian-type orogenic gold mineralization similar to the Curraghinalt and Cavanacaw deposits in Northern Ireland. The Company also recently entered into a strategic alliance with Benton Resources Inc. through three, large-scale, joint-venture properties including Grey River, Golden Hope, and Kepenkeck in Newfoundland.
Sokoman now controls, independently and through the Benton alliance, over 150,000 hectares (>6,000 claims – 1500 sq. km), making it one of the largest landholders in Newfoundland, in Canada’s newest and rapidly-emerging gold districts. The Company also retains an interest in an early-stage antimony/gold project (Startrek) in Newfoundland, optioned to White Metal Resources Inc., and in Labrador, the Company has a 100% interest in the Iron Horse (Fe) project which has Direct Shipping Ore (DSO) potential.
Canada Cobalt Works Corporate PresentationMomentumPR
Canada Cobalt Works Inc. (formerly Castle Silver Resources) is a growing cobalt focused Company with past producing Canadian cobalt/silver mines under exploration. The Company also owns a proprietary environmentally friendly metal separation technology for efficient cobalt extraction that was used in 2018 to produce a cobalt sulphate compound suitable for end use in battery production. The material used to produce the compound was taken directly from the first level adit at the historic Castle Silver Mine site. The Company continues to advance on several fronts with cobalt demand forecast to increase due to greater supply needs for battery producers to meet rising global demand for electric vehicles.
The Giro Gold Project covers a surface area of 610km2 and lies within the Kilo-Moto Belt in one of the world’s principal greenstone belts which hosts Randgold Resources’ multi-million ounce Kibali Gold deposits within 30km of Giro, Anglogold Ashanti’s deposits to the east, Loncore and Kilogold deposits to the south and 50Moz of gold discovered in Tanzania since 1994.
To learn more about this project, please visit:
http://www.panexresources.com
With a portable core drill, Nick tested some discovery outcropsStephan Bogner
Last year, Newfoundlander Nick Rodway, in his role as Professional Geologist and Director of Core Assets Corp., took a hike across the company‘s Blue Property in northern BC and stumbled upon some rusty outcrops. He chipped off samples, loaded his backpack and returned to civilization, where the rocks were analyzed for its metal content at an independent lab. The results came in late November, when Rockstone last reported, showing up to 9.92% copper, 2,020 g/t silver, 6.75 g/t gold, >30% zinc and >20% lead.
Impact Minerals (ASX:IPT) Company Presentation, Symposium Investor Roadshow A...Symposium
Impact Minerals' (ASX:IPT) presentation at Symposium's Investor Roadshow in Sydney and Melbourne to over 250 attendees, April 2014. Presentation was delivered by IPT's Managing Director, Dr Mike Jones.
Corporate Governance for South African Mining Companies (a practitioner's view)James AH Campbell
Corporate Governance for South African Mining Companies (a practitioner's view).
Compliance & Reporting in the Minerals Industry
15th September 2023
University of the Witwatersrand
(MINN7052A)
Investor Presentation delivered by Geopacific Resources' Director Mark Bojanjac, at the Gold Investment Symposium held in Sydney, 8th and 9th October 2014
Sokoman Minerals Corp. is a discovery-oriented company with projects in Newfoundland and Labrador, Canada. The Company's primary focus is its portfolio of gold projects: flagship Moosehead along the Central Newfoundland Gold Belt. The Company is also active on its district-scale Fleur de Lys project in northwestern Newfoundland, which is targeting Dalradian-type orogenic gold mineralization similar to the Curraghinalt and Cavanacaw deposits in Northern Ireland, and Cononish in Scotland.
The Company is actively participating in a strategic alliance with Benton Resources Inc. through three large-scale joint venture properties including Grey River, Golden Hope and Kepenkeck in Newfoundland. Sokoman now controls independently and through the Benton alliance over 150,000 hectares (>6,000 claims – 1,500 sq. km), making it one of the largest landholders in Newfoundland, Canada’s newest and rapidly-emerging gold districts.
The Company also retains an interest in an early-stage antimony/gold project (Startrek) in Newfoundland, optioned to White Metal Resources Inc., the Crippleback Lake (optioned to Trans Canada Gold Corp.) and the East Alder (optioned to Canterra Minerals Corporation) and, the Company has a 100% interest in the Iron Horse (Fe) project in Labrador, that has Direct Shipping Ore (DSO) potential.
About Equitorial Exploration Corp
Equitorial is aggressively developing three 100%-owned, high-potential, lithium projects in North America. The Little
Nahanni Pegmatite Group (LNPG) is a 43-101 compliant, hard rock, lithium property in the NWT. The Tule and Gerlach
Lithium Brine Projects are located in lithium-rich Utah and Nevada within easy reach of the Tesla Gigafactory #1
Objective Capital Rare Earths, Speciality and Minor Metals Investment Summit
Overview of the Tungsten Market and the
challenges of (re)opening the world’s next
tungsten mine
18 March 2010
by Brian Wesson, Woulfe Mining
Sokoman Minerals Corp. is a discovery-oriented company with projects in the province of Newfoundland and Labrador, Canada. The Company’s primary focus is its portfolio of gold projects; flagship, advanced-stage Moosehead, Crippleback Lake (optioned to Trans Canada Gold Corp.) and East Alder (optioned to Canterra Minerals Corporation) along the Central Newfoundland Gold Belt, and the district-scale Fleur de Lys project in northwestern Newfoundland, that is targeting Dalradian-type orogenic gold mineralization similar to the Curraghinalt and Cavanacaw deposits in Northern Ireland. The Company also recently entered into a strategic alliance with Benton Resources Inc. through three, large-scale, joint-venture properties including Grey River, Golden Hope, and Kepenkeck in Newfoundland.
Sokoman now controls, independently and through the Benton alliance, over 150,000 hectares (>6,000 claims – 1500 sq. km), making it one of the largest landholders in Newfoundland, in Canada’s newest and rapidly-emerging gold districts. The Company also retains an interest in an early-stage antimony/gold project (Startrek) in Newfoundland, optioned to White Metal Resources Inc., and in Labrador, the Company has a 100% interest in the Iron Horse (Fe) project which has Direct Shipping Ore (DSO) potential.
Canada Cobalt Works Corporate PresentationMomentumPR
Canada Cobalt Works Inc. (formerly Castle Silver Resources) is a growing cobalt focused Company with past producing Canadian cobalt/silver mines under exploration. The Company also owns a proprietary environmentally friendly metal separation technology for efficient cobalt extraction that was used in 2018 to produce a cobalt sulphate compound suitable for end use in battery production. The material used to produce the compound was taken directly from the first level adit at the historic Castle Silver Mine site. The Company continues to advance on several fronts with cobalt demand forecast to increase due to greater supply needs for battery producers to meet rising global demand for electric vehicles.
The Giro Gold Project covers a surface area of 610km2 and lies within the Kilo-Moto Belt in one of the world’s principal greenstone belts which hosts Randgold Resources’ multi-million ounce Kibali Gold deposits within 30km of Giro, Anglogold Ashanti’s deposits to the east, Loncore and Kilogold deposits to the south and 50Moz of gold discovered in Tanzania since 1994.
To learn more about this project, please visit:
http://www.panexresources.com
With a portable core drill, Nick tested some discovery outcropsStephan Bogner
Last year, Newfoundlander Nick Rodway, in his role as Professional Geologist and Director of Core Assets Corp., took a hike across the company‘s Blue Property in northern BC and stumbled upon some rusty outcrops. He chipped off samples, loaded his backpack and returned to civilization, where the rocks were analyzed for its metal content at an independent lab. The results came in late November, when Rockstone last reported, showing up to 9.92% copper, 2,020 g/t silver, 6.75 g/t gold, >30% zinc and >20% lead.
Impact Minerals (ASX:IPT) Company Presentation, Symposium Investor Roadshow A...Symposium
Impact Minerals' (ASX:IPT) presentation at Symposium's Investor Roadshow in Sydney and Melbourne to over 250 attendees, April 2014. Presentation was delivered by IPT's Managing Director, Dr Mike Jones.
Corporate Governance for South African Mining Companies (a practitioner's view)James AH Campbell
Corporate Governance for South African Mining Companies (a practitioner's view).
Compliance & Reporting in the Minerals Industry
15th September 2023
University of the Witwatersrand
(MINN7052A)
Attracting Funds to Develop the Diamond Potential of Southern AfricaJames AH Campbell
Attracting Funds to Develop the Diamond Potential of Southern Africa
JAHCampbell
24 Aug 2023
Presentation to the Kimberely International Diamond Conference.
Prospecting for Solutions: Challenges facing the South African Mining IndustryJames AH Campbell
Prospecting for Solutions: Challenges facing the South African Mining Industry
James Campbell
Presentation to Drexel University MBA group in Johannesburg on 11 May 2023.
Is there any overlap between Corporate Governance & Public Reporting?James AH Campbell
Is there any overlap between Corporate Governance & Public Reporting?
Presentation to the Geological Society of South Africa.
10th October 2022, Johannesburg.
Prospecting for Solutions: Challenges facing the South African Mining IndustryJames AH Campbell
Prospecting for Solutions: Challenges facing the South African Mining Industry.
Society of Economic Geologists, SA Chapter.
6th October 2022, University of the Witwatersrand.
Corporate Governance for South African Mining Companies (a practitioner's view)James AH Campbell
Corporate Governance for South African Mining Companies (a practitioner's view).
Compliance & Reporting in the Minerals Industry
27th September 2022,
University of the Witwatersrand
The Future of Botswana's Diamond Resources
James AH Campbell
Botswana Resources Infrastructure and Energy Forum ('BRIEF')
Gaborone, Botswana
16-17 May 2022
Volcanoes Presentation with material chiefly drawn from the Geological Society of the UK.
Presented to Reddam House Waterfall learners on 14 March 2022
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
1. The Discovery and Evaluation of
The Discovery and Evaluation of
the AK6 Kimberlite in Botswana
the AK6 Kimberlite in Botswana
Alex van Zyl
8 September 2006
3. 3
Agenda
Agenda
‹ AK06 kimberlite discovered by DB
in 1969 following geophysical
surveys
‹ Considered low interest
● ~3 cpht
● ~3.3 ha
● Moderate chemistry
6. 6
Exploration History
Exploration History
‹ From 1998 area revisited due to improved
exploration technologies
‹ Debot held AK6 under PL13/2000
‹ The Boteti JV agreement 2004, included 29
kimberlites
‹ Geophysics defines size of AK6 from 3.3ha to
c.9.5ha
‹ 2003/4: Bulk sampling with 12” LDD across
kimberlite to test for macro-diamonds: modeled
global grade 25cpht, modeled value of $138/ct
(1mm bottom cut-off).
‹ 2004/5: 6.5-inch Percussion drilling (44 holes,
6376m) to delineate surface outline.
‹ Results have led to current advanced
exploration phase of work
7. 7
Boteti Exploration Joint Venture
(AK6 Kimberlite)
• De Beers Botswana 51%
• AFD 49%
• De Beers is the Operator - 70% with
bankable feasibility study
Preliminary results from early stage
exploration
• Surface Area 9.5 hectares; modeled
grade 25 cpht
• Tonnage 40Mt (to 400m); total carats
10 Mcts (deposit / low inferred
classification)
Background
Background
N
8. 8
‹ Objective
‹ Evaluate AK06 kimberlite in
order to deliver a high
confidence “indicated” mineral
resource
‹ Contribute towards delivering a
bankable pre-feasibility study
for AK06
Advanced Exploration Programme
Advanced Exploration Programme
9. 9
Scope
‹ Delineation and Pilot Core Drilling
‹ 23-inch (584mm) Large Diameter (LDD)
Sampling to 400m
‹ On-site DMS Sample Processing
‹ Diamond Recovery at
● GEMDL
● MiDA in Kimberley
‹ Geological (core & chips) Logging
‹ On-site data management
‹ Geological Modeling and 3D Volume
generation
‹ Resource Estimation & Classification
Advanced Exploration Programme
Advanced Exploration Programme
11. 11
Update
Update -
- Phase 1 Delineation & Pilot Core Drilling
Phase 1 Delineation & Pilot Core Drilling
‹ Delineation and Pilot Core Drilling
commenced in February 2005
‹ Recovered core is used for detailed
geological logging, petrography for kimberlite
classification and modeling, Ore Dressing
Studies, microdiamond assessment and for
rock density measurements
‹ Delineation and pilot core drilling activities
were completed in October 2005. Kimberlite
larger at depth.
Scope Holes Actual
Metres drilled
Delineation
core
15 6594
Pilot core 13 3278
500m
Preliminary geological model
(Pyroclastic & Magmatic kimberlite present)
12. 12
Update
Update -
- Phase 1 LDD Drilling
Phase 1 LDD Drilling
‹ Commenced end July 2005,
contracted-out to De Wet Drilling using
the ‘Elephant 2’ rig
‹ 13 LDD holes to maximum 400m
completed 10 February 2006.
‹ All holes calipered
‹ Concentrate yield in the south lobe
higher than anticipated
‹ LDD programme completed June 2006
14. 14
Update
Update –
– Phase 1 Sample Processing
Phase 1 Sample Processing
‹ On-site DMS 10tph plant
‹ Samples delivered to plant on daily basis
‹ Metallurgical and plant utilisation statistics
collected daily
‹ Constant security monitoring & recording
cameras
‹ % concentrate yields based on current DMS
results
• Up to 15% in south lobe due to dense nature of
kimberlite (one of the highest known kimberlite densities)
• Approx 1% in north lobe
‹ Monthly delivery of concentrate to the Group
Exploration Macrodiamond Laboratory for final
diamond recovery. Shipments escorted by
Debswana security, Botswana Police and De
Beers Security (RSA)
‹ Final sieving, weighing & valuation at Harry
Oppenheimer House in Kimberley. Diamond
layout and return diamonds to Botswana
Diamond Valuing Company, Gaborone
15. 15
Summary of Phase 1 Results
Summary of Phase 1 Results
‹ Drilling from July 2005 to February 2006
‹ Macro-diamond results issued for all 13 LDD holes.
‹ A total of 10,485 diamonds weighing 726 carats, un-
acidised (vs. planned 500 carats) recovered from 2744
tonnes (calculated from callipered volume and
measured rock density) of in situ sample from 13 LDD
holes)
‹ Diamond layout on 7 July 2006
● North/Centre lobes = $170/carat
● South lobe = $125/carat
● $150/carat vs. previous modeled $138/carat
North and Central Lobes are sufficiently similar to
combine them for valuation purposes.
16. 16
Update
Update -
- SHE
SHE
‹ Safety
● Project LTIFR of zero
● 1 non-LTI to date: drill contractor helper fell
from 1m height (without harness)
● Calf from nearby cattle-post trapped in
unbarricaded sump, later died. Owner
compensated amicably.
‹ Environment
● Environmental and Social scan of Orapa
area completed
ƒ Impact of Debot activities to communities
and environment
ƒ Impact of current AK6 activities to
environment and communities
ƒ Impact of potential future AK6 mine to
environment and communities
17. 17
Update
Update –
– Conceptual Engineering Design
Conceptual Engineering Design
‹ A multi-disciplinary team is in the process of providing a framework for a
Conceptual Engineering Study report
‹ Preliminary conceptual mine and plant designs have been drafted
‹ A draft economic model has been compiled and will be populated once the
revenue and grade models are available
‹ The Conceptual Study Report will be available after the completion of
Phase 1 of Advanced Exploration (Q4 2006)
SHALE
SHALE
SHALE
SHALE
18. 18
Plant Designs
‹ Plant Design Studies
‹ Various block flow diagrams are currently
being considered
‹ Conventional block flow diagram -
baseline design
‹ ‘Voorspoed’ type design with High
Pressure Rolls Crusher in a secondary
application
‹ ‘Canadian’type block flow diagram
(Tahera etc)
‹ Application of autogenous Milling
‹ Capital and operating costing in progress
‹ Option for processing at Letlhakane still
to be considered
19. 19
Mine Planning
‹ Mine Planning
‹ Letlhakane Mine slope angles
assumed for conceptual study
‹ Geotechnical & hydro-
geological modeling planned
‹ Conventional shovel truck
method. Diesel powered fleet
‹ The mine will operate 353
days per year under a Contops
environment.
‹ Host rock mined from the
upper benches of the pit will
be used during construction.
20. 20
Mineral Resource Estimation & Classification
‹ Resource classified at a ‘High Inferred' level
‹ Phase 2 ‘pre-qualification’score: ‘High Indicated’
‹ Resource inventory to 400m:
● 11.6M carats
● 48.5M tons
● Average grade: 24cpht (+1.0mm)
‹ Diamond value estimate still a risk
‹ Conceptual Study to follow