This document discusses key challenges facing business leaders and how design can help address them. It summarizes the findings of a PwC survey that found the top concerns of CEOs are innovation, human capital, digital capabilities, competitive advantage, and customer experience. It then discusses each of these areas in more detail, focusing on innovation approaches like blue ocean strategy, disruptive innovation, and open innovation. It also covers human capital concepts from thinkers like Chris Argyris, Ikujiro Nonaka, and Henry Mintzberg. For digital capabilities, it emphasizes the importance of technological expertise. The document argues that addressing these challenges with design thinking can help companies capitalize on new opportunities.