This document provides a summary of the 2016-2020 Comprehensive Economic Development Strategy (CEDS) developed by Tanana Chiefs Conference (TCC) to identify ways to strengthen the regional economy in Interior Alaska. Key outcomes of the CEDS include analyzing the region's strengths, weaknesses, opportunities and threats through a SWOT analysis. Five goals and related objectives are identified to guide economic development, including promoting healthy communities, strengthening businesses and workforce development, improving infrastructure, expanding housing, and managing natural resources. Priority strategies are outlined such as pursuing self-governance, assessing traditional practices, expanding collaboration and education/training opportunities, improving energy efficiency, and increasing affordable housing. The development process included regional surveys, interviews, and input from