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Tuberculosis and Culture
The Silent Killer
Portrait by Richard Tennant Cooper
Introduction
Where did Tuberculosis
come from?
 Latest findings; Dr Granville’s
Mummy and/or Seals
Image: The Trustees
of the British Museum
Photo by Ricardo Bastida
Tuberculosis The
Disease
Etiologic Agent
 Mycobacterium Tuberculosis
 Pestilence
 Active vs latent (not
contagious)
Picture of Pestilence
Mycobacterium tuberculosis culture shows
the bacteria's colonial morphology.
Credit: George Kubica/CDC
Mycobacterium tuberculosis
bacteria, which cause tuberculosis.
Introduction
Where did Tuberculosis come from?
 Evolved from domestic cattle and
beaver? - M bovis
 Pasteurization of milk
Photograph: Natural Visions/Alamy
1822-1895, Invented Pasteurization
Photograph: biography.com
Introduction
Where did Tuberculosis
come from?
How TB Conquered the
World
TB bacteria accompanied people out of Africa about 50,000 years
ago (top). These strains then spread around the world as people
colonized Asia and the Americas (bottom).
Courtesy of Sebastien Gagneux
Tuberculosis The Disease
How TB Spreads
• Portal of entry-cough, sneeze, sing,
spit
• Infectious aerosol droplets
TB Spread by Sneezing
Courtesy of CDC
How TB Does
NOT Spread
Toilet Seats
Kissing
Shaking hands
Hugging
Sign Image Courtesy of
thecountryfurniturestore.co.uk
Tuberculosis The Disease
Types of TB
Pulmonary-80-85%
Extrapulmonary-15-20%
Scrofula. Source: National Library of Medicine
Photo Source: National Library of Medicine
Tuberculosis The Disease
Schiffman G (15 January 2009). "Tuberculosis Symptoms".
eMedicineHealth.
Tuberculosis The Disease
 Hippocrates 460-375 BC
-Phthisis meaning ‘to waste’
-Caused by evil air-not contagious
 Aristotle 384-322 BC
-Might be contagious due to bad,
heavy breathe
 Galen 129-216 AD
-Phthisis had been accepted, no
contagious agent could be found
-Defined it further
Aristotle Bust Image: Brittanica.com
Hippocrates Bust Image: Brittanica.com
Galen Image: Brittanica.com
How Tuberculosis Affects Culture
Etching by Pierre Firens extracted from the work of André du Laurens,
A. Laurentis of strumis earum causis and curiae (Paris, 1609). Henry is
shown touching scrofula (former French escrouelles), exercising its
power of thaumaturgy, v
Images from
sciencemuseum.org.uk
 Royal Touch
 1200’s to
1700’s (ending
with Queen Anne)
 Gold Angel
 Scrofula
How Tuberculosis Affects Culture
 Eleanora of Toledo-First
Modern Woman
 Securing the Medici
Dynasty
 1500’s
Agnolo Bronzino, Portrait of Eleonora of
Toledo, 1560 (Gemäldegalerie, Berlin)
Agnolo Bronzino, Portrait of Eleonora di
Toledo with her son Giovanni, 1544-1545
(Gemäldegalerie, Berlin)
How Tuberculosis Affects Culture
Industrial Revolution
‘Hell on Earth”
photocredit:ScienceMuseum/Science&SocietyPictureLibrary
How Tuberculosis Affects Culture
All Photos on this slide Courtesy of ensmuseum.org
1816 - Dr Laennec invents the
stethoscope
How Tuberculosis Affects Culture
“I have lov’d the principle of
beauty in all things,and if I had had
time I would have made myself
remembered,”
John Keats wrote to Fanny Brawne
in February, 1820, just after he
became ill with Tuberculosis.
John Keats Image: FamousAuthors.org
Fanny Brawne. Portrait photomechanical
print of a miniature, undated. MS Keats 10
(503). Gift of Arthur A. Houghton, Jr., 1940.
How Tuberculosis Affects Culture
1833 Factory Act
ChildLaborinFactories
Imagesfromwww.paigntononline.com
HandbookexplainingFactoryActs
Imagefromcalderdale.gov.uk
Ophelia, William
Shakespeare
character in Hamlet
Elizabeth Siddal (1829-
1862)
John Everett Millais
-artist
How Tuberculosis Affects Culture
Ophelia portrait by John Everett Millais (1851-52) at Tate,
London
Kathleen Newton
James Tissot the Artist
How Tuberculosis Affects Culture
Alll Photos Courtesy of jamestissot.org
How Tuberculosis Affects Culture
• Dr Edward Livingston Trudeau
• First US Sanitoria, 1894
• ‘The Magic Mountain’ by Thomas
Mann
DOCTORSATTRUDEAUINSTITUTE,1942
ImagefromADKMuseum.org
Image from TrudeauInstitute.org
How Tuberculosis Affects Culture
Sanitoriums
Photos by Lisa Beuning
The Firland Tuberculosis
Sanatorium
Walter Henry
Administration Building,
now the Martin Center,
was built in 1913
Paimio Sanitorium:
commons.wikimedia.org
How Tuberculosis Affects Culture
Edward Munch
The Sick Child
EdvardMunchTheSickChild1907,TATEMuseum
La Misery 1886
Christobal Riojas
Died of TB, age 32
How Tuberculosis Affects Culture
La miseria (1886).Cristobal Rojas - Obra de arte, Pintura de Cristóbal
Rojas (1857–1890) Galería de Arte Nacional, Caracas- Venezuela
Wilhelm Conrad Rontgen(1845-1923)
First W-Ray Machine
How Tuberculosis Affects Culture
Images: nobelprize.org
How Tuberculosis Affects Culture
 Robert Koch 1843-1910
 Attributed for discovery of
TB causing agent
 Nobel Prize in 1905
Photos on this slide Courtesy of
historyofvaccines.org
Tuberculosis The Disease
Prevention
Image from calderdale.gov.uk
Tuberculosis The Disease
TB Harlem1940
Collapsing of the Lung
AliceNeel,T.B.Harlem,1940;;NationalWomenoftheArts
How Tuberculosis Affects Culture
Movies
MoulinRougeimagecopied
fromIMDb.com
RENT image from
playbillvault.com
imagefromtheorwellprize.co.uk
imagefromlesmis.com
AnnaKareninaimagecopied
fromIMDb.com
Camilleimage
fromfineartamerica.com
Images from
IMDb.com
How Tuberculosis Affects Culture
Summary
Summary
Graph Image:westonaprice.org
Summary
Consumption Poem by William Cullen Bryant (1794-1878)
Ay, thou art for the grave; thy glances shine
Too brightly to shine long; another Spring
Shall deck her for men's eyes---but not for thine---
Sealed in a sleep which knows no wakening.
The fields for thee have no medicinal leaf,
And the vexed ore no mineral of power;
And they who love thee wait in anxious grief
Till the slow plague shall bring the final hour.
Glide softly to thy rest then; Death should come
Gently, to one of gentle mould like thee,
As light winds wandering through groves of bloom
Detach the delicate blossom from the tree.
Close thy sweet eyes, calmly, and without pain;
And we will trust in God to see thee yet again.
Summary
To Learn More…
Read the books-
Spitting Blood: The History of Tuberculosis by Helen Bynum
Fevered Lives: Tuberculosis in American Culture since 1870 by Katherine Ott
The Jungle by Upton Sinclair
Or Link to –
www.Nature.com

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Tb & culture (3)

  • 1. Tuberculosis and Culture The Silent Killer Portrait by Richard Tennant Cooper
  • 2. Introduction Where did Tuberculosis come from?  Latest findings; Dr Granville’s Mummy and/or Seals Image: The Trustees of the British Museum Photo by Ricardo Bastida
  • 3. Tuberculosis The Disease Etiologic Agent  Mycobacterium Tuberculosis  Pestilence  Active vs latent (not contagious) Picture of Pestilence Mycobacterium tuberculosis culture shows the bacteria's colonial morphology. Credit: George Kubica/CDC Mycobacterium tuberculosis bacteria, which cause tuberculosis.
  • 4. Introduction Where did Tuberculosis come from?  Evolved from domestic cattle and beaver? - M bovis  Pasteurization of milk Photograph: Natural Visions/Alamy 1822-1895, Invented Pasteurization Photograph: biography.com
  • 5. Introduction Where did Tuberculosis come from? How TB Conquered the World TB bacteria accompanied people out of Africa about 50,000 years ago (top). These strains then spread around the world as people colonized Asia and the Americas (bottom). Courtesy of Sebastien Gagneux
  • 6. Tuberculosis The Disease How TB Spreads • Portal of entry-cough, sneeze, sing, spit • Infectious aerosol droplets TB Spread by Sneezing Courtesy of CDC How TB Does NOT Spread Toilet Seats Kissing Shaking hands Hugging Sign Image Courtesy of thecountryfurniturestore.co.uk
  • 7. Tuberculosis The Disease Types of TB Pulmonary-80-85% Extrapulmonary-15-20% Scrofula. Source: National Library of Medicine Photo Source: National Library of Medicine
  • 8. Tuberculosis The Disease Schiffman G (15 January 2009). "Tuberculosis Symptoms". eMedicineHealth.
  • 9. Tuberculosis The Disease  Hippocrates 460-375 BC -Phthisis meaning ‘to waste’ -Caused by evil air-not contagious  Aristotle 384-322 BC -Might be contagious due to bad, heavy breathe  Galen 129-216 AD -Phthisis had been accepted, no contagious agent could be found -Defined it further Aristotle Bust Image: Brittanica.com Hippocrates Bust Image: Brittanica.com Galen Image: Brittanica.com
  • 10. How Tuberculosis Affects Culture Etching by Pierre Firens extracted from the work of André du Laurens, A. Laurentis of strumis earum causis and curiae (Paris, 1609). Henry is shown touching scrofula (former French escrouelles), exercising its power of thaumaturgy, v Images from sciencemuseum.org.uk  Royal Touch  1200’s to 1700’s (ending with Queen Anne)  Gold Angel  Scrofula
  • 11. How Tuberculosis Affects Culture  Eleanora of Toledo-First Modern Woman  Securing the Medici Dynasty  1500’s Agnolo Bronzino, Portrait of Eleonora of Toledo, 1560 (Gemäldegalerie, Berlin) Agnolo Bronzino, Portrait of Eleonora di Toledo with her son Giovanni, 1544-1545 (Gemäldegalerie, Berlin)
  • 12. How Tuberculosis Affects Culture Industrial Revolution ‘Hell on Earth” photocredit:ScienceMuseum/Science&SocietyPictureLibrary
  • 13. How Tuberculosis Affects Culture All Photos on this slide Courtesy of ensmuseum.org 1816 - Dr Laennec invents the stethoscope
  • 14. How Tuberculosis Affects Culture “I have lov’d the principle of beauty in all things,and if I had had time I would have made myself remembered,” John Keats wrote to Fanny Brawne in February, 1820, just after he became ill with Tuberculosis. John Keats Image: FamousAuthors.org Fanny Brawne. Portrait photomechanical print of a miniature, undated. MS Keats 10 (503). Gift of Arthur A. Houghton, Jr., 1940.
  • 15. How Tuberculosis Affects Culture 1833 Factory Act ChildLaborinFactories Imagesfromwww.paigntononline.com HandbookexplainingFactoryActs Imagefromcalderdale.gov.uk
  • 16. Ophelia, William Shakespeare character in Hamlet Elizabeth Siddal (1829- 1862) John Everett Millais -artist How Tuberculosis Affects Culture Ophelia portrait by John Everett Millais (1851-52) at Tate, London
  • 17. Kathleen Newton James Tissot the Artist How Tuberculosis Affects Culture Alll Photos Courtesy of jamestissot.org
  • 18. How Tuberculosis Affects Culture • Dr Edward Livingston Trudeau • First US Sanitoria, 1894 • ‘The Magic Mountain’ by Thomas Mann DOCTORSATTRUDEAUINSTITUTE,1942 ImagefromADKMuseum.org Image from TrudeauInstitute.org
  • 19. How Tuberculosis Affects Culture Sanitoriums Photos by Lisa Beuning The Firland Tuberculosis Sanatorium Walter Henry Administration Building, now the Martin Center, was built in 1913 Paimio Sanitorium: commons.wikimedia.org
  • 20. How Tuberculosis Affects Culture Edward Munch The Sick Child EdvardMunchTheSickChild1907,TATEMuseum
  • 21. La Misery 1886 Christobal Riojas Died of TB, age 32 How Tuberculosis Affects Culture La miseria (1886).Cristobal Rojas - Obra de arte, Pintura de Cristóbal Rojas (1857–1890) Galería de Arte Nacional, Caracas- Venezuela
  • 22. Wilhelm Conrad Rontgen(1845-1923) First W-Ray Machine How Tuberculosis Affects Culture Images: nobelprize.org
  • 23. How Tuberculosis Affects Culture  Robert Koch 1843-1910  Attributed for discovery of TB causing agent  Nobel Prize in 1905 Photos on this slide Courtesy of historyofvaccines.org
  • 25. Tuberculosis The Disease TB Harlem1940 Collapsing of the Lung AliceNeel,T.B.Harlem,1940;;NationalWomenoftheArts
  • 26. How Tuberculosis Affects Culture Movies MoulinRougeimagecopied fromIMDb.com RENT image from playbillvault.com imagefromtheorwellprize.co.uk imagefromlesmis.com AnnaKareninaimagecopied fromIMDb.com Camilleimage fromfineartamerica.com Images from IMDb.com
  • 30. Summary Consumption Poem by William Cullen Bryant (1794-1878) Ay, thou art for the grave; thy glances shine Too brightly to shine long; another Spring Shall deck her for men's eyes---but not for thine--- Sealed in a sleep which knows no wakening. The fields for thee have no medicinal leaf, And the vexed ore no mineral of power; And they who love thee wait in anxious grief Till the slow plague shall bring the final hour. Glide softly to thy rest then; Death should come Gently, to one of gentle mould like thee, As light winds wandering through groves of bloom Detach the delicate blossom from the tree. Close thy sweet eyes, calmly, and without pain; And we will trust in God to see thee yet again.
  • 31. Summary To Learn More… Read the books- Spitting Blood: The History of Tuberculosis by Helen Bynum Fevered Lives: Tuberculosis in American Culture since 1870 by Katherine Ott The Jungle by Upton Sinclair Or Link to – www.Nature.com

Editor's Notes

  1. ‘The Silent Killer’ or ‘Plague in Disguise’ because it’s an insidious disease-slow to develop. Also known at ‘White Plague’ due to the color of the skin (pale and emaciated) which at one time was thought a desired look. Black Plague raged for one year killing 50 thousand-Consumption, or TB, went on for centuries(1800’s – 1900”s) killing one million in Europe (early 1900’s) Untreated, TB has a fatality rate of 40%-60% What is this disease that was killing the young, the beautiful, the intelligent, by the thousands? And the poor and the working class by the millions? As quoted in Shakespeare’s play titled ‘Macbeth’- tis called ‘The Evil’
  2. Dr Granville’s Mummy – originally dissected in 1825 by gynecologist (Granville), The earliest known Egyptian mummy As recent as October of thes year, pinnipeds, or seals, were found to be the first carrier of TB to the New World.
  3. Pestilence defined-a fatal epidemic disease, especially bubonic plague. Microbacteria=microbes that cause TB, grow slowly (months to years) Latent TB can turn in to TB disease after weeks or years. No symptoms, non-contagious. Tubercles are small knots and modules that evolve to lung ulcers.
  4. TB was around before humankind 1999-M bovis strain found in bone tissue of a 17,000 year old bison proving the disease was around in prehistoric America before TB showed up in humans.
  5. TB typically infects the lungs but it may affect the bones, brain, kidneys, and other organs. Lymph nodes on neck are affected-swollen. Deformation of the spine called Pott’s disease after Sir Percival Pott, who described the condition in 1779.
  6. Coughing up blood, persistent cough, pain in chest, fever cold sweats, loss of appetite, fatigue.