This document discusses the history and impact of tuberculosis. It traces TB back to ancient times and describes how it spread throughout the world. Key details include how TB is caused by the Mycobacterium tuberculosis bacteria and spreads through the air. The document also explores how TB influenced culture through practices like the royal touch to cure scrofula, depictions in art and literature, and the development of sanatoriums in the late 19th century as a result of overcrowded cities from the Industrial Revolution. In summary, the document provides a comprehensive overview of tuberculosis from a medical and cultural perspective over centuries.
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
Do Not Forget To Visit Our Pages On Facebook on the following Links:
https://www.facebook.com/groups/569435236444761/
AND
https://www.facebook.com/groups/690331650977113/
The Most Deadly Pandemic Threaten the World by Dr. Mohamed Labib SalemProfMohamedLabibSale
The Most Deadly Pandemic Threaten the World
Dr. Mohamed Labib Salem, PhD
Prof. of Immunology, Faculty of Science
Director, Center of Excellence in Cancer Research, Tanta University, Egypt
بدعوة كريمة من: مجموعة العلم والمجتمع أحد مجموعات أكاديمية الشباب المصري – أكاديمية البحث العلمي والتكنولوجيا
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
Do Not Forget To Visit Our Pages On Facebook on the following Links:
https://www.facebook.com/groups/569435236444761/
AND
https://www.facebook.com/groups/690331650977113/
The Most Deadly Pandemic Threaten the World by Dr. Mohamed Labib SalemProfMohamedLabibSale
The Most Deadly Pandemic Threaten the World
Dr. Mohamed Labib Salem, PhD
Prof. of Immunology, Faculty of Science
Director, Center of Excellence in Cancer Research, Tanta University, Egypt
بدعوة كريمة من: مجموعة العلم والمجتمع أحد مجموعات أكاديمية الشباب المصري – أكاديمية البحث العلمي والتكنولوجيا
2. Introduction
Where did Tuberculosis
come from?
Latest findings; Dr Granville’s
Mummy and/or Seals
Image: The Trustees
of the British Museum
Photo by Ricardo Bastida
3. Tuberculosis The
Disease
Etiologic Agent
Mycobacterium Tuberculosis
Pestilence
Active vs latent (not
contagious)
Picture of Pestilence
Mycobacterium tuberculosis culture shows
the bacteria's colonial morphology.
Credit: George Kubica/CDC
Mycobacterium tuberculosis
bacteria, which cause tuberculosis.
4. Introduction
Where did Tuberculosis come from?
Evolved from domestic cattle and
beaver? - M bovis
Pasteurization of milk
Photograph: Natural Visions/Alamy
1822-1895, Invented Pasteurization
Photograph: biography.com
5. Introduction
Where did Tuberculosis
come from?
How TB Conquered the
World
TB bacteria accompanied people out of Africa about 50,000 years
ago (top). These strains then spread around the world as people
colonized Asia and the Americas (bottom).
Courtesy of Sebastien Gagneux
6. Tuberculosis The Disease
How TB Spreads
• Portal of entry-cough, sneeze, sing,
spit
• Infectious aerosol droplets
TB Spread by Sneezing
Courtesy of CDC
How TB Does
NOT Spread
Toilet Seats
Kissing
Shaking hands
Hugging
Sign Image Courtesy of
thecountryfurniturestore.co.uk
7. Tuberculosis The Disease
Types of TB
Pulmonary-80-85%
Extrapulmonary-15-20%
Scrofula. Source: National Library of Medicine
Photo Source: National Library of Medicine
9. Tuberculosis The Disease
Hippocrates 460-375 BC
-Phthisis meaning ‘to waste’
-Caused by evil air-not contagious
Aristotle 384-322 BC
-Might be contagious due to bad,
heavy breathe
Galen 129-216 AD
-Phthisis had been accepted, no
contagious agent could be found
-Defined it further
Aristotle Bust Image: Brittanica.com
Hippocrates Bust Image: Brittanica.com
Galen Image: Brittanica.com
10. How Tuberculosis Affects Culture
Etching by Pierre Firens extracted from the work of André du Laurens,
A. Laurentis of strumis earum causis and curiae (Paris, 1609). Henry is
shown touching scrofula (former French escrouelles), exercising its
power of thaumaturgy, v
Images from
sciencemuseum.org.uk
Royal Touch
1200’s to
1700’s (ending
with Queen Anne)
Gold Angel
Scrofula
11. How Tuberculosis Affects Culture
Eleanora of Toledo-First
Modern Woman
Securing the Medici
Dynasty
1500’s
Agnolo Bronzino, Portrait of Eleonora of
Toledo, 1560 (Gemäldegalerie, Berlin)
Agnolo Bronzino, Portrait of Eleonora di
Toledo with her son Giovanni, 1544-1545
(Gemäldegalerie, Berlin)
12. How Tuberculosis Affects Culture
Industrial Revolution
‘Hell on Earth”
photocredit:ScienceMuseum/Science&SocietyPictureLibrary
13. How Tuberculosis Affects Culture
All Photos on this slide Courtesy of ensmuseum.org
1816 - Dr Laennec invents the
stethoscope
14. How Tuberculosis Affects Culture
“I have lov’d the principle of
beauty in all things,and if I had had
time I would have made myself
remembered,”
John Keats wrote to Fanny Brawne
in February, 1820, just after he
became ill with Tuberculosis.
John Keats Image: FamousAuthors.org
Fanny Brawne. Portrait photomechanical
print of a miniature, undated. MS Keats 10
(503). Gift of Arthur A. Houghton, Jr., 1940.
16. Ophelia, William
Shakespeare
character in Hamlet
Elizabeth Siddal (1829-
1862)
John Everett Millais
-artist
How Tuberculosis Affects Culture
Ophelia portrait by John Everett Millais (1851-52) at Tate,
London
17. Kathleen Newton
James Tissot the Artist
How Tuberculosis Affects Culture
Alll Photos Courtesy of jamestissot.org
18. How Tuberculosis Affects Culture
• Dr Edward Livingston Trudeau
• First US Sanitoria, 1894
• ‘The Magic Mountain’ by Thomas
Mann
DOCTORSATTRUDEAUINSTITUTE,1942
ImagefromADKMuseum.org
Image from TrudeauInstitute.org
19. How Tuberculosis Affects Culture
Sanitoriums
Photos by Lisa Beuning
The Firland Tuberculosis
Sanatorium
Walter Henry
Administration Building,
now the Martin Center,
was built in 1913
Paimio Sanitorium:
commons.wikimedia.org
20. How Tuberculosis Affects Culture
Edward Munch
The Sick Child
EdvardMunchTheSickChild1907,TATEMuseum
21. La Misery 1886
Christobal Riojas
Died of TB, age 32
How Tuberculosis Affects Culture
La miseria (1886).Cristobal Rojas - Obra de arte, Pintura de Cristóbal
Rojas (1857–1890) Galería de Arte Nacional, Caracas- Venezuela
23. How Tuberculosis Affects Culture
Robert Koch 1843-1910
Attributed for discovery of
TB causing agent
Nobel Prize in 1905
Photos on this slide Courtesy of
historyofvaccines.org
30. Summary
Consumption Poem by William Cullen Bryant (1794-1878)
Ay, thou art for the grave; thy glances shine
Too brightly to shine long; another Spring
Shall deck her for men's eyes---but not for thine---
Sealed in a sleep which knows no wakening.
The fields for thee have no medicinal leaf,
And the vexed ore no mineral of power;
And they who love thee wait in anxious grief
Till the slow plague shall bring the final hour.
Glide softly to thy rest then; Death should come
Gently, to one of gentle mould like thee,
As light winds wandering through groves of bloom
Detach the delicate blossom from the tree.
Close thy sweet eyes, calmly, and without pain;
And we will trust in God to see thee yet again.
31. Summary
To Learn More…
Read the books-
Spitting Blood: The History of Tuberculosis by Helen Bynum
Fevered Lives: Tuberculosis in American Culture since 1870 by Katherine Ott
The Jungle by Upton Sinclair
Or Link to –
www.Nature.com
Editor's Notes
‘The Silent Killer’ or ‘Plague in Disguise’ because it’s an insidious disease-slow to develop.
Also known at ‘White Plague’ due to the color of the skin (pale and emaciated) which at one time was thought a desired look.
Black Plague raged for one year killing 50 thousand-Consumption, or TB, went on for centuries(1800’s – 1900”s) killing one million in Europe (early 1900’s)
Untreated, TB has a fatality rate of 40%-60%
What is this disease that was killing the young, the beautiful, the intelligent, by the thousands? And the poor and the working class by the millions?
As quoted in Shakespeare’s play titled ‘Macbeth’- tis called ‘The Evil’
Dr Granville’s Mummy – originally dissected in 1825 by gynecologist (Granville), The earliest known Egyptian mummy
As recent as October of thes year, pinnipeds, or seals, were found to be the first carrier of TB to the New World.
Pestilence defined-a fatal epidemic disease, especially bubonic plague.
Microbacteria=microbes that cause TB, grow slowly (months to years)
Latent TB can turn in to TB disease after weeks or years. No symptoms, non-contagious.
Tubercles are small knots and modules that evolve to lung ulcers.
TB was around before humankind
1999-M bovis strain found in bone tissue of a 17,000 year old bison proving the disease was around in prehistoric America before TB showed up in humans.
TB typically infects the lungs but it may affect the bones, brain, kidneys, and other organs.
Lymph nodes on neck are affected-swollen.
Deformation of the spine called Pott’s disease after Sir Percival Pott, who described the condition in 1779.
Coughing up blood, persistent cough, pain in chest, fever cold sweats, loss of appetite, fatigue.