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Summary presentation of beta lactam antibiotic penicillin
- 1. WIDE SPECTRUM ANTIBIOTIC PENICILLIN BY SUYIMSENLA LEMTUR PHARM D 3RD YEAR
- 2. WHAT IS PENICILLIN DRUG? Penicillin are a group of beta-lactam drugs that mainly works by inhibiting the synthesis of bacterial cell wall . They were the first antibiotics discovered by Alexander fleming in 1928 They are taken from the fungus PENICILLIN NOTATUM
- 3. NATURAL PENICILLINS PENICILLIN V PENICILLIN G ANTISTAPHYLOCOCCAL PENICILLIN METHICILLIN CLOXACILLIN OXACILLIN NAFCILLIN EXTENDED SPECTRUM PENICILLIN AMINO PENICILLIN AMPLICILLIN AMOXICILLIN CARBOXYPENICILLIN CARBENCILLIN TICARCILLIN UREIDOPENICLLINP PIPERACILLIN MEZLOCILLIN AZLOCILLIN Instruments Equipment Protection and security CLASSIFICATION OF PENICILLIN:
- 4. Beta-lactam antibiotics like Peniclllin works by interfering with the synthesis of cell wall Bacterial cell is composed of peptidoglycan containing NAM and NAG which makes the bacteria cell wall rigid The synthesis of the bacterial cell wall is completed by a enzyme called Transpeptidase for cross linking of NAM and NAG Penicillin anitibiotics inhibits the Transpeptidase so that cross linking does not occur by binding to PENICILLIN-BINDING PROTEIN Synthesis action takes place Bacteria cell lysis NAM=N-Acetyl muramic acid NAG=N-Acetyl glucosamime MECHANISM OF ACTION:
- 6. BACTERIA DEVELOP RESISTANCE DUE TO THE DECREASED ABILITY OF THE DRUG TO PENETRATE THE SIDE OF ACTION BACTERIA DEVELOP RESISTANCE DUE TO ALTERED PENICILLIN BINDING PROTEIN MAKING IT LESS AFFINITY FOR BETA LACTAMS BACTERIA DEVELOP RESISTANCE BECAUSE IT PRODUCES BETA- LACTAMASES WHICH DESTROYS BETA- LACTAM RINGS DRUG RESISTANCE TO PENICILLIN:
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