This document summarizes research on physical activity programs for promoting weight loss in obese adults with intellectual and developmental disabilities. It reviewed 8 studies that tested interventions combining nutrition education and exercise programs. The interventions showed some success in short-term weight loss but long-term effectiveness was unclear since most studies lacked follow-up data. Only 1 study directly tested for weight loss effects and found diminishing returns over 6 years. Overall, more research is still needed to identify interventions that can sustainably promote weight loss in this population.