This document outlines strategies for ensuring the long-term sustainability of university-based Medical Laboratory Sciences (MLS) programs in light of threats posed by the COVID-19 pandemic and economic challenges. It discusses how meeting the objectives of key stakeholders like university administrators, students, clinical affiliates, and faculty is critical. Suggested tactics include maintaining enrollment goals, promoting the program to similar majors, expanding clinical sites, creatively revising curriculum, and remaining flexible. The overall goal is for MLS programs to adapt effectively in pandemic times and beyond by satisfying stakeholder needs.