Starty comics “Starty explains START”.
In order to better address the targets of our communication about the approach and goals of our project, we have made our comics (Starty explains START) author J. Mascarenhas (LNEG).
PharmaLedger – The collaboration Platform (1st Iteration Report)PharmaLedger
The purpose of this delivery report is to describe the first iteration development of the Collaboration Platform, based on the Dynamic Knowledge Management (DKM) platform, customized as the engagement platform of the PharmaLedger project.
The requirements and customization activities performed in this task are linked with WP6, Task 6.2, Engagement through the collaboration platform. An iterative development process to ensure a goal-oriented development process aligned with users’ needs and requirements. The implementation of the GDPR is linked to WP5, delivery 5.1: PharmaLedger Ethical and Legal Inventory.
This deliverable summarises the development performed in Task 2.5 (WP2), which aim at customizing and building the Collaboration Platform meeting targeted users’ needs.
The results of this deliverable, WP2, Task 2.5, is a functional customized alpha version of the Collaboration Platform, iteration I. The alpha version of the Collaboration Platform, iteration I, includes setting up the overall infrastructure, UX improvements ensuring of responsive user experience, development of FEED containing user posts, capability to host iframes in pages (additional page-elements) and 3rd party JSON sources display, documented API layer, and working with MongoDB on the cloud. We are also developing user privacy and the right to erasure, as defined by the GDPR.
We plan to launch this version of the Collaboration Platform in M18 and engage patients, HCP groups and content managed by EFGCP/EPF. Also, this version will support working groups related to the PharmaLedger Project, subject to NDAs. We elaborated the user engagement in delivery 6.4: Healthcare industry digitization & engagement guidelines through collaboration platform.
PharmaLedger – Dissemination and In-Project Exploitation PlanPharmaLedger
This document provides an overview of the PharmaLedger dissemination and exploitation strategy, drawn up according to a 36-month plan (January 2020-December 2022), to be reviewed yearly, to ensure the maximum project visibility, transparency, awareness raising on the targeted communities and exploitation of results through the project life cycle.
The PharmaLedger dissemination and exploitation strategy is based on the following principles:
• The objectives of the dissemination and exploitation will support three perspectives, (1) Project Focus, (2) Engagement Focus, and (3) Result-driven Focus.
• Each dissemination pillar will be supported by five components: WHY (ensuring awareness of the project), WHO (target audiences), WHAT (Key messages of project assets), HOW (communication channels) and WHEN (implementation and time planner).
• The dissemination activities will be conceived as knowledge sharing of the eight prioritised use cases in three Domain Reference Applications (DRAs), supporting and raising awareness about all PharmaLedger’s activities and results.
• Establish collaboration with related national, international and EU funded projects and initiatives.
• Publish PharmaLedger results and tools/services related to the blockchain enabled healthcare system in relevant national and international scientific journals addressing the pharmaceuticals, healthcare, and IT communities.
• Organise focused networking events such as workshops etc. However, due to the Covid-19 pandemic physical workshops will be replaced by virtual sessions and webcasts.
• Participate in external events and conferences (virtual during pandemic) in Healthcare, Pharmaceuticals, ICT etc., produce press releases, brochures, and posters.
Independent report on a successful experience of e-prescrining in Andalusia region, Spain. This tool is currently available for all the 8.5 million people living in Andalusia, running in all the 3,500 pharmacies across the region, linking the EHR data with the pharmacist's computers, and saving 15 to 20% of the GP's time. The total amount of net benefits at 2010 exceeds € 60 Million. It is a case of the EHR Impact study commisioned by the DG INFSO and Media of the European Commision
This deliverable presents all the dissemination and communication material produced by the ANDROMEDA consortium within the second period of the project, i.e. September 2020 – July 2021. Particularly, it outlines the material created for the promotion of the first workshop (Sept. 2020) as well as the final one (Jun. 2021) of ANDROMEDA. Also, other materials created within the aforementioned period are described. It should be noted that the material produced within the first period of the project has been reported in deliverable D7.2 Initial Dissemination Materials.
D.7.3 is a public deliverable of this project, part of WP7 and additionally includes information about the project and a short description of WP7 in order to ensure that no prior knowledge related to the project, the DoA and the other WP7 deliverables is requested from the reader. Overall, it is based on, and is consistent with the DoA and the GA, but is not a substitute for reading these documents.
Lastly, it should be mentioned that the project has received a six-month extension of its lifecycle due to the COVID-19 impact on project’s activities and thus the submission date of this deliverable has been altered from M15 (Nov. 2020) as it was foreseen in DoA to M23 (Jul. 2021).
Project's Website: www.andromeda-project.eu
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 833881.
PharmaLedger – The collaboration Platform (1st Iteration Report)PharmaLedger
The purpose of this delivery report is to describe the first iteration development of the Collaboration Platform, based on the Dynamic Knowledge Management (DKM) platform, customized as the engagement platform of the PharmaLedger project.
The requirements and customization activities performed in this task are linked with WP6, Task 6.2, Engagement through the collaboration platform. An iterative development process to ensure a goal-oriented development process aligned with users’ needs and requirements. The implementation of the GDPR is linked to WP5, delivery 5.1: PharmaLedger Ethical and Legal Inventory.
This deliverable summarises the development performed in Task 2.5 (WP2), which aim at customizing and building the Collaboration Platform meeting targeted users’ needs.
The results of this deliverable, WP2, Task 2.5, is a functional customized alpha version of the Collaboration Platform, iteration I. The alpha version of the Collaboration Platform, iteration I, includes setting up the overall infrastructure, UX improvements ensuring of responsive user experience, development of FEED containing user posts, capability to host iframes in pages (additional page-elements) and 3rd party JSON sources display, documented API layer, and working with MongoDB on the cloud. We are also developing user privacy and the right to erasure, as defined by the GDPR.
We plan to launch this version of the Collaboration Platform in M18 and engage patients, HCP groups and content managed by EFGCP/EPF. Also, this version will support working groups related to the PharmaLedger Project, subject to NDAs. We elaborated the user engagement in delivery 6.4: Healthcare industry digitization & engagement guidelines through collaboration platform.
PharmaLedger – Dissemination and In-Project Exploitation PlanPharmaLedger
This document provides an overview of the PharmaLedger dissemination and exploitation strategy, drawn up according to a 36-month plan (January 2020-December 2022), to be reviewed yearly, to ensure the maximum project visibility, transparency, awareness raising on the targeted communities and exploitation of results through the project life cycle.
The PharmaLedger dissemination and exploitation strategy is based on the following principles:
• The objectives of the dissemination and exploitation will support three perspectives, (1) Project Focus, (2) Engagement Focus, and (3) Result-driven Focus.
• Each dissemination pillar will be supported by five components: WHY (ensuring awareness of the project), WHO (target audiences), WHAT (Key messages of project assets), HOW (communication channels) and WHEN (implementation and time planner).
• The dissemination activities will be conceived as knowledge sharing of the eight prioritised use cases in three Domain Reference Applications (DRAs), supporting and raising awareness about all PharmaLedger’s activities and results.
• Establish collaboration with related national, international and EU funded projects and initiatives.
• Publish PharmaLedger results and tools/services related to the blockchain enabled healthcare system in relevant national and international scientific journals addressing the pharmaceuticals, healthcare, and IT communities.
• Organise focused networking events such as workshops etc. However, due to the Covid-19 pandemic physical workshops will be replaced by virtual sessions and webcasts.
• Participate in external events and conferences (virtual during pandemic) in Healthcare, Pharmaceuticals, ICT etc., produce press releases, brochures, and posters.
Independent report on a successful experience of e-prescrining in Andalusia region, Spain. This tool is currently available for all the 8.5 million people living in Andalusia, running in all the 3,500 pharmacies across the region, linking the EHR data with the pharmacist's computers, and saving 15 to 20% of the GP's time. The total amount of net benefits at 2010 exceeds € 60 Million. It is a case of the EHR Impact study commisioned by the DG INFSO and Media of the European Commision
This deliverable presents all the dissemination and communication material produced by the ANDROMEDA consortium within the second period of the project, i.e. September 2020 – July 2021. Particularly, it outlines the material created for the promotion of the first workshop (Sept. 2020) as well as the final one (Jun. 2021) of ANDROMEDA. Also, other materials created within the aforementioned period are described. It should be noted that the material produced within the first period of the project has been reported in deliverable D7.2 Initial Dissemination Materials.
D.7.3 is a public deliverable of this project, part of WP7 and additionally includes information about the project and a short description of WP7 in order to ensure that no prior knowledge related to the project, the DoA and the other WP7 deliverables is requested from the reader. Overall, it is based on, and is consistent with the DoA and the GA, but is not a substitute for reading these documents.
Lastly, it should be mentioned that the project has received a six-month extension of its lifecycle due to the COVID-19 impact on project’s activities and thus the submission date of this deliverable has been altered from M15 (Nov. 2020) as it was foreseen in DoA to M23 (Jul. 2021).
Project's Website: www.andromeda-project.eu
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 833881.
A new study, co-authored by UNU-MERIT, says that Europe outperforms the USA for new start-ups and licence agreements. However, Europe trails the USA for patent applications, licence income and invention disclosures. The European Knowledge Transfer Report 2013 draws on the most geographically diverse survey of knowledge transfer activities in Europe, covering more than 700 organizations in over 30 countries. Researcher Nordine Es-Sadki explains the approach, data and details below. http://www.merit.unu.edu/permalink.php?id=968
This EURELECTRIC report addresses a number of fundamental questions that arise from the integration of distributed generation (DG) and other distributed energy resources (DER) into the energy system:
How can DSOs make the most efficient use of the existing network?
When are new infrastructure and changes in system architecture needed to better
integrate DG and DER?
Which types of system services are needed and how can they be procured?
How can renewable energy sources (RES), DG, and DER contribute to system security?
How should the regulatory framework develop?
Final report National Local service delivery surveyMelody Niwamanya
This national and local service delivery survey was commissioned by the United Nations Development Programme (UNDP) working together with other Development Partners in Lesotho that provide support to the Government’s Deepening Decentralisation Programme (DDP), the European Union (EU) and the United Nations Capital Development Fund (UNCDF). The survey was carried out by Henry H. Kellam III, PhD (FEI), Robert H Muwanga and Melody Niwamanya (EFICON).
The main purpose of the service delivery survey was to provide baseline information about the quality, quantity and accessibility of service delivery in Lesotho. This data is intended to provide a basis for measuring progress as a result of interventions to improve service delivery
EU START PROJECT. START-Newsletter_Issue_4.pdfStart Project
This edition of our Newsletter is a testament to our collective dedication and the exciting progress we’ve achieved.
The completion of our first Periodic Report marks a significant milestone, and the advancements in tetrahedrite mineral-based thermoelectric materials are not just promising -they are a lap towards a sustainable future.
We’re excited to share updates on our ongoing activities, our
synergistic collaborations with the EHRASE cluster and THERMOS project, and insightful technical information on thermoelectric generators. But that’s not all, join us on the Consortium Tour, where this time SGUDS and IGME-CSIC take centre stage. Plus, don’t miss the insightful interview with Doug Crane from our Scientific Advisory Board, whose expertise enriches our understanding of thermoelectrics.
This edition also features the fascinating adventures of Starty,
exploring the practical uses of thermoelectric devices in a narrative that’s both educational and engaging.
Looking ahead, we eagerly anticipate your visit to the START booth at the upcoming 40th International and 20th European Thermoelectric Conference, ICT/ECT 2024, in Krakow.
We hope this Newsletter serves not only as a source of information but also as an inspiration for continued excellence. Stay connected
with us for more exciting updates from START on our website and social media channels.
25 pages of information about all the topics covered by our project.
You will find first of all a new episode of the Starty comics! Show it to your kids! :-) 4 pages drawn by J. Mascarenhas, that will explain you about our will to substitute tellurium materials in thermoelectric devices.
In the news, you will find some hints that this objective can be achieved. We are working with our sulphide minerals and in the Technical Pill we also tell you something on how to optimise the composition with modelling. We have interviewed another member of the Scientific Advisory Board, Jean-Yves Escabasse of CEA (France), in addition to the updates on other project activities, on project events (our first Annual Meeting in Madrid!) and other dissemination topics. Finally, we present to you two consortium partners to present: ASGMI and GeniCore!
A new study, co-authored by UNU-MERIT, says that Europe outperforms the USA for new start-ups and licence agreements. However, Europe trails the USA for patent applications, licence income and invention disclosures. The European Knowledge Transfer Report 2013 draws on the most geographically diverse survey of knowledge transfer activities in Europe, covering more than 700 organizations in over 30 countries. Researcher Nordine Es-Sadki explains the approach, data and details below. http://www.merit.unu.edu/permalink.php?id=968
This EURELECTRIC report addresses a number of fundamental questions that arise from the integration of distributed generation (DG) and other distributed energy resources (DER) into the energy system:
How can DSOs make the most efficient use of the existing network?
When are new infrastructure and changes in system architecture needed to better
integrate DG and DER?
Which types of system services are needed and how can they be procured?
How can renewable energy sources (RES), DG, and DER contribute to system security?
How should the regulatory framework develop?
Final report National Local service delivery surveyMelody Niwamanya
This national and local service delivery survey was commissioned by the United Nations Development Programme (UNDP) working together with other Development Partners in Lesotho that provide support to the Government’s Deepening Decentralisation Programme (DDP), the European Union (EU) and the United Nations Capital Development Fund (UNCDF). The survey was carried out by Henry H. Kellam III, PhD (FEI), Robert H Muwanga and Melody Niwamanya (EFICON).
The main purpose of the service delivery survey was to provide baseline information about the quality, quantity and accessibility of service delivery in Lesotho. This data is intended to provide a basis for measuring progress as a result of interventions to improve service delivery
EU START PROJECT. START-Newsletter_Issue_4.pdfStart Project
This edition of our Newsletter is a testament to our collective dedication and the exciting progress we’ve achieved.
The completion of our first Periodic Report marks a significant milestone, and the advancements in tetrahedrite mineral-based thermoelectric materials are not just promising -they are a lap towards a sustainable future.
We’re excited to share updates on our ongoing activities, our
synergistic collaborations with the EHRASE cluster and THERMOS project, and insightful technical information on thermoelectric generators. But that’s not all, join us on the Consortium Tour, where this time SGUDS and IGME-CSIC take centre stage. Plus, don’t miss the insightful interview with Doug Crane from our Scientific Advisory Board, whose expertise enriches our understanding of thermoelectrics.
This edition also features the fascinating adventures of Starty,
exploring the practical uses of thermoelectric devices in a narrative that’s both educational and engaging.
Looking ahead, we eagerly anticipate your visit to the START booth at the upcoming 40th International and 20th European Thermoelectric Conference, ICT/ECT 2024, in Krakow.
We hope this Newsletter serves not only as a source of information but also as an inspiration for continued excellence. Stay connected
with us for more exciting updates from START on our website and social media channels.
25 pages of information about all the topics covered by our project.
You will find first of all a new episode of the Starty comics! Show it to your kids! :-) 4 pages drawn by J. Mascarenhas, that will explain you about our will to substitute tellurium materials in thermoelectric devices.
In the news, you will find some hints that this objective can be achieved. We are working with our sulphide minerals and in the Technical Pill we also tell you something on how to optimise the composition with modelling. We have interviewed another member of the Scientific Advisory Board, Jean-Yves Escabasse of CEA (France), in addition to the updates on other project activities, on project events (our first Annual Meeting in Madrid!) and other dissemination topics. Finally, we present to you two consortium partners to present: ASGMI and GeniCore!
Current commercial thermoelectric devices incorporate p-type semiconductor materials that are produced from expensive and rare elements, namely tellurium, which is toxic and predominantly sourced in China. As an alternative approach for the replacement of the tellurium-based p-type semiconductor materials, START proposes a unique technological solution and value-chain based on a “waste material-waste heat to power” methodology. This approach implies the production of sulphide p-type semiconductor materials that will incorporate, amongst others, discarded mining waste sulphides, mainly consisting of the tetrahedrite-tennantite mineral series. Thus, the project concept also includes the stages of material processing, device design and production, testing and validation (Fig. 2). The aim is to produce a TE device reaching TRL6, with the START TE device demonstrated in industrial processes. As a first step, several historical European mining sites have been targeted for collection of tetrahedrite-tennantite minerals, namely: a) Austria: Leogang (Nöckelberg, Barbarastollen) and Schwaz (Sandpocher, Antonihalde, Sigmundhalde), b), Germany: Rammelsberg mine, Bergwerkswohlfahrt mine, c) Portugal: Neves Corvo, Barrigão and Brancanes mines, d) Slovakia: Rožňava mine, e) Spain: La Sierrecilla, El Corriellu, Peña Negra, Torres de Albarracín, Lanteira mines, amongst others. The collected minerals are undergoing processing and will feed the material processing in the upcoming stages.
A vision for permanents magnets PM standardisation activities continuous powder production.
The START project: Creating a
sustainable supply chain for green energy harvesting products by Powder Metallurgy
Welcome to the second issue of the
START project Newsletter! In this issue,
we will share with you some highlights
from our recent events and activities,
and you will learn more about START
with STARTY, our friendly robot that
helps us explain the project scope. We
will also introduce you to the members of our Scientific Advisory
Board (SAB) , who provide us with valuable guidance and feedback
on our work. They are:
- Doug Crane: Chief Technology Officer (CTO) of DTP Thermoelectrics
and former Director of Thermoelectric Engineering at
Alphabet Energy, Inc.
- Jean-Yves Escabasse: Chemical Engineer and Doctor with 40
years of experience in R&D and innovation within several materials
industry sectors.
- Julie Hollis: Secretary General of EuroGeoSurveys (EGS) – The
Geological Surveys of Europe.
We are very grateful for their support and welcome them on this
journey! In this issue, we have an exclusive interview with Julie
Hollis, where she presents the mission and objectives of the
EuroGeoSurveys (EGS) and the contribution to the EU priorities
related with the Green Deal and the EU Action Plan on Critical Raw
Materials (CRM). She also shares her views on the EU’s resilience
towards CRM security and the possible synergies between EGS
and START.
In addition, we have two technical pills for you: one related to the
geology of tetrahedrites (the main mineral used in START) and
another describing the use of powder technology for processing
tetrahedrites into high-performance thermoelectric materials.
Finally, we will take you on a tour around two of our consortium
partners: TEGnology (from Denmark) and RGS Development (from
the Netherlands), both small enterprises that develop innovative
thermoelectric solutions for different sectors.
We hope you enjoy reading this Newsletter and we invite you
to stay tuned for more updates from START on our website and
social media channels.
RECOVER-REFORM-REUSE
for a Sustainable Future.
Welcome to the first issue of
the biannual Newsletter of the
START project ‘RECOVER-REFORMREUSE
for a Sustainable Future’.
The objective of the Newsletter
is not only to provide a summary of the activities and results of the project but also to address a variety of topics related to these activities, such as those related with raw materials sustainability, sustainable energy ecosystems and business-innovation opportunities. The Newsletter is then organized in different sections, some of them will be repeated in every issue. For this first issue we have five sections: a first section dedicated to a general presentation of the START project where we invite you to meet our robot STARTY that, through a comic story, will introduce the project in an readily comprehensible way; a second section called ‘START CHRONICLES’, with news on the
project’s activities; a third section of ‘TECHNICAL PILLS’, where you will have the opportunity to read two short technical documents, one dedicated to Minerals sustainability and another on what are Thermoelectric materials; the fourth section is the ‘CONSORTIUM TOUR’, in which we will introduce each of the START partners, and in this issue you will have the opportunity to learn more about LNEG and SINTEF; the fifth section is the ‘CONTACTS’ area, where you can find how to get in touch with us and how to follow our social media accounts.
Sustainable energy harvesting systems based on innovative mine waste recycling.Start Project
START factsheet (in English).
START project proposes a unique technological solution, based on the conversion of mining waste into materials for waste heat recovery, thus contributing to an efficient use of resources while promoting the use of green energy harvesting through thermoelectrics, in line with the
strategies outlined in the European Green Deal and in the EU Action Plans on Critical Raw Materials and on Circular Economy.
Sistemas sustentáveis de captura de energia baseados numa abordagem inovadora...Start Project
START Eacsheet (in Portuguese)
A mudança climática é um dos maiores desafios enfrentados pela
humanidade. O combate ao aquecimento global depende da rápida implementação de uma transição verde com a qual a União Europeia (UE) está totalmente comprometida por meio do Pacto Ecológico Europeu.
Presentation at Eu-Latin America RM Convention 2022
Presentation given by D. de Oliveira (LNEG), at the EU-Latin America Raw Materials Convention 2022, Santiago de Chile (3-4 November 2022).
SUSTAINABLE ENERGY HARVESTING SYSTEMS BASED ON INNOVATIVE MINE WASTE RECYCLING.
Topic HORIZON-CL4-2021-RESILIENCE-01-07
Building innovative value chains from raw materials to sustainable products.
Innovation Action:
Challenge: to develop innovative and sustainable technology and business
solutions for new high value added and sustainable products with enhanced
functional properties based on the EU produced raw materials.
Focus: on raw materials necessary for the renewable energy ecosystems.
Green energy harvesting aims to supply electricity to electric or electronic systems from an energy source present in
the environment [e.g., thermal energy (thermoelectricity)] without grid connection or utilization of batteries.
Green energy harvesting aims to supply electricity to electric or electronic systems from an energy source present in the environment (e.g., thermal energy (thermoelectricity)) without grid connection or utilisation of batteries. The possibility of using a thermoelectric (TE) device to capture and to directly convert this waste heat into electric power is a very attractive and valuable approach to improve the overall energy efficiency and, thus, promotes a sustainable future.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...
Starty-explains-START.pdf
1. DOI: 10.5281/zenodo.7746441
Co-funded by the European Union. Views and opinions expressed are however those of
the author(s) only and do not necessarily reflect those of the European Union or the Eu-
ropean Health and Digital Executive Agency. Neither the European Union nor the granting
authority can be held responsible for them
Sustainable Energy Harvesting Systems Based on
Innovative Mine Waste Recycling
A Horizon Europe Project
Project: 101058632 (Horizon-CL4-2021-Resilience-01)
Starty explains START
Issue 1
Multilingual edition
March 2023
www.START-HEproject.com