Evaluation of topical bioavailability of clotrimazole using dermato pharmaco ...IJSIT Editor
In this single-dose-one arm, open label two way parallel design, pharmacokinetic study of two
marketed formulations of Clotrimazole using 12 healthy Indian male subjects the pharmacokinetic
parameters of two marketed Clotrimazole topical formulations were compared . Marketed Clotrimazole
topical formulations (A & B) were applied on the pre-marked forearms of the subjects as per the dosing
schedule. Treatment sample B was used as a reference sample. Subjects received treatment A & treatment B
on both the arms simultaneously, following open label two way parallel design. Skin Stratum Corneum
samples were collected in sterile glass test tubes during the study period. The samples were collected predose and at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, & 6.0 hours post-dose application. The Stratum Corneum samples were
analysed for Clotrimazole concentrations only. Pharmacokinetic parameters of Clotrimazole were calculated
as Cmax, tmax, AUC (0-t) and AUC (0-∞) Clotrimazole was estimated in Stratum Corneum using a validated
Spectroscopic method. If the point estimate of the geometric mean ratio and the confidence intervals for the
entire log transformed pharmacokinetic parameters [Cmax, AUC (0-t) and AUC (0-∞)] were entirely included
in the range of 80-125%, then the treatments were claimed to be bio-equivalent.
In this book Huzur Faiz e Millat Alaeh Rehma has written about almost all the matters from the death of a person till he is buried in the grave. A great number of Qura'anic verses and Hadiths have been collected as reference. اس رسالے میں حضور فیض ملت علیہ الرحمہ نے موت سے قبر تک کے معمالات بیان فرمائیں ہیں نیز دین میں اس کے صحیح طریقے کی طرف توجہ دلائی ہے اور یہ بھی بتایا ہے کہ ہمارا عقیدہ اس سے متعلق کیا ہونا چاہیئے
Evaluation of topical bioavailability of clotrimazole using dermato pharmaco ...IJSIT Editor
In this single-dose-one arm, open label two way parallel design, pharmacokinetic study of two
marketed formulations of Clotrimazole using 12 healthy Indian male subjects the pharmacokinetic
parameters of two marketed Clotrimazole topical formulations were compared . Marketed Clotrimazole
topical formulations (A & B) were applied on the pre-marked forearms of the subjects as per the dosing
schedule. Treatment sample B was used as a reference sample. Subjects received treatment A & treatment B
on both the arms simultaneously, following open label two way parallel design. Skin Stratum Corneum
samples were collected in sterile glass test tubes during the study period. The samples were collected predose and at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, & 6.0 hours post-dose application. The Stratum Corneum samples were
analysed for Clotrimazole concentrations only. Pharmacokinetic parameters of Clotrimazole were calculated
as Cmax, tmax, AUC (0-t) and AUC (0-∞) Clotrimazole was estimated in Stratum Corneum using a validated
Spectroscopic method. If the point estimate of the geometric mean ratio and the confidence intervals for the
entire log transformed pharmacokinetic parameters [Cmax, AUC (0-t) and AUC (0-∞)] were entirely included
in the range of 80-125%, then the treatments were claimed to be bio-equivalent.
In this book Huzur Faiz e Millat Alaeh Rehma has written about almost all the matters from the death of a person till he is buried in the grave. A great number of Qura'anic verses and Hadiths have been collected as reference. اس رسالے میں حضور فیض ملت علیہ الرحمہ نے موت سے قبر تک کے معمالات بیان فرمائیں ہیں نیز دین میں اس کے صحیح طریقے کی طرف توجہ دلائی ہے اور یہ بھی بتایا ہے کہ ہمارا عقیدہ اس سے متعلق کیا ہونا چاہیئے
This book is one of the master pieces of Huzur Faiz e Millat Alaeh Rehma. In this book, he has written the history of infrastructural development of the holy Kaaba (The House of Allah Almighty). اس رسالے میں حضور فیض ملت علیہ الرحمہ نے خانہ کعبہ کی تعمیر مختصر مگر دلچسپ پیرائے میں بیان فرمائی ہے
Preparation and evaluation of kollidon sr matrix tablets of tinidazole for co...IJSIT Editor
Amoebiasis is an infection of the large intestine caused by Entamoeba histolytica, and it is mainly
present in the intra-intestinal lumen. The efficient treatment of amoebiasis and other colonic infections could
be achieved by targeting the drug to the colon. Tinidazole is the drug of choice for intestinal amoebiasis and
other colonic infections and the best approach for this drug is to target the drug to the colon which would
make the drug effective with low dose and prevent the potential hazards observed in conventional dose.
Moreover, addition of suitable polymers in the formulation could enhance the drug solubility. The aim of the
present investigation was to formulate matrix formulations using different concentrations of Kollidon SR and
PVP K-30, Eudragit S100 to prevent the premature drug release in the GI tract, the matrix formulations
further taken for compression to test the suitability for targeted drug delivery to the colon. The release
kinetics of the formulations was calculated. All the Matrix, compression coated formulations showed the
desired physicochemical properties as per the official limits. Based on the drug release study in pH 1.2 (0.1N
HCl), Phosphate buffer pH 6.8 and the results showed that among the 9 formulations FE2 and FL3 showed
good dissolution profile to control the drug release respectively.
This book is one of the master pieces of Huzur Faiz e Millat Alaeh Rehman. In this book he has proved one of the beliefs of Ahl e Sunnat Wa Jamma'at inface Islam that Kissing the nails of your thumbs on the name of The Holy Prophet Peace and blessing be upon him is not Bida'ah. اس رسالے میں حضور فیض ملت علیہ الرحمہ نے اہلسنت و جماعت کے ایک عقیدے سرکار علیہ الصلوۃ والسلام کے مبارک نام پر انگوٹھے چوم کر آنکھوں سے لگانے کا دفاع کیا ہے اورمستند حوالوں سے اس کو جائز ثابت کیا ہے۔ اور گمراہ فرقوں کے اہلسنت پر اعتراض کو غلط اور بے بنیاد ثابت کیا ہے
کیا فرماتے ہیں علمائے دین اس مسئلے میں کہ سرورکائنات فخر موجودات رسول خدا محمدمصطفی صلی اللہ تعالٰی علیہ وآلہٖ وسلم کے ماں باپ آدم علٰی نبینا وعلیہ السلام تک مومن تھے یا نہیں؟بینوا توجروا۔(عہ۱) (بیان کرو اجر پاؤگے ۔ت)
This book is one of the master pieces of Huzur Faiz e Millat Alaeh Rehma. In this book, he has written the history of infrastructural development of the holy Kaaba (The House of Allah Almighty). اس رسالے میں حضور فیض ملت علیہ الرحمہ نے خانہ کعبہ کی تعمیر مختصر مگر دلچسپ پیرائے میں بیان فرمائی ہے
Preparation and evaluation of kollidon sr matrix tablets of tinidazole for co...IJSIT Editor
Amoebiasis is an infection of the large intestine caused by Entamoeba histolytica, and it is mainly
present in the intra-intestinal lumen. The efficient treatment of amoebiasis and other colonic infections could
be achieved by targeting the drug to the colon. Tinidazole is the drug of choice for intestinal amoebiasis and
other colonic infections and the best approach for this drug is to target the drug to the colon which would
make the drug effective with low dose and prevent the potential hazards observed in conventional dose.
Moreover, addition of suitable polymers in the formulation could enhance the drug solubility. The aim of the
present investigation was to formulate matrix formulations using different concentrations of Kollidon SR and
PVP K-30, Eudragit S100 to prevent the premature drug release in the GI tract, the matrix formulations
further taken for compression to test the suitability for targeted drug delivery to the colon. The release
kinetics of the formulations was calculated. All the Matrix, compression coated formulations showed the
desired physicochemical properties as per the official limits. Based on the drug release study in pH 1.2 (0.1N
HCl), Phosphate buffer pH 6.8 and the results showed that among the 9 formulations FE2 and FL3 showed
good dissolution profile to control the drug release respectively.
This book is one of the master pieces of Huzur Faiz e Millat Alaeh Rehman. In this book he has proved one of the beliefs of Ahl e Sunnat Wa Jamma'at inface Islam that Kissing the nails of your thumbs on the name of The Holy Prophet Peace and blessing be upon him is not Bida'ah. اس رسالے میں حضور فیض ملت علیہ الرحمہ نے اہلسنت و جماعت کے ایک عقیدے سرکار علیہ الصلوۃ والسلام کے مبارک نام پر انگوٹھے چوم کر آنکھوں سے لگانے کا دفاع کیا ہے اورمستند حوالوں سے اس کو جائز ثابت کیا ہے۔ اور گمراہ فرقوں کے اہلسنت پر اعتراض کو غلط اور بے بنیاد ثابت کیا ہے
کیا فرماتے ہیں علمائے دین اس مسئلے میں کہ سرورکائنات فخر موجودات رسول خدا محمدمصطفی صلی اللہ تعالٰی علیہ وآلہٖ وسلم کے ماں باپ آدم علٰی نبینا وعلیہ السلام تک مومن تھے یا نہیں؟بینوا توجروا۔(عہ۱) (بیان کرو اجر پاؤگے ۔ت)