Gestão da Qualidade em Clínicas de Reprodução Humana AssistidaFabiola Bento
Este documento discute a gestão da qualidade em clínicas de reprodução humana assistida. Ele aborda conceitos-chave como qualidade, controle da qualidade, garantia da qualidade, melhoria da qualidade e gestão da qualidade. O documento também explica os requisitos básicos de um sistema de gestão da qualidade, incluindo controle de documentos, registros, auditorias internas e ações corretivas e preventivas.
The perfect integration between Lab SOP and clinical strategySandro Esteves
Standard operating procedures (SOPs) are needed in assisted reproductive technology (ART) clinics to standardize complex lab tasks and prevent errors. The document discusses how to develop SOPs that integrate both the clinical and lab perspectives. Key points include determining tests based on clinical needs, writing SOPs that provide information for clinical decisions, and effective communication between clinics and labs to determine the best strategies for patients. Developing SOPs requires considering what information doctors need from lab results and how to handle abnormal values. SOPs must also address specific clinical questions and allow clinicians to make informed decisions.
Gestão da Qualidade em Clínicas de Reprodução Assistida - 2013Fabiola Bento
O documento discute a importância da gestão da qualidade em clínicas de reprodução humana assistida. Resume os principais pontos da apresentação como: 1) A qualidade deve ser focada no atendimento às necessidades dos pacientes de forma individualizada e com tratamentos personalizados. 2) Um sistema de gestão da qualidade bem estruturado requer trabalho em equipe, liderança comprometida e melhoria contínua. 3) Os requisitos básicos incluem controle de documentos, registros, auditorias internas e ações corretivas.
This document discusses the management of non-obstructive azoospermia (NOA). It begins by defining NOA and providing statistics on prevalence. It then discusses the process of diagnosing NOA, including semen analysis and differential diagnosis. Etiologies of NOA including congenital and acquired causes are presented. Key points are made about selecting candidates for sperm retrieval based on etiology, biomarkers and genetic screening. Interventions prior to sperm retrieval for men with NOA and hypogonadism or clinical varicocele are discussed. The importance of proper laboratory handling of surgically extracted gametes is also mentioned. Overall, the document provides an overview of evaluating and managing men with NOA.
Gestão da Qualidade em Clínicas de Reprodução Humana AssistidaFabiola Bento
Este documento discute a gestão da qualidade em clínicas de reprodução humana assistida. Ele aborda conceitos-chave como qualidade, controle da qualidade, garantia da qualidade, melhoria da qualidade e gestão da qualidade. O documento também explica os requisitos básicos de um sistema de gestão da qualidade, incluindo controle de documentos, registros, auditorias internas e ações corretivas e preventivas.
The perfect integration between Lab SOP and clinical strategySandro Esteves
Standard operating procedures (SOPs) are needed in assisted reproductive technology (ART) clinics to standardize complex lab tasks and prevent errors. The document discusses how to develop SOPs that integrate both the clinical and lab perspectives. Key points include determining tests based on clinical needs, writing SOPs that provide information for clinical decisions, and effective communication between clinics and labs to determine the best strategies for patients. Developing SOPs requires considering what information doctors need from lab results and how to handle abnormal values. SOPs must also address specific clinical questions and allow clinicians to make informed decisions.
Gestão da Qualidade em Clínicas de Reprodução Assistida - 2013Fabiola Bento
O documento discute a importância da gestão da qualidade em clínicas de reprodução humana assistida. Resume os principais pontos da apresentação como: 1) A qualidade deve ser focada no atendimento às necessidades dos pacientes de forma individualizada e com tratamentos personalizados. 2) Um sistema de gestão da qualidade bem estruturado requer trabalho em equipe, liderança comprometida e melhoria contínua. 3) Os requisitos básicos incluem controle de documentos, registros, auditorias internas e ações corretivas.
This document discusses the management of non-obstructive azoospermia (NOA). It begins by defining NOA and providing statistics on prevalence. It then discusses the process of diagnosing NOA, including semen analysis and differential diagnosis. Etiologies of NOA including congenital and acquired causes are presented. Key points are made about selecting candidates for sperm retrieval based on etiology, biomarkers and genetic screening. Interventions prior to sperm retrieval for men with NOA and hypogonadism or clinical varicocele are discussed. The importance of proper laboratory handling of surgically extracted gametes is also mentioned. Overall, the document provides an overview of evaluating and managing men with NOA.
تيك كير | نظام ادارة مراكز التغذية الصحية والريجيمAtsc Group
نظام متكامل وشامل مبني على أعلى المعايير العالمية لإدارة مراكز التغذية الصحية والريجيم .
جميع الأنظمة الفرعية مترابطة وسهلة التطبيق على سلسلة مراكز أو مركز بغض النظر عن مستوى التعقيد أو حجم العمليات .
يوفر للإدارة العليا كل المعلومات المطلوبة التي تؤدي إلى نجاحها .
نظام مبني على متغيرات تستطيع تشكيل عمل المراكز بما يتناسب مع المتطلبات الخاصة لكل مركز .
Optimize oocyte yield to maximize live birth in ARTSandro Esteves
This document discusses strategies for optimizing ovarian response in ART to maximize live birth rates. It introduces the POSEIDON criteria for stratifying "low prognosis" ART patients based on age, ovarian reserve markers, and number of oocytes retrieved. The target is to retrieve over 15 oocytes to maximize cumulative live birth rates. Personalized gonadotropin protocols and adjuvant therapies can be used to optimize response based on POSEIDON stratification. This includes starting dose, supplementation with LH, and dual stimulation if needed to obtain the estimated number of oocytes for at least one euploid embryo transfer.
Oocyte number, female and male age, and ART outcomes Sandro Esteves
This document summarizes Sandro Esteves' presentation on optimizing ART success through individualizing oocyte retrieval targets based on a patient's age and ovarian reserve. It discusses:
1) The decline in blastocyst euploidy rates with increasing female age and the importance of oocyte quantity and quality for ART success.
2) The Poseidon criteria for stratifying "low prognosis" ART patients based on age and expected oocyte yield.
3) A mathematical model developed to estimate the minimum number of oocytes needed to achieve at least one euploid blastocyst based on a patient's age.
4) How individualizing treatment based on this oocyte target number can maximize ART efficiency
Luteal Phase Support: Key Variables to Achieve Success in ARTSandro Esteves
This document discusses luteal phase support in assisted reproductive technology cycles. It covers:
1. The pathophysiology of the luteal phase defect in stimulated cycles and the role of progesterone supplementation.
2. Different luteal phase support protocols after hCG trigger in fresh embryo transfer cycles, including progesterone alone versus progesterone plus hCG or GnRH agonist.
3. Luteal phase support considerations for frozen embryo transfer cycles, including the type and timing of estrogen and progesterone administration.
Understanding Strategies to Maximize Cumulative Live Birth RateSandro Esteves
1. The document discusses strategies for maximizing success in assisted reproductive technology (ART) treatment by stratifying patients based on factors that influence prognosis, such as age, ovarian reserve markers, and previous response to ovarian stimulation.
2. It introduces the Poseidon criteria for stratifying patients into four groups based on their predicted prognosis: two groups include younger or older patients with a previously suboptimal response, and two groups include those with expected poor ovarian reserve.
3. Stratifying patients according to factors of both oocyte quantity and quality allows for a more individualized treatment approach aimed at obtaining the estimated number of oocytes needed for achieving at least one euploid embryo transfer for each patient.
تيك كير | نظام ادارة مراكز التغذية الصحية والريجيمAtsc Group
نظام متكامل وشامل مبني على أعلى المعايير العالمية لإدارة مراكز التغذية الصحية والريجيم .
جميع الأنظمة الفرعية مترابطة وسهلة التطبيق على سلسلة مراكز أو مركز بغض النظر عن مستوى التعقيد أو حجم العمليات .
يوفر للإدارة العليا كل المعلومات المطلوبة التي تؤدي إلى نجاحها .
نظام مبني على متغيرات تستطيع تشكيل عمل المراكز بما يتناسب مع المتطلبات الخاصة لكل مركز .
Optimize oocyte yield to maximize live birth in ARTSandro Esteves
This document discusses strategies for optimizing ovarian response in ART to maximize live birth rates. It introduces the POSEIDON criteria for stratifying "low prognosis" ART patients based on age, ovarian reserve markers, and number of oocytes retrieved. The target is to retrieve over 15 oocytes to maximize cumulative live birth rates. Personalized gonadotropin protocols and adjuvant therapies can be used to optimize response based on POSEIDON stratification. This includes starting dose, supplementation with LH, and dual stimulation if needed to obtain the estimated number of oocytes for at least one euploid embryo transfer.
Oocyte number, female and male age, and ART outcomes Sandro Esteves
This document summarizes Sandro Esteves' presentation on optimizing ART success through individualizing oocyte retrieval targets based on a patient's age and ovarian reserve. It discusses:
1) The decline in blastocyst euploidy rates with increasing female age and the importance of oocyte quantity and quality for ART success.
2) The Poseidon criteria for stratifying "low prognosis" ART patients based on age and expected oocyte yield.
3) A mathematical model developed to estimate the minimum number of oocytes needed to achieve at least one euploid blastocyst based on a patient's age.
4) How individualizing treatment based on this oocyte target number can maximize ART efficiency
Luteal Phase Support: Key Variables to Achieve Success in ARTSandro Esteves
This document discusses luteal phase support in assisted reproductive technology cycles. It covers:
1. The pathophysiology of the luteal phase defect in stimulated cycles and the role of progesterone supplementation.
2. Different luteal phase support protocols after hCG trigger in fresh embryo transfer cycles, including progesterone alone versus progesterone plus hCG or GnRH agonist.
3. Luteal phase support considerations for frozen embryo transfer cycles, including the type and timing of estrogen and progesterone administration.
Understanding Strategies to Maximize Cumulative Live Birth RateSandro Esteves
1. The document discusses strategies for maximizing success in assisted reproductive technology (ART) treatment by stratifying patients based on factors that influence prognosis, such as age, ovarian reserve markers, and previous response to ovarian stimulation.
2. It introduces the Poseidon criteria for stratifying patients into four groups based on their predicted prognosis: two groups include younger or older patients with a previously suboptimal response, and two groups include those with expected poor ovarian reserve.
3. Stratifying patients according to factors of both oocyte quantity and quality allows for a more individualized treatment approach aimed at obtaining the estimated number of oocytes needed for achieving at least one euploid embryo transfer for each patient.
Role of LH in Controlled Ovarian StimulationSandro Esteves
1) The document discusses the role of LH in controlled ovarian hyperstimulation (COH). It notes that LH plays important roles in folliculogenesis and steroidogenesis.
2) It reviews rationales for LH supplementation in COH, such as lower endogenous LH levels and impaired steroidogenesis in certain patient groups.
3) Studies show LH supplementation can improve outcomes for poor responders and older patients, though effects may depend on the patient subgroup and study design. More research is still needed to determine which specific patient populations benefit most.
Air quality: is it that important? And if so, how to measure and control it?Sandro Esteves
Quality and Risk Management in the IVF Laboratory; Redlara Brasil, Belo Horizonte, 14-15 September 2016
Content:
1.Air quality: is it that important?
2. How to control?
3. How to measure?
Técnicas de Obtencão de Espermatozóides na Azoospermia - Como fazer?Sandro Esteves
This document discusses different techniques for obtaining sperm from men with azoospermia, including:
1) PESA, MESA, TESA, TESE, and Micro-TESE which are used to retrieve sperm from the epididymis or testicles.
2) Micro-TESE has higher sperm retrieval rates compared to conventional TESE, especially for men with non-obstructive azoospermia.
3) Sperm retrieved through Micro-TESE also has higher fertilization rates and live birth rates compared to TESE or techniques for obstructive azoospermia.
O documento discute varicocele e infertilidade masculina. Resume que:
1) Varicocele é causa comum de infertilidade masculina, associada a deterioração dos parâmetros seminais e função testicular;
2) A fisiopatologia envolve hipertermia, hipóxia e estresse oxidativo testicular devido ao refluxo venoso;
3) O tratamento da varicocele, seja cirúrgico ou por embolização, melhora os parâmetros seminais e fertilidade em muitos casos.
1. O documento discute como realizar uma revisão de artigos científicos de forma objetiva e construtiva.
2. São apresentados os objetivos da revisão por pares, as responsabilidades do revisor e dicas sobre como escrever comentários para o editor e autores.
3. O documento fornece diretrizes detalhadas para que os revisores avaliem com qualidade os artigos submetidos prestando um serviço útil aos editores e autores.
Este documento discute conceitos estatísticos importantes para a condução de pesquisas, como poder amostral, escolha do teste estatístico correto, intervalo de confiança e cálculo do tamanho amostral. O documento enfatiza que é crucial escolher o teste estatístico apropriado para o tipo de dados, evitar erros tipo I e II, e justificar o tamanho da amostra utilizada para validar conclusões.
Novel concepts in male factor infertility: clinical and laboratory perspectivesSandro Esteves
Presentation Objectives:
1. Update on the WHO reference values for semen parameters, and understand the role of sperm DNA fragmentation testing to decision-making strategies;
2. Learn how to counsel azoospermic men seeking fertility, and the role of gonadotropin therapy in this infertility condition;
3. Understand the benefits of microsurgery to both sperm retrieval and varicocele treatment;
4. Appraise the role of medical and surgical interventions to infertile men undergoing ART.
Public lecture - Stem Cell and Male InfertilitySandro Esteves
Reproductive Andrology Workshop III
17-21 January 2016 - Kuwait City - KUWAIT
Organized by: Al Jahra Reproductive Medicine Unit - Ministry of Health
Public Lecture - Stem Cell and Male Infertility
1. 实验室SOP与临床策略的完美
契合
Life
Summit
2014—ART
TQM
Forum,CHINA
Sandro
C.
Esteves,MD.,PhD.
Director,
ANDROFERT
Andrology
&
Human
ReproducMon
Clinic
Campinas,
BRAZIL