Christiaan van Gorkum gave a presentation - based on earlier work by Science Based Business from Leiden University - on the history and development of the Leiden Bio Science Park and its companies.

1. Science meets Business café 14 Feb '13
The Leiden (Bio) Science Park in a nutshell
A word of our sponsor...
Want to join the Pre-Incubation Programme of the BioPartner Starters office?
Ask Harmen Jousma (jousma@sbb.leidenuniv.nl) or Carien Stulemeijer (carien@biopartnerleiden.nl)
for more info!
SmB Cafè 14/02/13

2. Goal of the Science meets Business Cafè
Goals
 Meeting place for young professionals in Leiden’s Science & Business
 Keeping you up to date with (future) developments in Leiden
 A place where you can be inspired and where experiences can be shared
Side affects:
 Potentially leading to new opportunities / collaborations
 Potentially making the Leiden area stronger
 Having a monthly drink with your colleagues/peers
SmB Cafè 14/02/13

3. University Research Parks
Definition, adapted from Link and Scott (2006):
Clusters of technology-based companies organizations that locate on or near a
university campus in order to benefit from university’s and each other’s
knowledge base in a particular field

4. Number of organizations
25 years LBSP 100
80
• Start: 1984 60
• Founded by: 40
20
- Leiden University
0
- Leiden City 1983 1988 1993 1998 2003 2008
• Supported by Government Companies
grant Education & Research
• Initiative: Rob Schilperoort, Not-for-profit
Professor of Plant 88 Companies with ≈ 3000 people
Biotechnology 5 Education & Research with ≈
7000 people

5. 14 Feb '13
SmB café

6. At Leiden Bio Science Park

7. 7/10
14 Feb '13
SmB café 7/6

9. Observations
• “Once established, the ongoing performance depends on the
formation of spin-off companies and the arrival of new ones”
(Braunerhjelm (2008), in SCIENCE BUSINESS: How to make clusters happen?)
– Spin-offs: from institutions and companies, on park and elsewhere
– Independent start-ups
– Start of divisions of companies from elsewhere
– Merger/acquisition/joint venture
– Relocation of companies from elsewhere
• Institutional policies, start-up subsidies, incubation, people?

10. Type of Company Entry
Type of entry: Number and type of company entries
% of companies vs % of employees 35
60 30
25
50 20
40 15
10
30 5
0
20
1984-1988 1989-1993 1994-1998 1999-2003 2004-2008
10
startup spin-off merger
0 division start relocation joint venture
startup spin-off division start relocation
companies employees

11. Growth Characteristics
Endogenous vs exogenous
• Endogenous: involves/induced by organizations or people on park
• Exogenous: stemming from elswhere
• 63 % of company entries with 72 % of employees
New vs existing company
• New: new company (start-up, spin-off, joint venture)
• 74% of companies with 25% of employees
New operation vs relocation
• Relocation: 10% of entries with 22% of personnel

12. Some headlines from 2012
In Ovo wins encouragement prize at Herman Wijffels Innovation prize
Published : Thursday, November 15, 2012
Avery Dennison breaks ground on state-of-the-art european head office and R&D center in
the Leiden Area
Published : Wednesday, October 31, 2012
DC Prime moves from Amsterdam to Leiden
Aeon Astron Europe receives a grant of EURO 500,000 for its BioLens project
Published : Wednesday, February 1, 2012
Catexel takes off
Published : Wednesday, January 11, 2012
SmB Cafè 14/02/13

13. 5%
shares
with JnJ
Acquired in
2013 by
Life
Technologies
(USA)
In 2013, merged
with Bactimm-
Farma Holding to
form Sinensis (NL)
Acquired in 2009 by
Cell Signalling
Technologies (USA)

14. Public offer in
2012 by Dr.
Reddy’s
(India)
14/10

15. Acquired in
2011 by
Johnson&John
son (USA)

16. 14 March Spring Season 2013
How non-profit organizations can (and cannot) promote science entrepreneurship
Confirmed: Life Sciences Go Insparco
11 April
Mergers and Acquisitions: the impact of corporate cultures on a successful outcomes
Octoplus Genencor  DuPont Mentor  Janssen Proxy
16 May
From research to business: lessons learned from established companies
Confirmed: BabyBloom CHDR
ToBBB Cosine BAC New Catch
13 June
Eat or be eaten: How to become and stay successful? Or when to sell your research?
Confirmed: In Ovo
Baseclear HAL Allergy Cosine Nalco
SmB Cafè 14/02/13

17. Science meets Business café 14 Feb '13
The Leiden (Bio) Science Park in a nutshell
A word from our sponsor...
Want to join the Pre-Incubation Programme of the BioPartner Starters office?
Contact Harmen Jousma (jousma@sbb.leidenuniv.nl) or Carien Stulemeijer
(carien@biopartnerleiden.nl) for more info!
SmB Cafè 14/02/13

18. 2009:
• HAL Allergy
• NeCEN
2010:
• Accelerator
SmB Cafè 14/02/13

19. 2011:
• HAL Allergy
• NeCEN
2012:
• GGZ Rivierduinen
• Student houses
• Corpus
• Astellas EU HQ
2013:
• CHDR
SmB Cafè 14/02/13

20. SmB Cafè 14/02/13

21. 21/10

22. Service companies on the park:
Proxy: QA, QC, stability testing, assay development, validation
Galapagos: target discovery
Xendo: process development, drug development, validation, RA, GMP,
pharmaceutical engineering, clinical trials, bioanalytical service
Batavia Bioservices: early process development
Octoplus: drug delivery technology
TLC: drug delivery technology
TNO Quality of life: drug development
Millipore/Microsafe: microbiology testing
BaseClear: DNA sequencing, forensic support
CHDR: scientific development clinical trials
BioTop: Regulatory Affairs
ServiceXS: genomics service center

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