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2) Patients who experienced failure of non-sedation ("non-sedation failure") had similar baseline characteristics as those who did not require sedation ("non-sedation success") but had worse clinical outcomes including fewer days without sedation or mechanical ventilation.
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In the present study effect of intrathecal hyperbaric Bupivacaine 0.5% with low doses of Clonidine
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onset of sensory blockade was comparable in all the three groups. The onset of motor blockade was earlier by
about 1.3 mins in Dexmedetomidine group when compared to Clonidine and Fentanyl group. Duration of
sensory blockade was prolonged in Dexmedetomidine group (346mins) when compared to Clonidine (300mins)
and Fentanyl (302mins) group. Time duration of motor blockade was prolonged in Dexmedetomidine group
(269mins) when compared to Clonidine (223mins) and Fentanyl (220mins) group. The haemodynamic
parameters were clinically and statistically insignificant The time of first request for analgesics by the patients
was more in Dexmedetomidine group (250mins) when compared to Clonidine (194mins) and Fentanyl
(189mins) group. The use of intrathecal Dexmedetomidine as an adjuvant to Bupivacaine is an attractive
alternative to Fentanyl or Clonidine for long duration surgical procedures due to its profound intrathecal
anesthetic and analgesic properties combined with minimal side effects.
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This document summarizes key points from a conference on interrelated autoimmune diseases. It discusses the challenges of determining drug efficacy in clinical trials versus effectiveness in real-world use. For psoriasis treatments, clinical trials only provide a short-term view of efficacy, whereas effectiveness looks at long-term outcomes. A study on psoriasis patients found lower response rates in clinical practice than trials. For IBD treatments, combination therapy with immunosuppressants was more effective than monotherapy in one trial. Clinical trials also show the need for continuous high-dose biologic treatment to reduce antibody development and maintain response.
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This document discusses therapeutic drug monitoring (TDM), which refers to measuring drug concentrations in biological fluids to optimize drug therapy. TDM aims to maintain drug levels within the therapeutic window to maximize efficacy and minimize toxicity. It is useful for drugs with a narrow therapeutic index, large inter-individual variability, or in patients with organ dysfunction. Common drugs monitored include digoxin, aminoglycosides, phenytoin, and lithium. Factors like absorption, distribution, metabolism, excretion, drug interactions, and compliance can impact drug levels and require consideration during TDM interpretation. The document outlines the need, suitable/unsuitable drugs, therapeutic ranges, testing methods, and factors affecting TDM.
Tomato Flu ( Pooja R. Mundhe)
This document provides an overview of pharmacovigilance and discusses tomato flu. It defines pharmacovigilance as the science relating to detection, assessment, and prevention of adverse drug reactions. The document outlines the objectives of pharmacovigilance programs in India and ICH guidelines. It also summarizes tomato flu as a new viral disease affecting children under 9, spread through droplets, with symptoms like rash and joint pain. Treatment involves isolation, hygiene, and over-the-counter drugs like ibuprofen. The conclusion emphasizes continued monitoring and drug repurposing in the absence of antivirals or a vaccine for tomato flu.
Advances in pharmacology applied to maxillofacial anaesthesia
1. PONV has a significant impact on patients despite being a minor medical issue, with an incidence of approximately 25%. Risk factors include female gender, previous history, surgery type and anesthetic drugs used.
2. For effective PONV prophylaxis, it is best to reduce baseline risk when possible and use a combination of antiemetic drugs including a steroid, 5-HT3 antagonist, and D2 antagonist for high risk patients.
3. New analgesic drugs and delivery methods show promise, including intravenous paracetamol, COX-2 inhibitors, and opioid-sparing multimodal analgesia techniques. Developments in anesthetic drugs also continue with new propofol formulations and antie
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1. A significant milestone in cancer immunotherapy was the 2010 FDA approval of Provenge for prostate cancer, but most immunotherapies have failed due to low effectiveness.
2. New initiatives aim to better define biomarkers and endpoints to improve cancer immunotherapy trials by accounting for delayed responses and variable immune monitoring results.
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This study evaluated the use of pulsed radiofrequency (PRF) for treating pudendal neuralgia in 7 patients. PRF is a minimally invasive technique that uses radiofrequency energy to modulate nerves without damaging tissue. The average number of PRF treatments was 4.4, and the average duration of pain relief was 11.4 weeks. There were no complications reported. The study concludes that PRF may be an effective and safe treatment for pudendal neuralgia in patients where conservative treatments have not provided adequate relief, but larger controlled studies are still needed.
SciTech Development Testamonial Brochure
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Time for one-person trials.pdf
- Precision medicine requires a different type of clinical trial called N-of-1 trials that focus on individual responses to therapy rather than average responses.
- In N-of-1 trials, extensive data is collected from a single person over time while they receive different treatments to determine what works best for that individual.
- If enough N-of-1 trials are conducted systematically, they can provide useful information about treating subsets of the population and help move medicine towards more personalized treatment based on a person's unique genetic and environmental factors.
Recomendaciones ACR Medios de contraste 2023
This document provides an introduction and overview of the ACR Manual on Contrast Media, including its purpose and goals. It discusses the importance of assessing risks and benefits prior to contrast administration and being prepared to treat potential adverse reactions. The manual aims to assist radiologists in recognizing and managing risks of contrast media through providing guidance on patient screening, premedication, adverse reaction identification and emergency treatment. It emphasizes thorough preparation is needed to ensure safe and effective use of contrast agents for diagnostic imaging examinations.
Estudio NONSEDA.pdf
1) Approximately 40% of patients randomized to a non-sedation strategy in the NONSEDA trial experienced failure of non-sedation and required sedation.
2) Patients who experienced failure of non-sedation ("non-sedation failure") had similar baseline characteristics as those who did not require sedation ("non-sedation success") but had worse clinical outcomes including fewer days without sedation or mechanical ventilation.
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Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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routes of drug administration IN DENTISTRY.Pptx
- 2. PRESENTED BY : DR. AARTI TALWAR JR1 ORAL MEDICINE AND RADIOLOGY
- 4. • Drug (French: Drogue—a dry herb) It is the single active chemical entity present in a medicine that is used for diagnosis, prevention, treatment/cure of a disease. • The WHO (1966) has given a more comprehensive definition—“Drug is any substance or product that is used or is intended to be used to modify or explore physiological systems of pathological states for the benefit of the recipient.
- 7. Factors affecting interindividual variability of drug therapy Abbreviations: AAG, alpha-1-acid glycoprotein; CAM, complementary and alternative medicine DOI:10.1634/theoncologist.12-8-913 Source PubMed
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- 18. sdss
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- 69. • Among the various routes of drug administration, perhaps the least studied is intracerebroventricular (ICV) administration. • This route has been shown to be particularly useful in administering to the central nervous system (CNS) drugs that do not cross the blood- brain barrier readily. • As such, the ICV route is a valuable option for providing therapeutic CNS drug concentrations diseasesto treat patients with CNS infectious and neoplastic . • This route of drug administration also has the advantage of minimizing systemic toxicity. INTRACEREBRAL INJECTION
- 78. • What can happen to a patient if an IV injection is given via IM? • IV injections do pose some risks, such as pain, irritation, and bruising. More severe risks include infections and blood clots. If possible, a person should discuss the potential risks and complications of IV injections with a doctor before receiving treatment in this way.
- 79. We conclude that in our trial, prednisolone mouthwash with antioxidants was seen to be efficacious, safe, and reliable in the management of oral submucous fibrosis. Efficacy of Prednisolone Mouthwash in Management of Grade III Oral Submucous Fibrosis: A Newer Drug Regimen https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524902/
Editor's Notes
- GTN
- DOLOGEL CT
- BOLUS INJECTION= A bolus injection is the rapid administration of a concentrated dose of medication or substance directly into the blood stream