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The document discusses the history and lessons learned from an entrepreneurship venture called SLO Op started by Kristin and Yishai Horowitz in San Luis Obispo, California. It describes how they opened in 2009 with minimal space and have since expanded. Some of their successes include popular events, though one almost caused bankruptcy. The key lessons are to have passion for your purpose, constantly learn, don't quit if passionate, and value relationships over superficial networking.
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Gender stereotypes have historically defined strict boundaries between what roles men and women could occupy in society. However, these stereotypes have been breaking down over time. Women in the 1920s and 1930s paved the way for greater political participation and equality, though progress was difficult given the entrenched attitudes of the time. Today, women have made significant advances and occupy roles like senators, Supreme Court justices, and may someday become president, though full equality has yet to be achieved and stereotypes still influence perceptions and opportunities.
Rak slide show
The document describes a Random Acts of Kindness (R.A.K.) club that brings young people together to perform good deeds and make their school a better place. The club collected 147 toys in 2014 and their motto is about making others smile. The club is for those who want to help others by turning frowns upside down through acts of kindness.
Getting involved at college
Get involved in 1-3 clubs related to your interests that meet regularly, such as monthly, weekly, or biweekly. This allows you to get to know a variety of people while still being actively engaged. Attend organization fairs and introductory club meetings to meet new people easily. Consider rushing a sorority as it provides a built-in social network. However, get involved in things you genuinely enjoy rather than what you think will attract friends or a romantic partner.
Columbus Academy Trouble with Sameness
In some ways, sameness is great - we have same hobbies, we go to the same school, etc. But in what ways does sameness get us into trouble? How does sameness lead to stereotypes, bullying, and other things we don't want to see in the world?
Trouble with sameness
In some ways, sameness is great - we have same hobbies, we go to the same school, etc. But in what ways does sameness get us into trouble? How does sameness lead to stereotypes, bullying, and other things we don't want to see in the world? Learn how appreciating differences and becoming allies to one another can make a difference.
09_19_12_RYLA Presentation- How to Primp Life by Keeyma D. Beckley and Jasmin...
The document describes a book called "How to Primp Life: The Prim and Proper Guide For Young Ladies" written by Jasmine Jones and Keeyma D. Beckley. The book provides advice and guidance for girls ages 8-18 on topics like relationships, self-esteem, decision making, and life goals. It was inspired by the authors' involvement in a youth organization called W.A.I.T. that promotes abstinence and positive decision making. The book is intended to educate and empower young women so they can achieve their dreams.
Network to Love
This document outlines a process for finding love by selecting women from "Wisdom cultures" in countries like Eastern Europe and East Asia. It describes a 6 step process: 1) Selection of women from these cultures, 2) Messaging women on social media, 3) Interacting in a playful and sexual manner, 4) Coordinating in-person meetings, 5) Escalating physically, and 6) Committing through promises or marriage. It emphasizes selecting for "beta" or feminine qualities over beauty alone and avoiding feminist or moralistic women. The goal is for men to find true love through this selection and courtship process.
Sciennes Send a Cow P3 Harvest Appeal 29.9.17
On Friday 29th September 2017 at Assembly, a group of P3 pupils joined Send A Cow Ambassador, Robert Stephens, in presenting how they are taking action as global citizens in support of four of the Sustainable Development Goals.
Our three Primary Three classes are again leading the whole school Harvest Appeal with their Class Teachers and DHT Ms Anstruther, which this year is in support of the Send a Cow charity.
Each child in P3 is producing hand drawn collection envelopes which will be distributed to each of our families. If all our families contribute £1 we will reach a goal of £640 and be able to gift a cow to a family in Africa. Primary Three pupils are taking on different young workforce lead roles for their appeal campaign, such as Communications, Publicity and Finance.
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Primary Three invited everyone to help Make A Difference by supporting their appeal with donations in the envelopes and also contributing to their planned bake sale on Friday 13th October. We wish them great success in their endeavours and thank Robert for his gracious time supporting the children.
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Photoessay2
Gender stereotypes have historically defined strict boundaries between what roles men and women could occupy in society. However, these stereotypes have been breaking down over time. Women in the 1920s and 1930s paved the way for greater political participation and equality, though progress was difficult given the entrenched attitudes of the time. Today, women have made significant advances and occupy roles like senators, Supreme Court justices, and may someday become president, though full equality has yet to be achieved and stereotypes still influence perceptions and opportunities.
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The document describes a Random Acts of Kindness (R.A.K.) club that brings young people together to perform good deeds and make their school a better place. The club collected 147 toys in 2014 and their motto is about making others smile. The club is for those who want to help others by turning frowns upside down through acts of kindness.
Getting involved at college
Get involved in 1-3 clubs related to your interests that meet regularly, such as monthly, weekly, or biweekly. This allows you to get to know a variety of people while still being actively engaged. Attend organization fairs and introductory club meetings to meet new people easily. Consider rushing a sorority as it provides a built-in social network. However, get involved in things you genuinely enjoy rather than what you think will attract friends or a romantic partner.
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In some ways, sameness is great - we have same hobbies, we go to the same school, etc. But in what ways does sameness get us into trouble? How does sameness lead to stereotypes, bullying, and other things we don't want to see in the world?
Trouble with sameness
In some ways, sameness is great - we have same hobbies, we go to the same school, etc. But in what ways does sameness get us into trouble? How does sameness lead to stereotypes, bullying, and other things we don't want to see in the world? Learn how appreciating differences and becoming allies to one another can make a difference.
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The document describes a book called "How to Primp Life: The Prim and Proper Guide For Young Ladies" written by Jasmine Jones and Keeyma D. Beckley. The book provides advice and guidance for girls ages 8-18 on topics like relationships, self-esteem, decision making, and life goals. It was inspired by the authors' involvement in a youth organization called W.A.I.T. that promotes abstinence and positive decision making. The book is intended to educate and empower young women so they can achieve their dreams.
Network to Love
This document outlines a process for finding love by selecting women from "Wisdom cultures" in countries like Eastern Europe and East Asia. It describes a 6 step process: 1) Selection of women from these cultures, 2) Messaging women on social media, 3) Interacting in a playful and sexual manner, 4) Coordinating in-person meetings, 5) Escalating physically, and 6) Committing through promises or marriage. It emphasizes selecting for "beta" or feminine qualities over beauty alone and avoiding feminist or moralistic women. The goal is for men to find true love through this selection and courtship process.
Sciennes Send a Cow P3 Harvest Appeal 29.9.17
On Friday 29th September 2017 at Assembly, a group of P3 pupils joined Send A Cow Ambassador, Robert Stephens, in presenting how they are taking action as global citizens in support of four of the Sustainable Development Goals.
Our three Primary Three classes are again leading the whole school Harvest Appeal with their Class Teachers and DHT Ms Anstruther, which this year is in support of the Send a Cow charity.
Each child in P3 is producing hand drawn collection envelopes which will be distributed to each of our families. If all our families contribute £1 we will reach a goal of £640 and be able to gift a cow to a family in Africa. Primary Three pupils are taking on different young workforce lead roles for their appeal campaign, such as Communications, Publicity and Finance.
Send a Cow Ambassador, Robert Stephens, spoke with passion and eloquence to explain to the children how the charity works with families in Africa to provide training in not only animal husbandry but also in sanitation, irrigation and keyhole farming. He relayed the story of Jennifer whom he had visited in Uganda and saw first hand the huge difference the project had made to her life and that of her family. Jennifer was able not only to provide milk and vegetables for her own family, but could sell surplus at market to pay for tools, medicine and schooling. Perhaps most telling was Robert's final slide which showed that Jennifer had reached such a self-sufficient stage that she was able to purchase an ornamental vase, merely because she 'liked it.'
Primary Three invited everyone to help Make A Difference by supporting their appeal with donations in the envelopes and also contributing to their planned bake sale on Friday 13th October. We wish them great success in their endeavours and thank Robert for his gracious time supporting the children.
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1) Susanna Ma organized a project to raise money to provide free lunches for poor children in China.
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3) This money was donated to an NGO called "Free Lunch for Children" and provided 600 meals for children in need.
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The document provides information about the 2015 ELCA Youth Gathering and the Northeastern Minnesota Synod Journey event. Some key details include:
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- The Synod Journey will take place July 11-19, 2015, with participants staying at Michigan State University and participating in service projects in Lansing before joining the larger ELCA Gathering.
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We are HashtagNYU, the culture team at NYU. Our culture code outlines our core values:
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3) We are highly selective with our team, choosing people who will improve us and take our work seriously.
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Live above the line (bryen)
This document discusses the concept of "living above the line", which means choosing integrity, kindness, respect and good morals in how you treat others. It suggests living above the line can help build your character, make you a better person, and lead to positive outcomes like having a job, goals and friends. In contrast, living below the line through dishonesty or disrespect can damage relationships and trust. The document encourages readers to make the choice to live with good values.
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Nano-gold for Cancer Therapy chemistry investigatory project
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The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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- 1. Entrepreneurship in SLO Kristin and Yishai Horowitz
- 2. We run this
- 4. We ran to the aisle (and away)
- 5. SLO Op started here
- 6. Then we tore it down and built this .
- 7. Then we tore it down and built th
- 8. In 2009, we opened our doors with just this amount of walls.
- 9. Here we are today.
- 10. This is why SLO Op keeps going.
- 11. • Passion • Friends • Sacrifice • Community support • Slow growth • Hard work • Constantly improving • Building relationships
- 12. We are world famous for thi
- 13. And this is well liked!
- 14. This wasn’t as well liked, but we’re bringing it back with new blo
- 15. This may be our most popular event, but we almost went bankru
- 16. We spent years building these trails but only lost money and can’t bring it
- 17. This was our first east coast event.
- 18. • Passion • Risk taking • Making mistakes • Talking to people • Always learning • Forging relationships • Not quitting
- 19. This is why we kept going.
- 21. Entrepreneurship in SLO: • Have a passion and a greater purpose • Keep learning what you need to learn and what other people need from you • Don’t quit if you’re passion’s there at all • Never, ever take for granted the support you have • Forget networking: forge real relationships and keep them tight