This article discusses the history and potential sale of Bausch + Lomb (B+L), a Rochester-based company founded in 1853 through a handshake agreement between John Jacob Bausch and Henry Lomb. The company grew into a successful American business but struggled in the 1990s when "professional managers" prioritized personal gains over the company's long-term vision. After a series of problems including accounting issues, the company was taken private in 2007 by Warburg Pincus. It is now being shopped for sale, which the author argues does not bode well for Rochester due to potential job losses and loss of a Fortune 500 headquarters.