Dr Riccardo Magistroni Nephrologist Contact

Dr Riccardo Magistroni Tel: 059 422-2866
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Divisione di Nefrologia Dialisi e Trapianto Renale , Policlinico di Modena, Università di Modena
1
Dr. Riccardo Magistroni
CURRICULUM VITAE
Date of preparation : 18 October 2015
Personal Data :
Surname: Magistroni
Name: Riccardo
Place of birth: Bologna, Italy
Citizenship Italian
Mail address: Divisione di Nefrologia, Dialisi e Trapianto Renale,
Policlinico di Modena
V.del Pozzo 71
41100 Modena
Telephone: 059 4224135; 4224116; 4224175
Telefax: 059.4222167
E-mail: riccardo.magistroni@unimore.it
WORK EXPERIENCE
July 2014 – until now Assistant Professor, “Dipartimento Chirurgico, Medico, Odontoiatrico e di
Scienze Morfologiche con Interesse Trapiantologico, Oncologico e di Medicina
Rigenerativa” , Division of Nephrology.
University of Modena and Reggio Emilia Modena, Italy
Associate Research Scientist, Department of Internal Medicine, Division of
Nephrology
Columbia University New York, NY
Jan 2005 – June 2014 Assistant Professor with Clinical Integration, “Dipartimento Chirurgico, Medico,
Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico,
Oncologico e di Medicina Rigenerativa”, Division of Nephrology.
Nov 2004 –Dic 2004 Staff Nephrologist, Division of Nephrology
Azienda ospedaliero Universitaria Policlinico di Modena Modena, Italy
TRAINING AND COURSES
July 2014 – Present Columbia University, Department of Medicine New York, NY
Division of Nephrology

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Postdoctoral Research Fellow, Mentor: Ali G. Gharavi. Field:
Nephrology/Genetics.
During this period the researcher worked on the association analysis of rare and
common variants, collected by Genome Wide Exome Sequencing and Exome
Microarray Genotyping, in IgA Nephropathy. Furthermore Dr Riccardo Magistroni
participated to the project of Precision Medicine in Nephrology of the Columbia
University based on Exome Sequencing Technology.
Jan 2002 – Nov 2002 University of Toronto Toronto, Canada
Division of Nephrology, General Hospital
Postdoctoral Research Fellow, Mentor: York Pei. Field : Nephrology/Genetics.
During this period the researcher worked on the genotype – phenotype
correlation of Autosomal Dominant Polycystic Kidney Disease. Furthermore he
contributed to a project of positional cloning by linkage analysis in familial IgA
Nephropathy.
Sep 1999- Oct 2004 University of Modena and Reggio Emilia Modena, Italy
Division of Nephrology
Resident/Fellow in Nephrology
Sep 1993 - Sep1999 University of Modena and Reggio Emilia Modena, Italy
Division of Biochemical, Department of Biomedical Sciences, Mentor. Professor
Sergio Ferrari.
As medical student he learned the main techniques and strategies of research in
molecular biology: PCR, Northern Blot, Southern Blot, Western Blot,
Microsatellites Analysis, DNA Sanger Sequencing.
EDUCATION
Sep 1993 – Sep 1999 University of Modena and Reggio Emilia Modena, Italy
Faculty of Medicine and Surgery
MD degree at University Medical School, Sep 1999
Sep 1988 – Jul 1992 L.A. Muratori Liceo Modena, Italy
High school degree : ‘Maturità Classica’
LICENSURE
Sep 1999 Medical Licence Italy
ADDITIONAL TRAINING AND ADVANCED COURSES
Jun 2015 Genetic Association Course With Application to Sequence and Genotype Data
Max Delbruck Center for Molecular Medicine – Berlin, Germany
Jan 2010- Dic 2010 Advanced Course in “Statistics applied to clinical questions”

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Sep 2006- May2007 Advanced Course in Evidence Based Medicine and Methodology of Health
Research.
April 11-13, 2002: “II Course in genetics and renal disorders”, Sestri Levante (Genova, Italy).
PROFESSIONAL ORGANIZATIONS, SOCIETIES AND SERVICE
Memberships
2013 – 2014: American Society of Nephrology.
2004 – present: Italian Society of Nephrology.
Ad hoc reviewer
2010 – present Journal of Nephrology
FELLOWSHIP AND GRANT SUPPORT
2015 Inhibition of Glycolysis by 2-Deoxy-D-Glucose as a Therapeutic Strategy
for Polycystic KidneyDisease. Phase I Clinical Trial -Year 2015 – project
code RF-2013-02356802. Italian Ministry of Health
Principal Investigator : Dr.Riccardo Magistroni (Istituto San
Raffaele)
Groups Collaborating : Dr.ssa Alessandra Boletta (Istituto San
Raffaele)
Dr. Marco Lenonell (Azienda Ospedaliero
Universitaria Policlinico di Modena)
Dr. Mariano Capistrano (Presidio
Ospedaliero di Montichiari dell'Azienda
Spedali Civili di Brescia)
Total funding : : € 422.516
2008 Autosomal Dominant Polycystic Kidney Disease: from the clinic to the
cellular and molecular analysis: multidisciplinar approach for a diagnostic
and prognostic evaluation. RESEARCH PROJECT -Year 2007 - prot.
2007FJRB7H. Italian Ministry of University and Research
Principal Investigator : Riccardo Magistroni (Università di Modena e
Reggio Emilia)
Groups Collaborating : Maurizio Ferrari (Laboraf, Università Vita-
Salute San Raffaele)

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Alessandra Boletta (Dipartimento di Biologia
Molecolare e Genomica Funzionale,
Ospedale San Raffaele)
Laura del Senno (Dipartimento di Biologia
Molecolare, Università degli Studi di Ferrara)
Total funding : € 164.770
2007 Quantitative and functional analysis of PKD1 and PKD2 gene expressed
proteins: development and validation of a new diagnostic test widely
applicable in clinical practice of Autosomal Dominant Polycystic Kidney
Disease (ADPKD).
Research Program Regione-Università 2007-2009 Area 1a –
Innovative Research
Regione Emilia Romagna, Italy
Principal Investigator : Laura del Senno (Dipartimento di Biologia
Molecolare, Università degli Studi di Ferrara)
Groups Collaborating : Riccardo Magistroni (Università di Modena e
Reggio Emilia)
Luigi Catizone (Divisione di Nefrologia,
Ospedale S’Anna di Ferrara)
Total funding : € 215.000
2004 Membranous glomerulonephritis: researching prognostic factors for
treatment efficacy by urine and renal biopsy proteomic analysis.
RESEARCH PROJECT -Year 2004 - prot. 2004064212. Italian Ministry
of University and Research
COMMERCIAL COLLABORATION
2004 – 2010 Collaboration on clinical trial with Otsuka Pharmaceutical as Principal
Investigator : “A phase 3, Multi-center, Double Blind, Placebo-
controled, Parallel-arm Trial to Determine Long Term Safety and
Efficacy of Oral Tolvaptan Tablet Regimens in Adult Subjects with
Autosomal Dominant Polycystic Kidney Disease” Protocol No. 156-
04-251; EudraCT No. 2006-002768-24
Total turnover : € 126.785,00+IVA
2011 – present Collaboration on clinical trial with Otsuka Pharmaceutical as Principal
Investigator: “Multi-center, Open-label, Extension Study to Evaluate
the Long-term Efficacy and Safety of Oral Tolvaptan Tablet Regimens
in Subjects with Autosomal Dominant Polycystic Kidney Disease
(ADPKD)” Protocol: 156-08-271 ; EudraCT n: 2010-018401-10
Total turnover until now: € 77.253.17 +IVA
2012 – present Collaboration on clinical trial with Otsuka Pharmaceutical as Principal
Investigator: ““A Multi-center, Longitudinal, Observational Study of
Patients with Autosomal Dominant Polycystic Kidney Disease

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(ADPKD) to Establish the Rate, Characteristics, and Determinants of
Disease Progression” Protocol:156-10-291 ;
Total turnover (expected): € 75.000 +IVA
2013 – present member of the Advisory Board for Otsuka Pharmaceutical Europe Ltd
(OPEL) Autosomal dominant polycystic kidney disease Focus Group
4: Dosing and Titration (tolvaptan).
2014 – present member of the Advisory Board for Otsuka Pharmaceutical Italia :
“Gruppo di discussione per la implementazione clinica di Tolvaptan
nel trattamento di ADPKD”
TEACHING EXPERIENCE AND RESPONSIBILITIES
Jan 2005 – present University of Modena and Reggio Emilia Modena, Italy
Medical School
Course of Nephrology
Jan 2005 – present University of Modena and Reggio Emilia Modena, Italy
Nephrology Residency School
Course of Glomerulonephrites and Renal Genetic Diseases
Sep 2012 – Mar 2013 University of Modena and Reggio Emilia Modena, Italy
Glomerular and Renal Genetic Disease Course
Master of Renal Dietistic. Academic Master of level I.
Sep 2011 – present University of Modena and Reggio Emilia Modena, Italy
School of Medical Specialties - Dietistic
Course of Nephrology
Jan 2005 – Aug 2011 University of Modena and Reggio Emilia Modena, Italy
Medical School
Clinical Methodology

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PUBLICATIONS
Original, Peer Reviewed Articles
1. Magistroni R, D'Agati VD, Appel GB, Kiryluk K. New developments in the genetics, pathogenesis, and
therapy of IgA nephropathy. Kidney Int 2015
IF = 8.563
2. Turco D, Severi S, Mignani R, Aiello V, Magistroni R, Corsi C. Reliability of Total Renal Volume
Computation in Polycystic Kidney Disease From Magnetic Resonance Imaging. Acad Radiol 2015
IF = 1.751
3. Vergano L, Loiacono E, Albera R, Coppo R, Camilla R, Peruzzi L, Amore A, Donadio ME, Chiale F, Boido A,
Mariano F, Mazzucco G, Ravera S, Cancarini G, Magistroni R, Beltrame G, Rollino C, Stratta P, Quaglia M,
Bergia R, Cravero R, Cusinato S, Benozzi L, Savoldi S, Licata C. Can tonsillectomy modify the innate and
adaptive immunity pathways involved in IgA nephropathy? J Nephrol 2014
IF = 1.454
4. Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, Fasel D, Lata S, Prakash S, Shapiro S,
Fischman C, Snyder HJ, Appel G, Izzi C, Viola BF, Dallera N, Del Vecchio L, Barlassina C, Salvi E, Bertinetto
FE, Amoroso A, Savoldi S, Rocchietti M, Amore A, Peruzzi L, Coppo R, Salvadori M, Ravani P, Magistroni
R, Ghiggeri GM, Caridi G, Bodria M, Lugani F, Allegri L, Delsante M, Maiorana M, Magnano A, Frasca G,
Boer E, Boscutti G, Ponticelli C, Mignani R, Marcantoni C, Di Landro D, Santoro D, Pani A, Polci R, Feriozzi
S, Chicca S, Galliani M, Gigante M, Gesualdo L, Zamboli P, Battaglia GG, Garozzo M, Maixnerova D, Tesar
V, Eitner F, Rauen T, Floege J, Kovacs T, Nagy J, Mucha K, Paczek L, Zaniew M, Mizerska-Wasiak M,
Roszkowska-Blaim M, Pawlaczyk K, Gale D, Barratt J, Thibaudin L, Berthoux F, Canaud G, Boland A,
Metzger M, Panzer U, Suzuki H, Goto S, Narita I, Caliskan Y, Xie J, Hou P, Chen N, Zhang H, Wyatt RJ,
Novak J, Julian BA, Feehally J, Stengel B, Cusi D, Lifton RP, Gharavi AG. Discovery of new risk loci for IgA
nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet 2014; 46:
1187-1196
IF = 29.352
5. Corsi C, Mignani R, Turco D, Magistroni R, Severi S. Comment on the paper: 'novel approach to estimate
kidney and cyst volumes using mid-slice magnetic resonance images in polycystic kidney disease'. Am J
Nephrol 2014; 39: 163-164
IF = 2.669
6. Murtas C, Bruschi M, Candiano G, Moroni G, Magistroni R, Magnano A, Bruno F, Radice A, Furci L,
Argentiero L, Carnevali ML, Messa P, Scolari F, Sinico RA, Gesualdo L, Fervenza FC, Allegri L, Ravani P,
Ghiggeri GM. Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy.
Clin J Am Soc Nephrol 2012; 7: 1394-1400
IF = 5.068

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7. Cavazzini F and Magistroni R, Furci L, Lupo V, Ligabue G, Granito M, Leonelli M, Albertazzi A, Cappelli G.
Identification and characterization of a new autoimmune protein in membranous nephropathy by
immunoscreening of a renal cDNA library. PLoS One 2012; 7: e48845
IF = 3.73
8. Magistroni R, Cantu M, Ligabue G, Masellis M, Spisni E, Furci L, Lupo V, Genovese F, Cavazzini F,
Albertazzi A. Interstitial fluid obtained from kidney biopsy as new source of renal biomarkers. J Nephrol
2011; 24: 329-337
IF = 1.703
9. Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He
JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I,
Savoldi S, Magistroni R, Ghiggeri GM, Bodria M, Lugani F, Ravani P, Ponticelli C, Allegri L, Boscutti G,
Frasca G, Amore A, Peruzzi L, Coppo R, Izzi C, Viola BF, Prati E, Salvadori M, Mignani R, Gesualdo L,
Bertinetto F, Mesiano P, Amoroso A, Scolari F, Chen N, Zhang H, Lifton RP. Genome-wide association
study identifies susceptibility loci for IgA nephropathy. Nat Genet 2011; 43: 321-327
IF = 35.532
10. Bruschi M, Carnevali ML, Murtas C, Candiano G, Petretto A, Prunotto M, Gatti R, Argentiero L, Magistroni
R, Garibotto G, Scolari F, Ravani P, Gesualdo L, Allegri L, Ghiggeri GM. Direct characterization of target
podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and
borderline antigens. J Proteomics 2011; 74: 2008-2017
IF = 4.878
11. Papale M, Di Paolo S, Magistroni R, Lamacchia O, De Mattia A, Teresa Rocchetti M, Furci L, Pasquali S, De
Cosmo S, Cignarelli M, Gesualdo L. Urine Proteome Analysis May Allow Non-Invasive Differential
Diagnosis of Diabetic Nephropathy. Diabetes Care 2010
IF = 7.141
12. Magistroni R, Cantu M, Ligabue G, Masellis M, Spisni E, Furci L, Lupo V, Genovese F, Cavazzini F,
Albertazzi A. Interstitial fluid obtained from kidney biopsy as new source of renal biomarkers. J Nephrol
2010
IF = 1.623
13. Liu M, Shi S, Senthilnathan S, Yu J, Wu E, Bergmann C, Zerres K, Bogdanova N, Coto E, Deltas C, Pierides
A, Demetriou K, Devuyst O, Gitomer B, Laakso M, Lumiaho A, Lamnissou K, Magistroni R, Parfrey P,
Breuning M, Peters DJ, Torra R, Winearls CG, Torres VE, Harris PC, Paterson AD, Pei Y. Genetic variation
of DKK3 may modify renal disease severity in ADPKD. J Am Soc Nephrol 2010; 21: 1510-1520
IF = 8.288
14. Limardo M, Imbasciati E, Ravani P, Surian M, Torres D, Gregorini G, Magistroni R, Casellato D, Gammaro
L, Pozzi C. Pregnancy and progression of IgA nephropathy: results of an Italian multicenter study. Am J

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Kidney Dis 2010; 56: 506-512
IF = 5.242
15. Pei Y, Obaji J, Dupuis A, Paterson AD, Magistroni R, Dicks E, Parfrey P, Cramer B, Coto E, Torra R, San
Millan JL, Gibson R, Breuning M, Peters D, Ravine D. Unified criteria for ultrasonographic diagnosis of
ADPKD. J Am Soc Nephrol 2009; 20: 205-212
IF = 7.505
16. Magistroni R, Ligabue G, Lupo V, Furci L, Leonelli M, Manganelli L, Masellis M, Gatti V, Cavazzini F,
Tizzanini W, Albertazzi A. Proteomic analysis of urine from proteinuric patients shows a proteolitic
activity directed against albumin. Nephrol Dial Transplant 2009; 24: 1672-1681
IF = 3.306
17. Brezzi B, Del Prete D, Lupo A, Magistroni R, Gomez-Lira M, Bernich P, Anglani F, Mezzabotta F, Turco A,
Furci L, Ceol M, Antonucci F, Abaterusso C, Bonfante L, D'Angelo A, Albertazzi A, Gambaro G. Primary IgA
nephropathy is more severe in TGF-beta1 high secretor patients. J Nephrol 2009; 22: 747-759
IF = 1.252
18. Paterson AD, Liu XQ, Wang K, Magistroni R, Song X, Kappel J, Klassen J, Cattran D, St George-Hyslop P,
Pei Y. Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility
locus to chromosome 2q36. J Am Soc Nephrol 2007; 18: 2408-2415
IF = 7.111
19. Pereira TV, Nunes AC, Rudnicki M, Magistroni R, Albertazzi A, Pereira AC, Krieger JE. Influence of ACE I/D
gene polymorphism in the progression of renal failure in autosomal dominant polycystic kidney disease:
a meta-analysis. Nephrol Dial Transplant 2006; 21: 3155-3163
IF = 3.154
20. Magistroni R, Furci L, Leonelli M, Masellis M, Ligabue G, Lucchi L, Lupo A, Brezzi B, Gambaro G,
Manganelli L, Pedrazzi G, Ricardi M, Bormioli L, Albertazzi A. A validated model of disease progression in
IgA nephropathy. J Nephrol 2006; 19: 32-40
IF = 1.448
21. Paterson AD, Magistroni R, He N, Wang K, Johnson A, Fain PR, Dicks E, Parfrey P, St George-Hyslop P, Pei
Y. Progressive loss of renal function is an age-dependent heritable trait in type 1 autosomal dominant
polycystic kidney disease. J Am Soc Nephrol 2005; 16: 755-762
IF = 7.240
22. Magistroni R, Manfredini P, Furci L, Ligabue G, Martino C, Leonelli M, Scapoli C, Albertazzi A. Epidermal
growth factor receptor polymorphism and autosomal dominant polycystic kidney disease. J Nephrol
2003; 16: 110-115
IF = 1.025

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23. Magistroni R, He N, Wang K, Andrew R, Johnson A, Gabow P, Dicks E, Parfrey P, Torra R, San-Millan JL,
Coto E, Van Dijk M, Breuning M, Peters D, Bogdanova N, Ligabue G, Albertazzi A, Hateboer N, Demetriou
K, Pierides A, Deltas C, St George-Hyslop P, Ravine D, Pei Y. Genotype-renal function correlation in type 2
autosomal dominant polycystic kidney disease. J Am Soc Nephrol 2003; 14: 1164-1174
IF = 7.499
24. Del Prete D, Gambaro G, Lupo A, Anglani F, Brezzi B, Magistroni R, Graziotto R, Furci L, Modena F,
Bernich P, Albertazzi A, D'Angelo A, Maschio G. Precocious activation of genes of the renin-angiotensin
system and the fibrogenic cascade in IgA glomerulonephritis. Kidney Int 2003; 64: 149-159
IF = 5.302
Chapters of books
1. Furci L, Magistroni R, Albertazzi A. Le Sindromi Renali. Trattato italiano di Medicina Interna 6° edizione.
Teodori, Editor: Universo (2000). pp 829-837
2. P.F. Calmieri, R.Magistroni, A.Albertazzi. Le Nefropatie Glomerulari: glomerulonefriti primitive;
glomerulonefriti secondarie. Trattato di Medicina Interna Vol VII. Malattie del Rene, delle Vie Urinarie e
dell’Apparato Genitale Maschile. Alberto Albertazzi, Massimo Porena. Editore Piccin(2003). pp115-147.
New York, 18 October 2015
Riccardo Magistroni, MD

Dr Riccardo Magistroni Nephrologist Contact

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