1. Yotanna Dalavanga
CURRICULUM VITAE
-2016-
Associate Professor of Anatomy, Histology, and Embryology
Faculty of Medicine, School of Health Sciences
University of Ioannina
Ioannina, 45500, Greece
PERSONAL DATA
Personal Information
Born 15 February 1952 in Athens, Greece; Hellenic Nationality (EU)
Education
1970-1976 Athens Medical School, Greece, Summa cum Laude
1985 MD, University of Ioannina, Greece, Cum Laude; title: “Subclinical
manifestations of autoimmune rheumatic diseases in primary Raynaud's
phenomenon”
1985 Basic Principles of Immunology and Hypersensitivity; 3-month
course at the National Institutes of Health (NIH), Bethesda MD, USA
1985 Molecular and Cellular mechanisms of Immunity; 3-month course at
NIH
1986 Cell biology of Immunity and Inflammation; 3-month course at NIH
June 1990 Vascular Endothelium: Physiological Basis of Clinical Problems;
NATO Advanced Study Institute, Corfu, Greece

2. Languages
Greek, English, French (conversational).
TIME TABLE OF MY PROFESSIONAL ACTIVITIES
1977-1980
Specialised in Pneumonology in the Department of Lung Diseases, of the
University of Athens / Athens “SOTIRIA Lung Diseases Hospital”
1980
Medical Boards examination on pneumonology and nomination as
Pneumonologist.
1981-1983
obligatory service as a physician in the countryside in the Neokaisareia,
Ioannina health centre covered area. [one year service is obligatory, but
one can serve longer at wish]
1981-1983
Collaborating Scientist of the University of Ioannina Internal Medicine
Department
-Bronchoscopy Unit
-respiratory function test unit
-blood gas analysis unit
-immunology laboratory
1984-1986
Postdoctoral position :
National Institutes of Health [ NIH ] , Washington DC, USA
November 1984-August 1986
Fogarty Fellow National Institutes of Health (N.I.H.) Bethesda MD, USA
Immunology and Virology Section, National Eye Institute (N.E.I.)
September 1986-December 1986.

3. Visiting Scientist, Fungal and Mycobacterial Antigens Section,
Food and Drug Administration (FDA), Bethesda MD, USA 1985
Doctoral Thesis Presentation, University of Ioannina, Greece, Medical
School, “Subclinical manifestations of autoimmune rheumatic diseases in
primary Raynaud's phenomenon , “cum laude”
1986-1988
Collaborating Scientist of the University of Ioannina Internal Medicine
Department.
-Bronchoscopy Unit
-respiratory function test unit
-blood gazes analysis unit
-immunology laboratory
-establishment of the cellular immunity manifestations analysis unit -
Collaborating Scientist of the University of Ioannina Anatomy-Histology-
Embryology Department. Participation in the research and educational
activities of the department
1988-1992
Lecturer of Anatomy-Histology-Embryology of the Ioannina University
Medical school [Head of the Anatomy-Histology-Embryology Department,
O.V.Kotoulas, Professor of Anatomy-Histology-Embryology]
1992-1999
Assistant Professor of Anatomy-Histology-Embryology of the Ioannina
University Medical school
1994-1998
Acting Director of the Anatomy-Histology-Embryology Department, in
the absence of Professor Kotoulas, as he was appointed, at that period,
General Director of the “Alaxandra” University Hospital in Athens.
1999
Teniourship in the position of Assistant Professor of Anatomy-Histology-
Embryology of the

4. Ioannina University Medical school [Head of the Department,
O.V.Kotoulas, Professor of Anatomy-Histology-Embryology]
1999-2001
Elected Director of the Anatomy-Histology-Embryology Department, in
the 2 year period between the retirement of Professor Kotoulas and the
election of Dr P.Kanavaros at the position of the Professor of Anatomy
who also supervises Histology and Embryology, and who became
subsequently Head and Director of the Department
2002 to this day
Associated Professor of Anatomy-Histology-Embryology of the Ioannina
University Medical School
2004- 2005
Sabbatical leave
Ruhrland Klinik, Pulmonary Department Bronchoalveolar Lavage laboratory.
Professor Ulrich Costabel. Essen, Germany
POSTDOCTORAL EDUCATIONAL COURSES
1985: Basic Principles of Immunology and Hypersensitivity (3 month
course) N.I.H. Bethesda MD, USA.
1985: Molecular and Cellular mechanisms of Immunity (3 month course)
N.I.H. Bethesda MD, USA.
1986: Cell biology of Immunity and Inflammation (3 month course) N.I.H.
Bethesda MD, USA.
1990: Vascular Endothelium: Physiological Basis of Clinical Problems
(seminar) NATO. Advanced Study Institute. June 18-28, 1990, Corfu,
GREECE

5. RESEARCH INTRESTS
* Bronchoalveolar Lavage / BAL
* Lung immune response, in non occupational asbestos exposure and in
disorders and diseases of the intestitium
* stracture and function of the epithelium
* mesenchymal/epithelial interactions
* pathways of the epithelium response in both innate and acquired immune
mechanisms
RESEARCH WORK / MAIN ISSUES
The main research subject has been the analysis and evaluation of the
material (cells and supernatant fluid) collected through Bronchoalveolar
Lavage / BAL, from patients with various lung disorders.
A considerable work has been done using the BAL cells and fluid from
patients with non occupational exposure to asbestos This work is
considered as a crucial component to the identification of Metsovo Lung,
a lung disorder characterized by pleural calcifications, T4 lymphocytic
alveolitis and high incidence of malignant Mesothelioma.
Farther analysis of that material revealed the electrophoretic patern of
the BAL fluid, a pilot study which led to the more meticulous and
sophisticated proteome analysis of the Metsovo Lung BAL fluid with very
interesting findings.
BAL material has been also used for the evaluation and differential
diagnosis of Sarcoidosis and other interstitial lung diseases.
In the case of Sarcoidosis blood serum from these patient has also been
used in cell cultures, in order to evaluate its effect on the proliferation
rate of A549 and SKMES cell lines, the potential changes in the cytokine
profile and especially the EGFR expression (as EGFR is powerful receptor
in the case of epithelium proliferation and differentiation) and the
potential effect of an EGFR inhibitor in the process.
The BAL material has been also widely used in the evaluation of lung
involvement in autoimmune rheumatic diseases mainly Primary Sjogren
syndrome and the study of its pathogenetic mechanism.

6. Apart from the use of the BAL material as a research tool, its analysis is
always a valuable and in some rare diseases a sole contributor in the
diagnostic procedure, as has been proved during the 30 years of
successful collaboration with the Pulmonary Department of the Ioannina
University Hospital.
TEACHING DUTIES AND ACHIEVEMENTS
1978-1980
Participation in the educational program on pneumonology of the 5th year
Medical students of University of Athens
1981-1983
Teaching Pneumonology in the Ioannina “Hatzikosta” Hospital Nursing
School .
1987-1988
Participation in the educational program of Anatomy-Histology-
Embryology of the 1tst year Medical students of University of Ioannina
1989-to day
Participation in the teaching of chapters of the Respiratory System, in
the context of Pathophyciology, of the 3rd year Medical students of
Ioannina University [UOI]
1988-to day
Independent teaching of the hole bulk of Anatomy-Histology-Embryology
[both Lectures and Laboratory courses], of the 1st and 2nd year Medical
students of Ioannina University [UOI]
The Anatomy-Histology-Embryology Department is obliged to provide the
appropriate education of the 1st and 2nd year of UOI Medical students,
on the above three teaching units.
Histology and Embryology are both included in the same teaching unit
until 2015.
From this year forth, Embryology as a whole constitutes an independent
subject and teaching unit.

7. The number of students since 1988, when there were around 120,
increases steadily and around 1999 we were receiving 150 students per
annum, meaning that the Department had to accommodate and properly
educate around 300 students every year.
Since 2012 we are facing a shocking increase in the number of students
per annum, which has already reached the number of 190. [the laboratory
teaching facilities do not follow with due reflexes]
Teaching hours / week (X13 weeks, minimum, / semester)
-for each of the teaching units and
-for each of the 2 years the students are taking them :
Lectures : 4 hours/week , increased in 6 hours/week since 2002
Laboratory courses : 8 hours/week
The teaching obligations included the teaching of all the aspects of all
three subjects, [lectures and lab couching]
The amount of chapters to be covered was always corresponding to the
number of the members of the Department.
*And here was the catch.

8. In the best case until around 2002 the stuff consisted of 4 people.
[To day the stuff has been reached the number of seven -7- members]
1988-1989 three - 3 - (Prof O.Kotoulas, A.Kotoula, Y.Dalavanga)
1989-1992 four -4- (Prof O.Kotoulas, A.Kotoula, Y.Dalavanga, P.Paulakis)
1992-1994 three - 3 - (Prof O.Kotoulas, Y.Dalavanga, P.Paulakis)
1994-1998 two - 2 -( Y.Dalavanga, P.Paulakis).
1998 [few months of] one -1- (Y.Dalavanga)
1998-1999 four –4- (Prof O.Kotoulas, Y.Dalavanga, Ε..Johnson,
S.Kalamidas)
1999-2000 three – 3- (Y.Dalavanga, Ε..Johnson, S.Kalamidas)
Retirment of Professor O.V.Kotoulas
Elected Director/Teaching Director Yotanna Dalavanga
Since 1998 the Department offers a non obligatory couse as well
“Selected topics of Anatomy-Histology-Embryology” in the 2nd semester.
** 1998-2000.
Teaching Histology in the Biochemistry Department of UOI Medical
School [3 academic years]
2001-2007
Participation in the teaching of Anatomy-Histology-Embryology, according
to the teaching schedule set by the Director of the Department ,
professor P.Kanavaros
2007 - to day
Independent Teaching of Histology II / Embryology II to the 2nd year of
UOI Medical students [lectures, lab courses]

9. In collaboration with Dr S.Kalamidas, Assistant Professor of Anatomy-
Histology-Embryology, we introduced the systematic use of PCs and
digital microscopic samples in the teaching process of Histology II [organ
histology].
As the only members of the Histology II and Embryology II team, we are
fully responsible for the preparation of the teaching material [in oral and
digital form] and its distribution and also for the lectures, the lab
training of the students [constant presence in the lab during every course
-8 hours/week- for further teaching and coaching] and any technical
support concerning the handling of the digital material.
There has been no help from any other person or member of the
Department during this very demanding process of countless hours of
preparation of the digital material.
**with the exception of the invaluable help of Mrs Doussaba, secretary
responsible for the 2nd year students, in the organization of the courses
and their smooth function **
Structure and scope of Histology II :
The teaching procedure consists of lectures and laboratory courses.
1. Lectures / week : Histology II 4 hours / Embryology II 2 hours
2. Laboratory courses 8 hours / week : 2 hours for every student, [8
hours for the teachers]
The students are working in groups of 6-8 individuals.
The course includes both the study of histological specimens on glass
slides under the microscope and of digital material [virtual slides] with
the use of PC, through internet connection with selected sites from top
rate universities, giving free access in their histology material.
The students are obliged to construct an essay, using snap shots of
characteristic areas of the organ under study from the virtual slides, and
label the components of the sample. The essay then is sent to us to be
evaluated and to be returned with comments to the student.

10. Each study group is also involved in the preparation of an essay
concerning the detailed analysis of the structure of an organ, using digital
material and reference sources. The essay is to be presented and be sent
to the teachers, in digital form, at the end of the semester.
The communication with the students, for instructions, comments, or any
other help needed, is constant, either physical, during and lectures, lab
courses and appointed hours in the lab’ area, or virtual through internet
[any time and day]
Their progress control is succeeded through digital examinations at the
end of each teaching unit and a final lab exam at the end of the semester
consistent of testing their ability on recognising the given samples [as a
whole and on details] on both glass slides under the microscope and digital
material. Successful handling of the given material is obligatory for the
participation in the final written exams on the whole subject of Histology
II.
teaching hours / student / week X 13 weeks (min) :
-Lectures 4 hours Histology II / 2 hours Embryology II
-Lab 2 hours
** In the context of providing a better education, a group of volunteers
among students, with a special interest for Histology, has been organized
the ATLAS team. The objective of the team is the creation of an
Histology Atlas using material provided by the Michigan University virtual
slides site, [having first, naturally, secured the permission of the site’s
director]. Every completed chapter, is presented by members of the
ATLAS team, to the students during the respective lab course. Upon
completion the Histology Atlas will be incorporated in the teaching
material of Histology II and uploaded in the Histology II locus of the uoi,
e-course site.

11. The same process, except presently the lab training, is followed for the
teaching/testing of Embryology II.
In Embryology, the students are committed on preparing essays mainly
concerning on a particular organ development, genes, genetic paths and
mediators involved, possible errors during that process and possible
subsequent consequences.
The essays are orally presented in an open hearing and send in digital
form, to be uploaded in the Embryology II locus of the uoi, e-course site.
The teaching material of Histology II and Embryology II, is available
through the uoi, e-course site in the loci of Histology II and Embryology
II respectively, as well as any information concerning subjects of
interest as exams results, self estimation tests, new books, interesting
papers.
[ http://www.uoi.gr e-course : Histology II, Embryology II ]
2007 , 2008 , 2009
HISTOLOGY COURSES –optional--
given for the students of the Department of Biological Applications &
Technologies
Teacher Yotanna Dalavanga
teaching hours 4 / week consisting of lectures and laboratory training
*The lectures cover
- the methods used for the study of cells, tissues and organs under the
microscope.
-the structure, and properties resulted from that precise structure, of
all the tissues of the human body and the way this structure leads to the
special function of each tissue [but also the way a recommended function
could interfere with the structure of a tissue].

12. The teaching material is available through the BAT site
http://www.bat.uoi.gr/
*The lab courses consist of the study of histological samples on glass
slides under the microscope and the identification of the main structural
features of each tissue. The students had also the opportunity to
perform a simple histological staining [H&E] of cells and blood smears
[their own !] on glass slides and study them under the microscope.
For the final exams the students had the choice either to present an
essay on a subject of general interest for their studies, or to construct a
complete three dimensional model of a tissue. [photographed material
available on the site of BAT/UOI]. The models turned to be exceptionally
successful.
According to the students involved, [25, 4th year students / course] and
my personal impression, the course has been successful in the context of
acquired knowledge, team work and fan.
The course, unfortunately, terminated due to objections raised from the
Director of my Department, Dr Kanavaros, concerning the use of the lab’s
teaching equipment from students others than those of the medical
school, for fear of possible damages.
According to my own judgement , that without the lab practice
component, the course would be of no substantial value, it had been
cancelled.
ADMINISTRATIVE AND UNITS ORGANIZING WORK
Setting up clinical and research laboratory units
-1981-1984 participation in the establishment and operation of the
bronchoscopy unit of the pulmonary dept,UOI (dir.Prof
SHConstantopoulos)
-1984 participation in the foundation and operation of the immunology lab
of the internal medicine dept., uoi. (dir. Prof. HMMoutsopoulos)
-1987 foundation of cell culture unit in the immunology lab

13. -1987 establishment of the first laboratory for the study of
bronchoalveolar lavage –BAL-, in Greece, in the Anatomy-Histology-
Embryology dept. (in collaboration with the pulmonary dept) with
research and diagnostic purposes.
-1987 immunocytochemical unit in the Anatomy-Histology-Embryology
Dept
-1994 cell culture unit in the Anatomy-Histology-Embryology dept.
-2000 Opperation in the Anatomy-Histology-Embryology lab of the
Institute of Neurosurgery of UOI and close collaboration with the
Institute on the study of glial and epithelial cell lines in the context of
expression and alterations of innate immunity's markers and pathways
Administrative work
-Since 1992 acting director duties in case of absence of Professor
O.V.Kotoulas,
- 1994 - 1998, acting director of the Department due to the appointment
of Professor O.V.Kotoulas, as General Director of “Alexandra” University
Hospital in Athens
-1999-2001 Elected Director of the Department of Anatomy-Histology-
Embryology, during the time period, between the retirement of professor
O.V.Kotoulas and the election of Dr P.Kanavaros at the position of the
Professor of Anatomy who supervises Histology and Embryology, and who
became subsequently Head and Director of the Department
1988-2001 participation in the administrative bodies of the Medical
School as representative of the the Departmentf Anatomy-Histology-
Embryology.
-In collaboration with Dr P.Pavlakis, assistant professor of the dept. at
the time, reorganisation of the educational structure and function of the
Department of Anatomy-Histology- Embryology, especially after 1998, in
the new building of the Meedical School, in the University campus.

14. -De nono organisation of the laboratory teaching, the small groups of
students being the foundation concept
Participation in the 1st pilot project of the introduction of digital
material in the teaching process through which the lab has been supplied
with the first PVs and software related to all three areas of teaching
[1999]
Acquisition of system of PC / Microscope / digital camera for the
demonstration, on video wall, of the histology specimens the students
were obliged to study under the microscope.
The basic teaching model, set at that time, is still in operation
[improved and extended ]
Since 2007 with the collaboration of the assistant professor Dr
S.Kalamidas, we introduced the use of digital material in the laboratory
exercises, in order to improve our teaching methods and catch up with
the international model of teaching histology [detailed analysis has
already being given].
PARTICIPATION IN CONGRESS ORGANIZATION
Educational Seminars on Pneumonology every 2 years since 1990,
organized by thePneumonology Department of UOI.
-5o International Conference on Bronchoalveolar Lavage, (BAL Task
Group of European Respiratory Society), Corfu 1998.
National congress of thoracic diseases
9TH WASOG MEETING and 11TH BAL INTERNATIONAL
CONFERENCE, Athens June 19-22, 2008

15. PARTICIPATION/SUPERVISING OF DOCTORAL THESIS.
PARTICIPATION IN EVALUATING AND ELECTORAL COMITIES
* Five doctoral theses have being completed under my constant acting
supervision, in the facilities of the Anatomy-Histology-Embryology lab
* participation in the 3 member advisory committee of 16 doctoral
theses, of which 12 have being completed
*participation in the final evaluation 7 member committee of 21 doctoral
theses
**1990-present, member of the electoral body for the
evaluation/election of several members of the Faculty of Anatomy-
Histology-Embryology of Greek Universities.
**participation in the evaluation and election of all the Faculty members
of our Department
*** Since 1990 participation in examination comities for the
acceptance/admittance of students from other universities in our
facilities.
FELLOWSHIPS
1. Ι.Κ.Υ. [National Institute of students awards] award for excellent
performance for the 3rd και 4th year of Medical School
2. Fogarty Fellowship, N.I.H., USA (1985-1987)
AWARDS FOR RESEARCH WORK PRESENTED IN CONGRESSES
*1989 National Congress on thoracic diseases
*1990 EULAR (European League against Rheumatism), στο Χth European
Workshop for Rheumatology Research. Denmark
*1991 National Congress on thoracic diseases *1999 National Congress on
thoracic diseases
*2009 National Congress on thoracic diseases

16. RESEARCH FUNDING
* 1989 Ministry of Research and , for the study of the pathogenetic
mechanisms of primary Sjogren’s Syndrome and Metsivo Lung using
Bronchoalveopar Lavage material . Supervisor Professor HMMoutsopoulos
Collaborators / actual researchers : SHConstantopoulos, YDalavanga
** two research proposals were partially funded from Pharmaceutical
companies
DOCTORAL THESIS
1985 Subclinical manifestations of autoimmune rheumatic diseases in
primary Raynaud' s phenomenon.
CHAPTERS IN BOOKS
*Immune Mechanisms in HMMMoutsopoulos : Autoimmune Reumatic
Diseases. Ed. LITSAS, Athens, 1990
**Translation of the chapter “Pelvis and Rerineum” in K.L. Moore Clinically
Oriented Anatomy. Williams & Wilkins Baltimore, 1992. Geek Ed. Medical
Books PHPaschalidis Athens 1996
***Chapters concerning the Histology and Immune response of the
Respiratory System and Bronchoalveolar Lavage, in special editions of
educational events in the context of continuum Medical Education
BOOKS
1. “Embryology in brief” YDalavanga, VGalani, UOI editions 1999
2. “Histology in brief” for the “Histology” course of Biochemistry, UOI
editions 1999
3. “Histology supplementary notes of the Anatomy-Histology-Embryology
laboratory” UOI editions 1998
4. “Supplement of Histology I and Embryology I” P.Kanavaros,
Y.Dalavanga, S.Kalamidas, V.Galani, A.Charchandi, A.Barbouti. Anatomy-
Histology-Embryology dept, UOI editions 2014