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Respiratory Distress
 Presented By: Dr. Usama Masood
Central Park Teaching Hospital
 Review the initial assessment of patient in
respiratory distress
 Review management of specific causes of
respiratory distress
Upper airway obstruction
Lower airway obstruction
Lung tissue disease
Disordered control of breathing
Objectives
During a busy night, you get the following page:
FYI: Sally, a 2 year old
with PNA had a desat to
88% while on 4L NC.
What do you do next? What initial management steps
would you take?
.
How do you initially
assess a patient in
respiratory distress?
 Rapid assessment
 Quickly determine severity of respiratory condition and stabilize
child
 Respiratory distress can quickly lead to cardiac compromise
 Airway
 Support or open airway with jaw thrust
 Suction and position patient
 Breathing
 Provide high concentration oxygen
 Bag mask ventilation
 Prepare for intubation
 Administer medication ie albuterol, epinephrine
 Circulation
 Establish vascular access: IV/IO
Initial Assesment
History and Physical Exam
History
 Trauma
 Change in voice
 Onset of symptoms
 Associated symptoms
 Exposures
 Underlying medical
conditions
Physical Exam
 Mental status
 Position of comfort
 Nasal flaring
 Accessory muscle use
 Respiratory rate and
pattern
 Auscultation for abnormal
breath sounds
What initial studies
would you get for a
patient in respiratory
distress?
.
 Pulse oximetry
 May be difficult in agitated patient
 May be falsely decreased in very anemic patients
 Imaging
 Chest X Ray
 Consider in patients with focal lung findings or respiratory
distress of a unknown etiology
 Soft tissue radiograph of lateral neck
 May identify a retropharyngeal abscess or radiopaque foreign
body
 Labs
 ABG/VBG
 Chemistry: calculate anion gap
 Urine toxicology and glucose if patient has altered
mental status
Initial studies
What are some
examples of life
threatening conditions?
.
 Complete upper airway obstruction
 No effective air movement, speech or cough
 Respiratory failure
 Pallor or cyanosis, altered mental status, tachypnea,
bradypnea, apnea
 Tension pneumothorax
 Absent breath sounds on affected side, tracheal
deviation and compromised perfusion
 Pulmonary embolism
 Chest pain, tachycardia, tachypnea
 Cardiac tamponade
 Apnea, tachycardia, hypotension, respiratory distress
Life threatening conditions
Specific Causes of Respiratory
Distress
 Upper airway obstruction
 Lower airway obstruction
 Lung tissue disease
 Disordered control of breathing
 Causes: foreign body, tissue edema, trauma, viral infection,
intubation, tongue movement to posterior pharynx with
decreased consciousness
 Symptoms
 Partial obstruction: noisy inspiration (stridor), choking, gagging or
vocal changes
 Complete obstruction: no audible speech, cry or cough
 Management
 Rapidly decide if advanced airway is needed
 Avoid agitation
 Suction only if blood or debris are present
 Reduce airway swelling
 Inhaled epinephrine
 Corticosteroids
 Croup and anaphylaxis require additional management
Upper Airway Obstruction
 Bronchiolitis
 Symptoms: copious nasal secretions, wheezes and
crackles in child less than 2 years
 Management
 Oral or nasal suctioning
 Viral studies, CXR, ABG/VBG
 Trial of nebulized albuterol
 Asthma
 Symptoms: wheezing, tachypnea, hypoxia
 Management
 Mild-moderate: oxygen, albuterol, oral corticosteroids
 Moderate to severe: oxygen, albuterol-ipratropium (Duo-
Neb), corticosteroids (IV), magnesium sulfate
 Impending respiratory failure: oxygen, albuterol-ipratropium,
corticosteroids, assisted ventilation (bag-mask ventilation,
BiPAP, intubation), adjunctive agents (terbutaline,
magnesium sulfate), heliox
Lower Airway Obstruction
Your intern calls you from the bedside of
Jonathan, a 2 year old with Pompe’s
disease who is BiPAP dependent
overnight with settings of 18/5 and a
backup rate of 18. Over the past few
hours, he has had an increase in his
oxygen requirement from an FiO2 of 21 to
40% and has spiked to 39.2. What steps
do you take to evaluate and manage him
overnight?
Case 2
 Etiologies of lung tissue disease
 Infectious pneumonia
 Aspiration pneumonitis
 Non-cardiogenic pulmonary edema (ARDS)
 Cardiogenic pulmonary edema (ARDS)
 Consider positive expiratory pressure (CPAP,
BiPAP or mechanical ventilation with PEEP)
if hypoxemia is refractory to high
concentrations of oxygen
Lung Tissue Disease
 Abnormal respiratory pattern produces inadequate
minute ventilation
 Altered level of consciousness
 Elevated intracranial pressure
 Cushing’s triad
 Poisoning or drug overdose
 Administer specific antidote if available
 Hyperammonemia
 Metabolic acidosis
 Neuromuscular disease
 Restrictive lung disease => atelectasis, chronic pulmonary
insufficiency, respiratory failure
 Support oxygenation and ventilation while treating the
underlying problem
Disordered Control of Breathing
 The initial assessment of a patient in
respiratory distress should be rapid and
focused on quickly determining the
severity of respiratory distress and need
for emergent interventions
 Specific causes of respiratory distress can
be categorized as upper and lower airway
obstruction, lung tissue disease and
disordered control of breathing and require
specific interventions
Take Home Points
Albisett, M. Pathogenesis and clinical manifestations
of venous thrombosis and thromboembolism in
infants and children. June 2010. UpToDate.
Bailey, P. Oxygen delivery systems for infants,
children and adults. May 2010. UpToDate.
Ralston, M.et. al. Pediatric Advanced Life Support
Provider Manual. 2006. American Heart
Association.
Sherman, S.C. and Schindlbeck, M. When is venous
blood gas analysis enough? Emerg Med 38(12):44-
48, 2006
Simons, F. Anaphylaxis: Rapid recognition and
treatment. September 2010. UpToDate.
Weiner, D. Emergent evaluation of acute respiratory
distress in children. May 2010. UpToDate.
References

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RDS Usama.Masood.ppt

  • 1. Respiratory Distress  Presented By: Dr. Usama Masood Central Park Teaching Hospital
  • 2.  Review the initial assessment of patient in respiratory distress  Review management of specific causes of respiratory distress Upper airway obstruction Lower airway obstruction Lung tissue disease Disordered control of breathing Objectives
  • 3. During a busy night, you get the following page: FYI: Sally, a 2 year old with PNA had a desat to 88% while on 4L NC. What do you do next? What initial management steps would you take?
  • 4. . How do you initially assess a patient in respiratory distress?
  • 5.  Rapid assessment  Quickly determine severity of respiratory condition and stabilize child  Respiratory distress can quickly lead to cardiac compromise  Airway  Support or open airway with jaw thrust  Suction and position patient  Breathing  Provide high concentration oxygen  Bag mask ventilation  Prepare for intubation  Administer medication ie albuterol, epinephrine  Circulation  Establish vascular access: IV/IO Initial Assesment
  • 6. History and Physical Exam History  Trauma  Change in voice  Onset of symptoms  Associated symptoms  Exposures  Underlying medical conditions Physical Exam  Mental status  Position of comfort  Nasal flaring  Accessory muscle use  Respiratory rate and pattern  Auscultation for abnormal breath sounds
  • 7. What initial studies would you get for a patient in respiratory distress? .
  • 8.  Pulse oximetry  May be difficult in agitated patient  May be falsely decreased in very anemic patients  Imaging  Chest X Ray  Consider in patients with focal lung findings or respiratory distress of a unknown etiology  Soft tissue radiograph of lateral neck  May identify a retropharyngeal abscess or radiopaque foreign body  Labs  ABG/VBG  Chemistry: calculate anion gap  Urine toxicology and glucose if patient has altered mental status Initial studies
  • 9. What are some examples of life threatening conditions? .
  • 10.  Complete upper airway obstruction  No effective air movement, speech or cough  Respiratory failure  Pallor or cyanosis, altered mental status, tachypnea, bradypnea, apnea  Tension pneumothorax  Absent breath sounds on affected side, tracheal deviation and compromised perfusion  Pulmonary embolism  Chest pain, tachycardia, tachypnea  Cardiac tamponade  Apnea, tachycardia, hypotension, respiratory distress Life threatening conditions
  • 11. Specific Causes of Respiratory Distress  Upper airway obstruction  Lower airway obstruction  Lung tissue disease  Disordered control of breathing
  • 12.  Causes: foreign body, tissue edema, trauma, viral infection, intubation, tongue movement to posterior pharynx with decreased consciousness  Symptoms  Partial obstruction: noisy inspiration (stridor), choking, gagging or vocal changes  Complete obstruction: no audible speech, cry or cough  Management  Rapidly decide if advanced airway is needed  Avoid agitation  Suction only if blood or debris are present  Reduce airway swelling  Inhaled epinephrine  Corticosteroids  Croup and anaphylaxis require additional management Upper Airway Obstruction
  • 13.  Bronchiolitis  Symptoms: copious nasal secretions, wheezes and crackles in child less than 2 years  Management  Oral or nasal suctioning  Viral studies, CXR, ABG/VBG  Trial of nebulized albuterol  Asthma  Symptoms: wheezing, tachypnea, hypoxia  Management  Mild-moderate: oxygen, albuterol, oral corticosteroids  Moderate to severe: oxygen, albuterol-ipratropium (Duo- Neb), corticosteroids (IV), magnesium sulfate  Impending respiratory failure: oxygen, albuterol-ipratropium, corticosteroids, assisted ventilation (bag-mask ventilation, BiPAP, intubation), adjunctive agents (terbutaline, magnesium sulfate), heliox Lower Airway Obstruction
  • 14. Your intern calls you from the bedside of Jonathan, a 2 year old with Pompe’s disease who is BiPAP dependent overnight with settings of 18/5 and a backup rate of 18. Over the past few hours, he has had an increase in his oxygen requirement from an FiO2 of 21 to 40% and has spiked to 39.2. What steps do you take to evaluate and manage him overnight? Case 2
  • 15.  Etiologies of lung tissue disease  Infectious pneumonia  Aspiration pneumonitis  Non-cardiogenic pulmonary edema (ARDS)  Cardiogenic pulmonary edema (ARDS)  Consider positive expiratory pressure (CPAP, BiPAP or mechanical ventilation with PEEP) if hypoxemia is refractory to high concentrations of oxygen Lung Tissue Disease
  • 16.  Abnormal respiratory pattern produces inadequate minute ventilation  Altered level of consciousness  Elevated intracranial pressure  Cushing’s triad  Poisoning or drug overdose  Administer specific antidote if available  Hyperammonemia  Metabolic acidosis  Neuromuscular disease  Restrictive lung disease => atelectasis, chronic pulmonary insufficiency, respiratory failure  Support oxygenation and ventilation while treating the underlying problem Disordered Control of Breathing
  • 17.  The initial assessment of a patient in respiratory distress should be rapid and focused on quickly determining the severity of respiratory distress and need for emergent interventions  Specific causes of respiratory distress can be categorized as upper and lower airway obstruction, lung tissue disease and disordered control of breathing and require specific interventions Take Home Points
  • 18. Albisett, M. Pathogenesis and clinical manifestations of venous thrombosis and thromboembolism in infants and children. June 2010. UpToDate. Bailey, P. Oxygen delivery systems for infants, children and adults. May 2010. UpToDate. Ralston, M.et. al. Pediatric Advanced Life Support Provider Manual. 2006. American Heart Association. Sherman, S.C. and Schindlbeck, M. When is venous blood gas analysis enough? Emerg Med 38(12):44- 48, 2006 Simons, F. Anaphylaxis: Rapid recognition and treatment. September 2010. UpToDate. Weiner, D. Emergent evaluation of acute respiratory distress in children. May 2010. UpToDate. References

Editor's Notes

  1. Respiratory distress: characterized by signs of increased work of breathing stridor wheezing tachypnea and retractions abnormal pattern of respirations Respiratory distress may be due to: an attempt to improve minute ventilation in response to hypoxemia or hypercarbia disordered control of ventilation such as… respiratory depression from opioid overdose or head injury respiratory stimulation from metabolic acidosis, salicylate overdose, or hyperammonemia.
  2. Promptly assess the patient to elicit additional important information: such as the duration of the desaturation, her general appearance and mental status, other signs of respiratory distress such as tachypnea, use of accessory muscles, grunting or flaring If the patient is still hypoxic, what can you do to quickly correct the hypoxia? increase the flow of the nasal cannula OR switch to a new delivery device such as a simple face mask While nasal cannulas can deliver up to 6L/min, flow rates greater than 4L/min are irritating to the nares and therefore switching to a simple face mask may be better tolerated) Optimize the patient’s positioning and Suction away secretions, should they be present Consider a non-rebreather face mask with an increased flow or CPAP Call for backup (such as a supervising resident or hospitalist) Consider a trial of albuterol if wheezing is present Once the patient is stabilized, it may be helpful to obtain a new chest x ray to evaluate for worsening pneumonia or development of an effusion that may have contributed to her acute decompensation.
  3. Stop here. Have group suggest at least two ways they assess patients in respiratory distress. Answers on next slide.
  4. The initial assessment of a child in respiratory distress should be rapid and quickly determine if patient needs emergent interventions and rule out life threatening conditions.
  5. A brief history should be collected initially which should include these important points: A more detailed history can be collected once the child is stabilized When auscultating, listen for: wheezes crackles pleural rub prolonged expiration decreased breath sounds transmitted upper airway sounds
  6. Stop here. Have the group suggest two studies they would like to get for a patient in respiratory distress. Answers on the next slide.
  7. Advantages of VBG include less pain to the patient and ability to draw concurrently with other labs A normal venous pH, pCO2, and HCO3 rules out severe acid base abnormalities A venous pH of > 7.25 predicts an arterial pH of > 7.2 in 98% of cases (Conversely, a venous pH of < 7 predicts an arterial pH of < 7.2 in 98% of cases) A venous pCO2 of > 45 mm Hg is predictive of an arterial pCO2 of > 50 mm Hb Venous blood gasses do not allow adequate determination of the arterial concentration of oxgyen (paO2) and is not as useful to quantify oxygen delivery to target tissues
  8. Stop here. Have the group suggest three life threatening conditions. Answers on the next slide.
  9. Croup Symptoms: barking cough stridor retractions Treatment: Oral or IM dexamethasone Oxygen Keep NPO Nebulized racemic epinephrine with observation for at least 2 hours after treatment Anaphylaxis Symptoms: Stridor or wheezing Dizziness Vomiting or diarrhea Hives or facial swelling Treatment: IM/IV epinephrine Albuterol (if bronchospasm is present) Treat hypotension Diphenhydramine Ranitidine Methylprednisolone
  10. Assisted ventilation for patients with lower airway obstruction should be at a slow rate with adequate expiratory time to decrease the risk of air trapping and complications with high airway pressure including pneumothorax, gastric distension, regurgitation and aspiration.
  11. Patients with neuromuscular disorders and dependence on ventilatory support are at increased risk for development of pneumonia due to their underlying restrictive lung disease and propensity to develop atelectasis. In this patient, the new fever and significant increase in his oxygen requirement is suggestive of pneumonia therefore management should include… Obtaining a chest x ray to evaluate for the presence of an infiltrate If an infiltrate is present, antibiotics should be started promptly Anti-pyretics should be given. Obtain a venous blood gas to evaluate for retention of carbon dioxide Adjustment of the patient’s BiPAP based on the results of the blood gas should include: review of prior blood gasses consultation with the team primarily responsible for managing his BiPAP (likely Pulmonology) If the patient continues to worsen, transferring the patient to the PICU may be appropriate.
  12. For more information regarding specific etiologies of lung tissue disease: Infectious pneumonia Symptoms: fever, tachypnea, hypoxemia, increased work of breathing, crackles or decreased breath sounds Management: Ancillary testing: ABG/VBG, CXR, viral studies, CBC, BCx Antibiotics to treat gram + organisms, consider macrolide coverage Albuterol if wheezing Reduce temperature if febrile Aspiration pneumonia Symptoms: coughing or gagging associated with feeding, more common in children with abnormal neurologic status Management Respiratory support and antibiotics if infiltrate is present on CXR Non-cardiogenic pulmonary edema (ARDS) Symptoms: pulmonary or systemic insult to the alveolar-capillary unit with release of inflammatory mediators Management Correction of hypoxemia Intubate if hypoxemia is refractory to high inspired oxygen concentrations Cardiogenic pulmonary edema Symptoms: fluid accumulation in the lung interstitium due to elevated pulmonary capillary pressure Management Ventilatory support Support cardiovascular function
  13. Disordered control of breathing can be due to elevation of intracranial pressure or depressed level of consciousness due to CNS infection, seizures, metabolic disorders, poisoning or drug overdose.