Q1- Hemochromatosis is a rare autosomal recessive Mendelian disease- Y.docx

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Q1. Hemochromatosis is a rare autosomal recessive Mendelian disease. Y is the recessive disease allele and C is the normal one. In 110 healthy individuals (genotypes: CC or CY ), 20 were carriers (genotype: CY). Assume here that anyone homozygous for Y has the disease. Assuming HWE, answer the following questions. (i) Estimate the allele frequencies for C and Y. [20 marks] (ii) What percentage of people have hemochromatosis due to the genotype YY? [10 marks] .

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Please, answers all my question is for genetic class 3. Describe the pattern of inheritance shown in the pedigree below, giving evidence to support your answer. Give the genotypes for individuals II-2, II-4 and II-2. Include a legend for the symbols used. (10 marks) Describe the pattern of inheritance shown in the pedigree below, giving evidence to support your answer. Give the genotypes for individuals II-4, II-7 and III-7. Include a legend for the symbols used. ( 10 marks) 5. A type of hemophilia is due to an X-linked recessive allele. An affected man whose phenotype has been successfully managed now has children with a woman who is a carrier. Providing a legend for your, answer the following questions: a. What are the genotypes of the mother and father? (1 mark) b. What are the probabilities that i. a child will be affected with hemophilia. ii. a child is a carrier. iii. their daughter is a carrier. iv. their male fetus will be affected. (4 marks) 6. Genes for two different recessive disorders are linked on the X chromosome; they are 26 map units apart. A woman is a carrier for both disorder A and disorder B , with the alleles for these genes in cis. Her husband has normal alleles for both of these genes. The woman is pregnant with their first son. What is the probability (in percent) this son is affected with both disorders? Explain, showing the proportions and types of the woman's gametes and identifying them as parental or recombinant. (5 marks) 7. In certain human matings of albino and black-haired parents, the offspring are always blackhaired. When these black-haired offspring of the different families mate with each other (non-consanguineously) and their children are pooled to get significant data, these are the children's phenotypic proportions: 9 black-haired children 3 brown-haired children 4 albino children a. How many genes are involved in this trait? b. How many alleles of each gene are there? c. What type of gene interaction is occurring for this trait? Describe it. d. What are the genotypes of the initial albino and black-haired parents? Provide a legend. e. What are the genotypes of their offspring (all black-haired)? f. What are the genotypes and the specific proportions of the albino children in the third generation? g. What are the genotypes of the brown-haired children? 8. Which type of chromosomal aneuploidy typically has less severe effects on an individual: sex chromosome aneuploidy or autosomal aneuploidy? Explain why. (4 marks) 9. An organism has six chromosomes in its somatic cells. Determine the number of gametes with different chromosome compositions that this organism can potentially create. Explain your answer, including the genetic basis for your calculation. Ignore the allelic variation created by crossing over. ( 4 marks) 10. Compare the inheritance and transmission of Xlinked genes with that of mitochondrial genes. (4 marks) 11. A woman has a normal number of fingers and toes. She has many relatives with ex.

Please- answers all my question is for genetic class 3- Describe the.docx

Q1- Hemochromatosis is a rare autosomal recessive Mendelian disease- Y.docx

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Q1- Hemochromatosis is a rare autosomal recessive Mendelian disease- Y.docx