Professor Sima Lev - Cell signaling in cancer development and metastasis
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Major Goal: To gain molecular understanding of how breast cancer develops, progresses and spreads.
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Professor Sima Lev - Cell signaling in cancer development and metastasis
- 2. Will be diagnosed with breast cancer in her lifetime https://sites.psu.edu/breastcancerawarenesshub/category/facts/
- 3. ER+, PR+ Luminal A ER+, PR+,HER2- HER2+ HER2+ ER-, PR-,HER2+ Basal-like ER-, PR-,HER2- CK5/6 EGFR+ Normal-like Invasive Ductal Carcinomas ~80% of invasive breast cancer Luminal B ER+, PR+,HER2+ ER-, PR- Nipple Stroma Ducts Terminal duct Lobular units Breast stem cells Gives rise to both basal & luminal Basement Membrane Luminal cells Basal/myoepithelial cells
- 4. Major Goal To gain molecular understanding of how breast cancer develops, progresses and spreads. Major Focus Triple Negative Breast Cancer (TNBC) Major Challenge To identify therapeutic targets & combination therapy for TNBC subtypes
- 6. BD Lehmann et al, JCI, 2011
- 7. BD Lehmann et al, JCI, 2011
- 8. Ongoing projects Signaling Signatures of TNBC subtypes Drug Resistance Combination therapy: Chemotherapy & Targeted therapy Chemo-resistance, cancer stem cells, and Epithelial-Mesenchymal Transition (EMT) Targeted therapy: Focus on PYK2, FAK, AXL and cMet Crosstalk between TNBC and the tumor microenvironment: Focus on tumor associated macrophages (TAM)
Editor's Notes
- Breast cancer is the most prevalent cancer among women; approximately 1.3 million women are diagnosed with breast cancer every year, and about 465,000 die from the disease worldwide Breast cancer is the most prevalent cancer among women, and one of the leading causes of cancer death worldwide. The long-term goal of our studies is to gain a better molecular understanding of how this highly heterogeneous group of diseases develops, progresses and spreads. Part of our efforts is devoted to the identification of signaling molecules that regulate the progression and/or metastasis of breast cancer, and can also be potential targets for breast cancer therapy. We plan to establish a signaling signature for breast cancer subtypes and validate the potential role of signaling intermediates in breast cancer therapy.
- Luminal cells: Respond to hormonal stimulation,For milk production, ER+, PR+/- Basal Epithelia: Contractile cells for milk ejection, ER/PR-
- The long-term goal of our studies is to gain a better molecular understanding of how this highly heterogeneous group of diseases develops, progresses and spreads. Part of our efforts is devoted to the identification of signaling molecules that regulate the progression and/or metastasis of breast cancer, and can also be potential targets for breast cancer therapy. We plan to establish a signaling signature for breast cancer subtypes and validate the potential role of signaling intermediates in breast cancer therapy.