This document discusses a mild version of Grignard reagents that can be used in chemical processes with less waste and lower costs than traditional Grignard reagents. A mild Grignard reagent is developed that uses magnesium metal activated by ultrasound to drive chemical reactions without the need for harsh conditions or toxic alkyl halides. This new reagent offers a more environmentally friendly and economical process for pharmaceutical research and development.

1. Process Driven Research: A Mild
Version of Grignard Reagents
and Its Applications
Li Zhang
Chemical Development
Boehringer Ingelheim Pharmaceuticals, Inc.
Material
WasteCost