New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
presentation
1. Title Page
Guidelines
•You can choose your own design scheme.
•You have Title Page + maximum 7 slides
but you must use the headings below
•Font Pitch miniumum 18 point (this is 28)
•No more than 50 words on any one slide
•No restriction on images, diagrams within
the 7 slide limit
•No animations or links
2. Background
cribed a dominant oscillation of ∼10 Hz, which he termed alpha (Berger, 1929).
ined terms still used today to designate brain activity within specific frequency
), theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz), and gamma (>30 Hz).
• Use Comroe approach i.e. state:
• what we know (scientific literature, your
labs data)
• what we don’t not know (i.e. the main
thrust of your study)
3. Study Objective
• Must have a specific hypothesis
PPI is a reduction in the magnitude of the
startle reflex that occurs when mice are
presented with a non-startling stimulus (a
prepulse) before being presented with the
startling stimulus.
4. Experimental Design and Analysis
• You must specify your main analytical
method(s) and main statistic(s)
5. Anticipated Findings and likely
Interpretation
Postnatal NMDA receptor ablation in corticolimbic interneurons confers
schizophrenia-like phenotypes Juan E Belforte, Nature Neuroscience 13, 76–83
(2010) doi:10.1038/nn.2447 Received22 May 2009 Accepted07 October 2009 Published
online15 November 2009
dysfunction may underlie the
pathophysiology of psychiatric disorders
NMDAR hypofunction theory of
schizophrenia,
ketamine reproduced the theta-to-gamma
shift that has been seen in people with
schizophrenia.
Fig. 2. Mean±S.E.M. is displayed for basal (top) and evoked (bottom) theta
Fig. 3. Mean±S.E.M. is displayed for basal (top) and evoked
power for control (black) and drug (gray) conditions. * P<0.05, ** P<0.005.
(bottom) gamma power for control (black) and drug
(gray) conditions. * P<0.05, ** P<0.005.
7. Anticipated Findings and likely
Interpretation
• Spatiotemporal interaction between pyramidal cells and several classes of
interneuron during network oscillations, shown as a schematic summary of the
main synaptic connections of pyramidal cells (P), PVexpressing basket, axo-
axonic, bistratified, O-LM, and three classes of CCKexpressing interneurons.
usberger, T. & Somogyi, P. (2008) Neuronal diversity and temporal dynamics:
unity of hippocampal circuit operations. Science, 321, 53-57
