This document discusses key factors for successful global e-commerce and online-to-offline businesses. It identifies three main factors: 1) Developing a company culture of open innovation to spark creativity. 2) Localizing the customer experience by tailoring products, services, language and sizing to local markets. 3) Maintaining a strong, consistent global brand identity while allowing for local adaptations. Additional details are provided on external market factors to consider and the importance of partnerships for localization.