This document summarizes a research study on using resistant starch as an alternative strategy to improve vitamin D status in patients with type 2 diabetes. The study found that feeding resistant starch to diabetic rats prevented kidney damage and loss of vitamin D in the urine. Resistant starch maintained serum 25D concentrations in diabetic rats at 41% higher levels compared to a control diet. The conclusion is that resistant starch protects kidney health and maintains vitamin D status in type 2 diabetes.

1. What Is Good About
Resistant Starch?

2. Presenter: Yi Ting Loo
Resistant Starch As An
Alternative Strategy to
Improve Vitamin D
Status in Type 2
Diabetes

3.  Type 2 Diabetes (T2D) & Vitamin D (VD)
 About Resistant Starch
 About Research Study
 Objective
 Methods
 Results
 Conclusion
Agenda

4.  Two forms of VD- 25D & 1,25D
 Kidney is important for VD
 Kidney disease causes low VD status
 Kidney disease is common in T2D
25 D 1,25D
Activate
Relationship Between T2D & VD

5.  A type of fermentable fiber
 Not digested
 Fermented in colon
 Low glycemic food
What Is Resistant Starch (RS)?
Potential for Diabetes
Management

6. What Can RS Help in
Diabetes?

7. Objective of The Study
Prevent loss of VD Maintain serum
25 D concentrations
Zucker Diabetic Fatty Rats
(ZDF)

8. Control Diet
(Cornstarch)
Treatment Diet
(RS)
Lean Control
(LC group)
n= 8
ZDF
(DC group)
n= 8
ZDF
(DRS group)
n= 8
Diet

9.  After 6 weeks of treatment, we collected:
Urine
Blood
Kidney
Sample Collections

10. What we found…

11. Body Weight
LC
DRS
DC

12. 594mg/dL 351mg/dL
41% lower
Fasting Blood Glucose

13. Indications of Kidney Damage
Polyuria
↑ excretion of protein & albumin
↓ excretion of urinary creatinine
RS PREVENT these!

14. Urinary Volume, Protein,
Albumin, Creatinine

15. Urinary Volume, Protein,
Albumin, Creatinine

16. 21% lower
Kidney Damage

17. 41% higher
Serum 25D

18. 89%
lower
97%
lower
Urinary Loss of 25D & 1,25D

19. Conclusion
RS
protect kidney health
maintains VD status in T2D

20.  Gar Yee K, Whitley E, Rowling M, et al. Dietary Resistant Starch Prevents
Urinary Excretion of Vitamin D Metabolites and Maintains Circulating 25-
Hydroxycholecalciferol Concentrations in Zucker Diabetic Fatty Rats. Journal
Of Nutrition [serial online]. November 2014;144(11):1667-1673. Available
from: Academic Search Premier, Ipswich, MA. Accessed February 10, 2015.
References

21. Questions?

22. Thank You!