ppt CBNAAT.ppt

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sunil dhatwalia

xpert

Healthcare

Real Time based Diagnosis :Cartridge based NAAT
(CBNAAT)
• Single-use disposable Cartridge containing all
necessary elements
• Automated sample preparation, amplification &
detection
• Provides results from unprocessed sputum samples
• Digital read outs within 2 hours
• Limit of detection (LOD) of 133 CFU/ml sputum
• Xpert MTB/RIF Ultra: LOD of 10-100 CFU /ml (14)

Specimen Type Sensitivity
(%)
Specificity
(%)
Lymph Node Biopsy 93 (70-99)
98
(all
combined)
Lymph Node FNAC 96 (72-79)
Tissues all types 88 (76-94)
CSF 85 (75-100)
Pleural fluid 34 (24-44)
Other fluid samples
(Pericardial, Ascitic, Synovial)
67 (0-100)
Gastric aspirates 78% (68-85) 99%
Maynard et al. BMJ Inf Dis 2014:14:709
CBNAAT in Non respiratory specimen
• A positive test provides useful confirmation so that ATT can be
started promptly
• A negative test does not always rule out TB

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ppt CBNAAT.ppt

1. Real Time based Diagnosis :Cartridge based NAAT (CBNAAT) • Single-use disposable Cartridge containing all necessary elements • Automated sample preparation, amplification & detection • Provides results from unprocessed sputum samples • Digital read outs within 2 hours • Limit of detection (LOD) of 133 CFU/ml sputum • Xpert MTB/RIF Ultra: LOD of 10-100 CFU /ml (14)

3. Procedure – Xpert MTB/RIF Assay

4. Specimen Type Sensitivity (%) Specificity (%) Lymph Node Biopsy 93 (70-99) 98 (all combined) Lymph Node FNAC 96 (72-79) Tissues all types 88 (76-94) CSF 85 (75-100) Pleural fluid 34 (24-44) Other fluid samples (Pericardial, Ascitic, Synovial) 67 (0-100) Gastric aspirates 78% (68-85) 99% Maynard et al. BMJ Inf Dis 2014:14:709 CBNAAT in Non respiratory specimen • A positive test provides useful confirmation so that ATT can be started promptly • A negative test does not always rule out TB

5. Extra pulmonary TB – Xpert MTB/RIF

Editor's Notes

Some variation observed in sensitivity and specificity between Controlled trials, demonstration studies and evaluation studies
Urine, stool useful in disseminated TB for CBNAAT in HIV and infants. 50% sensitivity found in HIV + in African studies

ppt CBNAAT.ppt

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Editor's Notes