This study analyzed 191 medical emergency calls from an Asian international airline over 12 months to determine the types of in-flight medical issues. The most common were gastrointestinal problems (35.6%), vasovagal syncope (14.6%), and chest pain/palpitations (9.4%). Most issues were treated symptomatically with oxygen and rest. A recommendation to divert the flight occurred in 6 cases involving serious conditions such as heart issues or seizures. The availability of medical professionals on flights was low, with a doctor present in only 14% of cases.